Pioglitazone protects HDL(2&3) against oxidation in overweight and obese men.

abstract：BACKGROUND:In humans, leptin circulates in a free form and is also bound to macromolecules. The aim of the present study was to compare a rapid acid-ethanol precipitation (AEP) method of measuring bound leptin with the more laborious gel exclusion chromatography (GEC) reference procedure. Serum samples collected from h...

journal_title：Annals of clinical biochemistry

authors： Jamieson NB,McMillan DC,Brown DJ,Wallace AM

更新日期：2003-03-01 00:00:00

abstract：:A rapid vacuum-driven procedure, using pre-treated Sep-Pak C18 cartridges, has been developed for the simultaneous extraction of arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) from plasma. Non-specific interference was removed by fractional elution with an aqueous methanol/trifluoroacetic acid (TFA) m...

journal_title：Annals of clinical biochemistry

authors： Penney MD,Hampton D,Oleesky DA,Livingstone C,Mulkerrin E

更新日期：1992-11-01 00:00:00

abstract：:Mass spectrometry has for many years enabled us to rapidly identify and quantify many different compounds in biological samples. The equipment is currently available in specialist centres investigating metabolic disorders and in toxicology laboratories. Improvements in sample introduction and refinements in the mass s...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2003-11-01 00:00:00

abstract：:A comparison has been made between three methods for measuring capillary blood glucose collected on filter paper, including a new method using a Beckman glucose analyser 2. The methods are suitable for use with capillary blood spots collected onto filter paper for monitoring the control of diabetic patients. Their acc...

journal_title：Annals of clinical biochemistry

authors： Taylor RP,Pennock CA

更新日期：1982-01-01 00:00:00

abstract：:A case report is presented of a 37-year-old man who, largely by chance, was found to have a marked mixed hyperlipidaemia. As a teenager he had been treated for apparent idiopathic growth hormone deficiency, but had also never developed secondary sexual characteristics. Pituitary hormone measurement was now consistent ...

journal_title：Annals of clinical biochemistry

authors： Kilpatrick ES,Patmore JE,Rowland-Hill C,Atkin SL

更新日期：2004-07-01 00:00:00

abstract：:591 patients with a history of coronary heart disease had one or more biochemical markers of tobacco smoking measured. 26% were self reported smokers and a further 4% were apparent 'smoking deceivers'. The urinary nicotine metabolite concentration is an excellent marker for tobacco smoking; breath CO would be a suitab...

journal_title：Annals of clinical biochemistry

authors： Archbold GP,Cupples ME,McKnight A,Linton T

更新日期：1995-03-01 00:00:00

abstract：:There is an increasing need for sensitive and specific methods for toxicological screening. Development of a dual-column gas chromatography system for the screening of drugs and metabolites in the plasma of poisoned patients is described. The system has been evaluated using plasma from a well-documented series of pati...

journal_title：Annals of clinical biochemistry

authors： Jarvie DR,Simpson D

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Current practice requires regular venous blood samples for monitoring of tacrolimus concentrations post renal transplant requiring regular hospital visits. Mitra devices use volumetric absorptive microsampling technology and absorb a fixed amount of blood (10 μL) from a capillary blood sample. They are a via...

journal_title：Annals of clinical biochemistry

authors： Marshall DJ,Kim JJ,Brand S,Bryne C,Keevil BG

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Measurement of plasma-free metanephrine plus normetanephrine (PFM) is the best screening test for phaeochromocytoma. While clearly raised levels are diagnostic, borderline increases may be associated with factors such as stress and medications, and should prompt a repeat study after interfering factors are w...

journal_title：Annals of clinical biochemistry

authors： Anas SS,Vasikaran SD

更新日期：2010-11-01 00:00:00

abstract：:We examined the reproducibility of oral glucose tolerance tests (OGTT) using the World Health Organization criterion in 212 Chinese subjects (male 149, female 63) who underwent two 75 g OGTTs within a 6-week period. The overall reproducibility was 65.6% (139/212) of which 74 subjects had normal glucose tolerance, 24 h...

