Total parenteral nutrition and the clinical chemistry laboratory.

abstract：:The influence of the glucose concentration in urines being assayed as part of a pancreolauryl test was investigated. Paired patient urines (n = 5) were assayed at 60 degrees and 70 degrees C, before and after spiking to 5% glucose. The influence of assay temperature alone was assessed using glucose-free paired patient...

journal_title：Annals of clinical biochemistry

authors： Trewick AL

更新日期：1998-03-01 00:00:00

abstract：:Some inherited metabolic disorders (IMDs) can cause significant complications during pregnancy, affecting the mother and/or the fetus. Although it appears that only a minority of IMDs have these effects, experience is still being acquired. For some disorders, patients will not have reached child-bearing age. Pregnanci...

journal_title：Annals of clinical biochemistry

authors： Preece MA,Green A

更新日期：2002-09-01 00:00:00

abstract：:Eleven unfit bank executives in sedentary employment exercised daily for 10 weeks according to the Canadian Air-Force 5BX Exercise Programme. Over this period no changes were observed in the glucose or insulin responses to a standard breakfast or to intravenous glucose, or in the glucose response to intravenous insuli...

journal_title：Annals of clinical biochemistry

authors： Moore RA,Penfold WA,Simpson RD,Simpson RW,Mann JI,Turner RC

更新日期：1979-03-01 00:00:00

abstract：:Serum osteocalcin did not show any response to the onset of osteosarcoma in Paget's disease of bone whereas serum alkaline phosphatase increased rapidly. This suggests that osteocalcin is not useful in the diagnosis and management of Paget's osteosarcoma and does not reflect the same osteoblastic processes in bone as ...

journal_title：Annals of clinical biochemistry

authors： Davie MW,Worsfold M,Sharp CA

更新日期：1991-03-01 00:00:00

abstract：:The higher bias of serum cystine estimations by a HPLC method compared with those by ion exchange techniques is shown to be largely due to differences in the sample preparation procedures of the two techniques. The ion exchange methods utilised sulphosalicylic acid serum protein precipitation and post-column ninhydrin...

journal_title：Annals of clinical biochemistry

authors： Cooper JD,Turnell DC,Green B,Wright DJ,Coombes EJ

更新日期：1988-09-01 00:00:00

abstract：:A recently introduced turbidimetric immunoassay using shell/core particles for determination of myoglobin (Turbiquant Myoglobin, Behringwerke, Marburg, Germany) was evaluated on the Behring Turbitimer analyzer. Intra-assay CV varied between 1.0% and 3.2%; interassay CV was between 2.0% and 3.6%. Linear results were ob...

journal_title：Annals of clinical biochemistry

authors： Delanghe J,Chapelle JP,el Allaf M,De Buyzere M

更新日期：1991-09-01 00:00:00

abstract：:Auto-antibodies to oxidized low-density lipoprotein (ox-LDL) are thought to play a pivotal role in the pathogenesis of atherosclerosis. This study investigates the value of auto-antibodies to ox-LDL as a predictive marker of atherosclerosis in patients with both homozygous and heterozygous familial hypercholesterolaem...

journal_title：Annals of clinical biochemistry

authors： Paiker JE,Raal FJ,von Arb M

更新日期：2000-03-01 00:00:00

abstract：:The current search for new treatments to combat coronary heart disease (CHD) is centred on increasing HDL-cholesterol. The failure of the CETP inhibitor torcetrapib may force a rethink. This perspective briefly reviews the antiatherosclerotic properties of HDL and ways HDL-cholesterol concentration can be raised, but ...

journal_title：Annals of clinical biochemistry

authors： Mackness B,Mackness M

更新日期：2009-01-01 00:00:00

abstract：:A simultaneous deterioration in performance of several radioimmunoassays suggested that equipment was malfunctioning. Replicate counts from an automated gamma counter showed unacceptable variation during a 24-hour period; this variation was detected using Trigg's technique, a sensitive method for trend analysis, and w...

