Who shall control the controllers? A personal views.

abstract：BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...

journal_title：Annals of clinical biochemistry

authors： Whitehead SJ,Ford C,Gama R

更新日期：2014-01-01 00:00:00

abstract：:Background Point-of-care testing has been developed to provide rapid test results. Most published studies focus on analytical performance, neglecting its impact on patient outcomes. Objective To review the analytical performance and accuracy of point-of-care testing specifically planned for immunoassay and to evaluate...

journal_title：Annals of clinical biochemistry

authors： Pecoraro V,Banfi G,Germagnoli L,Trenti T

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:To assess the accuracy and precision of the Roche Performa and Medisense Optium Xceed (5 and 10 s reading) blood glucose meters. METHODS:Capillary blood samples were taken from 100 patients attending a diabetes centre and blood glucose measured on Roche Performa (n = 4) and Medisense Optium Xceed 5 s (n = 2...

journal_title：Annals of clinical biochemistry

authors： Florkowski C,Budgen C,Kendall D,Lunt H,Moore MP

更新日期：2009-07-01 00:00:00

abstract：:Acid-urea extract of rat brain was examined by glucagon-like peptide-1 (GLP-1) specific radioimmunoassay. A single peak was observed which co-eluted with GLP-1(7-36)amide on gel filtration and anion exchange chromatography. In contrast, GLP-1(1-37) was not detected under our experimental conditions. The fact that GLP-...

journal_title：Annals of clinical biochemistry

authors： Yoshimoto S,Hirota M,Ohboshi C,Shima K

更新日期：1989-03-01 00:00:00

abstract：:Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneou...

journal_title：Annals of clinical biochemistry

authors： Miike A,Ogawa Z,Sakurabayashi I

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:It is important to explain target proteins for the understanding of the pathogenesis of vitreoretinal diseases. In a previous study, we identified more than 100 proteins including seven angiogenic-modulated factors in vitreous humours (VHs). Although there have been many reports of expressed protein profiles...

journal_title：Annals of clinical biochemistry

authors： Mukai N,Nakanishi T,Shimizu A,Takubo T,Ikeda T

更新日期：2008-05-01 00:00:00

abstract：:Improvement in the control of diabetic patients is aided by a knowledge of blood glucose levels during a 'normal' (non-hospitalised) day. We have devised a 5 microliter capillary tube collection system as a 'kit' for home use by diabetics. Blood collected into 5 microliter capillary tubes is washed into a protein prec...

journal_title：Annals of clinical biochemistry

authors： Williams CP,Davies GK,Child DF

更新日期：1981-09-01 00:00:00

abstract：:We evaluated a new immunoselective enzyme assay of bone-specific alkaline phosphatase (ALP). The monoclonal antibody used in this assay was raised against purified bone-specific ALP obtained from SAOS-2 human osteosarcoma cell line. Calibration was based on the enzyme's own activity. The relative activity of the antib...

journal_title：Annals of clinical biochemistry

authors： Hata K,Tokuhiro H,Nakatsuka K,Miki T,Nishizawa Y,Morii H,Miura M

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:In a network of laboratories analytical variability between instruments, even of the same type, may exist for reasons beyond the control of laboratory staff. Controlling variability is a prerequisite for the application of shared reference ranges and for ensuring the transferability of patient test results. ...

journal_title：Annals of clinical biochemistry

authors： Jassam N,Lindsay C,Harrison K,Thompson D,Bosomworth MP,Barth JH

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Biological variation of an analyte is an important determinant of its usefulness. Intraindividual variation in serum thyroid hormones, parathyroid hormone (PTH) and insulin-like growth factor-1 (IGF-1) in healthy subjects was determined in this study. METHODS:Blood samples were taken at weekly intervals for...

journal_title：Annals of clinical biochemistry

authors： Ankrah-Tetteh T,Wijeratne S,Swaminathan R

更新日期：2008-03-01 00:00:00

abstract：:The extent of lipoprotein glycation was assessed in 82 patients diagnosed as diabetes mellitus type II. Glycated lipoprotein levels in serum were determined by agarose gel film electrophoresis in 48 non-diabetic control subjects, 56 diabetics with complications and 26 diabetics with no complications. All glycated lipo...

