Two cases of spuriously elevated cerebrospinal glucose concentration.

abstract：:A binding assay for sex hormone binding globulin (SHBG) has been developed in which SHBG is saturated with tritiated dihydrotestosterone (DHT). Separation of bound and free DHT is achieved by using Concanavalin A-Sepharose as a solid phase matrix. The method is described and its performance, including linearity, impre...

journal_title：Annals of clinical biochemistry

authors： Whittaker JA,Cawood ML,Oakey RE

更新日期：1992-03-01 00:00:00

abstract：:This paper summarises the views of the authors on the provision of a prolactin assay service. We discuss the pathophysiology of prolactin secretion and the clinical indications that arise from that. We cover the rather complex issue of the definition of normal and elevated prolactin levels. From these considerations, ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL,Bacon RR,Beastall GH,Diver MJ,Franks S,Seth J

更新日期：1986-11-01 00:00:00

abstract：:We evaluated a novel assay for the measurement of 1,25 dihydroxyvitamin D (1,25 (OH)2D). Immunoextraction of 1,25(OH)2D is performed using a mini column containing a solid-phase monoclonal antibody followed by radioimmunoassay (RIA) using an 125I-labelled 1,25(OH)2D derivative tracer and Sac-cell separation. The mean ...

journal_title：Annals of clinical biochemistry

authors： Fraser WD,Durham BH,Berry JL,Mawer EB

更新日期：1997-11-01 00:00:00

abstract：:The content of cytoplasmic 17 beta oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentratio...

journal_title：Annals of clinical biochemistry

authors： Sadan O,van Iddekinge B,van Gelderen CJ,Savage N,Becker PJ,van der Walt LA,Robinson M

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Unnecessary blood tests are estimated to contribute to 25% of wastage in the National Health Service. The aim of this study was to assess the financial implication of clinical need-focused blood tests guided by a senior clinician in a district general hospital. METHODS:We conducted an observational longitud...

journal_title：Annals of clinical biochemistry

authors： Mughal Z,Narayanan A,Gupta V,Reay-Jones N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:To investigate the reasons why general practitioners (GPs) request rheumatoid factor (RF) assays, we studied 200 consecutive requests for RF from general practice in 1995. METHOD:By means of an audit questionnaire, we studied 100 negative, 50 positive and 50 borderline RF results and compared these with the...

journal_title：Annals of clinical biochemistry

authors： Sinclair D,Hull RG

更新日期：2003-03-01 00:00:00

abstract：:We developed a binary gradient high-performance liquid chromatography (HPLC) method for measuring HbA2 in whole blood samples using a Pharmacia Mono Q column (1 mL) and measurement at 415 nm. The assay requires a simple lysis and centrifugation step before injection onto the column. We found good agreement of results ...

journal_title：Annals of clinical biochemistry

authors： Keevil BG,Maylor PW,Rowlands D

更新日期：1996-05-01 00:00:00

abstract：:We developed a new simple assay for potassium ion in serum using urea amidolyase (UAL) from yeast sp. The method is based on activation of the enzyme by potassium ion. We eliminated endogenous ammonium ion by use of glutamate dehydrogenase (GLDH), and then monitored the production of ammonium ion by UAL, urea, ATP, bi...

journal_title：Annals of clinical biochemistry

authors： Kimura S,Iyama S,Yamaguchi Y,Hayashi S,Fushimi R,Amino N

更新日期：1997-07-01 00:00:00

abstract：:A microtiter plate based Dual Analyte enzyme-immunoassay method for the simultaneous measurement of alpha-fetoprotein (AFP) and Free-beta human chorionic gonadotrophin (hCG) was evaluated. This rapid assay, which has application in both Neural Tube Defect screening and Down's screening, shows good precision with betwe...

journal_title：Annals of clinical biochemistry

authors： Macri JN,Spencer K,Anderson R

更新日期：1992-07-01 00:00:00

abstract：:We have studied 46 patients, 30 men and 16 women, with type 2 (non-insulin-dependent) diabetes in a follow-up period of 6-52 months (mean 30 months). The patients were consecutively entered in the study from the out-patient diabetic clinic. None had urinary tract infections nor proteinuria at entry. Investigations wer...

