当前位置： SCI文献检索 > JOURNAL OF PERIODONTAL RESEARCH期刊下所有文献 > Basic fibroblast growth factor suppresses tropoelastin gene expression in cultured human periodontal fibroblasts.

Basic fibroblast growth factor suppresses tropoelastin gene expression in cultured human periodontal fibroblasts.

Abstract：

:Growth factors are known to play a major role in the regeneration of the periodontium. Basic fibroblast growth factor (bFGF) is a polypeptide growth factor considered to have a role in chemotaxis and mitogenesis of periodontal ligament (PDL) cells. The aim of this study was to assess the effect of bFGF on the transcription level of tropoelastin. As known controls, we assessed the transcription levels of collagen type I, collagen type II and the housekeeping gene, actin. Initially, PDL cells were cultured without bFGF for 3, 7 and 14 days. At each time point. total RNA was extracted and the levels of transcription were assessed by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) assay. The results showed that tropoelastin mRNA is transcribed in PDL cells and its levels increased from minimal amounts by day 3 to maximal amounts by day 14 of culture. We further examined the effect of the addition of 10 ng/ml bFGF to the culture media by day 14. The results showed that the addition of bFGF suppressed the transcription level of tropoelastin. At that time, as expected, a decrease in collagen type I transcription level was shown, while the transcription level of collagen type III was not affected. The findings that elastin is transcribed in vitro by PDL cells, but only negligibly in vivo, imply mechanisms that downregulate or even shut down the expression of the elastin gene in the functioning PDL. Basic FGF might be one of the cytokines involved in control of elastin expression in vivo.

journal_name

J Periodontal Res

journal_title

Journal of periodontal research

authors

Palmon A,Roos H,Reichenberg E,Grosskop A,Bar Kana I,Pitaru S,Redlich M

doi

10.1034/j.1600-0765.2001.360201.x

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

65-70

issue

2

eissn

0022-3484

issn

1600-0765

journal_volume

36

pub_type

杂志文章

相关文献

JOURNAL OF PERIODONTAL RESEARCH文献大全
  • Crevicular fluid and serum IgG subclasses and corresponding mRNA expressing plasma cells in periodontitis lesions.

    abstract：:Recent reports suggest that specific serum IgG subclasses are a feature of several forms of periodontitis. GCF antibodies are both serum-derived and locally produced by the abundant plasma cells of the diseased periodontal tissue. Previous work has shown that crevicular fluid (GCF) levels of IgG may be reduced in acti...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1997.tb01401.x

    authors： Kinane DF,Takahashi K,Mooney J

    更新日期：1997-01-01 00:00:00

  • Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.

    abstract：BACKGROUND AND OBJECTIVE:This study analyzed the interaction of Porphyromonas gingivalis ATCC 33277 and Aggregatibacter actinomycetemcomitans Y4 with peripheral blood polymorphonuclear neutrophils taken from patients with aggressive periodontitis and chronic periodontitis. MATERIAL AND METHODS:Peripheral blood polymor...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2008.01113.x

    authors： Guentsch A,Puklo M,Preshaw PM,Glockmann E,Pfister W,Potempa J,Eick S

    更新日期：2009-06-01 00:00:00

  • Biochemical comparison of proteolytic enzymes present in rough- and smooth-surfaced capnocytophagas isolated from the subgingival plaque of periodontitis patients.

    abstract：:Four rough-surfaced (R) and three smooth-surfaced (S) clinical isolates of Capnocytophaga obtained from the subgingival plaque of periodontitis patients were studied for their peptidase and protease profiles. The results were compared with those obtained with C. gingivalis (which has a smooth morphology). All cell ext...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1991.tb01621.x

    authors： Söderling E,Mäkinen PL,Syed S,Mäkinen KK

    更新日期：1991-01-01 00:00:00

  • Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures.

    abstract：BACKGROUND AND OBJECTIVE:Tobacco use is associated with increased periodontal destruction in both cigarette smokers and smokeless tobacco users. Gingival keratinocytes are the first cells in contact with microbial and tobacco components and play a key role in the innate immune response to these agents. The objective of...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2009.01262.x

    authors： Johnson GK,Guthmiller JM,Joly S,Organ CC,Dawson DV

    更新日期：2010-08-01 00:00:00

  • Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.