journal_title：Annals of clinical biochemistry

authors： Challand GS,Cox L

更新日期：1978-03-01 00:00:00

abstract：:We present two cases of spuriously high cerebrospinal fluid glucose concentration with approximately normal blood glucose concentrations. The cause of these abnormal findings was the use of inappropriate collection tubes during the pre-analytical phase. Whilst no patient harm was identified following this error, signi...

journal_title：Annals of clinical biochemistry

authors： Broz P,Rajdl D,Racek J,Petr T,Vitek L

更新日期：2015-01-01 00:00:00

abstract：:A binding assay for sex hormone binding globulin (SHBG) has been developed in which SHBG is saturated with tritiated dihydrotestosterone (DHT). Separation of bound and free DHT is achieved by using Concanavalin A-Sepharose as a solid phase matrix. The method is described and its performance, including linearity, impre...

journal_title：Annals of clinical biochemistry

authors： Whittaker JA,Cawood ML,Oakey RE

更新日期：1992-03-01 00:00:00

abstract：:Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in 50 normal individuals (24 male)...

journal_title：Annals of clinical biochemistry

authors： Haq M,Haq S,Tutt P,Crook M

更新日期：1993-07-01 00:00:00

abstract：:The effect of acetate and bicarbonate haemodialysis (HD) on the concentrations of erythrocyte, whole-blood and plasma total carnitine (TC), free carnitine (FC), short- (SC) and long-chain acylcarnitine (LC) and acylcarnitine (AC) as well as the ratio of AC to FC was investigated in 30 healthy subjects (15 men and 15 w...

journal_title：Annals of clinical biochemistry

authors： Alhomida AS

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...

journal_title：Annals of clinical biochemistry

authors： Whitehead SJ,Ford C,Gama R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Urinary excretion of the low molecular weight protein cystatin C is a marker of renal disorders and a good predictor of the severity of acute tubular necrosis. We evaluated the measurement of urinary cystatin C and determined its reference range. METHODS:Measurement of urinary cystatin C by particle-enhance...

journal_title：Annals of clinical biochemistry

authors： Herget-Rosenthal S,Feldkamp T,Volbracht L,Kribben A

更新日期：2004-03-01 00:00:00

abstract：:Many contradictory results have been published on the stability of total non-esterified fatty acids in blood, plasma and serum under different storage conditions. The present study was undertaken to investigate the stability of non-esterified fatty acids, measured with an enzymatic method, in samples of EDTA-treated p...

journal_title：Annals of clinical biochemistry

authors： Menéndez LG,Fernández AL,Enguix A,Ciriza C,Amador J

更新日期：2001-05-01 00:00:00

abstract：:We evaluated a new immunoselective enzyme assay of bone-specific alkaline phosphatase (ALP). The monoclonal antibody used in this assay was raised against purified bone-specific ALP obtained from SAOS-2 human osteosarcoma cell line. Calibration was based on the enzyme's own activity. The relative activity of the antib...

journal_title：Annals of clinical biochemistry

authors： Hata K,Tokuhiro H,Nakatsuka K,Miki T,Nishizawa Y,Morii H,Miura M

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The stability of parathyroid hormone (PTH) in whole blood has not been well characterized. Previous studies show EDTA plasma samples to be more stable than serum samples. METHODS:Blood from 17 haemodialysis patients and five healthy volunteers was collected into serum separator tubes (SSTs) and potassium ED...

journal_title：Annals of clinical biochemistry

authors： English E,McFarlane I,Taylor KP,Halsall DJ

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:To assess the accuracy and precision of the Roche Performa and Medisense Optium Xceed (5 and 10 s reading) blood glucose meters. METHODS:Capillary blood samples were taken from 100 patients attending a diabetes centre and blood glucose measured on Roche Performa (n = 4) and Medisense Optium Xceed 5 s (n = 2...

journal_title：Annals of clinical biochemistry

authors： Florkowski C,Budgen C,Kendall D,Lunt H,Moore MP

更新日期：2009-07-01 00:00:00

abstract：:Two cases of hypercholesterolaemic patients are presented in whom raised plasma creatine kinase was noted during treatment with statins. The plasma creatine kinase failed to fall following cessation of therapy. Further investigation revealed the aetiology of the raised plasma creatine kinase to be due to previously un...