journal_title：Annals of clinical biochemistry

authors： Friis T,Pedersen LR

更新日期：1997-05-01 00:00:00

abstract：:Circulating insulin-like growth factor-1 (IGF-1) is increasingly being used as a screening test and in ongoing monitoring of treated acromegaly. We here present three cases of women (two of whom were on the oestrogen containing contraceptive pill at the time of presentation) who had normal circulating IGF-1 and no ove...

journal_title：Annals of clinical biochemistry

authors： Kalavalapalli S,Reid H,Kane J,Buckler H,Trainer P,Heald AH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Current guidelines define acute myocardial infarction (AMI) by the rise and/or fall of cardiac troponin with ≥1 value above the 99th percentile. Past troponin assays have been unreliable at the lower end of the range. Highly sensitive assays have therefore been developed to increase the clinical sensitivity ...

journal_title：Annals of clinical biochemistry

authors： Aldous SJ,Florkowski CM,Crozier IG,Elliott J,George P,Lainchbury JG,Mackay RJ,Than M,Flaws DF,Borowsky J

更新日期：2011-05-01 00:00:00

abstract：:The effect of oral vitamin E supplementation on the oxido-reductive status of red blood cells in normal mice and those subject to oxidative stress by chronic administration of the anti-tumour drug Adriamycin was investigated. Mice were randomly separated into three groups of 20 animals each and maintained on diets ide...

journal_title：Annals of clinical biochemistry

authors： Thabrew MI,Samarawickrema N,Chandrasena LG,Jayasekera S

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Circulating levels of bioavailable oestradiol and testosterone are often desirable for clinical practice or investigational studies of children. However, assays to measure circulating hormone levels might not always be accessible. We sought to validate the empirical calculation of circulating bioavailable te...

journal_title：Annals of clinical biochemistry

authors： Egleston BL,Chandler DW,Dorgan JF

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Thiopurine methyltransferase (TPMT) catalyses the S-methylation of 6-thiopurine drugs, which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation. TPMT activity is polymorphic as a result of gene mutations. Ethnic variations in phenotype and genotype have been identi...

journal_title：Annals of clinical biochemistry

authors： Laróvere LE,de Kremer RD,Lambooy LH,De Abreu RA

更新日期：2003-07-01 00:00:00

abstract：:Digoxin requesting patterns were studied prospectively over a 6-month period. Clinicians were not forewarned that the study was being undertaken. Many samples received in the laboratory were taken at incorrect times after the drug had been given. This led to inappropriate action being taken in some cases. Appropriate ...

journal_title：Annals of clinical biochemistry

authors： O'Donnell JG,Paterson NC,Pledger DR,Stewart MJ

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:It is not possible to diagnose acute kidney injury (AKI) in early stages with traditional biomarkers. Kidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predictin...

journal_title：Annals of clinical biochemistry

authors： Tekce BK,Uyeturk U,Tekce H,Uyeturk U,Aktas G,Akkaya A

更新日期：2015-01-01 00:00:00

abstract：:Three sensitive assays (Behring, Organon and LKB-Pharmacia) for measurement of serum thyrotropin (TSH) were evaluated. All three assays showed good precision, sensitivity, linearity and for practical purposes negligible high dose hook effects. The correlations between the assays were excellent, but due to standardisat...

journal_title：Annals of clinical biochemistry

authors： Bonte HA,Vermes I,v d Sluijs Veer G

更新日期：1989-11-01 00:00:00

abstract：:A series of experiments are described which show that second derivative spectroscopy can be used to quantify conjugated lipid dienes as markers of lipid peroxidation in heptane extracts of plasma from patients with rheumatoid arthritis, osteoarthritis, and healthy controls. Results obtained by this method gave reasona...

journal_title：Annals of clinical biochemistry

authors： Situnayake RD,Crump BJ,Zezulka AV,Davis M,McConkey B,Thurnham DI

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

journal_title：Annals of clinical biochemistry

authors： Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

更新日期：2016-09-01 00:00:00

abstract：:Hereditary renal hypouricaemia (HRH) is a genetic disorder commonly associated with exercise-induced acute kidney injury (AKI). We report the case of a 19-year-old man who was admitted to hospital with exercise-induced AKI and who was subsequently shown to have HRH. We believe this to be the first description of a cas...

