Abstract：
:Wernicke's encephalopathy is caused by thiamine deficiency and has a range of presenting features, including gait disturbance, altered cognitive state, nystagmus and other eye movement disorders. In the past, Wernicke's encephalopathy was described almost exclusively in the alcohol-dependent population. However, in current times, Wernicke's encephalopathy is also well recognized in many other patient groups, including patients following bariatric surgery, gastrointestinal surgery, cancer and pancreatitis. Early recognition of Wernicke's encephalopathy is vital, as prompt treatment can restore cognitive or ocular function and can prevent permanent disability. Unfortunately, Wernicke's encephalopathy is often undiagnosed - presumably because it is relatively uncommon and has a variable clinical presentation. Clinical biochemists have a unique role in advising clinicians about potential nutritional or metabolic causes of unexplained neurological symptoms and to prompt consideration of thiamine deficiency as a potential cause in high-risk patient groups. The aim of this review is to summarize the clinical features, diagnosis and treatment of Wernicke's encephalopathy and to highlight some non-traditional causes, such as after bariatric surgery.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Kohnke S,Meek CLdoi
10.1177/0004563220939604subject
Has Abstractpub_date
2021-01-01 00:00:00pages
38-46issue
1eissn
0004-5632issn
1758-1001journal_volume
58pub_type
杂志文章abstract：BACKGROUND:We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct) which measures sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). METHODS:The device was evaluated in comparison to the measurement of sweat chloride with the established quantitative piloca...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456306778520025
更新日期：2006-09-01 00:00:00
abstract：:A p-iodophenol-enhanced luminescent end-point has been incorporated into a commercially available heterogeneous competitive enzyme immunoassay for digoxin based on a horseradish peroxidase-digoxin conjugate. The luminescent end-point could be completed in less than 1 min and significantly reduced overall assay time. R...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328602300104
更新日期：1986-01-01 00:00:00
abstract：:The influence of the glucose concentration in urines being assayed as part of a pancreolauryl test was investigated. Paired patient urines (n = 5) were assayed at 60 degrees and 70 degrees C, before and after spiking to 5% glucose. The influence of assay temperature alone was assessed using glucose-free paired patient...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329803500212
更新日期：1998-03-01 00:00:00
abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328802500323
更新日期：1988-05-01 00:00:00
abstract：:Hypoglycaemia is an uncommon manifestation of hypopituitarism in non-diabetic adults. A 47-year-old woman with Cushing's disease was treated with bilateral adrenalectomy and pituitary radiotherapy following unsuccessful trans-sphenoidal surgery. Twenty years later, she presented with a tonic-clonic seizure and recurre...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Tiaprofenic acid is a non-steroidal anti-inflammatory drug which also has hypouriceamic effect. Studies involving 10 healthy volunteers were designed to investigate the mode of this effect. We postulate that the site of action of tiaprofenic acid is at the cell membrane, the mechanism being an interference with the tr...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328802500601
更新日期：1988-11-01 00:00:00
abstract：:Serum retinol-binding protein (RBP), with a biological half-life of less than 12 h, is a useful indicator of liver or kidney dysfunction. An automated immunoturbidimetric assay for the measurement of RBP has been developed using the Cobas-BIO centrifugal analyser and commercially available materials. Serum samples wit...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328802500309
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Measurement of aldosterone and/or renin is essential to aid the differential diagnosis of secondary hypertension, guide strategy for therapeutic management of hypertension and assess adequacy of mineralocorticoid replacement. AIM:The objective was to establish normative data for aldosterone and renin using ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563215603401
更新日期：2016-05-01 00:00:00
abstract：:We conducted an electrophoretic analysis of monoclonal gamma-globulin found in the serum of a patient with splenic marginal-zone lymphoma. This monoclonal protein showed electrophoretic mobility to the gamma region and reacted with anti-immunoglobulin (IgG) antiserum but not with anti-kappa or anti-lambda light chain ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456306776021490
更新日期：2006-03-01 00:00:00
abstract：:Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneou...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217732587
更新日期：2018-05-01 00:00:00
abstract：:The presence of antibodies in some patients' serum has long been known to be a potential source of interference in immunoassays, as shown by numerous case reports. These often appear after the introduction of a new analyte (e.g. troponin) and then decrease in number as the topic becomes exhausted. This highlights the ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/000456302760042128
更新日期：2002-07-01 00:00:00
abstract：:Background We investigated the in vitro effects of various phospholipids as emulsifiers on the hydrolysing activities of lipoprotein lipase (LPL) Arg243His against triolein as substrate. LPL Arg243His, identified in a patient with hyperchylomicronaemia, displays severely diminished activity for triolein when emulsifie...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217693258
更新日期：2017-11-01 00:00:00
abstract：:A case is presented of a 41-year-old man with a history of recurrent renal stones over 10 years. Analysis of the stone showed that, although it gave a positive reaction with the non-specific phosphotungstic acid test, uricase failed to identify any urate present. Analysis in a reference laboratory confirmed its compos...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456304322880087
更新日期：2004-03-01 00:00:00
abstract：:Further data suggesting that assessment of atypicality may be a valuable addition to Down's syndrome screening is presented, based on results from 1521 unaffected pregnancies and 190 chromosomally abnormal pregnancies. For a 1% increase in false positive rates (over the Down's screening-related false positives), it is...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329703400314
