A study of high-, middle- and low-molecular weight adiponectin in urine as a surrogate marker for early diabetic nephropathy using ultrasensitive immune complex transfer enzyme immunoassay.

abstract：:In monocytes at the secretory (oestrogen-progesterone dominant) phase of the menstrual cycle, expression of c-fms and macrophage colony-stimulating factor (M-CSF) receptor and activity of tyrosine kinase (TK) were increased by oestradiol with or without progesterone. In vivo, oestrogen may induce expression of c-fms a...

journal_title：Annals of clinical biochemistry

authors： Fujimoto J,Hori M,Ichigo S,Itoh T,Saio M,Takami T,Tamaya T

更新日期：1995-07-01 00:00:00

abstract：:The Myolex (Orion) and the RapiTex (Behringwerke) latex agglutination tests for the rapid detection of elevated levels of serum myoglobin were studied prospectively in patients suspected of acute myocardial infarction, who were admitted to hospital within 8 h of pain onset. Using admission blood samples drawn 3.4 +/- ...

journal_title：Annals of clinical biochemistry

authors： Konings CH,Funke Küpper AJ,Verheugt FW

更新日期：1989-05-01 00:00:00

abstract：:We report a 63-year-old man who presented with breathlessness and weight loss and was diagnosed on echocardiography to have carcinoid heart disease. It was later transpired that he underwent surgical removal of an ileal carcinoid tumour 19 years previously. ...

journal_title：Annals of clinical biochemistry

authors： Sulaiman R,Panting M,Bhogal G,Perry I,Ford C,Gama R

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Serum triglyceride concentrations are measured as total glycerides content in many Western countries. In Japan, glycerol-blanked triglycerides (TG-GB) are measured to identify postprandial hypertriglyceridaemia and to minimize the influence of glycerol formulation on serum triglyceride values. However, TG-GB...

journal_title：Annals of clinical biochemistry

authors： Koyama I,Imano H,Nakamura M,Kitamura A,Kiyama M,Miyamoto Y,Iso H

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In a network of laboratories analytical variability between instruments, even of the same type, may exist for reasons beyond the control of laboratory staff. Controlling variability is a prerequisite for the application of shared reference ranges and for ensuring the transferability of patient test results. ...

journal_title：Annals of clinical biochemistry

authors： Jassam N,Lindsay C,Harrison K,Thompson D,Bosomworth MP,Barth JH

更新日期：2011-03-01 00:00:00

abstract：:Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, "informatics"--the art and science of turning data into useful information--is becoming increasingly im...

journal_title：Annals of clinical biochemistry

authors： Jones R,O'Connor J

更新日期：2004-05-01 00:00:00

abstract：:Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in 50 normal individuals (24 male)...

journal_title：Annals of clinical biochemistry

authors： Haq M,Haq S,Tutt P,Crook M

更新日期：1993-07-01 00:00:00

abstract：:Iron status is influenced by inflammation when the normal control of iron metabolism is reorganized by the primary mediators of the acute phase response, tumour necrosis factor-alpha and interleukin-1. The objective of this review is to show how indices of iron status, particularly haemoglobin, serum ferritin and solu...

journal_title：Annals of clinical biochemistry

authors： Northrop-Clewes CA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

journal_title：Annals of clinical biochemistry

authors： Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

更新日期：2016-09-01 00:00:00

abstract：:We assayed interleukin 6 (IL-6) concentrations in cerebrospinal fluid (CSF) from patients affected by meningitis of different aetiologies, and verified whether IL-6 can be used as a diagnostic marker in the differential diagnosis of meningitis. We used a monoclonal antibody enzyme immunoassay to test 98 CSF samples cl...

journal_title：Annals of clinical biochemistry

authors： López-Cortés LF,Cruz-Ruiz M,Gómez-Mateos J,Jiménez-Hernández D,Viciana-Fernández P,Jiménez-Mejías E

