Stabilization of circulating thyroglobulin mRNA transcripts in patients treated for differentiated thyroid carcinoma.

abstract：:The two stages of a two-site immunoradiometric assay were investigated separately. In the first stage, the amount of ferritin bound to coated tubes initially showed a rapid increase with increasing concentration of added ferritin. This was followed by a plateau and then a further increase which appeared to be largely ...

journal_title：Annals of clinical biochemistry

authors： Perera P,Worwood M

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND AIM:Familial hypercholesterolaemia is caused by variants in the low-density lipoprotein cholesterol metabolic pathway involving LDLR, APOB and PCSK9 genes. A national genetic testing service in Wales, UK has observed that no familial hypercholesterolaemia variant is found in almost 80% patients with the ...

journal_title：Annals of clinical biochemistry

authors： Ashfield-Watt P,Haralambos K,Edwards R,Townsend D,Gingell R,Wa Li K,Humphries SE,McDowell I

更新日期：2019-01-01 00:00:00

abstract：:Background Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lupus anticoagulant or to complexes formed by phospholipids and protein ...

journal_title：Annals of clinical biochemistry

authors： Pelusa HF,Pezzarini E,Basiglio CL,Musuruana J,Bearzotti M,Svetaz MJ,Daniele SM,Bottai H,Arriaga SM

更新日期：2017-09-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the malignant proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. Diagnosis and management of patients with monoclonal gammopathies depend on accurate identification and characterization of monoclonal proteins. We present a 6...

journal_title：Annals of clinical biochemistry

authors： Aksungar FB,Ayer M,Serteser M,Coskun A,Unsal I

更新日期：2014-09-01 00:00:00

abstract：:17-Hydroxyprogesterone (17-OHP) is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase. An inherited deficiency of 21-hydroxylase leads to greatly increased serum concentrations of 17-OHP, while the absence of cortisol synthesis cause...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Abundant evidence indicate the increased levels of oxidative stress in patients with autism. Advanced glycation end products and advanced lipoxidation end products and their precursors play a major role in increased oxidative stress in numerous metabolic and neurologic diseases. Carnosine is a natural dipept...

journal_title：Annals of clinical biochemistry

authors： Ghodsi R,Kheirouri S,Nosrati R

更新日期：2019-01-01 00:00:00

abstract：:Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate...

journal_title：Annals of clinical biochemistry

authors： Pecoraro V,Banfi G,Germagnoli L,Trenti T

更新日期：2017-07-01 00:00:00

abstract：:The application of a DC plasma emission spectrometer to the measurement of copper, zinc and magnesium in serum and urine is reported. Each assay requires only a simple dilution in 1% nitric acid. Comparisons with standard atomic absorption techniques showed good analytical agreement, especially for copper and magnesiu...

journal_title：Annals of clinical biochemistry

authors： Roberts NB,Fairclough D,McLoughlin S,Taylor WH

更新日期：1985-09-01 00:00:00

abstract：:Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, "informatics"--the art and science of turning data into useful information--is becoming increasingly im...

journal_title：Annals of clinical biochemistry

authors： Jones R,O'Connor J

更新日期：2004-05-01 00:00:00

abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...

journal_title：Annals of clinical biochemistry

authors： Cooper JD,Turnell DC,Green B,Wright DJ,Coombes EJ

更新日期：1988-09-01 00:00:00

abstract：:Many techniques for the estimation of specific proteins measure light scattered by, or the turbidity of, suspensions of antigen:antibody aggregates formed in fluid-phase reactions. Although the shapes of reaction curves obtained are well documented, interpretation of the data in relation to the laws of light scatterin...

journal_title：Annals of clinical biochemistry

authors： Deverill I,Lock RJ

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Adding or incorporating clinical interpretative comments on biochemistry results is widespread in UK laboratories; although this consumes considerable human resource, there is still little evidence to suggest that it is either effective or appreciated by our clinical colleagues. I therefore decided to survey...

journal_title：Annals of clinical biochemistry

authors： Barlow IM

更新日期：2008-01-01 00:00:00

abstract：:Adverse reactions to foods may arise by a variety of mechanisms, both immune (IgE and non-IgE) and non-immune mediated. This article considers those assays useful in the diagnosis of Type 1 hypersensitivity to foods (IgE-based) and, importantly, discusses those assays where evidence is lacking for their use. In all ca...

journal_title：Annals of clinical biochemistry

authors： Lock RJ,Unsworth DJ

更新日期：2011-07-01 00:00:00

abstract：:The effects of inhibition of inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in guanine nucleotide de novo synthesis, on cell growth, cell viability, endogenous nucleotide concentrations and concentrations of extracellular nucleosides and bases were studied in Molt F4 human malignant lymphoblasts...

journal_title：Annals of clinical biochemistry

authors： Stet EH,De Abreu RA,Bökkerink JP,Lambooy LH,Vogels-Mentink TM,Keizer-Garritsen JJ,Trijbels FJ

更新日期：1994-03-01 00:00:00

abstract：:Erythrocuprein (superoxide dismutase) has recently been shown to have an enzymic function towards superoxide anions. The discovery of superoxide dismutase, its mode of action, and estimation are reviewed along with a brief introduction to oxygen activation and free-radical chemistry. The formation, activity, and destr...

journal_title：Annals of clinical biochemistry

authors： Gutteridge JM

更新日期：1976-05-01 00:00:00

abstract：:This paper summarises the views of the authors on the provision of a prolactin assay service. We discuss the pathophysiology of prolactin secretion and the clinical indications that arise from that. We cover the rather complex issue of the definition of normal and elevated prolactin levels. From these considerations, ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL,Bacon RR,Beastall GH,Diver MJ,Franks S,Seth J

