Atypicality revisited: further data on the effectiveness of the Mahalanobis distance in Down's syndrome screening.

abstract：:Tiaprofenic acid is a non-steroidal anti-inflammatory drug which also has hypouriceamic effect. Studies involving 10 healthy volunteers were designed to investigate the mode of this effect. We postulate that the site of action of tiaprofenic acid is at the cell membrane, the mechanism being an interference with the tr...

journal_title：Annals of clinical biochemistry

authors： Lyfar V,Fernandes L,Thornton E,Cook JG

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Lysophosphatidic acid (LPA) plays important roles in a variety of biological responses, especially in the area of vascular biology, and the determination of its plasma concentration is believed to be important. Several mechanisms are known to be involved in the metabolism of LPA. METHODS:To identify factors...

journal_title：Annals of clinical biochemistry

authors： Hosogaya S,Yatomi Y,Nakamura K,Ohkawa R,Okubo S,Yokota H,Ohta M,Yamazaki H,Koike T,Ozaki Y

更新日期：2008-07-01 00:00:00

abstract：:A simple and improved method of continuous-flow analysis for total and direct bilirubin in serum is described. Advantages of the method are: small serum and reagent volumes; the use of less concentrated caffeine solution in the accelerator; the substitution of distilled water for hydrochloric acid in the direct biliru...

journal_title：Annals of clinical biochemistry

authors： Lolekha PH

更新日期：1980-09-01 00:00:00

abstract：:The seasonal variation of serum 25-hydroxy vitamin D3 and 1,25-dihydroxy-vitamin D has been investigated. Blood was taken from 27 healthy volunteers, aged 21-44 years old at 3 monthly intervals over a period of 1 year. A scrolling monthly programme with 12 quarterly (3 month) time periods was developed. A summer assoc...

journal_title：Annals of clinical biochemistry

authors： Hine TJ,Roberts NB

更新日期：1994-01-01 00:00:00

abstract：:The present study was designed to re-evaluate the radioimmunoassay for desmosine in urine, which is currently used as a measure of elastin metabolism. Using ion exchange chromatography, gel filtration and affinity chromatography it was shown that at least five other compounds in hydrolysates of human urine competed fo...

journal_title：Annals of clinical biochemistry

authors： Starcher B,Scott M

更新日期：1992-01-01 00:00:00

abstract：:A p-iodophenol-enhanced luminescent end-point has been incorporated into a commercially available heterogeneous competitive enzyme immunoassay for digoxin based on a horseradish peroxidase-digoxin conjugate. The luminescent end-point could be completed in less than 1 min and significantly reduced overall assay time. R...

journal_title：Annals of clinical biochemistry

authors： Coyle PM,Thorpe GH,Kricka LJ,Whitehead TP

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The menstrual cycle-related changes in clinical laboratory values were analysed by use of data obtained in the Asian multicentre study aimed at derivation of common reference intervals for 85 major clinical laboratory tests. METHODS:Among 1876 healthy female volunteers, 893 had regular menstruation. They wer...

journal_title：Annals of clinical biochemistry

authors： Masuda S,Ichihara K,Yamanishi H,Hirano Y,Tanaka Y,Kamisako T,Scientific Committee for Asia-Pasific Federation of Clinical Biochemistry.

更新日期：2016-05-01 00:00:00

abstract：:ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...

journal_title：Annals of clinical biochemistry

authors： Holt H,Freedman DB

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Various conjugated cholesterol metabolites are excreted in urine of the patients with metabolic abnormalities and hepatobiliary diseases. We aimed to examine the usefulness of precursor ion scan and neutral loss scan for the characterization of conjugated cholesterol metabolites in urine. METHODS:A mixture ...

journal_title：Annals of clinical biochemistry

authors： Maekawa M,Shimada M,Ohno K,Togawa M,Nittono H,Iida T,Hofmann AF,Goto J,Yamaguchi H,Mano N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The analysis of steroids in biological matrices is challenging. One can apply immunoassay as well as gas and liquid chromatography with various types of detection, depending on the available equipment and the experience of the analyst. The question is how the methods are interchangeable between themselves. D...