更新日期：1997-03-01 00:00:00

abstract：:Background Accumulating evidence shows an over-abundance of Fusobacterium nucleatum in colorectal tumour tissues. Although stool DNA testing of Fusobacterium nucleatum might be a potential marker for the detection of colorectal tumours, the difficulty in detecting Fusobacterium nucleatum in stool by conventional metho...

journal_title：Annals of clinical biochemistry

authors： Suehiro Y,Sakai K,Nishioka M,Hashimoto S,Takami T,Higaki S,Shindo Y,Hazama S,Oka M,Nagano H,Sakaida I,Yamasaki T

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:LC-MS/MS is rapidly becoming the technology of choice for measuring steroid hormones. We have developed a rapid LC-MS/MS assay for the routine analysis of serum cortisol. We have used this assay to investigate the effects of gender and exogenous steroid interference on the immunoassay measurement of serum co...

journal_title：Annals of clinical biochemistry

authors： Owen LJ,Adaway JE,Davies S,Neale S,El-Farhan N,Ducroq D,Evans C,Rees DA,MacKenzie F,Keevil BG

更新日期：2013-07-01 00:00:00

abstract：:The deproteinised sample (150 microliters) is 'injected' into a continuously flowing stream of deionised water which is pumped, via a capillary tube, to the nebuliser of an atomic absorption spectrophotometer. Analytical readout is obtained, in the form of transient peaks, 6 s after sample injection. Before injection ...

journal_title：Annals of clinical biochemistry

authors： Rocks BF,Sherwood RA,Turner ZJ,Riley C

更新日期：1983-03-01 00:00:00

abstract：:The mechanisms of hypercalcaemia were assessed in 20 hypercalcaemic patients with breast cancer. Abnormalities suggestive of a PTH-related peptide (PTHrP) mechanism were observed in up to 60% of cases; urinary cyclic adenosine monophosphate (UcAMP) was elevated in nine patients (45%), renal tubular reabsorption of cal...

journal_title：Annals of clinical biochemistry

authors： Gallacher SJ,Fraser WD,Patel U,Logue FC,Soukop M,Boyle IT,Ralston SH

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Various conjugated cholesterol metabolites are excreted in urine of the patients with metabolic abnormalities and hepatobiliary diseases. We aimed to examine the usefulness of precursor ion scan and neutral loss scan for the characterization of conjugated cholesterol metabolites in urine. METHODS:A mixture ...

journal_title：Annals of clinical biochemistry

authors： Maekawa M,Shimada M,Ohno K,Togawa M,Nittono H,Iida T,Hofmann AF,Goto J,Yamaguchi H,Mano N

更新日期：2015-09-01 00:00:00

abstract：:In the last few years, the use of enzyme labels in immunoassays has been investigated. The aim of this review is to evaluate critically the role of such labels in clinical biochemistry. Special attention has been given to the problems involved in preparing enzyme labels and the ways in which such labels can be used in...

journal_title：Annals of clinical biochemistry

authors： O'Sullivan MJ,Bridges JW,Marks V

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Phlebotomy is a potential cause of preanalytical errors. We have observed phlebotomy in routine practice in a busy Emergency Department, to see how current practice compares with optimal blood sampling. METHODS:Phlebotomy episodes were audited and compared with standard procedures. A computer-based search o...

journal_title：Annals of clinical biochemistry

authors： Berg JE,Ahee P,Berg JD

更新日期：2011-11-01 00:00:00

abstract：:A series of experiments are described which show that second derivative spectroscopy can be used to quantify conjugated lipid dienes as markers of lipid peroxidation in heptane extracts of plasma from patients with rheumatoid arthritis, osteoarthritis, and healthy controls. Results obtained by this method gave reasona...

journal_title：Annals of clinical biochemistry

authors： Situnayake RD,Crump BJ,Zezulka AV,Davis M,McConkey B,Thurnham DI

更新日期：1990-05-01 00:00:00

abstract：:Hypogonadism in the male results from inadequate testicular function, especially defects in androgen synthesis and secretion, or action. Androgen action is important throughout normal male development: in the fetus, puberty, adult life and old age. Regulation is by variable activity of the hypothalamo-pituitary axis a...

