Are biochemistry interpretative comments helpful? Results of a general practitioner and nurse practitioner survey.

abstract：:A previously described method for mannitol in urine has been modified and improved. End product inhibition by fructose in the mannitol dehydrogenase method for mannitol has been minimized; the assay is linear over a sample mannitol concentration range of 0-12 mmol/L; no significant interference from other sugars or su...

journal_title：Annals of clinical biochemistry

authors： Blood J,Ingle AR,Allison N,Davies GR,Hill PG

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Sickle cell disease is a heterogenous disorder characterized by an abnormal haemoglobin and sickling phenomena of red cells. It is prevalent among certain nomadic tribes in Sudan. Painful, aplastic and haemolytic crises mark sickle cell anaemia. Haemoglobin S (HbS) is detected using haemoglobin electrophores...

journal_title：Annals of clinical biochemistry

authors： Nimir AA,Khalil EA,Musa AM,Yassin HM,El-Hassan AM

更新日期：2009-03-01 00:00:00

abstract：:The osmolality of plasma and heparinised whole blood samples collected from hospital patients was estimated using measurement of the depression of freezing point. There was no clinically significant difference between osmolality measurement made on either whole blood, or plasma taken from the same patient. Neither cel...

journal_title：Annals of clinical biochemistry

authors： Rocks BF,Sherwood RA,Cook JG

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:It is recommended that children receiving intravenous fluids should have frequent biochemical monitoring, in some situations 4-6 hourly. Small changes in sodium must be detected, requiring very high precision from sodium analyses. Some children are monitored using venous blood analysed by indirect ion-select...

journal_title：Annals of clinical biochemistry

authors： Loughrey CM,Hanna EV,McDonnell M,Archbold GP

更新日期：2006-11-01 00:00:00

abstract：:An investigation into the use of bilirubin oxidase to measure the apparent concentration of unbound bilirubin in solutions of bilirubin or bilirubin/human serum albumin demonstrated (1) near linearity of oxidation rate with bilirubin concentration up to 16 mumol/L, (2) linearity with respect to enzyme concentration up...

journal_title：Annals of clinical biochemistry

authors： Goldfinch ME,Maguire GA

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Plantain, a herbal remedy, has been reported to interfere with therapeutic drug monitoring of digoxin. We evaluated three commercially available plantain products for potential interference with therapeutic drug monitoring of digoxin and 13 other common drugs. METHOD:Dry content of plantain capsule or pla...

journal_title：Annals of clinical biochemistry

authors： Dasgupta A,Davis B,Wells A

更新日期：2006-05-01 00:00:00

abstract：:Immunoreactive melatonin has been studied in normal human volunteers, both men and women, at different times of day and different times of the year. At 2400, but not at 0800 or 1200, there are very large inter-individual variations in mean levels, the maximum difference being fivefold. Intra-individual variations are ...

journal_title：Annals of clinical biochemistry

authors： Arendt J,Wirz-Justice A,Bradtke J,Kornemark M

更新日期：1979-11-01 00:00:00

abstract：:Mitochondrial acetoacetyl-CoA thiolase deficiency (or beta-ketothiolase deficiency) is a rare metabolic disorder characterized by acute episodes of severe acidosis and ketosis. A case is presented of an 18-month-old boy who presented with vomiting and diarrhoea and was found to be markedly acidotic. When the acidosis ...

journal_title：Annals of clinical biochemistry

authors： Tilbrook LK,Slater J,Agarwal A,Cyriac J

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Since more than 90% of cortisol is bound to protein, serum free cortisol (SFC) may be a more appropriate marker of adrenal status than total cortisol. However, measurement of SFC is technically difficult and calculated SFC may offer a more practical alternative. METHODS:SFC, measured by equilibrium dialysis...

journal_title：Annals of clinical biochemistry

authors： Barlow NL,Holme J,Stockley RA,Clark PM

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. METHODS:Serum concentrat...

