The implementation of a system for managing analytical quality in networked laboratories.


BACKGROUND:In a network of laboratories analytical variability between instruments, even of the same type, may exist for reasons beyond the control of laboratory staff. Controlling variability is a prerequisite for the application of shared reference ranges and for ensuring the transferability of patient test results. Controlling variability requires a robust, non-conventional quality system to detect poor performance of analysers that are geographically distant. Essential to this quality system is a set of well-defined quality specifications. METHODS:The approach used in our study started with (1) selection of a model for quality specifications based on biological variation; the 'three-level model' (TLM) was selected on the basis of its flexibility to accommodate various levels of analytical performance; (2) determination of the performance characteristics of the 71 analytes measured in core biochemistry in terms of imprecision and bias; (3) defining quality requirements in the form of imprecision, bias and total error for 71 analytes measured routinely in core biochemistry; and (4) developing software to assist a consistent wide application of the quality specifications and to monitor analytical indices to the common quality specifications. RESULTS:In this paper we describe how we have implemented this model across our network. Forty-six of the 71 analytes in our core laboratory repertoire were allocated to the TLM. We were able to demonstrate equivalence of results on all analysers, for 42 out of 46 analytes allocated to this model. CONCLUSIONS:We propose that other networked laboratories should investigate the suitability of this quality system for use in their network.


Ann Clin Biochem


Jassam N,Lindsay C,Harrison K,Thompson D,Bosomworth MP,Barth JH




Has Abstract


2011-03-01 00:00:00




Pt 2










  • Cerebrospinal fluid biochemistry in the diagnosis of multiple sclerosis.

    abstract::The Poser criteria for diagnosing multiple sclerosis (MS) includes clinical, paraclinical and laboratory information. We studied the influence of cerebrospinal fluid (CSF) biochemistry results on the categorisation of patients with suspected MS. A retrospective study was made of 138 patients who had CSF samples sent o...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Ratnaike S,Kilpatrick T,Tress B,Davis S,Kilpatrick C,Byron K,Deam D

    更新日期:1990-05-01 00:00:00

  • Severely impaired activity of lipoprotein lipase Arg243His is partially ameliorated by emulsifying phospholipids in in vitro triolein hydrolysis analysis.

    abstract::Background We investigated the in vitro effects of various phospholipids as emulsifiers on the hydrolysing activities of lipoprotein lipase (LPL) Arg243His against triolein as substrate. LPL Arg243His, identified in a patient with hyperchylomicronaemia, displays severely diminished activity for triolein when emulsifie...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Yamaguchi T,Murano T,Tatsuno I,Hiruta N,Suzuki T,Sawada S,Katagiri H,Shirai K,Schneider WJ,Bujo H

    更新日期:2017-11-01 00:00:00

  • Identification of factors limiting the accurate measurement of plasma D-penicillamine in rheumatoid arthritis patients.

    abstract::Free and total reduced concentrations of D-penicillamine have been measured in the plasma of rheumatoid arthritis patients by HPLC and electro-chemical detection. A reverse-phase ion-pair separation in conjunction with a dual porous graphite electrode satisfied the requirements of robustness, sensitivity, selectivity ...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Webb BA,Richardson SJ,Haslock I

    更新日期:1988-03-01 00:00:00

  • Quality assessment of urinary organic acid analysis.

    abstract::The number of known inherited metabolic disorders resulting in an organic aciduria has increased steadily over the past two decades. Prompt and reliable detection is both clinically and technically demanding but is essential if appropriate treatment is to be undertaken. This is the first study of laboratory performanc...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Bonham JR,Downing M,Pollitt RJ,Manning NJ,Carpenter KH,Olpin SE,Allen JC,Worthy E

    更新日期:1994-03-01 00:00:00

  • A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100.

    abstract::Autosomal dominant hypercholesterolaemia is genetically heterogeneous, but most commonly (approximately 93%) caused by mutations in low-density lipoprotein receptor (LDLR), where the disease is known as familial hypercholesterolaemia (FH), or apolipoprotein B-100 (APOB) (approximately 5.5%), where the disease is known...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Taylor A,Bayly G,Patel K,Yarram L,Williams M,Hamilton-Shield J,Humphries SE,Norbury G

    更新日期:2010-09-01 00:00:00

  • A meta-analysis of leptin reference ranges in the healthy paediatric prepubertal population.

    abstract:OBJECTIVE:The initial discovery of leptin (1994) has given rise to a substantial number of published studies. This study aimed at identifying the published data on the reference ranges of total, free and bound leptin concentration in the healthy prepubertal population. METHODS:A search was conducted on original Englis...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章,meta分析


    authors: Venner AA,Doyle-Baker PK,Lyon ME,Fung TS

    更新日期:2009-01-01 00:00:00

  • Measurement of markers of tobacco smoking in patients with coronary heart disease.

