Prevalence of haemoglobin variants in a diabetic population and their effect on glycated haemoglobin measurement.

Abstract:

:The measurement of glycated haemoglobin (glycated Hb) by automated high pressure liquid chromatography enabled the prevalence of haemoglobin variants (Hb variant) to be determined in a large diabetic population within Leeds, UK. There were 16 patients showing a Hb variant amongst a total of 5300 diabetics, the majority of the variants being HbA/S traits. There were also 13 patients showing a slightly raised HbF in the range of 2% to 5%. A multi-centre study was carried out by distributing blood specimens from some of the patients with Hb traits. Significant differences in the percentage of glycated Hb were observed relating to the methodology used. However, glycated Hb is used to monitor glycaemic control and laboratories must be aware of Hb variant interferences on their methods. Also, screening for Hb variants should be considered for the at risk groups of diabetic patients.

journal_name

Ann Clin Biochem

authors

Allen KR,Hamilton AD,Bodansky HJ,Poon P

doi

10.1177/000456329202900410

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

426-9

eissn

0004-5632

issn

1758-1001

journal_volume

29 ( Pt 4)

pub_type

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