    abstract：BACKGROUND AND OBJECTIVES:In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approa...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12487

    authors： Jager J,Obst K,Lohan SB,Viktorov J,Staufenbiel S,Renz H,Unbehauen M,Haag R,Hedtrich S,Teutloff C,Meinke MC,Danker K,Dommisch H

    更新日期：2018-02-01 00:00:00

  • Fluoridation effects on periodontal disease among adults.

    abstract：:Numerous studies report that water fluoridation reduces caries in children, but little current evidence exists about fluoridation's effects on the periodontal health of adults. To address this issue, we estimated fluoridation effects on periodontal disease among 1066 Washington state employees and their spouses, aged ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1993.tb01065.x

    authors： Grembowski D,Fiset L,Spadafora A,Milgrom P

    更新日期：1993-05-01 00:00:00

  • Periodontal disease and quality of life: Umbrella review of systematic reviews.

    abstract：:This umbrella review appraised existing systematic reviews and meta-analysis to establish the impact of periodontal disease and therapy on general and oral health-related quality of life. A systematic electronic literature search was carried out in accordance with the PRISMA guideline up to January 2020 using PubMed, ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/jre.12805

    authors： Wong LB,Yap AU,Allen PF

    更新日期：2021-01-01 00:00:00

  • Mechanisms involved in the enhancement of osteoclast formation by enamel matrix derivative.

    abstract：BACKGROUND AND OBJECTIVE:Enamel matrix derivative (EMD) is used clinically to promote periodontal tissue regeneration, and it has been reported that EMD can induce the formation of osteoclasts in mouse marrow cultures. In the present study, we investigated the mechanisms of EMD-induced osteoclast formation using a mous...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2005.00868.x

    authors： Itoh N,Kasai H,Ariyoshi W,Harada E,Yokota M,Nishihara T

    更新日期：2006-08-01 00:00:00

  • T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.

    abstract：BACKGROUND AND OBJECTIVE:T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption i...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2008.01083.x

    authors： Yamaguchi M,Ukai T,Kaneko T,Yoshinaga M,Yokoyama M,Ozaki Y,Hara Y

    更新日期：2008-10-01 00:00:00

  • Effect of L-N6-(1-iminoethyl)-lysine, an inducible nitric oxide synthase inhibitor, on murine immune response induced by Actinobacillus actinomycetemcomitans lipopolysaccharide.

    abstract：BACKGROUND AND OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is known to regulate the immune response. The present study was carried out to determine the effect of L-N6-(1-iminoethyl)-lysine (L-NIL), an iNOS inhibitor, on the induction of immune response to Actinobacillus actinomycetemcomitans lipopolysacc...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2006.00925.x

    authors： Sosroseno W,Musa M,Ravichandran M,Fikri Ibrahim M,Bird PS,Seymour GJ

    更新日期：2007-04-01 00:00:00

  • Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients.

    abstract：BACKGROUND:Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2004.00772.x

    authors： Yamazaki K,Honda T,Oda T,Ueki-Maruyama K,Nakajima T,Yoshie H,Seymour GJ

    更新日期：2005-02-01 00:00:00

  • Experimental periodontitis induced by Porphyromonas gingivalis does not alter the onset or severity of diabetes in mice.

    abstract：BACKGROUND AND OBJECTIVE:Diabetes mellitus is believed to increase the risk and severity of periodontitis. However, less evidence is available on the converse effects of periodontitis on diabetes. The objective of the study was to investigate to what degree experimental periodontitis induced by Porphyromonas gingivalis...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12041

    authors： Li H,Yang H,Ding Y,Aprecio R,Zhang W,Wang Q,Li Y

    更新日期：2013-10-01 00:00:00

  • Relation between periodontal disease and arterial stiffness.

    abstract：BACKGROUND AND OBJECTIVE:Periodontal disease has been described as playing a role in the atherosclerosis process, and its relation with intimal thickness and vascular endothelial function (EF) has been investigated. The present study sought to determine whether there are differences in parameters of arterial stiffness ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12376

    authors： Nicolosi LN,Lewin PG,Rudzinski JJ,Pompeo M,Guanca F,Rodríguez P,Gelpi RJ,Rubio MC

    更新日期：2017-02-01 00:00:00

  • The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains.

