Some studies on the polyethylene glycol turbidity method for detecting immune complexes in serum.

abstract：:Ethylene glycol in plasma, urine or dialysis fluid is analysed as the phenylboronate derivative by mixing with acetonitrile/acidified 2,2-dimethoxypropane containing phenylboronic acid. After centrifugation, a portion of the supernatant is analysed directly by gas-liquid chromatography using a 3% OV-101 column at 150 ...

journal_title：Annals of clinical biochemistry

authors： Flanagan RJ,Dawling S,Buckley BM

更新日期：1987-01-01 00:00:00

abstract：:Despite sonographic detection of foetal goitre, uncertainty persists in the initial diagnosis of thyrotoxicosis and hypothyroidism. The aim of this study was to establish foetal and neonatal iodothyronine and thyrotrophin reference values for the ACS-180SE analyser. From 22 to 36 weeks of gestation, median foetal seru...

journal_title：Annals of clinical biochemistry

authors： Guibourdenche J,Noël M,Chevenne D,Vuillard E,Voluménie JL,Polak M,Boissinot C,Porquet D,Luton D

更新日期：2001-09-01 00:00:00

abstract：:591 patients with a history of coronary heart disease had one or more biochemical markers of tobacco smoking measured. 26% were self reported smokers and a further 4% were apparent 'smoking deceivers'. The urinary nicotine metabolite concentration is an excellent marker for tobacco smoking; breath CO would be a suitab...

journal_title：Annals of clinical biochemistry

authors： Archbold GP,Cupples ME,McKnight A,Linton T

更新日期：1995-03-01 00:00:00

abstract：:Some inherited metabolic disorders (IMDs) can cause significant complications during pregnancy, affecting the mother and/or the fetus. Although it appears that only a minority of IMDs have these effects, experience is still being acquired. For some disorders, patients will not have reached child-bearing age. Pregnanci...

journal_title：Annals of clinical biochemistry

authors： Preece MA,Green A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Calculated globulin fraction is derived from the liver function tests by subtracting albumin from the total protein. Since immunoglobulins comprise the largest component of the serum globulin concentration, increased or decreased calculated globulins and may identify patients with hypogammaglobulinaemia or h...

journal_title：Annals of clinical biochemistry

authors： Hoo T,Lim E,John M,D'Orsogna L,McLean-Tooke A

更新日期：2021-01-11 00:00:00

abstract：:Three sensitive assays (Behring, Organon and LKB-Pharmacia) for measurement of serum thyrotropin (TSH) were evaluated. All three assays showed good precision, sensitivity, linearity and for practical purposes negligible high dose hook effects. The correlations between the assays were excellent, but due to standardisat...

journal_title：Annals of clinical biochemistry

authors： Bonte HA,Vermes I,v d Sluijs Veer G

更新日期：1989-11-01 00:00:00

abstract：:Many attempt are now being made by external agencies to assess the quality of assay performance in hormone laboratories. Some of the problems associated with this are discussed and some remedies are proposed. ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL

更新日期：1981-01-01 00:00:00

abstract：:Neuropeptides are present in brain tissue as well as in cerebrospinal fluid. Studies from a variety of disciplines have demonstrated that neuropeptides have neuromodulatory activities. Such activities are apparent in the involvement of neuropeptides in the regulation of adaptive, autonomic, and endocrine functions of ...

journal_title：Annals of clinical biochemistry

authors： Burbach JP

更新日期：1982-07-01 00:00:00

abstract：:Salivary theophylline concentrations in neonates were measured by a homogeneous enzyme immunoassay and compared with serum concentrations. Free serum theophylline concentrations were also compared with salivary concentrations and the values obtained were almost identical. Results using the immunoassay agreed well with...

journal_title：Annals of clinical biochemistry

authors： Thompson SJ

更新日期：1994-05-01 00:00:00

abstract：:This paper summarises the views of the authors on the provision of a prolactin assay service. We discuss the pathophysiology of prolactin secretion and the clinical indications that arise from that. We cover the rather complex issue of the definition of normal and elevated prolactin levels. From these considerations, ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL,Bacon RR,Beastall GH,Diver MJ,Franks S,Seth J