journal_title：Annals of clinical biochemistry

authors： Barth JH,Brownjohn AM,Jamieson DR

更新日期：2003-09-01 00:00:00

abstract：:The measurement of carbamylated haemoglobin is a useful indicator of uraemic state during the preceding few weeks in patients with renal failure. In diabetic uraemic patients with hyperglycaemia, glycation of haemoglobin may interfere with its carbamylation, as both reactions involve the free amino groups of the prote...

journal_title：Annals of clinical biochemistry

authors： Hammouda AM,Mady GE

更新日期：2001-03-01 00:00:00

abstract：:Gestational diabetes is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating gestational diabetes improves maternal and fetal outcomes and allows for health promotion to reduce the mo...

journal_title：Annals of clinical biochemistry

authors： Meek CL

更新日期：2017-01-01 00:00:00

abstract：:Ethylene glycol in plasma, urine or dialysis fluid is analysed as the phenylboronate derivative by mixing with acetonitrile/acidified 2,2-dimethoxypropane containing phenylboronic acid. After centrifugation, a portion of the supernatant is analysed directly by gas-liquid chromatography using a 3% OV-101 column at 150 ...

journal_title：Annals of clinical biochemistry

authors： Flanagan RJ,Dawling S,Buckley BM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is an important but under-recognized condition. Recent national guidelines have recommended that biochemistry laboratories report estimated GFR (eGFR) to improve diagnosis of CKD and facilitate disease staging and management. Previous reports have suggested that intake of large a...

journal_title：Annals of clinical biochemistry

authors： Preiss DJ,Godber IM,Lamb EJ,Dalton RN,Gunn IR

更新日期：2007-01-01 00:00:00

abstract：:A fast electrophoretic method for measuring glycosylated haemoglobin (HbA1) is described. Eight samples per cell can be assayed in a single run. Results are compatible with those found by macro-column cation-exchange chromatography; precision is good. The practical short-comings of the commercially ready-made mini-col...

journal_title：Annals of clinical biochemistry

authors： Thornton WE,Schellekens AP,Sanders GT

更新日期：1981-05-01 00:00:00

abstract：:Proteinuria is the cardinal sign of renal disease, therefore accurate identification of clinically significant proteinuria is essential to the diagnosis and management of kidney disease. Spot samples are now widely used, namely protein: creatinine ratio (uPCR) and albumin: creatinine ratio (uACR). In this article we r...

journal_title：Annals of clinical biochemistry

authors： Methven S,MacGregor MS

更新日期：2013-07-01 00:00:00

abstract：:A study of conditions for the elution of apo A1 and B lipoproteins from dried blood spots has led to the development of an apo B/A1 ratio assay with results for dried blood spots which are comparable with serum assays. This assay has been developed to be suitable for large scale population screening. The concept of me...

journal_title：Annals of clinical biochemistry

authors： Hirst AD,Beswick K

更新日期：1993-09-01 00:00:00

abstract：:The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional popul...

journal_title：Annals of clinical biochemistry

authors： Ford RP

更新日期：1989-05-01 00:00:00

abstract：:Three sensitive assays (Behring, Organon and LKB-Pharmacia) for measurement of serum thyrotropin (TSH) were evaluated. All three assays showed good precision, sensitivity, linearity and for practical purposes negligible high dose hook effects. The correlations between the assays were excellent, but due to standardisat...

journal_title：Annals of clinical biochemistry

authors： Bonte HA,Vermes I,v d Sluijs Veer G

更新日期：1989-11-01 00:00:00

abstract：:Background The clinical utility of serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma may be compromised by the presence of endogenous antithyroglobulin antibodies. To prevent interference by antithyroglobulin antibodies several groups have developed real-time PCR-based assays for q...

journal_title：Annals of clinical biochemistry

authors： Feddersen S,Bastholt L,Pedersen SM

更新日期：2017-09-01 00:00:00