Pharmacometabonomics and personalized medicine.

abstract：BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

journal_title：Annals of clinical biochemistry

authors： Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

更新日期：2016-09-01 00:00:00

abstract：:Background We investigated the in vitro effects of various phospholipids as emulsifiers on the hydrolysing activities of lipoprotein lipase (LPL) Arg243His against triolein as substrate. LPL Arg243His, identified in a patient with hyperchylomicronaemia, displays severely diminished activity for triolein when emulsifie...

journal_title：Annals of clinical biochemistry

authors： Yamaguchi T,Murano T,Tatsuno I,Hiruta N,Suzuki T,Sawada S,Katagiri H,Shirai K,Schneider WJ,Bujo H

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The haptoglobin (Hp) 2-2 phenotype has been known to have less antioxidative activity than Hp 1-1 and Hp 2-1. However, few have reported the relationship between oxidative stress and Hp phenotypes by using oxidized LDL. The relationship between Hp phenotypes and oxidative stress was therefore investigated in...

journal_title：Annals of clinical biochemistry

authors： Lee YW,Min WK,Chun S,Lee W,Park H,Lee YK,Lee DH,Son JE

更新日期：2004-11-01 00:00:00

abstract：:Parenteral nutrition is a well-established technique for feeding patients with intestinal failure and other conditions which render enteral feeding impossible. Biochemical tests are required in the initial assessment of these patients, for monitoring their response to treatment and for the detection and management of ...

journal_title：Annals of clinical biochemistry

authors： Marshall WJ,Mitchell PE

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:For nearly 20 years, we and others have used a three-parameter power function as a direct estimation error model for immunoassays. The main application is imprecision profile plots (after translating from variance to coefficient of variation) but other uses include weighting functions for regression analysis...

journal_title：Annals of clinical biochemistry

authors： Sadler WA

更新日期：2008-09-01 00:00:00

abstract：:The calculation of within-laboratory imprecision in quality-assessment (QA) programmes normally involves combining data from different analyte concentrations to calculate an average standard deviation (SD) or coefficient of variation. However, for immunoassay neither of these parameters is concentration independent. T...

journal_title：Annals of clinical biochemistry

authors： Compton P,Cole B,Stuart M,Egan G

更新日期：1984-11-01 00:00:00

abstract：:The seasonal variation of serum 25-hydroxy vitamin D3 and 1,25-dihydroxy-vitamin D has been investigated. Blood was taken from 27 healthy volunteers, aged 21-44 years old at 3 monthly intervals over a period of 1 year. A scrolling monthly programme with 12 quarterly (3 month) time periods was developed. A summer assoc...

journal_title：Annals of clinical biochemistry

authors： Hine TJ,Roberts NB

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Plantain, a herbal remedy, has been reported to interfere with therapeutic drug monitoring of digoxin. We evaluated three commercially available plantain products for potential interference with therapeutic drug monitoring of digoxin and 13 other common drugs. METHOD:Dry content of plantain capsule or pla...

journal_title：Annals of clinical biochemistry

authors： Dasgupta A,Davis B,Wells A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：:We studied the serum protein binding of 3H-labelled progesterone, oestradiol and testosterone, and five 125I-labelled analogues of these steroids. All tracers investigated appeared to be bound by proteins in every serum sample tested. The addition of blocking agents caused a substantial reduction in serum protein bind...

journal_title：Annals of clinical biochemistry

authors： Micallef JV,Hayes MM,Latif A,Ahsan R,Sufi SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Measurement of HbA(1c) is the standard test for assessment of glycaemic control in diabetic subjects. Using new glucose sensing technology we re-evaluated the significance of HbA(1c) in terms of the aspects of the blood profile it measures in patients with diabetes. METHODS:In a group of 27 patients with ty...

journal_title：Annals of clinical biochemistry

authors： Sharp P,Rainbow S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Current practice requires regular venous blood samples for monitoring of tacrolimus concentrations post renal transplant requiring regular hospital visits. Mitra devices use volumetric absorptive microsampling technology and absorb a fixed amount of blood (10 μL) from a capillary blood sample. They are a via...

journal_title：Annals of clinical biochemistry

authors： Marshall DJ,Kim JJ,Brand S,Bryne C,Keevil BG

更新日期：2020-09-01 00:00:00

abstract：:Four hundred and fifty-four subjects with hyperamylasaemia were screened for the presence of macroamylase using polyethylene glycol precipitation (PEG) and the Beckman automated amylase assay based on the hydrolysis of maltotetraose. Twenty-five subjects (5.5%) exhibited PEG precipitation values suggestive of macroamy...

journal_title：Annals of clinical biochemistry

authors： Lawson GJ

更新日期：2001-01-01 00:00:00

abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...

journal_title：Annals of clinical biochemistry

authors： Cooper JD,Turnell DC,Green B,Wright DJ,Coombes EJ

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The stability of parathyroid hormone (PTH) in whole blood has not been well characterized. Previous studies show EDTA plasma samples to be more stable than serum samples. METHODS:Blood from 17 haemodialysis patients and five healthy volunteers was collected into serum separator tubes (SSTs) and potassium ED...

journal_title：Annals of clinical biochemistry

authors： English E,McFarlane I,Taylor KP,Halsall DJ

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Measurement of plasma-free metanephrine plus normetanephrine (PFM) is the best screening test for phaeochromocytoma. While clearly raised levels are diagnostic, borderline increases may be associated with factors such as stress and medications, and should prompt a repeat study after interfering factors are w...