journal_title：Annals of clinical biochemistry

authors： Belchetz PE,Barth JH,Kaufman JM

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. METHODS:Serum concentrat...

journal_title：Annals of clinical biochemistry

authors： Liu H,Wu J,Wang H,Sheng L,Tang N,Li Y,Hao T

更新日期：2015-03-01 00:00:00

abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...

journal_title：Annals of clinical biochemistry

authors： Cooper JD,Turnell DC,Green B,Wright DJ,Coombes EJ

更新日期：1988-09-01 00:00:00

abstract：:We describe a new electrochemical method for the determination of erythrocyte acetylcholinesterase activity (EC 3.1.1.7) and plasma cholinesterase (EC 3.1.1.8) activity, based on the measurements of pH variation due to release of acetic acid from acetylcholine. The major advantages of the differential pH procedure are...

journal_title：Annals of clinical biochemistry

authors： Barenghi L,Ceriotti F,Luzzana M,Ripamonti M,Mosca A,Bonini PA

更新日期：1986-09-01 00:00:00

abstract：:A real time data processing system for a group of three clinical chemistry laboratories (one base and two satellite) has been developed as a successor to one used previously. This paper describes both the inadequacies of the previous worksheet-based system and the advantages of the new system, including flexibility, f...

journal_title：Annals of clinical biochemistry

authors： Hirst AD,Naylor D,White HL,Walter M

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:It is not possible to diagnose acute kidney injury (AKI) in early stages with traditional biomarkers. Kidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predictin...

journal_title：Annals of clinical biochemistry

authors： Tekce BK,Uyeturk U,Tekce H,Uyeturk U,Aktas G,Akkaya A

更新日期：2015-01-01 00:00:00

abstract：:Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. C1-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods ...

journal_title：Annals of clinical biochemistry

authors： Starcević D,Jelić-Ivanović Z,Kalimanovska V

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Urinary excretion of the low molecular weight protein cystatin C is a marker of renal disorders and a good predictor of the severity of acute tubular necrosis. We evaluated the measurement of urinary cystatin C and determined its reference range. METHODS:Measurement of urinary cystatin C by particle-enhance...

journal_title：Annals of clinical biochemistry

authors： Herget-Rosenthal S,Feldkamp T,Volbracht L,Kribben A

更新日期：2004-03-01 00:00:00

abstract：:Study of the glycoprotein hormones, including hCG, is complex and evolving, and has benefited from recent major advances in analytical technology and molecular biology. It is important to be aware of the effect that these technological advances have, both on the analytical and the clinical requirements for provision o...

journal_title：Annals of clinical biochemistry

authors： Sturgeon CM,McAllister EJ

更新日期：1998-07-01 00:00:00

abstract：:Salivary theophylline concentrations in neonates were measured by a homogeneous enzyme immunoassay and compared with serum concentrations. Free serum theophylline concentrations were also compared with salivary concentrations and the values obtained were almost identical. Results using the immunoassay agreed well with...

journal_title：Annals of clinical biochemistry

authors： Thompson SJ

更新日期：1994-05-01 00:00:00

abstract：:ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...

journal_title：Annals of clinical biochemistry

authors： Holt H,Freedman DB

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Neutrophilic polymorphonuclear leukocytes play a crucial role in the host defence against bacterial and fungal infections. They participate in the inflammatory response through the liberation of peptides and enzymes like myeloperoxidase (MPO). Therefore, MPO has a potential as a marker enzyme for the diagnos...

journal_title：Annals of clinical biochemistry

authors： Hasmann A,Wehrschuetz-Sigl E,Marold A,Wiesbauer H,Schoeftner R,Gewessler U,Kandelbauer A,Schiffer D,Schneider KP,Binder B,Schintler M,Guebitz GM

更新日期：2013-05-01 00:00:00