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Recent NICE Guidelines have emphasized the need to have in place by 2007 the capability of offering screening to all women in the first trimester using a combination of maternal age with the ultrasound marker nuchal translucency thickness (NT) and the maternal serum biochemical markers free beta-hCG and preg...

journal_title：Annals of clinical biochemistry

authors： Spencer K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:A convenient method for the measurement of sialic acid in plasma apoB-containing lipoproteins is described. METHODS:Dextran sulphate-Mg(2+) precipitation and enzymatic sialic acid assay were combined and applied to analysis of plasma from 96 healthy controls and 136 hyperlipidaemic subjects of types IIa (n=...

journal_title：Annals of clinical biochemistry

authors： Shishino K,Yoshioka Y,Hashimoto K,Ochi M,Aono K,Murase M,Osawa H,Makino H,Saheki S

更新日期：2005-07-01 00:00:00

abstract：:Sequential measurements of plasma alkaline phosphatase activity were made in 84 pre-term infants delivered before 38 weeks gestation. In 67% of infants, without evidence of rickets but in whom three or more measurements were made and the peak activity was less than 10 times the adult reference range, the activity rose...

journal_title：Annals of clinical biochemistry

authors： Walters EG,Murphy JF,Henry P,Gray OP,Elder GH

更新日期：1986-11-01 00:00:00

abstract：:Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate...

journal_title：Annals of clinical biochemistry

authors： Pecoraro V,Banfi G,Germagnoli L,Trenti T

更新日期：2017-07-01 00:00:00

abstract：:This paper describes some factors to which attention should be paid when atrial natriuretic peptide (ANP) values are to be interpreted. Changing from the supine to the sitting position decreased ANP levels, while no further decrease was observed when the upright position was assumed. On the other hand, plasma renin ac...

journal_title：Annals of clinical biochemistry

authors： Tan AC,Kloppenborg PW,Benraad TJ

更新日期：1989-11-01 00:00:00

abstract：:The application of a DC plasma emission spectrometer to the measurement of copper, zinc and magnesium in serum and urine is reported. Each assay requires only a simple dilution in 1% nitric acid. Comparisons with standard atomic absorption techniques showed good analytical agreement, especially for copper and magnesiu...

journal_title：Annals of clinical biochemistry

authors： Roberts NB,Fairclough D,McLoughlin S,Taylor WH

更新日期：1985-09-01 00:00:00

abstract：:Addison's disease is a relatively common disorder to endocrinologists, but is rare and potentially fatal when presenting acutely. Treatment now involves replacement of glucocorticoids and mineralocorticoids with synthetic compounds, although historically patients took common salt and plant-based preparations. We descr...

journal_title：Annals of clinical biochemistry

authors： Cooper H,Bhattacharya B,Verma V,McCulloch AJ,Smellie WS,Heald AH

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Measurement of aldosterone and/or renin is essential to aid the differential diagnosis of secondary hypertension, guide strategy for therapeutic management of hypertension and assess adequacy of mineralocorticoid replacement. AIM:The objective was to establish normative data for aldosterone and renin using ...

journal_title：Annals of clinical biochemistry

authors： O'Shea P,Brady JJ,Gallagher N,Dennedy MC,Fitzgibbon M

更新日期：2016-05-01 00:00:00

abstract：:Background The clinical utility of serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma may be compromised by the presence of endogenous antithyroglobulin antibodies. To prevent interference by antithyroglobulin antibodies several groups have developed real-time PCR-based assays for q...

journal_title：Annals of clinical biochemistry

authors： Feddersen S,Bastholt L,Pedersen SM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Unnecessary blood tests are estimated to contribute to 25% of wastage in the National Health Service. The aim of this study was to assess the financial implication of clinical need-focused blood tests guided by a senior clinician in a district general hospital. METHODS:We conducted an observational longitud...

