Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium.

Abstract:

:The content of cytoplasmic 17 beta oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium (P = 0.0002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.

journal_name

Ann Clin Biochem

authors

Sadan O,van Iddekinge B,van Gelderen CJ,Savage N,Becker PJ,van der Walt LA,Robinson M

doi

10.1177/000456328702400304

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

263-7

eissn

0004-5632

issn

1758-1001

journal_volume

24 ( Pt 3)

pub_type

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