Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.

abstract：:Volume and amounts of myeloperoxidase (MPO), lactoferrin (LF), aryl sulfatase (AS) and lactate dehydrogenase (LDH) were measured in gingival crevicular fluid (GCF) collected from the mesial and distal proximal surfaces of the premolars and first and second molars of 3 subject groups. Group assignment was based on subj...

journal_title：Journal of periodontal research

authors： Smith QT,Au GS,Freese PL,Osborn JB,Stoltenberg JL

更新日期：1992-09-01 00:00:00

abstract：:A single-blind investigation was designed to study the effects of piroxicam in preventing gingival inflammation and plaque formation in beagle dogs. Twelve 1-year-old beagles were brought to optimum oral hygiene and gingival health. Thereafter, they were fed a moist plaque-promoting diet and were divided into three gr...

journal_title：Journal of periodontal research

authors： Howell TH,Fiorellini J,Weber HP,Williams RC

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Periodontitis is an increasingly prevalent complication of diabetes mellitus (known as diabetes mellitus-associated periodontitis), and 25-hydroxyvitamin D3 (25VD3 ) was recently found to be a critical regulator of innate immunity in this disease, but the underlying mechanisms remain poorly und...

journal_title：Journal of periodontal research

authors： Zhang P,Zhang W,Zhang D,Wang M,Aprecio R,Ji N,Mohamed O,Li Y,Ding Y,Wang Q

更新日期：2018-06-01 00:00:00

abstract：:The 3 human salivary cystatins S, SA and SN are multifunctional proteins that possess a cysteine protease inhibitory property, but their ability to act as such is very different (SN > SA > S). One form, S, also appears to possess antibacterial properties towards the bacterium Porphyromonas gingivalis, often associated...

journal_title：Journal of periodontal research

authors： Baron AC,Gansky SA,Ryder MI,Featherstone JD

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We recently proposed a novel mechanism linking periodontitis and systemic diseases, in which orally administered Porphyromonas gingivalis affects gut microbiota composition and subsequently leads to systemic inflammation. However, the mechanism by which P. gingivalis generates systemic effects...

journal_title：Journal of periodontal research

authors： Sato K,Yokoji M,Yamada M,Nakajima T,Yamazaki K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tooth loss (TL), one of the most visible results of the evolution of periodontitis, causes physiological and psychological impacts on a patient's life. This prospective study aimed to evaluate the incidence, underlying reasons and influence of risk predictors for the occurrence of TL in a progr...

journal_title：Journal of periodontal research

authors： Costa FO,Lages EJ,Cota LO,Lorentz TC,Soares RV,Cortelli JR

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Recent data have suggested that in the past 15 years there has been a dramatic increase in the incidence of diabetes mellitus in the USA. However, evidence suggests that approximately one-third of diabetes cases remain undiagnosed. Because 60% of Americans see a dentist at least once per year f...

journal_title：Journal of periodontal research

authors： Borrell LN,Kunzel C,Lamster I,Lalla E

更新日期：2007-12-01 00:00:00

abstract：:Four rough-surfaced (R) and three smooth-surfaced (S) clinical isolates of Capnocytophaga obtained from the subgingival plaque of periodontitis patients were studied for their peptidase and protease profiles. The results were compared with those obtained with C. gingivalis (which has a smooth morphology). All cell ext...

journal_title：Journal of periodontal research

authors： Söderling E,Mäkinen PL,Syed S,Mäkinen KK

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to investigate reactions of periodontal ligament epithelial cell clusters and major histocompatibility complex class II (OX6)-immunopositive cells to simultaneously induced tooth movement and periodontitis employing Waldo's method. MATERIAL AND METHODS:Elastic gums we...

journal_title：Journal of periodontal research

authors： Tadokoro O,Kawahara I,Vandevska-Radunovic V

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressi...

journal_title：Journal of periodontal research

authors： Wang X,Li W,Song W,Xu L,Zhang L,Feng X,Lu R,Meng H

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Heat shock protein (HSP) can be utilized as a vaccine to cross-protect against multiple pathogenic species. The present study was performed to evaluate Porphyromonas gingivalis heat shock protein 60 (HSP60) as a vaccine candidate to inhibit multiple bacteria-induced alveolar bone loss. MATERIAL AND METHODS:...

journal_title：Journal of periodontal research

authors： Lee JY,Yi NN,Kim US,Choi JS,Kim SJ,Choi JI

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The -2518MCP-1(A/G) polymorphism has been implicated as a risk or susceptibility factor...

journal_title：Journal of periodontal research

authors： Zhu XL,Meng HX,Zhang L,Xu L,Chen ZB,Shi D,Feng XH,Zhang X

更新日期：2012-06-01 00:00:00

abstract：:Collagenolysis in periodontitis is thought to be modulated by the expression of three genes, collagenase, tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2). We assessed the possible difference in TIMP-1, TIMP-2 and collagenase mRNA levels between gingival samples from patients with periodontitis and tho...

journal_title：Journal of periodontal research

authors： Nomura T,Takahashi T,Hara K

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The jaw bone, unlike most other bones, is derived from neural crest stem cells, so we hypothesized that it may have different characteristics to bones from other parts of the body, especially in the nature of its periosteum. The periosteum exhibits osteogenic potential and has received consider...

journal_title：Journal of periodontal research

authors： Ichikawa Y,Watahiki J,Nampo T,Nose K,Yamamoto G,Irie T,Mishima K,Maki K

更新日期：2015-08-01 00:00:00

abstract：:The effectiveness of an ideal antimicrobial agent depends on its ability to kill microbes with minimal toxicity to host cells. Depending on the treatment regimen, antimicrobial agents come into contact with host cells for various intervals of time. Sanguinarium (SANG), chlorhexidine (CHX) and tetracycline (TET) are 3 ...