journal_title：Annals of clinical biochemistry

authors： Kosicka K,Siemiątkowska A,Szpera-Goździewicz A,Krzyścin M,Bręborowicz G,Główka F

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In the enzyme reaction for the determination of the unbound (free) bilirubin concentration by glucose oxidase and peroxidase, materials with low affinity for serum protein are reactive. The influence of these materials on the determination of serum unbound bilirubin was investigated. METHODS Serum samples fr...

journal_title：Annals of clinical biochemistry

authors： Itoh S,Kawada K,Kusaka T,Yasuda S,Okada H,Imai T,Isobe K

更新日期：2002-11-01 00:00:00

abstract：:Thyroglobulin (Tg) is a tumour marker for differentiated thyroid cancer. Interpretation requires a knowledge of the current thyrotropin (TSH) concentration as secretion is TSH-dependent. While a raised serum Tg may be indicative of residual or recurrent thyroid cancer, trauma to the thyroid (e.g. surgical, biopsy or d...

journal_title：Annals of clinical biochemistry

authors： Clark P,Franklyn J

更新日期：2012-07-01 00:00:00

abstract：:Background After adrenalectomy, urinary fractionated metanephrine concentrations are expected to be reduced. However, there are few studies suggesting cut-offs for adrenalectomy patients. Methods Urinary metanephrine and normetanephrine concentrations in adrenalectomy patients and two controls were compared and hormon...

journal_title：Annals of clinical biochemistry

authors： Cho YY,Kim YN,Kim JH,Jeong BC,Lee SY,Kim JH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Supported liquid extraction (SLE) techniques are relatively new compared to other sample preparation approaches such as solid phase extraction (SPE), liquid-liquid extraction (LLE) and protein precipitation (PPE). We investigated the use of SLE as an alternative to SPE for the liquid chromatography tandem ma...

journal_title：Annals of clinical biochemistry

authors： Owen LJ,Keevil BG

更新日期：2013-09-01 00:00:00

abstract：:Haptoglobin is an acute-phase protein with three major phenotypes: Hp 1-1, Hp 2-1 and Hp 2-2. Studies have shown that functional differences between these phenotypes have important consequences in a number of pathological disorders (e.g. cardiovascular disease, autoimmune disorders, infectious disease), making phenoty...

journal_title：Annals of clinical biochemistry

authors： Wassell J,Keevil B

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Our study aims to explore the effect of serum long non-coding RNA (lncRNA) H19 level on the long-term prognosis of endoscopic keyhole surgery or craniotomy for glioma. METHODS:A total of 264 glioma patients were selected. Patients were randomly divided into the Craniotomy-high H19 group, the Craniotomy-low ...

journal_title：Annals of clinical biochemistry

authors： Shen L,Xu M,Wang Z,Yu Z

更新日期：2020-09-01 00:00:00

abstract：:Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in 50 normal individuals (24 male)...

journal_title：Annals of clinical biochemistry

authors： Haq M,Haq S,Tutt P,Crook M

更新日期：1993-07-01 00:00:00

abstract：:Clinical biochemists have long known the analytical and clinical limitations of creatinine and creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This background is reviewed in the article before assessing the utility of cystatin C, the most promising replacement biochemical marker...

journal_title：Annals of clinical biochemistry

authors： Newman DJ

更新日期：2002-03-01 00:00:00

abstract：:The effect of oral vitamin E supplementation on the oxido-reductive status of red blood cells in normal mice and those subject to oxidative stress by chronic administration of the anti-tumour drug Adriamycin was investigated. Mice were randomly separated into three groups of 20 animals each and maintained on diets ide...

journal_title：Annals of clinical biochemistry

authors： Thabrew MI,Samarawickrema N,Chandrasena LG,Jayasekera S

更新日期：1999-03-01 00:00:00

abstract：:Antibodies to glutamic acid decarboxylase (GAD) are a useful autoimmune marker for type 1 diabetes mellitus in Caucasians. We examined antibodies to GAD and their relationships with clinical features and pancreatic beta cell function in 140 young Chinese diabetic patients. Over an 18-month period beginning in 1995, 14...

