Abstract：
BACKGROUND:Measurement of plasma-free metanephrine plus normetanephrine (PFM) is the best screening test for phaeochromocytoma. While clearly raised levels are diagnostic, borderline increases may be associated with factors such as stress and medications, and should prompt a repeat study after interfering factors are withdrawn. METHODS:PFM results reported by a teaching hospital laboratory over a 12-month period were extracted from the laboratory information system. All borderline raised results were examined for a subsequent repeat test (as recommended by attached interpretative comment) and those not repeated were followed up by examination of case-notes or questionnaires to doctors. RESULTS:Of 111 patients with borderline increased PFM which did not normalize on repeat measurement, 33 were from the hospital and 78 from outside locations. Hospital notes for 27 out of 33 hospital-patients (82%) could be reviewed, and 49 completed questionnaires (63% of 78 sent out) were received from outside locations. Of these 76 patients thus followed up, the test was not repeated in 55 (72%) cases with borderline increased PFM. Of 10 patients with an adrenal mass and borderline PFM, only three had PFM repeated. Of another nine patients with undetermined final diagnosis and borderline PFM, only three had the test repeated. CONCLUSION:Seventy-two per cent of borderline increased PFM results were not followed up with appropriate repeat testing, potentially leading to missed detection of phaeochromocytoma. A stronger interpretative comment may encourage appropriate repeat testing in more cases with borderline increased PFM and suspected phaeochromocytoma.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Anas SS,Vasikaran SDdoi
10.1258/acb.2010.010131subject
Has Abstractpub_date
2010-11-01 00:00:00pages
554-8issue
Pt 6eissn
0004-5632issn
1758-1001pii
acb.2010.010131journal_volume
47pub_type
杂志文章abstract：BACKGROUND:Patient-based real-time quality control (PBRTQC) techniques have been described in clinical chemistry for over 50 years. PBRTQC has a number of advantages over traditional quality control including commutability, cost and the opportunity for real-time monitoring. However, there are few systematic investigati...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563220902174
更新日期：2020-05-01 00:00:00
abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328802500323
更新日期：1988-05-01 00:00:00
abstract：:The seasonal variation of serum 25-hydroxy vitamin D3 and 1,25-dihydroxy-vitamin D has been investigated. Blood was taken from 27 healthy volunteers, aged 21-44 years old at 3 monthly intervals over a period of 1 year. A scrolling monthly programme with 12 quarterly (3 month) time periods was developed. A summer assoc...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329403100105
更新日期：1994-01-01 00:00:00
abstract：:The effect of ambient temperature on the analytical and clinical performance of a glucose meter was examined. A total of 114 venous whole blood samples were analysed for glucose by a reference method, and by a glucose meter at 21-22 degrees C, room temperatures, 26-27 degrees C and 33-34 degrees C. Glucose meter readi...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/0004563011901091
更新日期：2001-11-01 00:00:00
abstract：:The deproteinised sample (150 microliters) is 'injected' into a continuously flowing stream of deionised water which is pumped, via a capillary tube, to the nebuliser of an atomic absorption spectrophotometer. Analytical readout is obtained, in the form of transient peaks, 6 s after sample injection. Before injection ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328302000202
更新日期：1983-03-01 00:00:00
abstract：:Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneou...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217732587
更新日期：2018-05-01 00:00:00
abstract：:Auto-antibodies to oxidized low-density lipoprotein (ox-LDL) are thought to play a pivotal role in the pathogenesis of atherosclerosis. This study investigates the value of auto-antibodies to ox-LDL as a predictive marker of atherosclerosis in patients with both homozygous and heterozygous familial hypercholesterolaem...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/0004563001899177
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563215581651
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The high-dose hook effect is a well-known phenomenon of two-site immunoassays including those for human chorionic gonadotrophin (hCG). We investigated the occurrence of a high-dose hook effect in six routinely available hCG assays using a sample with a total hCG concentration of approximately 3,600,000 IU/L....