更新日期：1986-11-01 00:00:00

abstract：:The concentrations of serum calcium, parathyroid hormone (PTH), 25 Hydroxyvitamin D (25OHD), and 1,25 Dihydroxyvitamin D (1,25(OH)2D) were determined in 99 Saudi patients with sickle cell disease and in 104 matching healthy controls. Serum calcium and 25OHD were significantly lower in the patients, with 14% and 12% of...

journal_title：Annals of clinical biochemistry

authors： Mohammed S,Addae S,Suleiman S,Adzaku F,Annobil S,Kaddoumi O,Richards J

更新日期：1993-01-01 00:00:00

abstract：:There is an increasing need for sensitive and specific methods for toxicological screening. Development of a dual-column gas chromatography system for the screening of drugs and metabolites in the plasma of poisoned patients is described. The system has been evaluated using plasma from a well-documented series of pati...

journal_title：Annals of clinical biochemistry

authors： Jarvie DR,Simpson D

更新日期：1984-03-01 00:00:00

abstract：:Most UK clinical laboratories use alkaline phosphatase (ALP) methods similar to that proposed by the International Federation of Clinical Chemistry (IFCC), based on the use of 2-amino-2-methyl-1-propanol (AMP) buffer. We present evidence of significant differences in results produced by apparently similar commercial A...

journal_title：Annals of clinical biochemistry

authors： Lamb EJ,Browne M,John WG,Price CP

更新日期：1998-01-01 00:00:00

abstract：:We assayed interleukin 6 (IL-6) concentrations in cerebrospinal fluid (CSF) from patients affected by meningitis of different aetiologies, and verified whether IL-6 can be used as a diagnostic marker in the differential diagnosis of meningitis. We used a monoclonal antibody enzyme immunoassay to test 98 CSF samples cl...

journal_title：Annals of clinical biochemistry

authors： López-Cortés LF,Cruz-Ruiz M,Gómez-Mateos J,Jiménez-Hernández D,Viciana-Fernández P,Jiménez-Mejías E

更新日期：1997-03-01 00:00:00

abstract：:Mass spectrometry has for many years enabled us to rapidly identify and quantify many different compounds in biological samples. The equipment is currently available in specialist centres investigating metabolic disorders and in toxicology laboratories. Improvements in sample introduction and refinements in the mass s...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2003-11-01 00:00:00

abstract：:Background We investigated the in vitro effects of various phospholipids as emulsifiers on the hydrolysing activities of lipoprotein lipase (LPL) Arg243His against triolein as substrate. LPL Arg243His, identified in a patient with hyperchylomicronaemia, displays severely diminished activity for triolein when emulsifie...

journal_title：Annals of clinical biochemistry

authors： Yamaguchi T,Murano T,Tatsuno I,Hiruta N,Suzuki T,Sawada S,Katagiri H,Shirai K,Schneider WJ,Bujo H

更新日期：2017-11-01 00:00:00

abstract：:Most thyroid-stimulating hormone (TSH) assays now have the sensitivity required by thyroid guidelines and allow the reliable identification of patients with both overt and subclinical hyperthyroidism. Clinical guidelines usually quote decision limits for TSH, but often ignore the issue of whether variability in bias b...

journal_title：Annals of clinical biochemistry

authors： Beckett G,MacKenzie F

更新日期：2007-05-01 00:00:00

abstract：:A simple procedure is described for the preparation of a stable precision quality control material for use in the measurement of level of ionised calcium in serum at or near the reference range. Repeat analyses on a Nova 2 ionised calcium analyser of serum pools stored at different temperatures over a period of three ...

journal_title：Annals of clinical biochemistry

authors： Fyffe JA,Jenkins AS,Bolland CJ,Dryburgh FJ,Gardner MD

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Measurement of serum natriuretic peptides is recommended in patients with suspected heart failure. Assays for N-terminal pro-B-type natriuretic peptide (NT-proBNP) are available on several platforms and can be measured in serum or heparinized plasma. Siemens Healthcare Diagnostics do not recommend the use of...

journal_title：Annals of clinical biochemistry

authors： Peake RW,Turner HE,Leaper W,Deans KA,Hannah A,Croal BL

更新日期：2012-09-01 00:00:00

abstract：:The last 10 years have witnessed radical changes in the definition and diagnosis of the acute coronary syndrome (ACS), including myocardial infarction, as a result of the introduction of sensitive and specific markers of myocardial damage, the cardiac troponins. One barrier to the universal acceptance of these markers...

journal_title：Annals of clinical biochemistry

authors： Lamb EJ,Webb MC,Abbas NA

更新日期：2004-01-01 00:00:00

abstract：:Guaiac-based faecal occult blood tests (gFOBT) are still used in asymptomatic population bowel screening programmes but are being replaced by faecal immunochemical tests (FIT) for haemoglobin. gFOBT have many well-documented disadvantages and there is little evidence for their use in assessment of the symptomatic. Man...

journal_title：Annals of clinical biochemistry

authors： Fraser CG

更新日期：2012-11-01 00:00:00

abstract：:Many contradictory results have been published on the stability of total non-esterified fatty acids in blood, plasma and serum under different storage conditions. The present study was undertaken to investigate the stability of non-esterified fatty acids, measured with an enzymatic method, in samples of EDTA-treated p...

journal_title：Annals of clinical biochemistry

authors： Menéndez LG,Fernández AL,Enguix A,Ciriza C,Amador J

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:The initial discovery of leptin (1994) has given rise to a substantial number of published studies. This study aimed at identifying the published data on the reference ranges of total, free and bound leptin concentration in the healthy prepubertal population. METHODS:A search was conducted on original Englis...

journal_title：Annals of clinical biochemistry

authors： Venner AA,Doyle-Baker PK,Lyon ME,Fung TS

更新日期：2009-01-01 00:00:00