Abstract：
BACKGROUND AND OBJECTIVE:The jaw bone, unlike most other bones, is derived from neural crest stem cells, so we hypothesized that it may have different characteristics to bones from other parts of the body, especially in the nature of its periosteum. The periosteum exhibits osteogenic potential and has received considerable attention as a grafting material for the repair of bone and joint defects. MATERIAL AND METHODS:Gene expression profiles of jaw bone and periosteum were evaluated by DNA microarray and real-time polymerase chain reaction. Furthermore, we perforated an area 2 mm in diameter on mouse frontal and parietal bones. Bone regeneration of these calvarial defects was evaluated using microcomputed tomography and histological analysis. RESULTS:The DNA microarray data revealed close homology between the gene expression profiles within the ilium and femur. The gene expression of Wnt-1, SOX10, nestin, and musashi-1 were significantly higher in the jaw bone than in other locations. Microcomputed tomography and histological analysis revealed that the jaw bone had superior bone regenerative abilities than other bones. CONCLUSION:Jaw bone periosteum exhibits a unique gene expression profile that is associated with neural crest cells and has a positive influence on bone regeneration when used as a graft material to repair bone defects. A full investigation of the biological and mechanical properties of jaw bone as an alternative graft material for jaw reconstructive surgery is recommended.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Ichikawa Y,Watahiki J,Nampo T,Nose K,Yamamoto G,Irie T,Mishima K,Maki Kdoi
10.1111/jre.12229subject
Has Abstractpub_date
2015-08-01 00:00:00pages
468-78issue
4eissn
0022-3484issn
1600-0765journal_volume
50pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:For ethical reasons it is becoming increasingly more difficult to obtain, from clinical studies, histological data on infrabony defects treated with guided tissue regeneration (GTR) techniques. The aim of this systematic review was to find the value of extrapolating animal data on treatment of ...
journal_title：Journal of periodontal research
pub_type： 杂志文章,meta分析,评审
doi：10.1111/jre.12130
更新日期：2014-08-01 00:00:00
abstract：:Karyometric and cytophotometric measurements of DNA and RNA have been evaluated in gingival graft epithelium. The study was conducted during the first 20 hours from the time of grafting when the graft epithelium undergoes a process of autolysis. Both basal cell and prickle cell layers were used. The results showed an ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1975.tb00002.x
更新日期：1975-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Periodontal disease has been described as playing a role in the atherosclerosis process, and its relation with intimal thickness and vascular endothelial function (EF) has been investigated. The present study sought to determine whether there are differences in parameters of arterial stiffness ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12376
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Cannabinoid receptor CB2, expressed in osteoblasts and osteoclasts, plays a crucial role in the regulation of bone metabolism. Since periodontal ligament (PDL) cells can differentiate into osteoblasts, this study was undertaken to investigate CB2 expression and the effect of CB2 activation on o...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2009.01265.x
更新日期：2010-08-01 00:00:00
abstract：:Colonization or emergence of microbial pathogens may result in tissue destruction by activation of one or more of five distinct host degradative pathways (matrix metalloproteinase pathway, plasminogen-dependent pathway, phagocytic pathway, PMN-serine proteinase pathway and osteoclastic bone resorption) or by direct cl...
journal_title：Journal of periodontal research
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0765.1993.tb02113.x
更新日期：1993-11-01 00:00:00
abstract：:The three-dimensional physiological tooth movement synchronized with heartbeat, periodontal pulsation, has already been demonstrated by previous researchers. The purpose of this study was to estimate physiological tooth movements within clinically normal periodontal tissues, thus establishing periodontal pulsation sta...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2001.00665.x
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:A tumor-necrosis factor-alpha (TNF-alpha) antagonist, the WP9QY peptide, was designed based on the crystal structure of the TNF-beta/TNF-receptor complex in order to overcome the disadvantages of macromolecules such as antibodies or soluble receptors by reducing the molecular size of TNF-alpha antagonists. I...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2005.00812.x
更新日期：2006-04-01 00:00:00
abstract：:The diagnosis of periodontal disease is commonly based on objective evaluations of the patient's medical/dental history as well as clinical and radiographic examinations. However, periodontal disease should also be evaluated subjectively through measures that quantify its impact on oral health-related quality of life....
journal_title：Journal of periodontal research
pub_type： 杂志文章,评审
doi：10.1111/jre.12436
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to design a tripolyphosphate-chitosan cross-linked tetracycline-containing (TPP-TC) sponge that slowly releases tetracycline, for future periodontal applications. MATERIAL AND METHODS:Chitosan sponge was made by freezing and drying 2.5% chitosan solution. Tripolyphosp...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2007.01045.x
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to evaluate the effects of increased oxygen availability on gene expression and on collagen deposition/maturation in the periodontium following disease. MATERIAL AND METHODS:Male Wistar rats had ligatures placed around their molars to induce periodontal disease, and a...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12408
更新日期：2017-06-01 00:00:00
abstract：:Polymorphonuclear neutrophils (PMNs) are essential in host defense against periodontopathic bacteria such as Porphyromonas gingivalis. The uptake of immunoglobulin G (IgG)-opsonized bacteria via IgG Fc receptors (Fc gamma R) on PMN constitutes a central defense mechanism in periodontium. Fc gamma RIIIb is the most abu...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2000.035002065.x
更新日期：2000-04-01 00:00:00
abstract：:The pattern of cytokeratin expression has been extensively described in the normal and inflamed periodontium. However, there is no information regarding the pattern of cytokeratin expression in the periodontium which has been reformed following regenerative periodontal surgery. The aim of the present investigation was...