    abstract::591 patients with a history of coronary heart disease had one or more biochemical markers of tobacco smoking measured. 26% were self reported smokers and a further 4% were apparent 'smoking deceivers'. The urinary nicotine metabolite concentration is an excellent marker for tobacco smoking; breath CO would be a suitab...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Archbold GP,Cupples ME,McKnight A,Linton T

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    abstract:BACKGROUND:Golgi protein-73 (GP73) is a newly identified candidate serum marker for liver diseases. The utility of this biomarker remains limited, largely due to the lack of quantitative information. The aims of this study were to quantify serum GP73 (sGP73) in healthy individuals and in patients with liver diseases, a...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Gu Y,Chen W,Zhao Y,Chen L,Peng T

    更新日期:2009-01-01 00:00:00

  • A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide.

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    pub_type: 杂志文章


    authors: Sugita O,Ishizawa N,Matsuto T,Okada M,Kayahara N

    更新日期:2004-01-01 00:00:00

  • Postprandial effect of a high fat meal on plasma lipid, lipoprotein cholesterol and apolipoprotein measurements.

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    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Rifai N,Merrill JR,Holly RG

    更新日期:1990-09-01 00:00:00

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    abstract::The diagnostic usefulness of fasting total serum bile acids (SBA/F) in the detection of liver diseases and assessment of different aspects of hepatic function alteration was evaluated in 61 healthy subjects and 186 patients with liver disease. The value of SBA/F was compared with other routine tests. In 49 healthy sub...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Cravetto C,Molino G,Biondi AM,Cavanna A,Avagnina P,Frediani S

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    abstract::Most thyroid-stimulating hormone (TSH) assays now have the sensitivity required by thyroid guidelines and allow the reliable identification of patients with both overt and subclinical hyperthyroidism. Clinical guidelines usually quote decision limits for TSH, but often ignore the issue of whether variability in bias b...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Beckett G,MacKenzie F

    更新日期:2007-05-01 00:00:00

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    abstract:BACKGROUND:Method-dependent variation of caeruloplasmin measurement is significant and necessitates the requirement for assay-specific reference intervals. Local determination becomes necessary in the absence of suitable published or manufacturer-quoted reference intervals. METHODS:Applicability of the Beckman Coulter...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Kaye OE,Cook P

    更新日期:2021-01-27 00:00:00

  • Evaluation of the effect of clinical validation of out of hours critical laboratory results.

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    pub_type: 杂志文章


    authors: Chandrajay D,Narayanan D,Barth JH

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    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Spencer K

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    authors: Chammas NK,Teale JD,Quin JD

    更新日期:2003-11-01 00:00:00

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    authors: Tilbrook LK,Slater J,Agarwal A,Cyriac J

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    authors: Taylor RP,Pennock CA

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    pub_type: 杂志文章


    authors: Moore RA,Turner M,Cousins J,Gales M

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    abstract::A patient with sepsis and jaundice was admitted for diagnosis and treatment. Associated biochemical changes included increased C-reactive protein, conjugated bilirubin and gamma-glutamyltransferase, the duration of which was protracted. High urine coproporphyrin isomer-1 and immunostaining of liver tissue suggested Du...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Devgun MS,El-Nujumi AM,O'Dowd GJ,Barbu V,Poupon R

    更新日期:2012-11-01 00:00:00

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    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Bankson DD,Rifai N,Silverman LM

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    abstract::The application of a DC plasma emission spectrometer to the measurement of copper, zinc and magnesium in serum and urine is reported. Each assay requires only a simple dilution in 1% nitric acid. Comparisons with standard atomic absorption techniques showed good analytical agreement, especially for copper and magnesiu...

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    authors: Roberts NB,Fairclough D,McLoughlin S,Taylor WH

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    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Thompson SJ

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    pub_type: 杂志文章


    authors: Peake RW,Turner HE,Leaper W,Deans KA,Hannah A,Croal BL

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    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Pecoraro V,Banfi G,Germagnoli L,Trenti T

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    pub_type: 杂志文章


    authors: Losty HC,Wheatley H,Doull I

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    pub_type: 临床试验,杂志文章


    authors: Owen LJ,Adaway JE,Davies S,Neale S,El-Farhan N,Ducroq D,Evans C,Rees DA,MacKenzie F,Keevil BG

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    pub_type: 杂志文章


    authors: Gleeson M,Herd L,Burns C

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Barlow IM

    更新日期:2008-01-01 00:00:00