journal_title：Annals of clinical biochemistry

authors： Yeğin A,Ozben T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Emergency abdominal surgery carries considerable postoperative morbidity and mortality. Hypovolaemia is considered to be a cause of renal hypoperfusion, which is associated with a decreased clearance of serum urea and creatinine. This study examines whether the perioperative serum urea and creatinine concent...

journal_title：Annals of clinical biochemistry

authors： Harten J,Hay A,McMillan DC,McArdle CS,O'Reilly DS,Kinsella J

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIM:Familial hypercholesterolaemia is caused by variants in the low-density lipoprotein cholesterol metabolic pathway involving LDLR, APOB and PCSK9 genes. A national genetic testing service in Wales, UK has observed that no familial hypercholesterolaemia variant is found in almost 80% patients with the ...

journal_title：Annals of clinical biochemistry

authors： Ashfield-Watt P,Haralambos K,Edwards R,Townsend D,Gingell R,Wa Li K,Humphries SE,McDowell I

更新日期：2019-01-01 00:00:00

abstract：:The number of known inherited metabolic disorders resulting in an organic aciduria has increased steadily over the past two decades. Prompt and reliable detection is both clinically and technically demanding but is essential if appropriate treatment is to be undertaken. This is the first study of laboratory performanc...

journal_title：Annals of clinical biochemistry

authors： Bonham JR,Downing M,Pollitt RJ,Manning NJ,Carpenter KH,Olpin SE,Allen JC,Worthy E

更新日期：1994-03-01 00:00:00

abstract：:A 19-year-old man who developed extensive oesophageal lye (Alkali) stricture and received long-term enteral nutrition (eight months) with a jejunostomy tube developed macrocytic anaemia (Hb: 41 g/L) with leucopenia (white blood cell [WBC]: 3.0 x 10(9)/L). The patient's serum vitamin B12, folate, iron and liver functio...

journal_title：Annals of clinical biochemistry

authors： Jayakumar S,Micallef-Eynaud PD,Lyon TD,Cramb R,Jilaihawi AN,Prakash D

更新日期：2005-05-01 00:00:00

abstract：:This paper describes some factors to which attention should be paid when atrial natriuretic peptide (ANP) values are to be interpreted. Changing from the supine to the sitting position decreased ANP levels, while no further decrease was observed when the upright position was assumed. On the other hand, plasma renin ac...

journal_title：Annals of clinical biochemistry

authors： Tan AC,Kloppenborg PW,Benraad TJ

更新日期：1989-11-01 00:00:00

abstract：:We studied the serum protein binding of 3H-labelled progesterone, oestradiol and testosterone, and five 125I-labelled analogues of these steroids. All tracers investigated appeared to be bound by proteins in every serum sample tested. The addition of blocking agents caused a substantial reduction in serum protein bind...

journal_title：Annals of clinical biochemistry

authors： Micallef JV,Hayes MM,Latif A,Ahsan R,Sufi SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:It has been suggested that for the accurate measurement of calcium in urine, samples must be collected into bottles containing acid. Acidification poses risks to both patients and laboratory staff. Here we reappraise whether acidification is a preanalytical necessity. METHODS:Twenty-four-hour urine samples ...

journal_title：Annals of clinical biochemistry

authors： Sodi R,Bailey LB,Glaysher J,Allars L,Roberts NB,Marks EM,Fraser WD

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:There are few data on oxidative stresses during and after pregnancy, although aggravation of autoimmune disease is implicated in oxidative stress and occurs frequently in the postpartum period. Thioredoxin (TRX) is a stress-inducible protein, and is used as a good biomarker for oxidative stress. To clarify t...

journal_title：Annals of clinical biochemistry

authors： Kuroda S,Watanabe M,Santo T,Shimizuishi Y,Takano T,Hidaka Y,Kimura T,Iwatani Y

更新日期：2010-01-01 00:00:00

abstract：:Parenteral nutrition is a well-established technique for feeding patients with intestinal failure and other conditions which render enteral feeding impossible. Biochemical tests are required in the initial assessment of these patients, for monitoring their response to treatment and for the detection and management of ...