journal_title：Annals of clinical biochemistry

authors： Liu H,Wu J,Wang H,Sheng L,Tang N,Li Y,Hao T

更新日期：2015-03-01 00:00:00

abstract：:Inherited metabolic disorders account for a small but significant number of sudden unexplained deaths in neonates, infants and occasionally older children. In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity t...

journal_title：Annals of clinical biochemistry

authors： Olpin SE

更新日期：2004-07-01 00:00:00

abstract：:It is increasingly easy for the general public to access a wide range of laboratory tests. Tests can be ordered online with little or no input from a health professional. The complementary and alternative medicine (CAM) community promote and sell a wide range of tests, many of which are of dubious clinical significanc...

journal_title：Annals of clinical biochemistry

authors： Jones SL,Campbell B,Hart T

更新日期：2019-05-01 00:00:00

abstract：:There is an increasing need for sensitive and specific methods for toxicological screening. Development of a dual-column gas chromatography system for the screening of drugs and metabolites in the plasma of poisoned patients is described. The system has been evaluated using plasma from a well-documented series of pati...

journal_title：Annals of clinical biochemistry

authors： Jarvie DR,Simpson D

更新日期：1984-03-01 00:00:00

abstract：:Improvement in the control of diabetic patients is aided by a knowledge of blood glucose levels during a 'normal' (non-hospitalised) day. We have devised a 5 microliter capillary tube collection system as a 'kit' for home use by diabetics. Blood collected into 5 microliter capillary tubes is washed into a protein prec...

journal_title：Annals of clinical biochemistry

authors： Williams CP,Davies GK,Child DF

更新日期：1981-09-01 00:00:00

abstract：:An audit of troponin measurement protocols in use in Wales showed significant variations in practice with no consensus on analytical methods, or in the selection of a decision limit for the diagnosis of myocardial damage. Peer review data on assay imprecision at concentrations approaching the analytical limit of detec...

journal_title：Annals of clinical biochemistry

authors： Thomas MA,Singh GK,Williams EJ,McDowell IF,Tovey JA,Wayte AM,All Wales Clinical Biochemistry Audit Group.

更新日期：2005-09-01 00:00:00

abstract：:The current search for new treatments to combat coronary heart disease (CHD) is centred on increasing HDL-cholesterol. The failure of the CETP inhibitor torcetrapib may force a rethink. This perspective briefly reviews the antiatherosclerotic properties of HDL and ways HDL-cholesterol concentration can be raised, but ...

journal_title：Annals of clinical biochemistry

authors： Mackness B,Mackness M

更新日期：2009-01-01 00:00:00

abstract：:The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional popul...

journal_title：Annals of clinical biochemistry

authors： Ford RP

更新日期：1989-05-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the malignant proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. Diagnosis and management of patients with monoclonal gammopathies depend on accurate identification and characterization of monoclonal proteins. We present a 6...

journal_title：Annals of clinical biochemistry

authors： Aksungar FB,Ayer M,Serteser M,Coskun A,Unsal I

更新日期：2014-09-01 00:00:00

abstract：:A case is presented of a 41-year-old man with a history of recurrent renal stones over 10 years. Analysis of the stone showed that, although it gave a positive reaction with the non-specific phosphotungstic acid test, uricase failed to identify any urate present. Analysis in a reference laboratory confirmed its compos...

journal_title：Annals of clinical biochemistry

authors： Wilkinson H,Samuell C,Stower M

更新日期：2004-03-01 00:00:00

abstract：:Digoxin requesting patterns were studied prospectively over a 6-month period. Clinicians were not forewarned that the study was being undertaken. Many samples received in the laboratory were taken at incorrect times after the drug had been given. This led to inappropriate action being taken in some cases. Appropriate ...

journal_title：Annals of clinical biochemistry

authors： O'Donnell JG,Paterson NC,Pledger DR,Stewart MJ

更新日期：1987-07-01 00:00:00

abstract：:Auto-antibodies to oxidized low-density lipoprotein (ox-LDL) are thought to play a pivotal role in the pathogenesis of atherosclerosis. This study investigates the value of auto-antibodies to ox-LDL as a predictive marker of atherosclerosis in patients with both homozygous and heterozygous familial hypercholesterolaem...

