当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Interferon gamma is not required for recurrent herpetic stromal keratitis.

Interferon gamma is not required for recurrent herpetic stromal keratitis.

Abstract：

:The role that interferon-gamma (IFNgamma) plays during herpetic stromal keratitis (HSK) has not been definitively determined. In primary HSK most reports suggest that IFNgamma may help control viral replication and contribute to corneal pathology. However, its role in recurrent HSK has not been directly addressed. The present study addresses its role in recurrent HSK by comparing HSK in latently infected normal and IFNgamma gene knockout (GKO) on the C57BL/6 background. We initially evaluated HSK following primary infection and observed that GKO mice had higher tear film virus titers, but virtually identical ocular disease as normal mice. In contrast, following reactivation of latent virus, GKO mice had a greater incidence and severity of opacity, neovascularization, and blepharitis. Interestingly, the incidence of reactivation after UV-B exposure was equivalent in GKO and normal mice, but virus shedding was increased in the GKO groups. We also observed diminished delayed-type hypersensitivity responses in GKO mice, as expected. These data indicate that IFNgamma is important for the control of virus replication in both primary and recurrent ocular HSV infection in C57BL/6 mice. The enhanced recurrent disease seen in GKO mice may be the result of increased viral titers and persistence in these mice which act to prolong the stimulation of an inflammatory response.

journal_name

Virology

journal_title

Virology

authors

Keadle TL,Alexander DE,Leib DA,Stuart PM

doi

10.1016/j.virol.2008.07.018

subject

Has Abstract

pub_date

2008-10-10 00:00:00

pages

46-51

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(08)00459-5

journal_volume

380

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Cytoskeleton-associated Pr65gag and assembly of retrovirus temperature-sensitive mutants in chronically infected cells.

    abstract：:Certain temperature-sensitive (ts) mutants of murine leukemia virus (MuLV) were observed to be defective in virus assembly. These mutants also accumulated intracellular core protein precursor, Pr65gag, at 39 degrees, the nonpermissive temperature. At 39 degrees, virions released from cells infected with the various ts...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90306-4

    authors： Edbauer CA,Naso RB

    更新日期：1984-04-30 00:00:00

  • Cell clones cured of persistent poliovirus infection display selective permissivity to the wild-type poliovirus strain Mahoney and partial resistance to the attenuated Sabin 1 strain and Mahoney mutants.

    abstract：:We report the isolation and characterization of HEp-2c cell clones obtained after two successive persistent poliovirus (PV) infections. Once cured, some of the cell clones displayed selective permissivity toward the wild-type Mahoney strain and partial resistance to particular mutants of this strain, including the Sab...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1488

    authors： Calvez V,Pelletier I,Couderc T,Pavio-Guédo N,Blondel B,Colbère-Garapin F

    更新日期：1995-10-01 00:00:00

  • A comparison of viruses infecting two different Chlorella-like green algae.

    abstract：:Five plaque-forming viruses (Pbi viruses) of the unicellular, eukaryotic, exsymbiotic Chlorella-like green alga strain Pbi were isolated from fresh water collected in Germany. The viruses were compared to two previously characterized plaque-forming viruses (NC64A viruses) of Chlorella strain NC64A. The Pbi viruses do ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90063-3

    authors： Reisser W,Burbank DE,Meints SM,Meints RH,Becker B,Van Etten JL

    更新日期：1988-11-01 00:00:00

  • Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells.

    abstract：:Adenovirus vectors are known to induce certain genes and impact innate response networks, but a broad understanding of this process and its mechanisms is currently lacking. For this reason, we chose to investigate and characterize Ad innate immunity using homogeneous, primary MEF cells replete with all the elements of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.08.041

    authors： Hartman ZC,Black EP,Amalfitano A

    更新日期：2007-02-20 00:00:00

  • Properties of a human cytomegalovirus-induced protein kinase.

