Superoxide dismutase (erythrocuprein) and free radicals in clinical chemistry.

abstract：BACKGROUND:It is recommended that children receiving intravenous fluids should have frequent biochemical monitoring, in some situations 4-6 hourly. Small changes in sodium must be detected, requiring very high precision from sodium analyses. Some children are monitored using venous blood analysed by indirect ion-select...

journal_title：Annals of clinical biochemistry

authors： Loughrey CM,Hanna EV,McDonnell M,Archbold GP

更新日期：2006-11-01 00:00:00

abstract：:A simple HPLC method for the determination of caffeine and theophylline in plasma is described. Separation of theobromine, paraxanthine, theophylline, beta-hydroxyethyltheophylline and caffeine is obtained using a mobile phase of 1% acetic acid/methanol (83:17, v/v) and a Waters Associates NOVA-PAK C18 column protecte...

journal_title：Annals of clinical biochemistry

authors： Pickard CE,Stewart AD,Hartley R,Lucock MD

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Thiopurine methyltransferase (TPMT) catalyses the S-methylation of 6-thiopurine drugs, which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation. TPMT activity is polymorphic as a result of gene mutations. Ethnic variations in phenotype and genotype have been identi...

journal_title：Annals of clinical biochemistry

authors： Laróvere LE,de Kremer RD,Lambooy LH,De Abreu RA

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:It is now established that the bioactive lipid lysophosphatidic acid (LPA) contributes to cancer initiation, progression and metastasis, including those of prostate cancer. LPA is produced in the serum and plasma mainly by conversion from lysophospholipids through the action of lysophospholipase D (lysoPLD),...

journal_title：Annals of clinical biochemistry

authors： Nakamura K,Takeuchi T,Ohkawa R,Okubo S,Yokota H,Tozuka M,Aoki J,Arai H,Ikeda H,Ohshima N,Kitamura T,Yatomi Y

更新日期：2007-11-01 00:00:00

abstract：:The primary antibody deficiency syndromes are a group of rare disorders characterized by an inability to produce clinically effective immunoglobulin responses. Some of these disorders result from genetic mutations in genes involved in B cell development, whereas others appear to be complex polygenic disorders. They mo...

journal_title：Annals of clinical biochemistry

authors： Wood P

更新日期：2009-03-01 00:00:00

abstract：:We have studied 46 patients, 30 men and 16 women, with type 2 (non-insulin-dependent) diabetes in a follow-up period of 6-52 months (mean 30 months). The patients were consecutively entered in the study from the out-patient diabetic clinic. None had urinary tract infections nor proteinuria at entry. Investigations wer...

journal_title：Annals of clinical biochemistry

authors： Friis T,Pedersen LR

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Patient-based real-time quality control (PBRTQC) techniques have been described in clinical chemistry for over 50 years. PBRTQC has a number of advantages over traditional quality control including commutability, cost and the opportunity for real-time monitoring. However, there are few systematic investigati...

journal_title：Annals of clinical biochemistry

authors： Smith JD,Badrick T,Bowling F

更新日期：2020-05-01 00:00:00

abstract：:A series of experiments are described which show that second derivative spectroscopy can be used to quantify conjugated lipid dienes as markers of lipid peroxidation in heptane extracts of plasma from patients with rheumatoid arthritis, osteoarthritis, and healthy controls. Results obtained by this method gave reasona...

journal_title：Annals of clinical biochemistry

authors： Situnayake RD,Crump BJ,Zezulka AV,Davis M,McConkey B,Thurnham DI

更新日期：1990-05-01 00:00:00

abstract：:A real time data processing system for a group of three clinical chemistry laboratories (one base and two satellite) has been developed as a successor to one used previously. This paper describes both the inadequacies of the previous worksheet-based system and the advantages of the new system, including flexibility, f...

journal_title：Annals of clinical biochemistry

authors： Hirst AD,Naylor D,White HL,Walter M

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia (plasma cholesterol concentration â¥5.2 mmol/L) is a risk factor for cardiovascular disease and stroke. Many different cholesterol self-tests are readily available at general stores, pharmacies and web shops. However, there is limited information on their analytical and diagnostic perfor...

journal_title：Annals of clinical biochemistry

authors： Kurstjens S,Gemen E,Walk S,Njo T,Krabbe J,Gijzen K,Elisen MGLM,Kusters R

更新日期：2021-01-21 00:00:00

abstract：OBJECTIVE:The menstrual cycle-related changes in clinical laboratory values were analysed by use of data obtained in the Asian multicentre study aimed at derivation of common reference intervals for 85 major clinical laboratory tests. METHODS:Among 1876 healthy female volunteers, 893 had regular menstruation. They wer...

journal_title：Annals of clinical biochemistry

authors： Masuda S,Ichihara K,Yamanishi H,Hirano Y,Tanaka Y,Kamisako T,Scientific Committee for Asia-Pasific Federation of Clinical Biochemistry.