journal_title：Journal of periodontal research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-0765.2001.036004260.x
更新日期：2001-08-01 00:00:00
abstract：:Bradykinin stimulated production of prostaglandin E2 (PGE2) and the release of 3H-arachidonic acid by gingival fibroblasts in a time- and dose-dependent manner. The effect on PGE2 biosynthesis was seen already after 15 seconds and was maximal after 5 minutes. Several structurally unrelated inhibitors of arachidonic ac...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1990.tb00928.x
更新日期：1990-11-01 00:00:00
abstract：:Quantitative assessment of osseous changes attributable to periodontal disease is made possible by digital subtraction radiography. Tissues through which x rays travel to produce dental radiographs essential to this process alter the energy spectrum of the beam such that calibration errors result when densitometry is ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1989.tb00857.x
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2004.00772.x
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Alveolar bone resorption is a characteristic feature of periodontal diseases and involves removal of both the mineral and the organic constituents of the bone matrix, a process mainly carried out by multinucleated osteoclast cells. (-)-Epigallocatechin gallate, the main constituent of green tea...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2006.00935.x
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. The...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12836
更新日期：2020-12-31 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To ascertain whether interdental cleaning behaviours of Australian adults were associated with lower levels of plaque, gingivitis and periodontal disease. MATERIAL AND METHODS:Data were obtained from the National Survey of Adult Oral Health 2004-06. Outcome variables were three indicators of o...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2011.01420.x
更新日期：2012-04-01 00:00:00
abstract：:Interleukin-8 (IL-8) is believed to play an important role in the pathogenesis of various forms of periodontitis. In addition, the anti-IL-8 autoantibody has been recently recognized as a potent modulator of IL-8 function. In the current study, the concentrations of IL-8 and its autoantibody in gingival crevicular flu...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2003.02001.x
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Osteonecrosis of the jaw (ONJ) is associated with bisphosphonate (BP) therapy. BPs alter osteoblast production of mediators of osteoclastogenesis, including interleukin (IL)-6, RANKL and osteoprotegerin (OPG), a RANKL antagonist. This can inhibit bone turnover and lead to necrosis. There is lit...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2010.01306.x
更新日期：2011-02-01 00:00:00
abstract：AIM:This subgroup analysis of a 12-week randomized, double-blind, and two-center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome. MATERIAL AND METHODS:Forty one mild to moderate periodontitis patients used as an adjunct to periodontal treatment ei...
journal_title：Journal of periodontal research
pub_type： 杂志文章,随机对照试验
doi：10.1111/jre.12645
更新日期：2019-08-01 00:00:00
abstract：:The changes in vascular adhesion molecule expression and numbers of infiltrating leukocytes during a 21-day experimental gingivitis episode were investigated immunohistochemically. Monoclonal antibodies to ELAM-1 (1.2B6), ICAM-1 (6.5B5), CD3 (OKT3-pan-T cell) and neutrophils (PMN-elastase) were used to identify positi...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1992.tb01746.x
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Smoking cigarettes increases the risk of oral tissue damage leading to periodontal disease. Gingival fibroblasts, the predominant cell type inhabiting gingival connective tissue, play a critical role in remodeling and maintaining gingival structure. The objective of this study was to investigat...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12223
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:The role of water in the etiology of periodontal disease is poorly understood. OBJECTIVES:The objective of this study was to examine the association amongst water softness, risk for periodontitis, and smoking status. METHODS:We examined the association between use of water 'softening and conditioning syste...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2004.00769.x
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVES:Distinct periodontal phenotypes have been identified by cluster analysis, which is an explorative method with very low external validity. The aim of the present study was to investigate variance components of facial gingival thickness in young adults with mild gingivitis. MATERIAL AND METHODS:Thirty-three n...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2005.00798.x
更新日期：2005-06-01 00:00:00
abstract：:Growth factors are known to play a major role in the regeneration of the periodontium. Basic fibroblast growth factor (bFGF) is a polypeptide growth factor considered to have a role in chemotaxis and mitogenesis of periodontal ligament (PDL) cells. The aim of this study was to assess the effect of bFGF on the transcri...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2001.360201.x
更新日期：2001-04-01 00:00:00
abstract：:The periodontium is a highly hierarchically organized organ composed of gingiva, alveolar bone, periodontal ligament and cementum. Periodontitis leads to the destruction of hard and soft tissues ultimately leading to a loss of the teeth supporting apparatus. Current treatments are capable of limiting the disease progr...
journal_title：Journal of periodontal research
pub_type： 杂志文章,评审
doi：10.1111/jre.12729
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Studies have shown that bacterial plaque and the associated gingival inflammation increase the severity of gingival overgrowth induced by cyclosporine-A (CsA). This in vitro study aimed to evaluate the effect of CsA on the activities of MMPs from the co-culture of human gingival fibroblasts and...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2011.01450.x
更新日期：2012-08-01 00:00:00
abstract：:Neuropeptides, including substance P (SP) may play a role in neurogenic inflammation. Although SP-immunoreactive (SP-IR) axons are known to be present within the oral mucosa (OM) and salivary glands, the functional significance of SP in oral mucosa and sublingual salivary gland (SLG) is not fully understood. The prese...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1995.tb01271.x
更新日期：1995-05-01 00:00:00
abstract：:Materials used in guided tissue regeneration were examined in an in vitro model for regenerating human junctional epithelium. The extent of epithelial migration from gingival explants (epibolus) between the explant and an experimental substratum was significantly greater with a Millipore filter (HA) than with a teflon...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1990.tb00907.x
更新日期：1990-07-01 00:00:00