    abstract：:A human cytomegalovirus (HCMV)-induced polypeptide of 68,000 Da (p68) with protein kinase activity was identified using a monoclonal antibody (F6b) produced against HCMV-infected cell proteins. p68 was detected by immunoprecipitation from 3 to 120 hr after infection and was induced by several strains of human and not ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90295-2

    authors： Michelson S,Tardy-Panit M,Bârzu O

    更新日期：1984-04-30 00:00:00

  • Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

    abstract：:LP-BM5, a retroviral isolate, induces a disease featuring an acquired immunodeficiency syndrome termed murine AIDS (MAIDS). Many of the features of the LP-BM5-initiated disease are shared with HIV/AIDS. Our lab has shown that the interaction of B and CD4 T cells that is central to MAIDS pathogenesis requires ligation ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.10.002

    authors： Li W,Green WR

    更新日期：2007-03-30 00:00:00

  • Enterovirus infections of the central nervous system.

    abstract：:Enteroviruses (EV) frequently infect the central nervous system (CNS) and induce neurological diseases. Although the CNS is composed of many different cell types, the spectrum of tropism for each EV is considerable. These viruses have the ability to completely shut down host translational machinery and are considered ...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2010.12.014

    authors： Rhoades RE,Tabor-Godwin JM,Tsueng G,Feuer R

    更新日期：2011-03-15 00:00:00

  • Identification of novel virus-specific antigens by CD4⁺ and CD8⁺ T cells from asymptomatic HSV-2 seropositive and seronegative donors.

    abstract：:Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controllin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.07.018

    authors： Long D,Skoberne M,Gierahn TM,Larson S,Price JA,Clemens V,Baccari AE,Cohane KP,Garvie D,Siber GR,Flechtner JB

    更新日期：2014-09-01 00:00:00

  • Quasispecies, error catastrophe, and the antiviral activity of ribavirin.

    abstract：:Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of r...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1006/viro.2002.1487

    authors： Graci JD,Cameron CE

    更新日期：2002-07-05 00:00:00

  • Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease.

    abstract：:Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, has caused significant damage to the Asian and American pork industries. Coronavirus 3C-like protease (3CL(pro)), which is involved in the processing of viral polyproteins for viral replication, is an appealing antiviral drug target. Here,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.04.018

    authors： Ye G,Deng F,Shen Z,Luo R,Zhao L,Xiao S,Fu ZF,Peng G

    更新日期：2016-07-01 00:00:00

  • Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.

    abstract：:An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m(7)G-capped, nonpolyadenylated positive-sense RNA genome. We have recently identified sequences within the DEN 3' untranslated region (UTR) that modulate viral translation. Here, we show that the DEN type 2 (DEN2) 3'UTR ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.08.004

    authors： Holden KL,Harris E

    更新日期：2004-11-10 00:00:00

  • Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr.

    abstract：:The virion-associated Vpr protein of human immunodeficiency virus type 1 (HIV-1) alters cell cycle progression from the G2 phase, influences the virus in vivo mutation rate, and participates in the nuclear translocation of viral DNA. While many Vpr-interacting proteins have been identified, the functional relevance of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0791

    authors： Mansky LM,Preveral S,Le Rouzic E,Bernard LC,Selig L,Depienne C,Benarous R,Benichou S

    更新日期：2001-03-30 00:00:00

  • A novel type D simian retrovirus naturally infecting the Indian Hanuman langur (Semnopithecus entellus).

    abstract：:As a simian species, the langurs are not known to harbor simian retroviruses, except for one report on a simian Type D endogenous retrovirus from the spectacled langur (Trachypithecus obscurus) from Malaysia. The present report describes for the first time natural infection of the common Hanuman langur (Semnopithecus ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0567

    authors： Nandi JS,Bhavalkar-Potdar V,Tikute S,Raut CG

    更新日期：2000-11-10 00:00:00

  • Epigenetics of human papillomaviruses.

    abstract：:Human papilllomaviruses (HPVs) are common human pathogens that infect cutaneous or mucosal epithelia in which they cause warts, self-contained benign lesions that commonly regress. The HPV life cycle is intricately tied to the differentiation of the host epithelium it infects. Mucosotropic HPVs are the most common sex...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.07.016

    authors： Johannsen E,Lambert PF

    更新日期：2013-10-01 00:00:00

  • Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient.