更新日期：1997-05-01 00:00:00
abstract：:Background For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultrasensitive immune complex transfer enzyme immunoassay to measure adiponectin in urine. Methods We developed immune complex transfer enzyme immunoassay for adiponectin and measured urinary adiponecti...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217748681
更新日期：2018-09-01 00:00:00
abstract：:We examined the reproducibility of oral glucose tolerance tests (OGTT) using the World Health Organization criterion in 212 Chinese subjects (male 149, female 63) who underwent two 75 g OGTTs within a 6-week period. The overall reproducibility was 65.6% (139/212) of which 74 subjects had normal glucose tolerance, 24 h...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329803500107
更新日期：1998-01-01 00:00:00
abstract：:In a 1 year prospective study we evaluated the effect of feedback of laboratory data on the requesting behaviour of physicians in general medicine. Data on within-hours and out-of-hours clinical chemistry laboratory usage and revenue expenditure for inpatients and outpatients, expressed in terms of clinical workload, ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329102800204
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:The worldwide epidemic of obesity is a major public health concern and is persuasively linked to the rising prevalence of diabetes and cardiovascular disease. Obesity is often associated with an abnormal lipoprotein profile, which may be partly negated by pioglitazone intervention, as this can influence the ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,随机对照试验
doi：10.1258/acb.2012.012019
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Angiogenesis is involved in the pathogenesis of diabetic retinopathy. Osteoprotegerin, a recently identified glycoprotein belonging to the tumour necrosis factor receptor superfamily, has been implicated to be correlated with angiogenesis. This study aims to determine whether serum and vitreous concentration...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563214533669
更新日期：2015-03-01 00:00:00
abstract：:Salivary theophylline concentrations in neonates were measured by a homogeneous enzyme immunoassay and compared with serum concentrations. Free serum theophylline concentrations were also compared with salivary concentrations and the values obtained were almost identical. Results using the immunoassay agreed well with...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329403100311
更新日期：1994-05-01 00:00:00
abstract：:Background The aim of the present study is to evaluate the utility of extraction versus non-extraction-based commercial melatonin ELISA kits for determining the melatonin concentration in amniotic fluid obtained in early and late pregnancy. Methods Pregnancy duration less than 28 weeks was defined as early and from 28...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563216645123
更新日期：2017-01-01 00:00:00
abstract：:A rapid and simple method for detecting circulating immune complexes based on turbidity measurements following polyethylene glycol precipitation was studied with regard to its suitability as a routine assay in clinical laboratories. This method was found to have an acceptable degree of precision provided the temperatu...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328101800610
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Serum triglyceride concentrations are measured as total glycerides content in many Western countries. In Japan, glycerol-blanked triglycerides (TG-GB) are measured to identify postprandial hypertriglyceridaemia and to minimize the influence of glycerol formulation on serum triglyceride values. However, TG-GB...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563220921884
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:LC-MS/MS is rapidly becoming the technology of choice for measuring steroid hormones. We have developed a rapid LC-MS/MS assay for the routine analysis of serum cortisol. We have used this assay to investigate the effects of gender and exogenous steroid interference on the immunoassay measurement of serum co...
journal_title：Annals of clinical biochemistry
pub_type： 临床试验,杂志文章
doi：10.1177/0004563212473448
更新日期：2013-07-01 00:00:00
abstract：:A bloodspot assay for testosterone has been developed using an antiserum raised against testosterone-3-carboxymethyloxime-bovine serum albumin (T-3 CMO-BSA) conjugate and 125I-T-3CMO-histamine tracer. The method has a detection limit of 0.4 nmol/L with between-batch precision of less than 15% for testosterone values b...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329903600411
更新日期：1999-07-01 00:00:00
abstract：:Inherited metabolic disorders account for a small but significant number of sudden unexplained deaths in neonates, infants and occasionally older children. In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity t...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/0004563041201473
更新日期：2004-07-01 00:00:00
abstract：:Neuropeptides are present in brain tissue as well as in cerebrospinal fluid. Studies from a variety of disciplines have demonstrated that neuropeptides have neuromodulatory activities. Such activities are apparent in the involvement of neuropeptides in the regulation of adaptive, autonomic, and endocrine functions of ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1177/000456328201900416
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:Refeeding syndrome (RS) is a potentially fatal condition that can occur following the re-introduction of nutrition after a period of starvation. Hypophosphataemia following the reintroduction of nutrition is often the only reliable biochemical marker of RS. Refeeding index (RI) generated from baseline insuli...
journal_title：Annals of clinical biochemistry
pub_type： 临床试验,杂志文章
doi：10.1177/0004563214523739
更新日期：2015-01-01 00:00:00
abstract：:Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217694377
更新日期：2017-07-01 00:00:00
abstract：:The Bhattacharya method and the 'average of normals' method for internal quality control were compared. Both are based on unselected patient test results. The Bhattacharya method is mostly used in clinical chemistry for calculation of reference intervals but could be modified for quality control procedures. Using the ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329102800413
更新日期：1991-07-01 00:00:00