journal_title：Annals of clinical biochemistry

authors： Marshall WJ,Mitchell PE

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:We evaluated procalcitonin (PCT) assay in the emergency diagnosis of neonatal bacterial infection, especially in preterm infants, relative to C-reactive protein (CRP) and fibrinogen. METHODS:One hundred and twenty neonates (32 preterm), of whom 21 were infected, were tested. RESULTS:Concentrations of PCT, ...

journal_title：Annals of clinical biochemistry

authors： Guibourdenche J,Bedu A,Petzold L,Marchand M,Mariani-Kurdjian P,Hurtaud-Roux MF,Aujard Y,Porquet D

更新日期：2002-03-01 00:00:00

abstract：:The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56 degrees C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for alpha-1-antitrypsin, beta-2-microglobulin, IgE, fibrinogen,...

journal_title：Annals of clinical biochemistry

authors： Gleeson M,Herd L,Burns C

更新日期：1990-11-01 00:00:00

abstract：:The total cost of a haematology and clinical chemistry laboratory, including external and hospital costs, was studied in a district general hospital in The Netherlands. The main conclusion is that the number of samples analysed is the most important cost-setting factor, but that reduction in the number of requests doe...

journal_title：Annals of clinical biochemistry

authors： Leijten JF,van der Geer F,Scholten MN,Goldschmidt HM

更新日期：1984-03-01 00:00:00

abstract：:The Poser criteria for diagnosing multiple sclerosis (MS) includes clinical, paraclinical and laboratory information. We studied the influence of cerebrospinal fluid (CSF) biochemistry results on the categorisation of patients with suspected MS. A retrospective study was made of 138 patients who had CSF samples sent o...

journal_title：Annals of clinical biochemistry

authors： Ratnaike S,Kilpatrick T,Tress B,Davis S,Kilpatrick C,Byron K,Deam D

更新日期：1990-05-01 00:00:00

abstract：:We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), alpha-1-antichymotrypsin (ACT) and alpha-1-acid glycoprotein (AGP) were deter...

journal_title：Annals of clinical biochemistry

authors： Casl MT,Sabljar-Matovinović M,Kovacević S,Pocanić D,Preden-Kereković V,Jagarinec N

更新日期：1993-05-01 00:00:00

abstract：:Background Analysis of dried blood specimens has been an integral part of laboratory medicine dating back to the early 1960s when they were introduced as part of neonatal screening programs. More recently, they have been used in Down syndrome screening programmes. Dried blood spot specimens can be collected either by ...

journal_title：Annals of clinical biochemistry

authors： Krantz DA,Carmichael JB

更新日期：2013-11-01 00:00:00

abstract：:Erythrocuprein (superoxide dismutase) has recently been shown to have an enzymic function towards superoxide anions. The discovery of superoxide dismutase, its mode of action, and estimation are reviewed along with a brief introduction to oxygen activation and free-radical chemistry. The formation, activity, and destr...

journal_title：Annals of clinical biochemistry

authors： Gutteridge JM

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND AND METHODS:We report a case of insulinoma in which the diagnosis was very challenging as some of the biochemical data were consistently equivocal. In order to assess the relative reliability of the analytical tests, retrospective biochemical data on 45 other cases of histologically confirmed insulinoma were...

journal_title：Annals of clinical biochemistry

authors： Chammas NK,Teale JD,Quin JD

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Measurement of serum natriuretic peptides is recommended in patients with suspected heart failure. Assays for N-terminal pro-B-type natriuretic peptide (NT-proBNP) are available on several platforms and can be measured in serum or heparinized plasma. Siemens Healthcare Diagnostics do not recommend the use of...

journal_title：Annals of clinical biochemistry

authors： Peake RW,Turner HE,Leaper W,Deans KA,Hannah A,Croal BL

更新日期：2012-09-01 00:00:00

abstract：:The measurement of glycated haemoglobin (glycated Hb) by automated high pressure liquid chromatography enabled the prevalence of haemoglobin variants (Hb variant) to be determined in a large diabetic population within Leeds, UK. There were 16 patients showing a Hb variant amongst a total of 5300 diabetics, the majorit...

journal_title：Annals of clinical biochemistry

authors： Allen KR,Hamilton AD,Bodansky HJ,Poon P

更新日期：1992-07-01 00:00:00