journal_title：Annals of clinical biochemistry

authors： Anas SS,Vasikaran SD

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:It has been suggested that for the accurate measurement of calcium in urine, samples must be collected into bottles containing acid. Acidification poses risks to both patients and laboratory staff. Here we reappraise whether acidification is a preanalytical necessity. METHODS:Twenty-four-hour urine samples ...

journal_title：Annals of clinical biochemistry

authors： Sodi R,Bailey LB,Glaysher J,Allars L,Roberts NB,Marks EM,Fraser WD

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20. METHODS:Various concentrations of ascorb...

journal_title：Annals of clinical biochemistry

authors： Meng QH,Irwin WC,Fesser J,Massey KL

更新日期：2005-11-01 00:00:00

abstract：:ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...

journal_title：Annals of clinical biochemistry

authors： Holt H,Freedman DB

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:We evaluated the diagnostic discrimination of a new micro-flow cell device (Nanoduct) which measures sweat conductivity in situ at a regional referral centre for cystic fibrosis (CF). METHODS:The device was evaluated in comparison to the measurement of sweat chloride with the established quantitative piloca...

journal_title：Annals of clinical biochemistry

authors： Losty HC,Wheatley H,Doull I

更新日期：2006-09-01 00:00:00

abstract：:The activity of serum deoxycytidylate deaminase, not hitherto reported to increase after myocardial infarction, has been investigated and the results have been related to other cardiac enzymes, including the MB fraction of creatine phosphokinase. Deoxycytidylate deaminase was found to increase to maximum activity on t...

journal_title：Annals of clinical biochemistry

authors： Roberts RG,Davies AG,Jones DD

更新日期：1978-11-01 00:00:00

abstract：:The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional popul...

journal_title：Annals of clinical biochemistry

authors： Ford RP

更新日期：1989-05-01 00:00:00

abstract：:17-Hydroxyprogesterone (17-OHP) is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase. An inherited deficiency of 21-hydroxylase leads to greatly increased serum concentrations of 17-OHP, while the absence of cortisol synthesis cause...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Current guidelines document persistent rectal bleeding as an alarm symptom in patients presenting to primary care. We studied whether a faecal immunochemical test could assist in their assessment. METHODS:From December 2015, faecal immunochemical tests were routinely available to primary care when assessing...

journal_title：Annals of clinical biochemistry

authors： Digby J,Strachan JA,McCann R,Steele RJ,Fraser CG,Mowat C

更新日期：2020-07-01 00:00:00

abstract：:A bloodspot assay for testosterone has been developed using an antiserum raised against testosterone-3-carboxymethyloxime-bovine serum albumin (T-3 CMO-BSA) conjugate and 125I-T-3CMO-histamine tracer. The method has a detection limit of 0.4 nmol/L with between-batch precision of less than 15% for testosterone values b...

journal_title：Annals of clinical biochemistry

authors： Walker J,Hughes IA,Wood PJ

更新日期：1999-07-01 00:00:00

abstract：:Background The clinical utility of serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma may be compromised by the presence of endogenous antithyroglobulin antibodies. To prevent interference by antithyroglobulin antibodies several groups have developed real-time PCR-based assays for q...

journal_title：Annals of clinical biochemistry

authors： Feddersen S,Bastholt L,Pedersen SM

更新日期：2017-09-01 00:00:00

abstract：:Quadriceps muscle specimens from autopsy of 28 neonates (gestational age 25-42 weeks) were investigated to determine pyruvate and malate oxidation rates and several enzymes of the mitochondrial oxidative process. In general, the levels of all mitochondrial parameters measured, including carnitine levels, were lower in...

journal_title：Annals of clinical biochemistry

authors： Sperl W,Sengers RC,Trijbels JM,Ruitenbeek W,Doesburg WH,Smeitink JA,Kollée LA,Boon JM

更新日期：1992-11-01 00:00:00

abstract：:A simultaneous deterioration in performance of several radioimmunoassays suggested that equipment was malfunctioning. Replicate counts from an automated gamma counter showed unacceptable variation during a 24-hour period; this variation was detected using Trigg's technique, a sensitive method for trend analysis, and w...

journal_title：Annals of clinical biochemistry

authors： Challand GS,Cox L

更新日期：1978-03-01 00:00:00

abstract：:Using a high-performance liquid chromatography method, we measured seven commonly prescribed benzodiazepines (chlordiazepoxide, nitrazepam, nordiazepam, oxazepam, lorazepam, temazepam and diazepam) in 100 urine samples obtained from patients attending the Leeds Addiction Unit. All of the urines selected for investigat...

journal_title：Annals of clinical biochemistry

authors： Garretty DJ,Wolff K,Hay AW,Raistrick D

更新日期：1997-01-01 00:00:00

abstract：:Neuropeptides are present in brain tissue as well as in cerebrospinal fluid. Studies from a variety of disciplines have demonstrated that neuropeptides have neuromodulatory activities. Such activities are apparent in the involvement of neuropeptides in the regulation of adaptive, autonomic, and endocrine functions of ...

journal_title：Annals of clinical biochemistry

authors： Burbach JP

更新日期：1982-07-01 00:00:00