journal_title：Journal of periodontal research

authors： Agarwal S,Piesco NP,Peterson DE,Charon J,Suzuki JB,Godowski KC,Southard GL

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Aggregatibacter actinomycetemcomitans is one of the etiological pathogens implicated in the onset of periodontal disease. This pathogen produces cytolethal distending toxin (CDT) that acts as a genotoxin to induce cell cycle arrest and cellular distension in cultured cell lines. Therefore, CDT is a possible ...

journal_title：Journal of periodontal research

authors： Ohara M,Miyauchi M,Tsuruda K,Takata T,Sugai M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from Porphyromonas gingivalis HSP60. P. gingivalis is the major pathogen of chronic periodontitis, which is a global epidemic prev...

journal_title：Journal of periodontal research

authors： Jeong E,Lee JY,Kim SJ,Choi J

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the production of proteolytic enzymes. Mice deficient in epidermal growth factor receptor (EGFR) show a re...

journal_title：Journal of periodontal research

authors： Smith PC,Guerrero J,Tobar N,Cáceres M,González MJ,Martínez J

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The responsiveness of the sympathetic nervous system (SNS) and the hypothalamic--pituitary--adrenal (HPA) axis plays a major role in immune regulation and for the outcome of infections and inflammatory disorders. This study was designed to investigate whether chemical SNS denervation with the noradrenaline-se...

journal_title：Journal of periodontal research

authors： Breivik T,Gundersen Y,Opstad PK,Fonnum F

更新日期：2005-08-01 00:00:00

abstract：:The three-dimensional physiological tooth movement synchronized with heartbeat, periodontal pulsation, has already been demonstrated by previous researchers. The purpose of this study was to estimate physiological tooth movements within clinically normal periodontal tissues, thus establishing periodontal pulsation sta...

journal_title：Journal of periodontal research

authors： Ioi H,Morishita T,Nakata S,Nakasima A,Nanda RS

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Treponema denticola is a key pathogen associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. In the present study, we investigated the response of human macrophage-like cells to stimulation by peptidoglycan isolated from T. denticola. We also studied t...

journal_title：Journal of periodontal research

authors： Tanabe SI,Bodet C,Grenier D

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The gingiva is the first oral tissue directly exposed to cigarette smoke (CS). Exposure to CS compromises the structure and function of gingival tissue. Damaging or altering the gingival epithelium leads to a compromised protective barrier of the periodontium, resulting in several diseases. The...

journal_title：Journal of periodontal research

authors： Alharbi IA,Rouabhia M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Neutrophils are the primary white blood cells that are recruited to fight the initial phases of microbial infections. While healthy norms have been determined for circulating blood neutrophil counts in order to identify patients with suspected systemic infections, the levels of oral neutrophils...

journal_title：Journal of periodontal research

authors： Landzberg M,Doering H,Aboodi GM,Tenenbaum HC,Glogauer M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Porphyromonas gingivalis, a black-pigmented, gram-negative anaerobe, is found in periodontitis lesions and its presence in subgingival plaque significantly increases the risk for periodontitis. We have previously shown that patients with aggressive forms of periodontitis that are seropositive for P. gingival...

journal_title：Journal of periodontal research

authors： Califano JV,Chou D,Lewis JP,Rogers JD,Best AM,Schenkein HA

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Connective tissue grafts are frequently applied, together with Emdogain(®) , for root coverage. However, it is unknown whether fibroblasts from the gingiva and from the palate respond similarly to Emdogain. The aim of this study was therefore to evaluate the effect of Emdogain(®) on fibroblasts...

journal_title：Journal of periodontal research

authors： Gruber R,Stähli A,Miron RJ,Bosshardt DD,Sculean A

更新日期：2015-02-01 00:00:00

abstract：:Portions of clinically healthy non-keratinized and keratinized oral epithelia were removed from adult vervet monkeys (Cercopithecus aethiops). The epithelium was separated from the underlying lamina propria by trypsin digestion, following which the epithelial cells were separated from the various epithelial layers. ...

journal_title：Journal of periodontal research

authors： Cleaton-Jones P

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:Parotid secretory protein (PSP) is a major salivary protein that is thought to possess both antibacterial and anti-inflammatory activity. A major question is whether PSP expression can be regulated by humoral factors and bacteria. Periodontitis is an inflammatory lesion initiated by interaction between gingi...

journal_title：Journal of periodontal research

authors： Shiba H,Venkatesh SG,Gorr SU,Barbieri G,Kurihara H,Kinane DF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The association between periodontal disease and nutrient intake was examined using linked data from the 2005 National Health and Nutrition Survey, the Comprehensive Survey of Living Conditions and the Survey of Dental Diseases from the same year 'using linked data from the National Health and N...

journal_title：Journal of periodontal research

authors： Hamasaki T,Kitamura M,Kawashita Y,Ando Y,Saito T

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (...

journal_title：Journal of periodontal research

authors： Öngöz Dede F,Gökmenoğlu C,Deveci ET,Çelen S,Avci B,Kara C,Çanakçi V

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cigarette smoking has detrimental effects on periodontal tissue, and is known to be a risk factor for periodontal disease, including the loss of alveolar bone and ligament tissue. However, the direct effects of cigarette smoking on periodontal tissue remain unclear. Recently, we demonstrated th...

journal_title：Journal of periodontal research

authors： Monnouchi S,Maeda H,Yuda A,Serita S,Wada N,Tomokiyo A,Akamine A

更新日期：2016-12-01 00:00:00