Measurement of bone-specific alkaline phosphatase by an immunoselective enzyme assay method.

abstract：:Further data suggesting that assessment of atypicality may be a valuable addition to Down's syndrome screening is presented, based on results from 1521 unaffected pregnancies and 190 chromosomally abnormal pregnancies. For a 1% increase in false positive rates (over the Down's screening-related false positives), it is...

journal_title：Annals of clinical biochemistry

authors： Reynolds TM

更新日期：1997-05-01 00:00:00

abstract：:Hypoglycaemia is an uncommon manifestation of hypopituitarism in non-diabetic adults. A 47-year-old woman with Cushing's disease was treated with bilateral adrenalectomy and pituitary radiotherapy following unsuccessful trans-sphenoidal surgery. Twenty years later, she presented with a tonic-clonic seizure and recurre...

journal_title：Annals of clinical biochemistry

authors： McAulay V,Seckl JR,Strachan MW

更新日期：2005-01-01 00:00:00

abstract：:This paper reviews the physiology and pathology of oxygen transport from the atmosphere to the cells in critically ill patients. A thorough understanding of this allows a rational approach to monitoring and managing an hypoxic patient in the intensive care setting. ...

journal_title：Annals of clinical biochemistry

authors： Clapham MC

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Measurement of aldosterone and/or renin is essential to aid the differential diagnosis of secondary hypertension, guide strategy for therapeutic management of hypertension and assess adequacy of mineralocorticoid replacement. AIM:The objective was to establish normative data for aldosterone and renin using ...

journal_title：Annals of clinical biochemistry

authors： O'Shea P,Brady JJ,Gallagher N,Dennedy MC,Fitzgibbon M

更新日期：2016-05-01 00:00:00

abstract：:This paper describes some factors to which attention should be paid when atrial natriuretic peptide (ANP) values are to be interpreted. Changing from the supine to the sitting position decreased ANP levels, while no further decrease was observed when the upright position was assumed. On the other hand, plasma renin ac...

journal_title：Annals of clinical biochemistry

authors： Tan AC,Kloppenborg PW,Benraad TJ

更新日期：1989-11-01 00:00:00

abstract：:Four hundred and fifty-four subjects with hyperamylasaemia were screened for the presence of macroamylase using polyethylene glycol precipitation (PEG) and the Beckman automated amylase assay based on the hydrolysis of maltotetraose. Twenty-five subjects (5.5%) exhibited PEG precipitation values suggestive of macroamy...

journal_title：Annals of clinical biochemistry

authors： Lawson GJ

更新日期：2001-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the malignant proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. Diagnosis and management of patients with monoclonal gammopathies depend on accurate identification and characterization of monoclonal proteins. We present a 6...

journal_title：Annals of clinical biochemistry

authors： Aksungar FB,Ayer M,Serteser M,Coskun A,Unsal I

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Ischaemia-modified albumin (IMA) is a relatively new marker of ischaemia. IMA has not been studied previously in pleural effusions due to congestive heart failure (CHF). The aim of our study was to assess the diagnostic value of IMA in the pleural fluid (PF) and serum for the identification of pleural effusi...

journal_title：Annals of clinical biochemistry

authors： Ozsu S,Gulsoy A,Karahan SC,Mentese A,Nuhoglu I,Ozlu T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia (plasma cholesterol concentration â¥5.2 mmol/L) is a risk factor for cardiovascular disease and stroke. Many different cholesterol self-tests are readily available at general stores, pharmacies and web shops. However, there is limited information on their analytical and diagnostic perfor...

journal_title：Annals of clinical biochemistry

authors： Kurstjens S,Gemen E,Walk S,Njo T,Krabbe J,Gijzen K,Elisen MGLM,Kusters R

更新日期：2021-01-21 00:00:00

abstract：:Salivary theophylline concentrations in neonates were measured by a homogeneous enzyme immunoassay and compared with serum concentrations. Free serum theophylline concentrations were also compared with salivary concentrations and the values obtained were almost identical. Results using the immunoassay agreed well with...

