Abstract：
:The purpose of this study was to assess retrospectively the prevalence of severe hyponatraemia in a hospital population and its laboratory investigation, treatment and clinical outcome. Over a 6-month period 47 patients (27 women and 20 men) were found to have a plasma sodium concentration of < or = 120 mmol/L (this number made up less than 0.17% of all plasma sodium requests over that time period). The mean patient age was 75 +/- 16 years and the average hospital stay was 37 +/- 45 days (1-179 days). Patient mortality was 51% (women 57% and men 43%). The mean initial plasma sodium concentration was 116 +/- 4.5 mmol/L, rising after therapeutic intervention to a mean of 130 +/- 4.2 mmol/L. The mean plasma sodium correction rate was 4.7 +/- 4.3 mmol/L/24 h (0.9-17.5 range). Twelve per cent of the patients had their plasma sodium raised at a rate of greater than 10 mmol/L/24 h after their initial presentation. Two patients may have had symptoms and signs suggestive of cerebral oedema/cortical dysfunction: in one patient the sodium concentration was raised at a rate of 9.5 mmol/L/24 h and in the other at 12.0 mmol/L/24 h. Sixty-one per cent of the patients had a chest infection, 44% were on diuretics, 28% had congestive cardiac failure, 28% were post-operative (9% orthopaedic procedures), 19% had carcinoma and 9% were on a selective serotonin re-uptake inhibitor. Regarding laboratory investigations, 56% had liver function tests, 41% had thyroid function tests, 36% had plasma osmolality determination, 36% had urinary electrolytes including urinary osmolality and < 2% had tests to exclude hypoadrenalism.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Crook MA,Velauthar U,Moran L,Griffiths Wdoi
10.1177/000456329903600204subject
Has Abstractpub_date
1999-03-01 00:00:00pages
158-62eissn
0004-5632issn
1758-1001journal_volume
36 ( Pt 2)pub_type
杂志文章abstract：:The magnitude of the inflammatory response to surgery depends on the degree of injury during surgical procedures. Laparoscopic techniques are generally associated with less postoperative pain and shorter hospital stay compared with open procedures, presumably due to less tissue injury and reduced inflammatory response...
journal_title：Annals of clinical biochemistry
pub_type： 临床试验,杂志文章
doi：10.1177/000456329703400509
更新日期：1997-09-01 00:00:00
abstract：:Erythrocuprein (superoxide dismutase) has recently been shown to have an enzymic function towards superoxide anions. The discovery of superoxide dismutase, its mode of action, and estimation are reviewed along with a brief introduction to oxygen activation and free-radical chemistry. The formation, activity, and destr...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456327601300125
更新日期：1976-05-01 00:00:00
abstract：:Proteinuria is the cardinal sign of renal disease, therefore accurate identification of clinically significant proteinuria is essential to the diagnosis and management of kidney disease. Spot samples are now widely used, namely protein: creatinine ratio (uPCR) and albumin: creatinine ratio (uACR). In this article we r...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1177/0004563212473283
更新日期：2013-07-01 00:00:00
abstract：:A sensitive radioimmunoassay method for sodium cromoglycate in human plasma is described. The lowest quantifiable concentration of sodium cromoglycate is 0.93 nmol/l when 0.1 ml plasma samples are analysed. Direct analysis of sodium cromoglycate concentrations in plasma samples collected up to several hours after the ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328302000105
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:We evaluated the recently released chemiluminescence assay for 25-hydroxy vitamin D (25-OHD) on the Immunodiagnostic Systems iSYS (IDS-iSYS) automated analyser. METHODS:The IDS-iSYS comparison was performed using patient samples previously measured for 25-OHD by a validated liquid chromatography-tandem mass...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/acb.2011.011018