    abstract：:Poliovirus type 1 was isolated from an immunodeficient patient 4 days after onset of paresis (IS1) and after 5.5 years of prolonged enteral virus replication (IS2). Antigenic characterization revealed that IS1 was Sabin 1-like, whereas IS2 reacted like poliovirus 1 Mahoney. Complete genomic sequencing demonstrated the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0003

    authors： Bellmunt A,May G,Zell R,Pring-Akerblom P,Verhagen W,Heim A

    更新日期：1999-12-20 00:00:00

  • A C-terminal deletion mutant of pokeweed antiviral protein inhibits programmed +1 ribosomal frameshifting and Ty1 retrotransposition without depurinating the sarcin/ricin loop of rRNA.

    abstract：:Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein characterized by its ability to depurinate the sarcin/ricin (S/R) loop of the large rRNA of prokaryotic and eukaryotic ribosomes. Here, a series of PAP mutants were used to examine the relationship between depurination of the S/R loop and inhibition o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0647

    authors： Hudak KA,Hammell AB,Yasenchak J,Tumer NE,Dinman JD

    更新日期：2001-01-05 00:00:00

  • SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes.

    abstract：:The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an acutely pathogenic lentivirus that causes severe gastrointestinal disease in macaque monkeys. The studies reported here examine the basis for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric analysis of cultured macaque lymphocytes ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0010

    authors： Gummuluru S,Novembre FJ,Seshi B,Dewhurst S

    更新日期：1996-01-01 00:00:00

  • Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography.

    abstract：:Using high resolution electron microscopic autoradiography and immunocytochemistry with monoclonal antibodies against poliovirus proteins of the P2 genomic region, the location of these proteins in respect to the virus-induced vesicle formation and the viral RNA synthesis was followed during the viral replication cycl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90063-8

    authors： Bienz K,Egger D,Pasamontes L

    更新日期：1987-09-01 00:00:00

  • A physical map of caprine arthritis-encephalitis provirus.

    abstract：:Terminally redundant linear proviral DNA of approximately 9.5 kb was the major unintegrated species recovered in the Hirt supernatant fraction of caprine synovial membrane cells infected with strain 75-G63 caprine arthritis-encephalitis virus. A physical map based on the cleavage sites of 13 restriction endonucleases ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90318-0

    authors： Roberson SM,Cheevers WP

    更新日期：1984-04-30 00:00:00

  • Sequence of a bovine herpesvirus type-1 glycoprotein gene that is homologous to the herpes simplex gene for the glycoprotein gB.

    abstract：:The 130-kDa bovine herpesvirus-1 (BHV-1) glycoprotein GVP 6 was found to cross-react immunologically with the herpes simplex glycoprotein gB. Antibodies in polyclonal serum against gB immunoprecipitated GVP 6 and its cleavage products from a lysate of BHV-1-infected cells. Conversely, polyclonal serum against GVP 6 pr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90525-9

    authors： Misra V,Nelson R,Smith M

    更新日期：1988-10-01 00:00:00

  • Recurrence of WHV integration in the b3n locus in woodchuck hepatocellular carcinoma.

    abstract：:Frequent occurrence of woodchuck hepatitis virus DNA (WHV DNA) integration into or in proximity to myc oncogenes and in the win locus of cellular genome in woodchuck hepatocellular carcinomas (HCC) has been described by several authors. We report a further cellular locus as a recurrent target for WHV integration in wo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.9936

    authors： Bruni R,Argentini C,D'Ugo E,Giuseppetti R,Ciccaglione AR,Rapicetta M

    更新日期：1995-12-01 00:00:00

  • Grapevine viroid 1B, a new member of the apple scar skin viroid group contains the left terminal region of tomato planta macho viroid.