journal_title：Annals of clinical biochemistry

authors： Ko GT,Chan JC,Yeung VT,Chow CC,Li JK,Lau MS,Mackay IR,Rowley MJ,Zimmet P,Cockram CS

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Potassium is usually the most important analyte affected by in vitro haemolysis and the result obtained may falsely indicate or disguise a life-threatening abnormality and so give rise to inappropriate treatment. The purpose of the study was to provide a solution to the problem of reporting potassium on haem...

journal_title：Annals of clinical biochemistry

authors： Dimeski G,Clague AE,Hickman PE

更新日期：2005-03-01 00:00:00

abstract：:Background Proglucagon-derived hormones represent a family of peptides mainly produced in the pancreas and the intestine. While several proglucagon-derived peptides play key roles in metabolic diseases, little is known about glicentin. The aim of the present study was to investigate serum glicentin concentrations in i...

journal_title：Annals of clinical biochemistry

authors： Raffort J,Panaïa-Ferrari P,Lareyre F,Blois M,Bayer P,Staccini P,Fénichel P,Chinetti G

更新日期：2018-03-01 00:00:00

abstract：:Total serum cholesterol was measured in 1320 normal Saudi children aged 0-14 years. The result was 3.88 (0.83) mmol/L [mean (SD)] and there was no statistical difference between girls and boys. Results were lowest in the 0-4 year age group and highest in the 5-9 year age group. Percentile values were established for t...

journal_title：Annals of clinical biochemistry

authors： Rafii ZS,al Nasser AA,Budair A,Tufail M

更新日期：1994-07-01 00:00:00

abstract：:A rapid gas liquid chromatography method has been developed which is suitable for emergency estimations of paracetamol in overdose. The method is compared with a standard ultraviolet method. ...

journal_title：Annals of clinical biochemistry

authors： Stewart MJ,Willis RG

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:To investigate the reasons why general practitioners (GPs) request rheumatoid factor (RF) assays, we studied 200 consecutive requests for RF from general practice in 1995. METHOD:By means of an audit questionnaire, we studied 100 negative, 50 positive and 50 borderline RF results and compared these with the...

journal_title：Annals of clinical biochemistry

authors： Sinclair D,Hull RG

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:There are few data on oxidative stresses during and after pregnancy, although aggravation of autoimmune disease is implicated in oxidative stress and occurs frequently in the postpartum period. Thioredoxin (TRX) is a stress-inducible protein, and is used as a good biomarker for oxidative stress. To clarify t...

journal_title：Annals of clinical biochemistry

authors： Kuroda S,Watanabe M,Santo T,Shimizuishi Y,Takano T,Hidaka Y,Kimura T,Iwatani Y

更新日期：2010-01-01 00:00:00

abstract：:The extent of lipoprotein glycation was assessed in 82 patients diagnosed as diabetes mellitus type II. Glycated lipoprotein levels in serum were determined by agarose gel film electrophoresis in 48 non-diabetic control subjects, 56 diabetics with complications and 26 diabetics with no complications. All glycated lipo...

journal_title：Annals of clinical biochemistry

authors： Yeğin A,Ozben T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Measurement of HbA(1c) is the standard test for assessment of glycaemic control in diabetic subjects. Using new glucose sensing technology we re-evaluated the significance of HbA(1c) in terms of the aspects of the blood profile it measures in patients with diabetes. METHODS:In a group of 27 patients with ty...

journal_title：Annals of clinical biochemistry

authors： Sharp P,Rainbow S

更新日期：2002-09-01 00:00:00

abstract：:Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneou...

journal_title：Annals of clinical biochemistry

authors： Miike A,Ogawa Z,Sakurabayashi I

更新日期：2018-05-01 00:00:00

abstract：:The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional popul...

journal_title：Annals of clinical biochemistry

authors： Ford RP

更新日期：1989-05-01 00:00:00