Measurement of faecal haemoglobin with a faecal immunochemical test can assist in defining which patients attending primary care with rectal bleeding require urgent referral.

abstract：:We describe a new electrochemical method for the determination of erythrocyte acetylcholinesterase activity (EC 3.1.1.7) and plasma cholinesterase (EC 3.1.1.8) activity, based on the measurements of pH variation due to release of acetic acid from acetylcholine. The major advantages of the differential pH procedure are...

journal_title：Annals of clinical biochemistry

authors： Barenghi L,Ceriotti F,Luzzana M,Ripamonti M,Mosca A,Bonini PA

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Our study aims to explore the effect of serum long non-coding RNA (lncRNA) H19 level on the long-term prognosis of endoscopic keyhole surgery or craniotomy for glioma. METHODS:A total of 264 glioma patients were selected. Patients were randomly divided into the Craniotomy-high H19 group, the Craniotomy-low ...

journal_title：Annals of clinical biochemistry

authors： Shen L,Xu M,Wang Z,Yu Z

更新日期：2020-09-01 00:00:00

abstract：:The magnitude of the inflammatory response to surgery depends on the degree of injury during surgical procedures. Laparoscopic techniques are generally associated with less postoperative pain and shorter hospital stay compared with open procedures, presumably due to less tissue injury and reduced inflammatory response...

journal_title：Annals of clinical biochemistry

authors： Labib M,Palfrey S,Paniagua E,Callender R

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Various conjugated cholesterol metabolites are excreted in urine of the patients with metabolic abnormalities and hepatobiliary diseases. We aimed to examine the usefulness of precursor ion scan and neutral loss scan for the characterization of conjugated cholesterol metabolites in urine. METHODS:A mixture ...

journal_title：Annals of clinical biochemistry

authors： Maekawa M,Shimada M,Ohno K,Togawa M,Nittono H,Iida T,Hofmann AF,Goto J,Yamaguchi H,Mano N

更新日期：2015-09-01 00:00:00

abstract：:The purpose of this study was to assess retrospectively the prevalence of severe hyponatraemia in a hospital population and its laboratory investigation, treatment and clinical outcome. Over a 6-month period 47 patients (27 women and 20 men) were found to have a plasma sodium concentration of < or = 120 mmol/L (this n...

journal_title：Annals of clinical biochemistry

authors： Crook MA,Velauthar U,Moran L,Griffiths W

更新日期：1999-03-01 00:00:00

abstract：:The diagnostic performance of a new enzyme linked immunosorbent assay for the cardiac structural protein troponin T in the differential diagnosis of ischaemic cardiac damage was assessed. A well documented set of patients admitted to the coronary care unit of a district general hospital were studied. At a cutoff value...

journal_title：Annals of clinical biochemistry

authors： Collinson PO,Moseley D,Stubbs PJ,Carter GD

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Urinary excretion of the low molecular weight protein cystatin C is a marker of renal disorders and a good predictor of the severity of acute tubular necrosis. We evaluated the measurement of urinary cystatin C and determined its reference range. METHODS:Measurement of urinary cystatin C by particle-enhance...

journal_title：Annals of clinical biochemistry

authors： Herget-Rosenthal S,Feldkamp T,Volbracht L,Kribben A

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Current guidelines define acute myocardial infarction (AMI) by the rise and/or fall of cardiac troponin with ≥1 value above the 99th percentile. Past troponin assays have been unreliable at the lower end of the range. Highly sensitive assays have therefore been developed to increase the clinical sensitivity ...

journal_title：Annals of clinical biochemistry

authors： Aldous SJ,Florkowski CM,Crozier IG,Elliott J,George P,Lainchbury JG,Mackay RJ,Than M,Flaws DF,Borowsky J

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:We evaluated the recently released chemiluminescence assay for 25-hydroxy vitamin D (25-OHD) on the Immunodiagnostic Systems iSYS (IDS-iSYS) automated analyser. METHODS:The IDS-iSYS comparison was performed using patient samples previously measured for 25-OHD by a validated liquid chromatography-tandem mass...