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Pregnancy represents a major risk factor for deep vein thrombosis (DVT). Most coagulation/fibrinolysis markers currently utilized change during pregnancy, and therefore they cannot accurately evaluate thrombotic events in pregnancy because the rate of false positive results is high. Fibrin monomer complex (F...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456307781646076
更新日期：2007-09-01 00:00:00
abstract：:The two stages of a two-site immunoradiometric assay were investigated separately. In the first stage, the amount of ferritin bound to coated tubes initially showed a rapid increase with increasing concentration of added ferritin. This was followed by a plateau and then a further increase which appeared to be largely ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328402100510
更新日期：1984-09-01 00:00:00
abstract：:The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional popul...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328902600314
更新日期：1989-05-01 00:00:00
abstract：:Antibodies to glutamic acid decarboxylase (GAD) are a useful autoimmune marker for type 1 diabetes mellitus in Caucasians. We examined antibodies to GAD and their relationships with clinical features and pancreatic beta cell function in 140 young Chinese diabetic patients. Over an 18-month period beginning in 1995, 14...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329803500609
更新日期：1998-11-01 00:00:00
abstract：:Serum concentrations of total thyroid hormones, thyroid hormone binding proteins, free thyroid hormones and thyroid stimulating hormone (TSH) were measured in a large group of healthy normal subjects (n = 218) to determine the influence of age and sex on tests of thyroid function. No effect of age on measurements of t...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328502200506
更新日期：1985-09-01 00:00:00
abstract：:A radioimmoassay for digoxin is described which uses commercially available reagents. Two assay procedures are used, one for batch assays, and another, which needs a 5 minute incubation only, for 'stat' assays. The methods are shown to be simple, rapid, precise and inexpensive and the batch procedure compared well wit...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328502200216
更新日期：1985-03-01 00:00:00
abstract：:Auto-antibodies to oxidized low-density lipoprotein (ox-LDL) are thought to play a pivotal role in the pathogenesis of atherosclerosis. This study investigates the value of auto-antibodies to ox-LDL as a predictive marker of atherosclerosis in patients with both homozygous and heterozygous familial hypercholesterolaem...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/0004563001899177
更新日期：2000-03-01 00:00:00
abstract：:Two cases of hypercholesterolaemic patients are presented in whom raised plasma creatine kinase was noted during treatment with statins. The plasma creatine kinase failed to fall following cessation of therapy. Further investigation revealed the aetiology of the raised plasma creatine kinase to be due to previously un...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456303322326542
更新日期：2003-09-01 00:00:00
abstract：:We conducted an electrophoretic analysis of monoclonal gamma-globulin found in the serum of a patient with splenic marginal-zone lymphoma. This monoclonal protein showed electrophoretic mobility to the gamma region and reacted with anti-immunoglobulin (IgG) antiserum but not with anti-kappa or anti-lambda light chain ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456306776021490
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:To know whether metformin improves postprandial hyperglycaemia, we examined the effect of metformin on the glycated albumin (GA) to glycated haemoglobin (HbA1c) ratio (GA/HbA1c ratio) in patients with newly diagnosed type 2 diabetes. METHODS:Metformin and lifestyle interventions were initiated in 18 patient...
