Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.

abstract：BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. The...

journal_title：Journal of periodontal research

authors： Gao Q,Yang C,Meng L,Wang Z,Chen D,Peng Y,Yang K,Bian Z

更新日期：2020-12-31 00:00:00

abstract：BACKGROUND AND OBJECTIVE:During periodontitis or orthodontic tooth movement, the periodontal vasculature is severely impaired by chronic inflammation or excessive mechanical force. This leads to a hypoxic microenvironment of the periodontal cells and enhances the expression of various cytokines and growth factors that ...

journal_title：Journal of periodontal research

authors： Wu Y,Cao H,Yang Y,Zhou Y,Gu Y,Zhao X,Zhang Y,Zhao Z,Zhang L,Yin J

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the effects of methylglyoxal on gingival cells are still poorly unders...

journal_title：Journal of periodontal research

authors： Retamal IN,Hernández R,González-Rivas C,Cáceres M,Arancibia R,Romero A,Martínez C,Tobar N,Martínez J,Smith PC

更新日期：2016-12-01 00:00:00

abstract：:Previous observations suggest that interleukin-1 (IL-1) may play an important role in the progression of periodontitis. In the present study, we investigated whether a cell-associated IL-1 alpha (CAIL-1 alpha) produced in human gingival fibroblasts (HGF) induces biological activities related to the progression of peri...

journal_title：Journal of periodontal research

authors： Okamatsu Y,Kobayashi M,Nishihara T,Hasegawa K

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The origin of cells in the mature periodontium, and the location of their progenitors, are still unknown. It is also unknown whether inflammation influences the number and distribution of these cells within the periodontium. Molecules such as STRO-1, CD146 and CD44 have been identified on a var...

journal_title：Journal of periodontal research

authors： Chen SC,Marino V,Gronthos S,Bartold PM

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontit...

journal_title：Journal of periodontal research

authors： Magán-Fernández A,O'Valle F,Abadía-Molina F,Muñoz R,Puga-Guil P,Mesa F

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Vitamin D-1,25(OH)2 D3 or 1,25D3-maintains healthy osseous tissue, stimulates the production of the antimicrobial peptide cathelicidin and has anti-inflammatory effects, but it can cause hypercalcemia. Evidence links diminished serum levels of 1,25D3 with increased gingival inflammation. Period...

journal_title：Journal of periodontal research

authors： Nakashyan V,Tipton DA,Karydis A,Livada R,Stein SH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cyclosporine A treatment is important in the therapy of a number of medical conditions; however, alveolar bone loss is an important negative side-effect of this drug. As such, we evaluated whether concomitant administration of simvastatin would minimize cyclosporine A-associated alveolar bone l...

journal_title：Journal of periodontal research

authors： Nassar PO,Nassar CA,Guimarães MR,Aquino SG,Andia DC,Muscara MN,Spolidorio DM,Rossa C Jr,Spolidorio LC

更新日期：2009-08-01 00:00:00

abstract：:Using an agar-skim milk gel method, over 300 oral bacterial isolates were tested for their ability to produce trypsin or chymotrypsin inhibitor. Eleven bacterial strains, including seven isolates identified as Bacteroides intermedius, were found to inhibit both proteolytic activities. The inhibitory factors of the 11 ...

journal_title：Journal of periodontal research

authors： Grenier D

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:A tumor-necrosis factor-alpha (TNF-alpha) antagonist, the WP9QY peptide, was designed based on the crystal structure of the TNF-beta/TNF-receptor complex in order to overcome the disadvantages of macromolecules such as antibodies or soluble receptors by reducing the molecular size of TNF-alpha antagonists. I...

journal_title：Journal of periodontal research

authors： Suzuki Y,Aoki K,Saito H,Umeda M,Nitta H,Baron R,Ohya K

更新日期：2006-04-01 00:00:00

abstract：:The goal of a single step therapy has been an important consideration in the development of guided tissue regeneration devices. It would spare the patient from the need for repeated surgery and eliminate many problems associated with a non-resorbable barrier. Animal studies of a collagen membrane extracted from porcin...