journal_title：Annals of clinical biochemistry

authors： Cluse ZN,Fudge AN,Whiting MJ,McWhinney B,Parkinson I,O'Loughlin PD

更新日期：2012-03-01 00:00:00

abstract：:Study of the glycoprotein hormones, including hCG, is complex and evolving, and has benefited from recent major advances in analytical technology and molecular biology. It is important to be aware of the effect that these technological advances have, both on the analytical and the clinical requirements for provision o...

journal_title：Annals of clinical biochemistry

authors： Sturgeon CM,McAllister EJ

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:For nearly 20 years, we and others have used a three-parameter power function as a direct estimation error model for immunoassays. The main application is imprecision profile plots (after translating from variance to coefficient of variation) but other uses include weighting functions for regression analysis...

journal_title：Annals of clinical biochemistry

authors： Sadler WA

更新日期：2008-09-01 00:00:00

abstract：:A real time data processing system for a group of three clinical chemistry laboratories (one base and two satellite) has been developed as a successor to one used previously. This paper describes both the inadequacies of the previous worksheet-based system and the advantages of the new system, including flexibility, f...

journal_title：Annals of clinical biochemistry

authors： Hirst AD,Naylor D,White HL,Walter M

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:With the recent outbreak in West Africa, hospitals worldwide have been developing protocols for suspect of cases of Ebola virus disease. Patients with Ebola virus disease present with a severe gastroenteritis leading to dehydration and electrolyte abnormalities and as such, routine chemistry analysis is esse...

journal_title：Annals of clinical biochemistry

authors： LeBlanc JJ,Heinstein C,MacDonald J,Gallant R,Roberts C,Jackson C,Lou A,Nassar BA,Hatchette TF

更新日期：2016-03-01 00:00:00

abstract：:Measurement of genetically altered DNA shed from tumours into the circulation can potentially provide a new generation of blood-based cancer biomarkers. Compared with tissue DNA biomarkers which require surgery or biopsy, samples for circulating tumour DNA assays can be obtained with minimal inconvenience and at lower...

journal_title：Annals of clinical biochemistry

authors： Duffy MJ

更新日期：2019-01-01 00:00:00

abstract：:Guaiac-based faecal occult blood tests (gFOBT) are still used in asymptomatic population bowel screening programmes but are being replaced by faecal immunochemical tests (FIT) for haemoglobin. gFOBT have many well-documented disadvantages and there is little evidence for their use in assessment of the symptomatic. Man...

journal_title：Annals of clinical biochemistry

authors： Fraser CG

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The reporting interval is the incremental value chosen in reporting analyte concentration. Reporting intervals for different analytes are often inappropriately narrow, when analytical imprecision and biological variability are considered. METHODS:We have used statistical techniques to determine intervals fo...

journal_title：Annals of clinical biochemistry

authors： Badrick T,Wilson SR,Dimeski G,Hickman PE

更新日期：2004-09-01 00:00:00

abstract：:Inherited metabolic disorders account for a small but significant number of sudden unexplained deaths in neonates, infants and occasionally older children. In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity t...

journal_title：Annals of clinical biochemistry

authors： Olpin SE

更新日期：2004-07-01 00:00:00

abstract：:Clinical biochemists have long known the analytical and clinical limitations of creatinine and creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This background is reviewed in the article before assessing the utility of cystatin C, the most promising replacement biochemical marker...

journal_title：Annals of clinical biochemistry

authors： Newman DJ

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Interpretative commenting constitutes an important aspect of the post-analytical phase in chemical pathology, but has only recently been the subject of quality assessment. The Royal College of Pathologists of Australasia (RCPA)-Australasian Association of Clinical Biochemists (AACB) Chemical Pathology Patien...

journal_title：Annals of clinical biochemistry

authors： Vasikaran SD,Penberthy L,Gill J,Scott S,Sikaris KA

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Calculated globulin fraction is derived from the liver function tests by subtracting albumin from the total protein. Since immunoglobulins comprise the largest component of the serum globulin concentration, increased or decreased calculated globulins and may identify patients with hypogammaglobulinaemia or h...