journal_title：Annals of clinical biochemistry

authors： Ko GT,Chan JC,Woo J,Lau E,Yeung VT,Chow CC,Cockram CS

更新日期：1998-01-01 00:00:00

abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...

journal_title：Annals of clinical biochemistry

authors： Cooper JD,Turnell DC,Green B,Wright DJ,Coombes EJ

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Potassium is usually the most important analyte affected by in vitro haemolysis and the result obtained may falsely indicate or disguise a life-threatening abnormality and so give rise to inappropriate treatment. The purpose of the study was to provide a solution to the problem of reporting potassium on haem...

journal_title：Annals of clinical biochemistry

authors： Dimeski G,Clague AE,Hickman PE

更新日期：2005-03-01 00:00:00

abstract：:Three characteristics of a sample of AutoAnalyzer Sampler II modules have been measured: eccentricity of the cam, eccentricity of the spindle driving the cam, and the lengths of the chords of the cam lobes. Imprecision in timing may make a significant contribution to analytical error. ...

journal_title：Annals of clinical biochemistry

authors： McLelland AS,Fleck A,Wagstaff D,Robinson R

更新日期：1975-07-01 00:00:00

abstract：:The measurement of carbamylated haemoglobin is a useful indicator of uraemic state during the preceding few weeks in patients with renal failure. In diabetic uraemic patients with hyperglycaemia, glycation of haemoglobin may interfere with its carbamylation, as both reactions involve the free amino groups of the prote...

journal_title：Annals of clinical biochemistry

authors： Hammouda AM,Mady GE

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Since more than 90% of cortisol is bound to protein, serum free cortisol (SFC) may be a more appropriate marker of adrenal status than total cortisol. However, measurement of SFC is technically difficult and calculated SFC may offer a more practical alternative. METHODS:SFC, measured by equilibrium dialysis...

journal_title：Annals of clinical biochemistry

authors： Barlow NL,Holme J,Stockley RA,Clark PM

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Method-dependent variation of caeruloplasmin measurement is significant and necessitates the requirement for assay-specific reference intervals. Local determination becomes necessary in the absence of suitable published or manufacturer-quoted reference intervals. METHODS:Applicability of the Beckman Coulter...

journal_title：Annals of clinical biochemistry

authors： Kaye OE,Cook P

更新日期：2021-01-27 00:00:00

abstract：:In a 1 year prospective study we evaluated the effect of feedback of laboratory data on the requesting behaviour of physicians in general medicine. Data on within-hours and out-of-hours clinical chemistry laboratory usage and revenue expenditure for inpatients and outpatients, expressed in terms of clinical workload, ...

journal_title：Annals of clinical biochemistry

authors： Gama R,Nightingale PG,Broughton PM,Peters M,Bradby GV,Berg J,Ratcliffe JG

更新日期：1991-03-01 00:00:00

abstract：:The total cost of a haematology and clinical chemistry laboratory, including external and hospital costs, was studied in a district general hospital in The Netherlands. The main conclusion is that the number of samples analysed is the most important cost-setting factor, but that reduction in the number of requests doe...

journal_title：Annals of clinical biochemistry

authors： Leijten JF,van der Geer F,Scholten MN,Goldschmidt HM

更新日期：1984-03-01 00:00:00

abstract：:Many techniques for the estimation of specific proteins measure light scattered by, or the turbidity of, suspensions of antigen:antibody aggregates formed in fluid-phase reactions. Although the shapes of reaction curves obtained are well documented, interpretation of the data in relation to the laws of light scatterin...

journal_title：Annals of clinical biochemistry

authors： Deverill I,Lock RJ

更新日期：1983-07-01 00:00:00

abstract：:Heterophilic antibodies are well described, but poorly appreciated interferents and is often not a recognized problem affecting most immunoassays. We report a patient presented with ectopic Cushing's syndrome (CS), but repeated plasma adrenocorticotropic hormone (ACTH) concentrations conducted by immunoassay were inap...