journal_title：Annals of clinical biochemistry

authors： Thompson SJ

更新日期：1994-05-01 00:00:00

abstract：:Study of the glycoprotein hormones, including hCG, is complex and evolving, and has benefited from recent major advances in analytical technology and molecular biology. It is important to be aware of the effect that these technological advances have, both on the analytical and the clinical requirements for provision o...

journal_title：Annals of clinical biochemistry

authors： Sturgeon CM,McAllister EJ

更新日期：1998-07-01 00:00:00

abstract：:This study was undertaken to investigate the extent of the reported discrepancy between serum and plasma albumin concentrations measured by the bromocresol purple (BCP) method. We have shown that plasma albumin concentrations are falsely increased by turbidity due to the precipitation of fibrinogen when plasma is dilu...

journal_title：Annals of clinical biochemistry

authors： Hill PG,Wells TN

更新日期：1983-09-01 00:00:00

abstract：:The analysis of serum albumin by bromocresol purple (BCP), by bromocresol green (BCG), and by electroimmunoassay (EIA) has been compared in a mixed group of 100 hospital patients. Good agreement between the immunochemical and BCP methods, but a positive bias with the BCG method led to routine use of the BCP method. In...

journal_title：Annals of clinical biochemistry

authors： Wells FE,Addison GM,Postlethwaite RJ

更新日期：1985-05-01 00:00:00

abstract：AIM:The aim of the study was to review the clinical validation process of out of hours critical biochemistry results by a clinical biochemist and its effect on primary care services. METHODS:A prospective study was conducted of all critical results for primary care patients who were analysed out of hours. The nine-mon...

journal_title：Annals of clinical biochemistry

authors： Chandrajay D,Narayanan D,Barth JH

更新日期：2016-03-01 00:00:00

abstract：:Many attempt are now being made by external agencies to assess the quality of assay performance in hormone laboratories. Some of the problems associated with this are discussed and some remedies are proposed. ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL

更新日期：1981-01-01 00:00:00

abstract：:We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), alpha-1-antichymotrypsin (ACT) and alpha-1-acid glycoprotein (AGP) were deter...

journal_title：Annals of clinical biochemistry

authors： Casl MT,Sabljar-Matovinović M,Kovacević S,Pocanić D,Preden-Kereković V,Jagarinec N

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:We evaluated procalcitonin (PCT) assay in the emergency diagnosis of neonatal bacterial infection, especially in preterm infants, relative to C-reactive protein (CRP) and fibrinogen. METHODS:One hundred and twenty neonates (32 preterm), of whom 21 were infected, were tested. RESULTS:Concentrations of PCT, ...

journal_title：Annals of clinical biochemistry

authors： Guibourdenche J,Bedu A,Petzold L,Marchand M,Mariani-Kurdjian P,Hurtaud-Roux MF,Aujard Y,Porquet D

更新日期：2002-03-01 00:00:00

abstract：:Pancreatic elastase 1 (E1), a digestive protease, is synthesized by the acinar cells of the pancreas. Using an enzyme-linked immunosorbent assay, we evaluated stool E1 levels in the following groups of patients. (a) Specimens submitted for occult blood examination from 20 adults, over 3 consecutive days, to assess the...

journal_title：Annals of clinical biochemistry

authors： Phillips IJ,Rowe DJ,Dewar P,Connett GJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:We evaluated the recently released chemiluminescence assay for 25-hydroxy vitamin D (25-OHD) on the Immunodiagnostic Systems iSYS (IDS-iSYS) automated analyser. METHODS:The IDS-iSYS comparison was performed using patient samples previously measured for 25-OHD by a validated liquid chromatography-tandem mass...

journal_title：Annals of clinical biochemistry

authors： Cluse ZN,Fudge AN,Whiting MJ,McWhinney B,Parkinson I,O'Loughlin PD

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:To assess the accuracy and precision of the Roche Performa and Medisense Optium Xceed (5 and 10 s reading) blood glucose meters. METHODS:Capillary blood samples were taken from 100 patients attending a diabetes centre and blood glucose measured on Roche Performa (n = 4) and Medisense Optium Xceed 5 s (n = 2...