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/acb.2010.090304
更新日期：2010-07-01 00:00:00
abstract：:Background For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultrasensitive immune complex transfer enzyme immunoassay to measure adiponectin in urine. Methods We developed immune complex transfer enzyme immunoassay for adiponectin and measured urinary adiponecti...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563217748681
更新日期：2018-09-01 00:00:00
abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328802500516
更新日期：1988-09-01 00:00:00
abstract：AIM:The aim of the study was to review the clinical validation process of out of hours critical biochemistry results by a clinical biochemist and its effect on primary care services. METHODS:A prospective study was conducted of all critical results for primary care patients who were analysed out of hours. The nine-mon...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563215595251
更新日期：2016-03-01 00:00:00
abstract：:A 41-year-old lady presented with classical symptoms of a phaeochromocytoma and markedly elevated urinary adrenaline concentration. Urinary fractionated metanephrine and normetanephrine concentrations were within the normal reference range. Computed tomography of the abdomen/pelvis and I(123) meta-iodobenzylguanidine ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/acb.2007.007106
更新日期：2008-03-01 00:00:00
abstract：:Most thyroid-stimulating hormone (TSH) assays now have the sensitivity required by thyroid guidelines and allow the reliable identification of patients with both overt and subclinical hyperthyroidism. Clinical guidelines usually quote decision limits for TSH, but often ignore the issue of whether variability in bias b...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456307780480945
更新日期：2007-05-01 00:00:00
abstract：:Eccentric exercise causes release of muscle creatine kinase (CK) 3-4 days after exercise. Racial variation in basal serum CK has been reported but the reasons for this are unknown. We studied 30 subjects of different ethnic origin (Caucasian, Afro-Caribbean, Asian) before and after eccentric exercise. Basal serum CK w...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329603300407
更新日期：1996-07-01 00:00:00
abstract：:Insulin resistance is a common condition, recognized to be a central feature of the metabolic syndrome, and strongly associated with an increased risk of cardiovascular disease and diabetes. The quantitative assessment of insulin sensitivity is not used for routine clinical purposes, but the emerging importance of ins...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/000456307780945778
更新日期：2007-07-01 00:00:00
abstract：:The osmolality of plasma and heparinised whole blood samples collected from hospital patients was estimated using measurement of the depression of freezing point. There was no clinically significant difference between osmolality measurement made on either whole blood, or plasma taken from the same patient. Neither cel...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328602300115
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Circulating levels of bioavailable oestradiol and testosterone are often desirable for clinical practice or investigational studies of children. However, assays to measure circulating hormone levels might not always be accessible. We sought to validate the empirical calculation of circulating bioavailable te...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,随机对照试验
doi：10.1258/acb.2010.009112
更新日期：2010-05-01 00:00:00
abstract：:It is crucially important to detect subarachnoid haemorrhage (SAH) in all patients in whom it has occurred to select patients for angiography and preventative surgery. A computerized tomography (CT) scan is positive in up to 98% of patients with SAH presenting within 12 h, but is positive in only 50% of those presenti...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/acb.2008.007257
更新日期：2008-05-01 00:00:00
abstract：:During incubation with rabbit blood in vitro rabbit-muscle lactate dehydrogenase-5 was inactivated at a rate similar to that observed in vivo. By contrast plasma and plasma containing erythrocytes had no effect on the enzyme activity, but plasma containing leucocytes inactivated the enzyme at the same rate as whole bl...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456327701400109
更新日期：1977-01-01 00:00:00
abstract：:Iron status is influenced by inflammation when the normal control of iron metabolism is reorganized by the primary mediators of the acute phase response, tumour necrosis factor-alpha and interleukin-1. The objective of this review is to show how indices of iron status, particularly haemoglobin, serum ferritin and solu...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/acb.2007.007167
更新日期：2008-01-01 00:00:00
abstract：:A simultaneous deterioration in performance of several radioimmunoassays suggested that equipment was malfunctioning. Replicate counts from an automated gamma counter showed unacceptable variation during a 24-hour period; this variation was detected using Trigg's technique, a sensitive method for trend analysis, and w...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456327801500126
更新日期：1978-03-01 00:00:00
abstract：BACKGROUND:We found a unique cholesteryl ester transfer protein (CETP) deficient case with markedly elevated serum triglyceride (TG) as well as high-density lipoprotein cholesterol (HDL-C) levels. Most of the CETP deficiency cases were reported to have normal or reduced serum TG with elevated HDL-C. METHODS:The case s...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/acb.2009.008249
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:We evaluated procalcitonin (PCT) assay in the emergency diagnosis of neonatal bacterial infection, especially in preterm infants, relative to C-reactive protein (CRP) and fibrinogen. METHODS:One hundred and twenty neonates (32 preterm), of whom 21 were infected, were tested. RESULTS:Concentrations of PCT, ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/0004563021901874
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Patients with mutations of succinate dehydrogenase B (SDHB) and succinate dehydrogenase D (SDHD) are at high risk of paraganglioma necessitating surveillance. Chromogranin A has been proposed as a biochemical marker of paraganglioma. We sought to determine the diagnostic utility of chromogranin A in a popula...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563218811865
更新日期：2019-01-01 00:00:00
abstract：:Three characteristics of a sample of AutoAnalyzer Sampler II modules have been measured: eccentricity of the cam, eccentricity of the spindle driving the cam, and the lengths of the chords of the cam lobes. Imprecision in timing may make a significant contribution to analytical error. ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456327501200135
更新日期：1975-07-01 00:00:00
abstract：:Gestational diabetes is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating gestational diabetes improves maternal and fetal outcomes and allows for health promotion to reduce the mo...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1177/0004563216674743
更新日期：2017-01-01 00:00:00
abstract：:Fasting glycosylated haemoglobin was analysed in 535 consecutive patients having an oral 75 g glucose tolerance test for diagnostic purposes. A reference range for fasting glycosylated haemoglobin was established from patients with a non-diabetic glucose tolerance test as defined by the World Health Organisation Exper...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328502200106
更新日期：1985-01-01 00:00:00
abstract：:We studied the serum protein binding of 3H-labelled progesterone, oestradiol and testosterone, and five 125I-labelled analogues of these steroids. All tracers investigated appeared to be bound by proteins in every serum sample tested. The addition of blocking agents caused a substantial reduction in serum protein bind...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329503200609
更新日期：1995-11-01 00:00:00
abstract：:Background Measurement of serum dexamethasone during the overnight dexamethasone-suppression test has been recommended to reduce false-positive results when investigating Cushing's syndrome or increasingly commonly found adrenal incidentalomas. Despite this, there remains a paucity of well-validated dexamethasone meth...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563218766566
更新日期：2018-11-01 00:00:00
