Abstract:
:There is no definitive treatment protocol for alkaptonuria. A patient with alkaptonuria was treated with ascorbic acid (0.5 g/day) from the age of 4 years. He developed episodes of severe recurrent joint pain at 9.5 years of age after which a protein-restricted diet (1.3 g/kg/day) was started. Protein restriction in combination with ascorbic acid therapy (1 g/day in two divided doses) resulted in a significant decrease but not a normalization of the urinary homogentisic acid excretion. Joint pain resolved and the radiological evidence of 'moth-eaten' irregularities on the articular surface in both knees disappeared. He is currently well, growing normally and in nitrogen balance. Our findings document a reversal of bone abnormalities and clinical symptoms in a case of alkaptonuria. The results should be confirmed in a larger study. We suggest that protein restriction should be applied in combination with ascorbic acid in affected patients as soon as joint pain occurs.
journal_name
Ann Clin Biochemjournal_title
Annals of clinical biochemistryauthors
Morava E,Kosztolányi G,Engelke UF,Wevers RAdoi
10.1258/000456303321016268subject
Has Abstractpub_date
2003-01-01 00:00:00pages
108-11issue
Pt 1eissn
0004-5632issn
1758-1001journal_volume
40pub_type
杂志文章abstract::Digoxin requesting patterns were studied prospectively over a 6-month period. Clinicians were not forewarned that the study was being undertaken. Many samples received in the laboratory were taken at incorrect times after the drug had been given. This led to inappropriate action being taken in some cases. Appropriate ...
journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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更新日期:1994-07-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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更新日期:2011-05-01 00:00:00
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更新日期:1984-07-01 00:00:00
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journal_title:Annals of clinical biochemistry
pub_type: 杂志文章
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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journal_title:Annals of clinical biochemistry
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