更新日期：2016-05-01 00:00:00

abstract：:The extent of lipoprotein glycation was assessed in 82 patients diagnosed as diabetes mellitus type II. Glycated lipoprotein levels in serum were determined by agarose gel film electrophoresis in 48 non-diabetic control subjects, 56 diabetics with complications and 26 diabetics with no complications. All glycated lipo...

journal_title：Annals of clinical biochemistry

authors： Yeğin A,Ozben T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:It is not possible to diagnose acute kidney injury (AKI) in early stages with traditional biomarkers. Kidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predictin...

journal_title：Annals of clinical biochemistry

authors： Tekce BK,Uyeturk U,Tekce H,Uyeturk U,Aktas G,Akkaya A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

journal_title：Annals of clinical biochemistry

authors： Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

更新日期：2016-09-01 00:00:00

abstract：:Serum retinol-binding protein (RBP), with a biological half-life of less than 12 h, is a useful indicator of liver or kidney dysfunction. An automated immunoturbidimetric assay for the measurement of RBP has been developed using the Cobas-BIO centrifugal analyser and commercially available materials. Serum samples wit...

journal_title：Annals of clinical biochemistry

authors： Bankson DD,Rifai N,Silverman LM

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:The high-dose hook effect is a well-known phenomenon of two-site immunoassays including those for human chorionic gonadotrophin (hCG). We investigated the occurrence of a high-dose hook effect in six routinely available hCG assays using a sample with a total hCG concentration of approximately 3,600,000 IU/L....

journal_title：Annals of clinical biochemistry

authors： Al-Mahdili HA,Jones GR

更新日期：2010-07-01 00:00:00

abstract：:We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic ch...

journal_title：Annals of clinical biochemistry

authors： van Heyningen C,Hanid TK,Hopkinson I

更新日期：1986-07-01 00:00:00

abstract：:Inherited metabolic disorders account for a small but significant number of sudden unexplained deaths in neonates, infants and occasionally older children. In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity t...

journal_title：Annals of clinical biochemistry

authors： Olpin SE

更新日期：2004-07-01 00:00:00

abstract：:This paper reviews the physiology and pathology of oxygen transport from the atmosphere to the cells in critically ill patients. A thorough understanding of this allows a rational approach to monitoring and managing an hypoxic patient in the intensive care setting. ...

journal_title：Annals of clinical biochemistry

authors： Clapham MC

更新日期：1991-01-01 00:00:00

abstract：:We present two cases of spuriously high cerebrospinal fluid glucose concentration with approximately normal blood glucose concentrations. The cause of these abnormal findings was the use of inappropriate collection tubes during the pre-analytical phase. Whilst no patient harm was identified following this error, signi...

journal_title：Annals of clinical biochemistry

authors： Broz P,Rajdl D,Racek J,Petr T,Vitek L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Circulating levels of bioavailable oestradiol and testosterone are often desirable for clinical practice or investigational studies of children. However, assays to measure circulating hormone levels might not always be accessible. We sought to validate the empirical calculation of circulating bioavailable te...

journal_title：Annals of clinical biochemistry

authors： Egleston BL,Chandler DW,Dorgan JF

更新日期：2010-05-01 00:00:00

abstract：:A p-iodophenol-enhanced luminescent end-point has been incorporated into a commercially available heterogeneous competitive enzyme immunoassay for digoxin based on a horseradish peroxidase-digoxin conjugate. The luminescent end-point could be completed in less than 1 min and significantly reduced overall assay time. R...

journal_title：Annals of clinical biochemistry

authors： Coyle PM,Thorpe GH,Kricka LJ,Whitehead TP

更新日期：1986-01-01 00:00:00

abstract：:Direct assays have been described for the estimation of progesterone in serum and saliva. Both methods showed good inter-assay precision over a year, and the serum assay is now being used routinely in clinical laboratories. A highly significant correlation was obtained for progesterone concentrations in matched serum ...

journal_title：Annals of clinical biochemistry

authors： Webley GE,Edwards R

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:It has been suggested that for the accurate measurement of calcium in urine, samples must be collected into bottles containing acid. Acidification poses risks to both patients and laboratory staff. Here we reappraise whether acidification is a preanalytical necessity. METHODS:Twenty-four-hour urine samples ...

journal_title：Annals of clinical biochemistry

authors： Sodi R,Bailey LB,Glaysher J,Allars L,Roberts NB,Marks EM,Fraser WD

更新日期：2009-11-01 00:00:00

abstract：:Background For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultrasensitive immune complex transfer enzyme immunoassay to measure adiponectin in urine. Methods We developed immune complex transfer enzyme immunoassay for adiponectin and measured urinary adiponecti...

journal_title：Annals of clinical biochemistry

authors： Yamamoto M,Fujimoto Y,Hayashi S,Hashida S

更新日期：2018-09-01 00:00:00

abstract：:We developed a new simple assay for potassium ion in serum using urea amidolyase (UAL) from yeast sp. The method is based on activation of the enzyme by potassium ion. We eliminated endogenous ammonium ion by use of glutamate dehydrogenase (GLDH), and then monitored the production of ammonium ion by UAL, urea, ATP, bi...

journal_title：Annals of clinical biochemistry

authors： Kimura S,Iyama S,Yamaguchi Y,Hayashi S,Fushimi R,Amino N

更新日期：1997-07-01 00:00:00

abstract：:Background Detection of alcohol consumption in clients undergoing treatment for alcohol dependence can be difficult. The ethanol metabolites ethyl glucuronide and ethyl sulphate are detectable for longer in urine than either breath ethanol or urine ethanol. Our aim was to develop a liquid chromatography-tandem mass sp...

journal_title：Annals of clinical biochemistry

authors： Armer JM,Allcock RL

更新日期：2017-01-01 00:00:00

abstract：AIM:The aim of the study was to review the clinical validation process of out of hours critical biochemistry results by a clinical biochemist and its effect on primary care services. METHODS:A prospective study was conducted of all critical results for primary care patients who were analysed out of hours. The nine-mon...

journal_title：Annals of clinical biochemistry

authors： Chandrajay D,Narayanan D,Barth JH

更新日期：2016-03-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the malignant proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. Diagnosis and management of patients with monoclonal gammopathies depend on accurate identification and characterization of monoclonal proteins. We present a 6...

journal_title：Annals of clinical biochemistry

authors： Aksungar FB,Ayer M,Serteser M,Coskun A,Unsal I

更新日期：2014-09-01 00:00:00