journal_title：Journal of periodontal research

authors： Lu HK,Lee SY,Lin FP

更新日期：1998-07-01 00:00:00

abstract：:We investigated the co-localization of lysosomal cathepsins B, H and L, and horseradish peroxidase (HRP) in junctional epithelial (JE) cells both as a fluid-phase endocytotic marker to demonstrate the fluid-phase endocytotic capacity of JE cells, and to understand the morphological relationships of the endocytosed for...

journal_title：Journal of periodontal research

authors： Yamaza T,Kido MA,Kiyoshima T,Nishimura Y,Himeno M,Tanaka T

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The gingiva is the first oral tissue directly exposed to cigarette smoke (CS). Exposure to CS compromises the structure and function of gingival tissue. Damaging or altering the gingival epithelium leads to a compromised protective barrier of the periodontium, resulting in several diseases. The...

journal_title：Journal of periodontal research

authors： Alharbi IA,Rouabhia M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Treponema denticola is a key pathogen associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. In the present study, we investigated the response of human macrophage-like cells to stimulation by peptidoglycan isolated from T. denticola. We also studied t...

journal_title：Journal of periodontal research

authors： Tanabe SI,Bodet C,Grenier D

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Studies have shown that bacterial plaque and the associated gingival inflammation increase the severity of gingival overgrowth induced by cyclosporine-A (CsA). This in vitro study aimed to evaluate the effect of CsA on the activities of MMPs from the co-culture of human gingival fibroblasts and...

journal_title：Journal of periodontal research

authors： Kuo PJ,Tu HP,Chin YT,Lu SH,Chiang CY,Chen RY,Fu E

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Periodontal ligament stem cells (PDLSCs) have potential for osteogenic differentiation and show a great foreground in treating bone diseases. Histone three lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a critical epigenetic modifier and plays an important role in regulating ost...

journal_title：Journal of periodontal research

authors： Jiang H,Jia P

更新日期：2020-12-24 00:00:00

abstract：:Using the high iron diamine thiocarbohydrazide silver proteinate (HID-TCH-SP) staining technique, we investigated ultrastructural localization of sulfated glycosaminoglycans (GAGs) in the rat gingiva shortly after eruption, especially those associated with internal and external basal laminae. In the apical portion of ...

journal_title：Journal of periodontal research

authors： Kogaya Y,Haruna S,Vojinovic J,Iwayama Y,Akisaka T

更新日期：1989-05-01 00:00:00

abstract：:Bradykinin stimulated production of prostaglandin E2 (PGE2) and the release of 3H-arachidonic acid by gingival fibroblasts in a time- and dose-dependent manner. The effect on PGE2 biosynthesis was seen already after 15 seconds and was maximal after 5 minutes. Several structurally unrelated inhibitors of arachidonic ac...

journal_title：Journal of periodontal research

authors： Modéer T,Ljunggren O,Lerner UH

更新日期：1990-11-01 00:00:00

abstract：:We have studied the polymorphonuclear leukocyte (PMN) phagocytosis of Porphyromonas gingivalis (Bacteroides gingivalis) and Prevotella intermedia (Bacteroides intermedius) in three-dimensional fibrin meshworks formed by either clotting human plasma or by clotting purified fibrinogen with human serum incorporated. PMN ...

journal_title：Journal of periodontal research

authors： Hurst TJ,Wilton JM

更新日期：1992-03-01 00:00:00

abstract：:Glycosaminoglycans in normal and cyclosporin-induced gingival overgrowth were extracted by papain digestion and purified by Mono Q-FPLC chromatography. The purified glycosaminoglycans were analyzed by agarose gel electrophoresis and by the pattern of degradation products formed by chondroitin lyases on HPLC chromatogr...

journal_title：Journal of periodontal research

authors： Rocha LA,Martins RC,Werneck CC,Feres-Filho EJ,Silva LC

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tooth loss (TL), one of the most visible results of the evolution of periodontitis, causes physiological and psychological impacts on a patient's life. This prospective study aimed to evaluate the incidence, underlying reasons and influence of risk predictors for the occurrence of TL in a progr...