journal_title：Annals of clinical biochemistry

authors： Hoo T,Lim E,John M,D'Orsogna L,McLean-Tooke A

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Patients with mutations of succinate dehydrogenase B (SDHB) and succinate dehydrogenase D (SDHD) are at high risk of paraganglioma necessitating surveillance. Chromogranin A has been proposed as a biochemical marker of paraganglioma. We sought to determine the diagnostic utility of chromogranin A in a popula...

journal_title：Annals of clinical biochemistry

authors： Thompson MJ,Parameswaran V,Burgess JR

更新日期：2019-01-01 00:00:00

abstract：:The analysis of serum albumin by bromocresol purple (BCP), by bromocresol green (BCG), and by electroimmunoassay (EIA) has been compared in a mixed group of 100 hospital patients. Good agreement between the immunochemical and BCP methods, but a positive bias with the BCG method led to routine use of the BCP method. In...

journal_title：Annals of clinical biochemistry

authors： Wells FE,Addison GM,Postlethwaite RJ

更新日期：1985-05-01 00:00:00

abstract：:The development and evaluation in routine clinical practice of a simple, rapid, high-throughput, immunoradiometric assay (IRMA) for alpha-foetoprotein (AFP) in serum and amniotic fluid is described. The assay uses readily available reagents; a radioiodinated mouse monoclonal antibody produced by the authors and the im...

journal_title：Annals of clinical biochemistry

authors： Stevenson JD,Chapman RS,Perry B,Logue FC

更新日期：1987-07-01 00:00:00

abstract：:In monocytes at the secretory (oestrogen-progesterone dominant) phase of the menstrual cycle, expression of c-fms and macrophage colony-stimulating factor (M-CSF) receptor and activity of tyrosine kinase (TK) were increased by oestradiol with or without progesterone. In vivo, oestrogen may induce expression of c-fms a...

journal_title：Annals of clinical biochemistry

authors： Fujimoto J,Hori M,Ichigo S,Itoh T,Saio M,Takami T,Tamaya T

更新日期：1995-07-01 00:00:00

abstract：:Background Analysis of dried blood specimens has been an integral part of laboratory medicine dating back to the early 1960s when they were introduced as part of neonatal screening programs. More recently, they have been used in Down syndrome screening programmes. Dried blood spot specimens can be collected either by ...

journal_title：Annals of clinical biochemistry

authors： Krantz DA,Carmichael JB

更新日期：2013-11-01 00:00:00

abstract：:We studied the serum protein binding of 3H-labelled progesterone, oestradiol and testosterone, and five 125I-labelled analogues of these steroids. All tracers investigated appeared to be bound by proteins in every serum sample tested. The addition of blocking agents caused a substantial reduction in serum protein bind...

journal_title：Annals of clinical biochemistry

authors： Micallef JV,Hayes MM,Latif A,Ahsan R,Sufi SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...

journal_title：Annals of clinical biochemistry

authors： Whitehead SJ,Ford C,Gama R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Method-dependent variation of caeruloplasmin measurement is significant and necessitates the requirement for assay-specific reference intervals. Local determination becomes necessary in the absence of suitable published or manufacturer-quoted reference intervals. METHODS:Applicability of the Beckman Coulter...

journal_title：Annals of clinical biochemistry

authors： Kaye OE,Cook P

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:There are few data on oxidative stresses during and after pregnancy, although aggravation of autoimmune disease is implicated in oxidative stress and occurs frequently in the postpartum period. Thioredoxin (TRX) is a stress-inducible protein, and is used as a good biomarker for oxidative stress. To clarify t...

journal_title：Annals of clinical biochemistry

authors： Kuroda S,Watanabe M,Santo T,Shimizuishi Y,Takano T,Hidaka Y,Kimura T,Iwatani Y

更新日期：2010-01-01 00:00:00

abstract：:It is increasingly easy for the general public to access a wide range of laboratory tests. Tests can be ordered online with little or no input from a health professional. The complementary and alternative medicine (CAM) community promote and sell a wide range of tests, many of which are of dubious clinical significanc...

journal_title：Annals of clinical biochemistry

authors： Jones SL,Campbell B,Hart T

更新日期：2019-05-01 00:00:00