    abstract：BACKGROUND AND OBJECTIVE:Aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. The level of conservation of cagE, and ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12462

    authors： Johansson A,Claesson R,Höglund Åberg C,Haubek D,Oscarsson J

    更新日期：2017-10-01 00:00:00

  • Diabetes in the dental office: using NHANES III to estimate the probability of undiagnosed disease.

    abstract：BACKGROUND AND OBJECTIVE:Recent data have suggested that in the past 15 years there has been a dramatic increase in the incidence of diabetes mellitus in the USA. However, evidence suggests that approximately one-third of diabetes cases remain undiagnosed. Because 60% of Americans see a dentist at least once per year f...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2007.00983.x

    authors： Borrell LN,Kunzel C,Lamster I,Lalla E

    更新日期：2007-12-01 00:00:00

  • Subcutaneous and continuous administration of lipopolysaccharide increases serum levels of triglyceride and monocyte chemoattractant protein-1 in rats.

    abstract：OBJECTIVES:Previous studies have suggested an association between chronic infection and cardiovascular disease, and combined infection/inflammation is frequently related with hypertriglyceridemia, which may be a risk factor of cardiovascular disease. In fact, experimental transient or intermittent administration of lip...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2004.00716.x

    authors： Uchiumi D,Kobayashi M,Tachikawa T,Hasegawa K

    更新日期：2004-04-01 00:00:00

  • Preconditioning with Porphyromonas gingivalis lipopolysaccharide may confer cardioprotection and improve recovery of the electrically induced intracellular calcium transient during ischemia and reperfusion.

    abstract：BACKGROUND AND OBJECTIVE:Porphyromonas gingivalis lipopolysaccharide (LPS) is a ligand for cell surface toll-like receptors (TLR), TLR2 and TLR4 while stimulation of either leads to cardioprotection. We hypothesized that: (1) pretreatment with P. gingivalis LPS at appropriate concentrations would induce cardioprotectio...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2009.01206.x

    authors： Fan MH,Wong KL,Wu S,Leung WK,Yam WC,Wong TM

    更新日期：2010-02-01 00:00:00

  • Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A.

    abstract：BACKGROUND AND OBJECTIVE:The use of cyclosporine A induces fibrous enlargement of the gingival connective tissue. Existing treatment modalities, although effective, do not necessarily prevent the recurrence of the lesion. Emerging evidence indicates that tanshinone IIA (Tan IIA) could effectively attenuate a variety of...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12335

    authors： Ma S,Liu W,Liu P,Liu J,Chen L,Qin C

    更新日期：2016-10-01 00:00:00

  • Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells.

    abstract：BACKGROUND AND OBJECTIVES:The expression of A Disintegrin and Metalloproteinase 8 (ADAM8) is associated with several inflammatory diseases. Elevated ADAM8 levels have been shown in gingival crevicular fluid of patients with chronic periodontitis. The objective of this study was to investigate ADAM8 expression in chroni...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12426

    authors： Aung WPP,Chotjumlong P,Pata S,Montreekachon P,Supanchart C,Khongkhunthian S,Sastraruji T,Krisanaprakornkit S

    更新日期：2017-06-01 00:00:00

  • Effects of periodontal treatment on inflammation and oxidative stress markers in patients with metabolic syndrome.

    abstract：BACKGROUND AND OBJECTIVE:Metabolic syndrome (MetS) is a combination of risk factors (e.g. impaired glucose tolerance, hypertension, and dyslipidaemia) that significantly contribute to the development of cardiovascular diseases. The aim of the study was to compare the effects of nonsurgical periodontal treatment (NSPT) ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12328

    authors： Torumtay G,Kırzıoğlu FY,Öztürk Tonguç M,Kale B,Calapoğlu M,Orhan H

    更新日期：2016-08-01 00:00:00

  • Expression of endothelin-1 in gingival epithelial cells.

    abstract：OBJECTIVES AND BACKGROUND:Endothelin-1 (ET-1) is a 21-amino acid peptide with multifunctional regulation. ET-1 expresses in various cells during inflammation. The present study aimed to examine the ET-1 expression in oral epithelial cells after infection with the periodontal pathogen and to investigate the presence of ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1034/j.1600-0765.2003.00668.x

    authors： Yamamoto E,Awano S,Koseki T,Ansai T,Takehara T

    更新日期：2003-08-01 00:00:00

  • Ultrastructure of cementogenesis as affected by growth hormone in the molar periodontium of the hypophysectomized rat.