journal_title：Annals of clinical biochemistry

authors： Chakraborty S,Sural S

更新日期：2013-05-01 00:00:00

abstract：:Eleven unfit bank executives in sedentary employment exercised daily for 10 weeks according to the Canadian Air-Force 5BX Exercise Programme. Over this period no changes were observed in the glucose or insulin responses to a standard breakfast or to intravenous glucose, or in the glucose response to intravenous insuli...

journal_title：Annals of clinical biochemistry

authors： Moore RA,Penfold WA,Simpson RD,Simpson RW,Mann JI,Turner RC

更新日期：1979-03-01 00:00:00

abstract：:Plasma creatine kinase (CK) activity and lean body mass (LBM) (by anthropometry) were measured in 120 women (20-82 years) and 70 men (20-82 years). Plasma CK activity and LBM was higher in men than in women. In men plasma CK activity was significantly correlated (product moment correlation coefficient) with LBM and ne...

journal_title：Annals of clinical biochemistry

authors： Swaminathan R,Ho CS,Donnan SP

更新日期：1988-07-01 00:00:00

abstract：:Further data suggesting that assessment of atypicality may be a valuable addition to Down's syndrome screening is presented, based on results from 1521 unaffected pregnancies and 190 chromosomally abnormal pregnancies. For a 1% increase in false positive rates (over the Down's screening-related false positives), it is...

journal_title：Annals of clinical biochemistry

authors： Reynolds TM

更新日期：1997-05-01 00:00:00

abstract：:Hypogonadism in the male results from inadequate testicular function, especially defects in androgen synthesis and secretion, or action. Androgen action is important throughout normal male development: in the fetus, puberty, adult life and old age. Regulation is by variable activity of the hypothalamo-pituitary axis a...

journal_title：Annals of clinical biochemistry

authors： Belchetz PE,Barth JH,Kaufman JM

更新日期：2010-11-01 00:00:00

abstract：:The aim of this study was to assess the performance of a commercially available procedure for detecting anti-Sjögren's syndrome A (anti-SSA) and anti-Sjögren's syndrome B (anti-SSB) antibodies by immunoblotting (IB) and compare it with double immunodiffusion (DID). We also studied the clinical significance of these pr...

journal_title：Annals of clinical biochemistry

authors： Yago M,Belmonte MA,Olmos MJ,Beltran J,Teruel C,Segarra M

更新日期：1999-05-01 00:00:00

abstract：:Guaiac-based faecal occult blood tests (gFOBT) are still used in asymptomatic population bowel screening programmes but are being replaced by faecal immunochemical tests (FIT) for haemoglobin. gFOBT have many well-documented disadvantages and there is little evidence for their use in assessment of the symptomatic. Man...

journal_title：Annals of clinical biochemistry

authors： Fraser CG

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:To know whether metformin improves postprandial hyperglycaemia, we examined the effect of metformin on the glycated albumin (GA) to glycated haemoglobin (HbA1c) ratio (GA/HbA1c ratio) in patients with newly diagnosed type 2 diabetes. METHODS:Metformin and lifestyle interventions were initiated in 18 patient...

journal_title：Annals of clinical biochemistry

authors： Sumitani S,Morita S,Deguchi R,Hirai K,Mukai K,Utsu Y,Miki S,Sato B,Nakamura H,Kasayama S,Koga M

更新日期：2015-01-01 00:00:00

abstract：:We report the case of a 78-year-old patient with late diagnosis of hyperoxaluria type III (PH3). He developed renal failure after nephrectomy for clear cell papillary renal carcinoma and complained of recurrent urolithiasis for some 30 years, whose aetiology was never identified. Biochemical laboratory investigations ...

journal_title：Annals of clinical biochemistry

authors： Richard E,Blouin JM,Harambat J,Llanas B,Bouchet S,Acquaviva C,de la Faille R

更新日期：2017-05-01 00:00:00