journal_title：Annals of clinical biochemistry

authors： Mughal Z,Narayanan A,Gupta V,Reay-Jones N

更新日期：2016-09-01 00:00:00

abstract：:Acid-urea extract of rat brain was examined by glucagon-like peptide-1 (GLP-1) specific radioimmunoassay. A single peak was observed which co-eluted with GLP-1(7-36)amide on gel filtration and anion exchange chromatography. In contrast, GLP-1(1-37) was not detected under our experimental conditions. The fact that GLP-...

journal_title：Annals of clinical biochemistry

authors： Yoshimoto S,Hirota M,Ohboshi C,Shima K

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：:The System 1 produced results for glucose and urea which were precise and accurate. It proved suitable as a general laboratory instrument as it samples 28 mul of specimen, is able to calibrate itself, produces results in three minutes, and has the capacity to analyse 56 samples an hour. ...

journal_title：Annals of clinical biochemistry

authors： Potezny N,Quelch J,Fuller B,Geary TD

更新日期：1977-09-01 00:00:00

abstract：:Autosomal dominant hypercholesterolaemia is genetically heterogeneous, but most commonly (approximately 93%) caused by mutations in low-density lipoprotein receptor (LDLR), where the disease is known as familial hypercholesterolaemia (FH), or apolipoprotein B-100 (APOB) (approximately 5.5%), where the disease is known...

journal_title：Annals of clinical biochemistry

authors： Taylor A,Bayly G,Patel K,Yarram L,Williams M,Hamilton-Shield J,Humphries SE,Norbury G

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia (plasma cholesterol concentration â¥5.2 mmol/L) is a risk factor for cardiovascular disease and stroke. Many different cholesterol self-tests are readily available at general stores, pharmacies and web shops. However, there is limited information on their analytical and diagnostic perfor...

journal_title：Annals of clinical biochemistry

authors： Kurstjens S,Gemen E,Walk S,Njo T,Krabbe J,Gijzen K,Elisen MGLM,Kusters R

更新日期：2021-01-21 00:00:00

abstract：:γ-glutamyltransferase plays a key role in the synthesis and metabolism of extracellular glutathione, a major antioxidant in several defence mechanisms in the body. γ-glutamyltransferase is affected by environmental and genetic factors, and is raised when there is depletion of glutathione. Hence, it is a marker of oxid...

journal_title：Annals of clinical biochemistry

authors： Bulusu S,Sharma M

更新日期：2016-05-01 00:00:00

abstract：BACKGROUNDS:Diabetic patients with end-stage renal disease who are not on haemodialysis show low concentrations of HbA1c and glycated albumin due to renal anaemia and proteinuria, respectively. In the present study, we examined whether serum albumin-adjusted glycated albumin could accurately reflect glycaemic control i...

journal_title：Annals of clinical biochemistry

authors： Fukami K,Shibata R,Nakayama H,Yamada K,Okuda S,Koga M

更新日期：2015-07-01 00:00:00

abstract：:Background After adrenalectomy, urinary fractionated metanephrine concentrations are expected to be reduced. However, there are few studies suggesting cut-offs for adrenalectomy patients. Methods Urinary metanephrine and normetanephrine concentrations in adrenalectomy patients and two controls were compared and hormon...

journal_title：Annals of clinical biochemistry

authors： Cho YY,Kim YN,Kim JH,Jeong BC,Lee SY,Kim JH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Adding or incorporating clinical interpretative comments on biochemistry results is widespread in UK laboratories; although this consumes considerable human resource, there is still little evidence to suggest that it is either effective or appreciated by our clinical colleagues. I therefore decided to survey...

journal_title：Annals of clinical biochemistry

authors： Barlow IM

更新日期：2008-01-01 00:00:00

abstract：:It is increasingly easy for the general public to access a wide range of laboratory tests. Tests can be ordered online with little or no input from a health professional. The complementary and alternative medicine (CAM) community promote and sell a wide range of tests, many of which are of dubious clinical significanc...

journal_title：Annals of clinical biochemistry

authors： Jones SL,Campbell B,Hart T

更新日期：2019-05-01 00:00:00