Abstract:
:Hypogonadism in the male results from inadequate testicular function, especially defects in androgen synthesis and secretion, or action. Androgen action is important throughout normal male development: in the fetus, puberty, adult life and old age. Regulation is by variable activity of the hypothalamo-pituitary axis at different phases of the life span. Clinical aspects include: genetic aspects presenting at birth and pubertal failure/arrest. Aspects in adult life embrace sexuality, somatic symptoms and osteoporosis. Acquired causes of hypogonadism may arise from various forms of testicular damage (primary hypogonadism), pituitary and hypothalamic disorders, as well as aetiologies acting at several sites. Measurement of testosterone (T) is crucial to the diagnosis of hypogonadism and the technologies continue to develop, with recent major advances. A growing problem relates to the diagnosis and treatment of hypogonadism in the ageing male. T therapy is available in several forms, with major improvements in more newly available modalities.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Belchetz PE,Barth JH,Kaufman JMdoi
10.1258/acb.2010.010150subject
Has Abstractpub_date
2010-11-01 00:00:00pages
503-15issue
Pt 6eissn
0004-5632issn
1758-1001pii
acb.2010.010150journal_volume
47pub_type
杂志文章,评审abstract::Background Red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) have been reported to be associated with outcomes of acute cerebral infarction. However, their prognostic value in patients with subarachnoid haemorrhage (SAH) remains largely unknown. The aim of this study was to investigate t...
journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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doi:10.1177/000456329102800309
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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abstract:BACKGROUND:Patient-based real-time quality control (PBRTQC) techniques have been described in clinical chemistry for over 50 years. PBRTQC has a number of advantages over traditional quality control including commutability, cost and the opportunity for real-time monitoring. However, there are few systematic investigati...
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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doi:10.1177/000456328502200216
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journal_title:Annals of clinical biochemistry
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doi:10.1177/000456329102800509
更新日期:1991-09-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456329102800216
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...
journal_title:Annals of clinical biochemistry
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更新日期:2014-01-01 00:00:00
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journal_title:Annals of clinical biochemistry
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更新日期:2009-07-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456329102800113
更新日期:1991-01-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456328502200506
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abstract:BACKGROUND:About 10 years ago, a survey showed significant deficiencies in the quality of gastrointestinal investigations performed by UK laboratories. Subsequently, several clinical guidelines have been developed and external quality assessment schemes introduced. This survey was performed to assess whether earlier de...
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更新日期:2007-03-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章,评审
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更新日期:2004-07-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
doi:10.1177/000456328802500309
更新日期:1988-05-01 00:00:00
abstract::During incubation with rabbit blood in vitro rabbit-muscle lactate dehydrogenase-5 was inactivated at a rate similar to that observed in vivo. By contrast plasma and plasma containing erythrocytes had no effect on the enzyme activity, but plasma containing leucocytes inactivated the enzyme at the same rate as whole bl...
journal_title:Annals of clinical biochemistry
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更新日期:2003-11-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00