journal_title：Annals of clinical biochemistry

authors： Saiegh L,Odeh M,Chen-Konak L,Elias N,Sheikh-Ahmad M,Reut M,Slobodin G,Bejar J,Shechner C

更新日期：2014-07-01 00:00:00

abstract：:Experience in the use of an in-house urinary free catecholamine assay for the investigation of possible neural crest tumours in a District General Hospital laboratory is described. Elevated excretion of catecholamines and vanillylmandelic acid was found in a number of cases including phaeochromocytoma and neuroblastom...

journal_title：Annals of clinical biochemistry

authors： Davidson DF

更新日期：1987-09-01 00:00:00

abstract：:A sensitive immunochemiluminometric assay with a detection limit of 1.1 microU/L was developed for the measurement of urinary growth hormone (UGH). The assay was shown to be specific and precise. There was a good correlation between serum growth hormone (GH) and UGH concentrations in 20 patients with acromegaly and si...

journal_title：Annals of clinical biochemistry

authors： Turner G,Brown RC,Weeks I,Butler GE,Creagh FN,Woodhead JS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Neutrophilic polymorphonuclear leukocytes play a crucial role in the host defence against bacterial and fungal infections. They participate in the inflammatory response through the liberation of peptides and enzymes like myeloperoxidase (MPO). Therefore, MPO has a potential as a marker enzyme for the diagnos...

journal_title：Annals of clinical biochemistry

authors： Hasmann A,Wehrschuetz-Sigl E,Marold A,Wiesbauer H,Schoeftner R,Gewessler U,Kandelbauer A,Schiffer D,Schneider KP,Binder B,Schintler M,Guebitz GM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Patient-based real-time quality control (PBRTQC) techniques have been described in clinical chemistry for over 50 years. PBRTQC has a number of advantages over traditional quality control including commutability, cost and the opportunity for real-time monitoring. However, there are few systematic investigati...

journal_title：Annals of clinical biochemistry

authors： Smith JD,Badrick T,Bowling F

更新日期：2020-05-01 00:00:00

abstract：:ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...

journal_title：Annals of clinical biochemistry

authors： Holt H,Freedman DB

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The stability of parathyroid hormone (PTH) in whole blood has not been well characterized. Previous studies show EDTA plasma samples to be more stable than serum samples. METHODS:Blood from 17 haemodialysis patients and five healthy volunteers was collected into serum separator tubes (SSTs) and potassium ED...

journal_title：Annals of clinical biochemistry

authors： English E,McFarlane I,Taylor KP,Halsall DJ

更新日期：2007-05-01 00:00:00

abstract：:Many contradictory results have been published on the stability of total non-esterified fatty acids in blood, plasma and serum under different storage conditions. The present study was undertaken to investigate the stability of non-esterified fatty acids, measured with an enzymatic method, in samples of EDTA-treated p...

journal_title：Annals of clinical biochemistry

authors： Menéndez LG,Fernández AL,Enguix A,Ciriza C,Amador J

更新日期：2001-05-01 00:00:00

abstract：:Fasting glycosylated haemoglobin was analysed in 535 consecutive patients having an oral 75 g glucose tolerance test for diagnostic purposes. A reference range for fasting glycosylated haemoglobin was established from patients with a non-diabetic glucose tolerance test as defined by the World Health Organisation Exper...

journal_title：Annals of clinical biochemistry

authors： Albutt EC,Nattrass M,Northam BE

更新日期：1985-01-01 00:00:00

abstract：:Clinical biochemists have long known the analytical and clinical limitations of creatinine and creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This background is reviewed in the article before assessing the utility of cystatin C, the most promising replacement biochemical marker...

journal_title：Annals of clinical biochemistry

authors： Newman DJ

更新日期：2002-03-01 00:00:00

abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...

journal_title：Annals of clinical biochemistry

authors： Kind CN

更新日期：1988-05-01 00:00:00