journal_title：Annals of clinical biochemistry
pub_type： 临床试验,杂志文章
doi：10.1177/0004563214522984
更新日期：2015-01-01 00:00:00
abstract：:In monocytes at the secretory (oestrogen-progesterone dominant) phase of the menstrual cycle, expression of c-fms and macrophage colony-stimulating factor (M-CSF) receptor and activity of tyrosine kinase (TK) were increased by oestradiol with or without progesterone. In vivo, oestrogen may induce expression of c-fms a...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329503200408
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Oxidative stress may play an aetiological role in the development and progression of cardiovascular disease (CVD). However, evidence on its biochemical markers has been controversial. This article aimed to assess the role of F2-isoprostanes, a marker for measuring in vivo lipid oxidation, as a biomarker for ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/acb.2012.011263
更新日期：2013-03-01 00:00:00
abstract：:Background Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported to be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients with subarachnoid haemorrhage (SAH) remains largely unknown. The aim of this study was to investigate t...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563216686623
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Pharmacometabonomics is a new branch of science, first described in 2006 and defined as 'the prediction of the effects of a drug on the basis of a mathematical model of pre-dose metabolite profiles'. Pharmacometabonomics has been used to predict drug metabolism, pharmacokinetics (PK), drug safety and drug ef...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1177/0004563213497929
更新日期：2013-11-01 00:00:00
abstract：:We present two cases of spuriously high cerebrospinal fluid glucose concentration with approximately normal blood glucose concentrations. The cause of these abnormal findings was the use of inappropriate collection tubes during the pre-analytical phase. Whilst no patient harm was identified following this error, signi...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563214547284
更新日期：2015-01-01 00:00:00
abstract：:We examined the reactivity of human serum albumin-bound bilirubin and its photoisomers as substrates for a direct bilirubin assay using bilirubin oxidase. The reduction of (EZ)-cyclobilirubin reached 100% 5 min after addition of the enzyme at any pH tested (3.5-7.4) in 0.1 mol/L phosphate buffer, whereas the reduction...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456320003700404
更新日期：2000-07-01 00:00:00
abstract：:Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, "informatics"--the art and science of turning data into useful information--is becoming increasingly im...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1258/000456304323019532
更新日期：2004-05-01 00:00:00
abstract：:The extent of lipoprotein glycation was assessed in 82 patients diagnosed as diabetes mellitus type II. Glycated lipoprotein levels in serum were determined by agarose gel film electrophoresis in 48 non-diabetic control subjects, 56 diabetics with complications and 26 diabetics with no complications. All glycated lipo...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329503200505
更新日期：1995-09-01 00:00:00
abstract：:The measurement of galactose-1-phosphate has been advocated for monitoring galactosaemia. A radioenzymatic method is described in which red-cell haemolysates are incubated with radiolabelled uridine diphospho-glucose and exogenous galactose-1-phosphate uridyl transferase. Labelled glucose-1-phosphate is formed in prop...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328602300313
更新日期：1986-05-01 00:00:00
abstract：:Hypogonadism in the male results from inadequate testicular function, especially defects in androgen synthesis and secretion, or action. Androgen action is important throughout normal male development: in the fetus, puberty, adult life and old age. Regulation is by variable activity of the hypothalamo-pituitary axis a...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章,评审
doi：10.1258/acb.2010.010150
更新日期：2010-11-01 00:00:00
abstract：:The application of a DC plasma emission spectrometer to the measurement of copper, zinc and magnesium in serum and urine is reported. Each assay requires only a simple dilution in 1% nitric acid. Comparisons with standard atomic absorption techniques showed good analytical agreement, especially for copper and magnesiu...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456328502200512
更新日期：1985-09-01 00:00:00
abstract：:The present study was designed to re-evaluate the radioimmunoassay for desmosine in urine, which is currently used as a measure of elastin metabolism. Using ion exchange chromatography, gel filtration and affinity chromatography it was shown that at least five other compounds in hydrolysates of human urine competed fo...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329202900111
更新日期：1992-01-01 00:00:00
abstract：:In a group of 121 adult patients with end-stage chronic renal failure who had been undergoing maintenance haemodialysis for up to 10 years a number of biochemical variables have been measured and related to a set of objective radiological changes in the same patients. The changes in plasma calcium, magnesium, phosphat...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456327501200126
更新日期：1975-05-01 00:00:00
abstract：:We developed a new simple assay for potassium ion in serum using urea amidolyase (UAL) from yeast sp. The method is based on activation of the enzyme by potassium ion. We eliminated endogenous ammonium ion by use of glutamate dehydrogenase (GLDH), and then monitored the production of ammonium ion by UAL, urea, ATP, bi...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/000456329703400408
更新日期：1997-07-01 00:00:00
abstract：:Background Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lupus anticoagulant or to complexes formed by phospholipids and protein ...
journal_title：Annals of clinical biochemistry
pub_type： 杂志文章
doi：10.1177/0004563216672248
更新日期：2017-09-01 00:00:00
