Benchtop mass spectrometry in clinical biochemistry.

Abstract:

:Mass spectrometry has for many years enabled us to rapidly identify and quantify many different compounds in biological samples. The equipment is currently available in specialist centres investigating metabolic disorders and in toxicology laboratories. Improvements in sample introduction and refinements in the mass spectrometry hardware now allow higher sample throughput without extensive sample purification. Many mass spectrometers are compact and operated by computers that also assist data handling. Mass spectrometry has the potential to change hospital laboratory operations generally. Consideration of the practical and financial aspects of its application may reveal cost-effective means of improving the specificity of analyte assay. Considerable advantages are expected in the analysis of metabolites and drugs and in proteomics.

journal_name

Ann Clin Biochem

authors

Honour JW

doi

10.1258/000456303770367216

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

628-38

issue

Pt 6

eissn

0004-5632

issn

1758-1001

journal_volume

40

pub_type

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