    abstract：:To document the effect of hypophysectomy and growth hormone replacement on the ultrastructure of cementogenesis in the developing rat third molar, 12 female Wistar rats were randomly allocated to normal control, hypophysectomized or hypophysectomized plus human growth hormone (for 10 days) treatment groups. The result...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1994.tb01221.x

    authors： Clayden AM,Young WG,Zhang CZ,Harbrow D,Romaniuk K,Waters MJ

    更新日期：1994-07-01 00:00:00

  • Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis.

    abstract：OBJECTIVES:Reactive oxygen species (ROS) are implicated in the destruction of the periodontium during inflammatory periodontal diseases. The imbalance in oxidant/antioxidant activity may be a key factor in the damaging effects of ROS. This study aimed to determine the lipid peroxidation levels in gingival crevicular fl...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2005.00818.x

    authors： Tsai CC,Chen HS,Chen SL,Ho YP,Ho KY,Wu YM,Hung CC

    更新日期：2005-10-01 00:00:00

  • Common target genes of palatal and gingival fibroblasts for EMD: the microarray approach.

    abstract：BACKGROUND AND OBJECTIVE:Connective tissue grafts are frequently applied, together with Emdogain(®) , for root coverage. However, it is unknown whether fibroblasts from the gingiva and from the palate respond similarly to Emdogain. The aim of this study was therefore to evaluate the effect of Emdogain(®) on fibroblasts...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12186

    authors： Gruber R,Stähli A,Miron RJ,Bosshardt DD,Sculean A

    更新日期：2015-02-01 00:00:00

  • Effect of substance P administration on vascular permeability in the rat oral mucosa and sublingual gland.

    abstract：:Neuropeptides, including substance P (SP) may play a role in neurogenic inflammation. Although SP-immunoreactive (SP-IR) axons are known to be present within the oral mucosa (OM) and salivary glands, the functional significance of SP in oral mucosa and sublingual salivary gland (SLG) is not fully understood. The prese...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1995.tb01271.x

    authors： Györfi A,Fazekas A,Irmes F,Rosivall L

    更新日期：1995-05-01 00:00:00

  • Effect of model fitting artifacts on the stepwise approach to identifying patterns of attachment loss.

    abstract：:The stepwise approach to the determination of periodontal attachment loss involves fitting linear, logarithmic, and exponential models to individual site data and concluding that the form of loss is consistent with the model that has the greatest r-value, provided that the model predicts loss in excess of a site-speci...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1996.tb00458.x

    authors： Cohen ME

    更新日期：1996-01-01 00:00:00

  • A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice.

    abstract：BACKGROUND:A tumor-necrosis factor-alpha (TNF-alpha) antagonist, the WP9QY peptide, was designed based on the crystal structure of the TNF-beta/TNF-receptor complex in order to overcome the disadvantages of macromolecules such as antibodies or soluble receptors by reducing the molecular size of TNF-alpha antagonists. I...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2005.00812.x

    authors： Suzuki Y,Aoki K,Saito H,Umeda M,Nitta H,Baron R,Ohya K

    更新日期：2006-04-01 00:00:00

  • Is self interdental cleaning associated with dental plaque levels, dental calculus, gingivitis and periodontal disease?

    abstract：BACKGROUND AND OBJECTIVE:To ascertain whether interdental cleaning behaviours of Australian adults were associated with lower levels of plaque, gingivitis and periodontal disease. MATERIAL AND METHODS:Data were obtained from the National Survey of Adult Oral Health 2004-06. Outcome variables were three indicators of o...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2011.01420.x

    authors： Crocombe LA,Brennan DS,Slade GD,Loc DO

    更新日期：2012-04-01 00:00:00

  • Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells.

    abstract：BACKGROUND AND OBJECTIVES:Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the effects of methylglyoxal on gingival cells are still poorly unders...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12365

    authors： Retamal IN,Hernández R,González-Rivas C,Cáceres M,Arancibia R,Romero A,Martínez C,Tobar N,Martínez J,Smith PC

    更新日期：2016-12-01 00:00:00

  • Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.

    abstract：BACKGROUND AND OBJECTIVE:CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressi...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12658

    authors： Wang X,Li W,Song W,Xu L,Zhang L,Feng X,Lu R,Meng H

    更新日期：2019-10-01 00:00:00