journal_title：Journal of periodontal research

authors： Costa FO,Lages EJ,Cota LO,Lorentz TC,Soares RV,Cortelli JR

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:After tooth formation is complete, it is suggested that continuity exists between the epithelial cell rests of Malassez (ERM), reduced enamel epithelium (REE) and subsequently the junctional epithelium. However, the junctional epithelium was reported to differ from REE and ERM. The developmenta...

journal_title：Journal of periodontal research

authors： Li S,Ge S,Yang P

更新日期：2015-12-01 00:00:00

abstract：:Multinucleated cells (MNCs) that appeared after hydroxyapatite (HAP) implantation into experimentally-produced bone defects in rat periodontal tissues were investigated both ultrastructurally and ultracytochemically. At day 5 after implantation, MNCs first appeared along the HAP surface. They had no features of typica...

journal_title：Journal of periodontal research

authors： Kawaguchi H,Ogawa T,Shirakawa M,Okamoto H,Akisaka T

更新日期：1992-01-01 00:00:00

abstract：:This study was designed to study wound strength at the dentine/connective tissue interface and at the bone/connective tissue interface following full thickness flap surgery. Flaps of uniform dimension were outlined in four young adult beagle dogs using a standardised double bladed knife and vertical incisions 10 mm ap...

journal_title：Journal of periodontal research

authors： Werfully S,Areibi G,Toner M,Bergquist J,Walker J,Renvert S,Claffey N

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Races and Gm(23) allotypes can modify the serum levels of IgG subclasses. The average serum levels of IgG subclasses of African-Americans have been reported to be higher than those of Caucasians in both healthy young adults and patients with aggressive periodontitis; Gm(23)-positive subjects generally had hi...

journal_title：Journal of periodontal research

authors： Chung HY,Lu HC,Chen WL,Lu CT,Yang YH,Tsai CC

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and have anti-inflammatory effects independent of cholesterol lowering. Recent clinical studies have indicated that statin intake has a beneficial effect on periodontal disease. However, the underlying mechanisms have not...

journal_title：Journal of periodontal research

authors： Jin J,Zhang X,Lu Z,Li Y,Lopes-Virella MF,Yu H,Haycraft CJ,Li Q,Kirkwood KL,Huang Y

更新日期：2014-08-01 00:00:00

abstract：:The influence of occlusal loading on periodontal fibroblasts was investigated in hypoloaded (shortened out of occlusion), functionally loaded and hyperloaded (constant linguointrusive mechanical loads of 9.4 +/- 0.06 g) lower left rat incisors. One hour following injection of 3H-thymidine, half of the animals in each ...

journal_title：Journal of periodontal research

authors： Michaeli Y,Shamir D,Weinreb M,Steigman S

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Osteonecrosis of the jaw (ONJ) is associated with bisphosphonate (BP) therapy. BPs alter osteoblast production of mediators of osteoclastogenesis, including interleukin (IL)-6, RANKL and osteoprotegerin (OPG), a RANKL antagonist. This can inhibit bone turnover and lead to necrosis. There is lit...

journal_title：Journal of periodontal research

authors： Tipton DA,Seshul BA,Dabbous MKh

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:  The junctional epithelium provides the front-line defense against periodontal bacterial infection. The migration of neutrophils into the junctional epithelium might represent a protective reaction against bacterial infections. However, neutrophils penetrate into the junctional epithelium even...

journal_title：Journal of periodontal research

authors： Tsukamoto Y,Usui M,Yamamoto G,Takagi Y,Tachikawa T,Yamamoto M,Nakamura M

更新日期：2012-12-01 00:00:00

abstract：:A single-blind investigation was designed to study the effects of piroxicam in preventing gingival inflammation and plaque formation in beagle dogs. Twelve 1-year-old beagles were brought to optimum oral hygiene and gingival health. Thereafter, they were fed a moist plaque-promoting diet and were divided into three gr...

journal_title：Journal of periodontal research

authors： Howell TH,Fiorellini J,Weber HP,Williams RC

更新日期：1991-05-01 00:00:00