    abstract：:GV1B is one of five viroids that have recently been purified from grapevines. GV1B has now been sequenced and its 363 nucleotide residues can potentially form the typical rod-like structure of viroids with 67% of nucleotides base-paired. GV1B has highest sequence similarity with grapevine yellow speckle viroid (GYSV; ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90450-9

    authors： Koltunow AM,Rezaian MA

    更新日期：1989-06-01 00:00:00

  • Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence.

    abstract：:Two genetically distinct infectious recombinant virus clones (pMLV, constructed from Ingelvac PRRS MLV and pMN184, constructed from virulent strain MN184) were developed to study attenuation of contemporary porcine reproductive and respiratory syndrome virus (PRRSV) strain MN184. Two reciprocal chimeric clones (pMLVOR...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.09.032

    authors： Wang Y,Liang Y,Han J,Burkhart KM,Vaughn EM,Roof MB,Faaberg KS

    更新日期：2008-02-20 00:00:00

  • A varicella-zoster virus mutant impaired for latency in rodents, but not impaired for replication in cell culture.

    abstract：:While trying to generate a site-directed deletion in the ORF63 latency-associated gene of varicella-zoster virus (VZV) Oka, we constructed a virus with an unexpected rearrangement. The virus has a small deletion in both copies of ORF63 and two copies of a cassette inserted between ORFs 64/65 and 68/69 containing (a) t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.01.007

    authors： Ambagala AP,Krogmann T,Qin J,Pesnicak L,Cohen JI

    更新日期：2010-04-10 00:00:00

  • Analysis of the phosphorylation status of Epstein-Barr virus LMP2A in epithelial cells.

    abstract：:LMP2A deletion and point mutants, with mutations in phosphotyrosine-containing protein-protein interaction motifs, were transiently expressed in 293 cells and their phosphorylation was examined in immune complex kinase assays as well as in vivo. In vitro LMP2A phosphorylation depended on tyrosine 112. In vivo, mutatio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1197

    authors： Scholle F,Longnecker R,Raab-Traub N

    更新日期：2001-12-20 00:00:00

  • Induction of circular episomes during rescue and replication of adeno-associated virus in experimental models of virus latency.

    abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0504

    authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

    更新日期：2000-09-30 00:00:00

  • Transcriptional regulation of the open reading frame 35 encoded by Kaposi's sarcoma-associated herpesvirus.

    abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the Gammaherpesvirinae and is causally associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The KSHV genome encodes over 85 genes; the function of some is entirely unknown. We have characterized the transcriptio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.08.023

    authors： Masa SR,Lando R,Sarid R

    更新日期：2008-02-05 00:00:00

  • Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.

    abstract：:The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rH...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.011

    authors： Schaap-Nutt A,D'Angelo C,Amaro-Carambot E,Nolan SM,Davis S,Wise SM,Higgins C,Bradley K,Kim O,Mayor R,Skiadopoulos MH,Collins PL,Murphy BR,Schmidt AC

    更新日期：2010-10-10 00:00:00

  • Identification of bases required for P2 integrase core binding and recombination.

    abstract：:Temperate coliphage P2 integrates its genome into the host chromosome upon lysogenization via a site-specific recombination event mediated by an integrase belonging to the complex family of tyrosine recombinases. The host integration site attB (BOB') is localized in the end of the cyaR gene and shares 27 nucleotides w...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.05.009

    authors： Sylwan L,Frumerie C,Haggård-Ljungquist E

    更新日期：2010-09-01 00:00:00

  • Mutations in the measles virus C protein that up regulate viral RNA synthesis.

    abstract：:The measles virus RNA-dependent RNA polymerase consists of two virus-encoded subunits, the phosphoprotein (P) and the large (L) protein. The P mRNA also codes for a C protein in the +1 reading frame relative to P. The activities of the measles P and C proteins from the vaccine strain, EdB, a wild-type CM strain, and a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.0962

    authors： Reutter GL,Cortese-Grogan C,Wilson J,Moyer SA

    更新日期：2001-06-20 00:00:00