journal_title：Annals of clinical biochemistry

authors： Paiker JE,Raal FJ,von Arb M

更新日期：2000-03-01 00:00:00

abstract：:A total of 3227 urine specimens were analysed to investigate the applicability of a firefly luciferase assay of microbial adenosine triphosphate (ATP) for the rapid screening of bacteriuria in clinical specimens. Urine sediment, dipslide culture, and three plate cultures were also investigated in the majority of the u...

journal_title：Annals of clinical biochemistry

authors： Ruokonen A,Koskinen M,Leinonen M,Tiilikainen A,Vihko R

更新日期：1982-11-01 00:00:00

abstract：:A high-pressure liquid chromatography procedure for the measurement of free catecholamines in urine is described. 'On-line' sample preparation using a cartesian robot combined with the ASTED process ensures minimal operator intervention and reduced costs. ...

journal_title：Annals of clinical biochemistry

authors： Green B,Cooper JD,Turnell DC

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:The worldwide epidemic of obesity is a major public health concern and is persuasively linked to the rising prevalence of diabetes and cardiovascular disease. Obesity is often associated with an abnormal lipoprotein profile, which may be partly negated by pioglitazone intervention, as this can influence the ...

journal_title：Annals of clinical biochemistry

authors： McEneny J,McPherson PA,McGinty A,Hull SS,McCance DR,Young IS

更新日期：2013-01-01 00:00:00

abstract：:Plasma C1 inhibitor (C1-INH) was determined in 64 patients with different malignant diseases and in 58 healthy persons. C1-INH antigen concentration was measured by radial immunodiffusion (RID), whereas its functional activity was assayed with chromogenic substrate. Within-run and day-to-day precision of both methods ...

journal_title：Annals of clinical biochemistry

authors： Starcević D,Jelić-Ivanović Z,Kalimanovska V

更新日期：1991-11-01 00:00:00

abstract：:We evaluated a novel assay for the measurement of 1,25 dihydroxyvitamin D (1,25 (OH)2D). Immunoextraction of 1,25(OH)2D is performed using a mini column containing a solid-phase monoclonal antibody followed by radioimmunoassay (RIA) using an 125I-labelled 1,25(OH)2D derivative tracer and Sac-cell separation. The mean ...

journal_title：Annals of clinical biochemistry

authors： Fraser WD,Durham BH,Berry JL,Mawer EB

更新日期：1997-11-01 00:00:00

abstract：:Gestational diabetes is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating gestational diabetes improves maternal and fetal outcomes and allows for health promotion to reduce the mo...

journal_title：Annals of clinical biochemistry

authors： Meek CL

更新日期：2017-01-01 00:00:00

abstract：:Proteinuria is the cardinal sign of renal disease, therefore accurate identification of clinically significant proteinuria is essential to the diagnosis and management of kidney disease. Spot samples are now widely used, namely protein: creatinine ratio (uPCR) and albumin: creatinine ratio (uACR). In this article we r...

journal_title：Annals of clinical biochemistry

authors： Methven S,MacGregor MS

更新日期：2013-07-01 00:00:00

abstract：:A comparison of the Roche Cobas Core and Hybritech TANDEM-E PSA (prostate specific antigen) assays revealed a large difference in the reactivity of each assay to the separated free and complexed forms of serum PSA in patients with prostatic carcinoma. The Roche assay was relatively much more responsive to the free for...

journal_title：Annals of clinical biochemistry

authors： Tillyer CR,Konings M,Gobin PT,Iqbal J

更新日期：1994-09-01 00:00:00

abstract：:A recently introduced turbidimetric immunoassay using shell/core particles for determination of myoglobin (Turbiquant Myoglobin, Behringwerke, Marburg, Germany) was evaluated on the Behring Turbitimer analyzer. Intra-assay CV varied between 1.0% and 3.2%; interassay CV was between 2.0% and 3.6%. Linear results were ob...

journal_title：Annals of clinical biochemistry

authors： Delanghe J,Chapelle JP,el Allaf M,De Buyzere M

更新日期：1991-09-01 00:00:00