Immunohistochemical identification of squamous carcinoma of the head and neck with monoclonal antibody SQM1.

Abstract:

:Frozen tissue sections of biopsies from head and neck squamous cancer lesions were examined for immunohistochemical staining with a recently developed monoclonal antibody, designated as SQM1 antibody and directed against the surface membrane of squamous carcinoma cells. SQM1 antibody stained selectively squamous carcinoma, while normal mucosa and cells of the stroma were non-reactive. Positive staining of tumor was found in 33/35 specimens obtained from several major sites of the head and neck area and was observed in primary manifestations and lymph node metastases as well as in recurrences. The most consistent reactivity was seen with carcinomas of the tongue. Well differentiated squamous carcinomas contained a higher proportion of SQM1 positive tumor cells than poorly differentiated carcinomas. We suggest that the SQM1 antibody may aid in the immunohistochemical identification of squamous carcinoma of the head and neck area.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Böheim K,Schwarzfurtner H,Böheim C,Frei E 3rd,Bernal SD

doi

10.3109/00016488609108684

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

333-40

issue

3-4

eissn

0001-6489

issn

1651-2251

journal_volume

102

pub_type

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