journal_title：Annals of clinical biochemistry

authors： Florkowski C,Budgen C,Kendall D,Lunt H,Moore MP

更新日期：2009-07-01 00:00:00

abstract：:A method for the determination of metanephrine (MN; also known as metadrenaline), normetanephrine (NMN; also known as normetadrenaline) and 3-methoxytyramine (3-MT) in human urine using high-performance liquid chromatography followed by electrochemical detection (ECD) was validated primarily by comparing the results w...

journal_title：Annals of clinical biochemistry

authors： Willemsen JJ,Ross HA,Wolthers BG,Sweep CG,Kema IP

更新日期：2001-11-01 00:00:00

abstract：:We examined the reactivity of human serum albumin-bound bilirubin and its photoisomers as substrates for a direct bilirubin assay using bilirubin oxidase. The reduction of (EZ)-cyclobilirubin reached 100% 5 min after addition of the enzyme at any pH tested (3.5-7.4) in 0.1 mol/L phosphate buffer, whereas the reduction...

journal_title：Annals of clinical biochemistry

authors： Itoh S,Kusaka T,Imai T,Isobe K,Onishi S

更新日期：2000-07-01 00:00:00

abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...

journal_title：Annals of clinical biochemistry

authors： Kind CN

更新日期：1988-05-01 00:00:00

abstract：:We evaluated a novel assay for the measurement of 1,25 dihydroxyvitamin D (1,25 (OH)2D). Immunoextraction of 1,25(OH)2D is performed using a mini column containing a solid-phase monoclonal antibody followed by radioimmunoassay (RIA) using an 125I-labelled 1,25(OH)2D derivative tracer and Sac-cell separation. The mean ...

journal_title：Annals of clinical biochemistry

authors： Fraser WD,Durham BH,Berry JL,Mawer EB

更新日期：1997-11-01 00:00:00

abstract：:Free and total reduced concentrations of D-penicillamine have been measured in the plasma of rheumatoid arthritis patients by HPLC and electro-chemical detection. A reverse-phase ion-pair separation in conjunction with a dual porous graphite electrode satisfied the requirements of robustness, sensitivity, selectivity ...

journal_title：Annals of clinical biochemistry

authors： Webb BA,Richardson SJ,Haslock I

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Recent NICE Guidelines have emphasized the need to have in place by 2007 the capability of offering screening to all women in the first trimester using a combination of maternal age with the ultrasound marker nuchal translucency thickness (NT) and the maternal serum biochemical markers free beta-hCG and preg...

journal_title：Annals of clinical biochemistry

authors： Spencer K

更新日期：2005-01-01 00:00:00

abstract：:The spectral interference caused by haemoglobin in the calcium-cresolphthalein complexone reaction was investigated. The results show that the nature of the haemoglobin derivative in the reaction mixture influences the degree of interference; in turn, the derivative formed depends on the order in which the sample and ...

journal_title：Annals of clinical biochemistry

authors： Corns CM

更新日期：1990-03-01 00:00:00

abstract：:A case report is presented of a 37-year-old man who, largely by chance, was found to have a marked mixed hyperlipidaemia. As a teenager he had been treated for apparent idiopathic growth hormone deficiency, but had also never developed secondary sexual characteristics. Pituitary hormone measurement was now consistent ...

journal_title：Annals of clinical biochemistry

authors： Kilpatrick ES,Patmore JE,Rowland-Hill C,Atkin SL

更新日期：2004-07-01 00:00:00

abstract：:We have studied 46 patients, 30 men and 16 women, with type 2 (non-insulin-dependent) diabetes in a follow-up period of 6-52 months (mean 30 months). The patients were consecutively entered in the study from the out-patient diabetic clinic. None had urinary tract infections nor proteinuria at entry. Investigations wer...

journal_title：Annals of clinical biochemistry

authors： Friis T,Pedersen LR

更新日期：1997-05-01 00:00:00

abstract：:Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, "informatics"--the art and science of turning data into useful information--is becoming increasingly im...

journal_title：Annals of clinical biochemistry

authors： Jones R,O'Connor J

更新日期：2004-05-01 00:00:00