Abstract:
:The incidence of cutaneous melanoma has increased substantially in most white populations during the past several decades. Despite improvements in the early recognition of melanoma and the use of novel diagnostic techniques that enhance our diagnostic capabilities, disease-related mortality remains a significant public health issue. In the absence of effective treatment approaches for advanced disease, the best means for reducing deaths by melanoma are screening as well as professional and public education. The role of population-or community-based screening remains controversial, but evidence from self-selected screening campaigns, health care professional surveillance, and specialized pigmented lesions clinics underscores the value of screening and early detection programs, particularly in high-risk groups. Annual screening campaigns coupled with intense media promotion have become commonplace in many countries, and despite their low yield of melanoma detection, the dissemination of educational material and information to the public during these events is important in increasing public awareness. Future directions should include using screening campaigns to target middle-aged and older men and persons of lower socioeconomic status, who suffer most from the burden of the disease and its associated mortality. On a worldwide scale, comprehensive educational and screening campaigns should be implemented or intensified in underserved areas and geographic regions with lower survival rates, such as Eastern European countries. A better understanding of the biology of the disease, already occurring with notable strides, will help us to define better those individuals who will benefit most from screening and early detection efforts. Technologic advances and new diagnostic modalities will afford a more reliable and vigilant surveillance of high-risk individuals, whereas the wide use of the Internet will enhance the distribution of relevant information to the public with the ultimate goal of achieving a better control of melanoma.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Stratigos AJ,Katsambas ADdoi
10.1016/j.clindermatol.2008.09.002subject
Has Abstractpub_date
2009-01-01 00:00:00pages
10-25issue
1eissn
0738-081Xissn
1879-1131pii
S0738-081X(08)00179-Xjournal_volume
27pub_type
杂志文章abstract::Shortly after syphilis appeared in Europe at the time of Columbus' voyage to the New World, the big pox, as it was often known, became a serious issue in Russia for diagnosis, treatment, and prevention. Members of the Russian royal family were made aware of the disease from adolescence onward. Czar Peter the Great had...
journal_title:Clinics in dermatology
pub_type: 历史文章,杂志文章
doi:10.1016/j.clindermatol.2019.09.002
更新日期:2020-01-01 00:00:00
abstract::The Accreditation Council for Graduate Medical Education and the Royal College of Physicians and Surgeons of Canada both require the teaching and demonstration of general competencies, which include professionalism and ethics as a condition of training program accreditation and specialty certification, respectively. R...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2009.02.015
更新日期:2009-07-01 00:00:00
abstract::From ancient times, light has played a significant role in the treatment of diseases. The modern discoveries (eg, ultraviolet radiation) and modern inventions (eg, the electric generator or the electric lightbulb), as well as balneologic experiences of the treatment with sunlight, contributed to the transition from he...
journal_title:Clinics in dermatology
pub_type: 历史文章,杂志文章
doi:10.1016/j.clindermatol.2016.05.002
更新日期:2016-09-01 00:00:00
abstract::Skin phototyping refers to a skin classification scheme based on how the skin responds to sun exposure. The Fitzpatrick classification is the most widely accepted method of skin phototyping, based on a person's tendency to sunburn and ability to tan. Apart from estimating the initial therapeutic dose of UV light, skin...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2019.07.010
更新日期:2019-01-01 00:00:00
abstract::The gut is the largest lymphoid organ in the body. The human microbiome is composed of trillions of bacteria. The DNA of these bacteria dwarfs the human genome. Diet and ethanol can cause rapid shifts in the number and types of bacteria in the gut. The psoriatic microbiome is similar to that seen in alcoholics; there ...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2018.03.011
更新日期:2018-01-01 00:00:00
abstract::Dr. Ida Lystic completed her MD degree at the prestigious Harvey Medical School (which has since been renamed the Harvey Provider School) and her residency in internal medicine and gastroenterology fellowship at the OTHER (Owen T. Henry and Eugene Rutherford) Medical Center. She was subsequently hired as an assistant ...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2017.03.002
更新日期:2017-01-01 00:00:00
abstract::Infective dermatitis represents a severe form of recurrent eczematous skin change that presents in childhood. It was first described in 1966. Later, the association of infective dermatitis with an underlying human T-cell lymphotropic virus infection was recognized. Chronic infective dermatitis is associated with an in...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2008.10.007
更新日期:2009-05-01 00:00:00
abstract::Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) ...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2018.08.005
更新日期:2018-01-01 00:00:00
abstract::Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the under...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2016.02.004
更新日期:2016-05-01 00:00:00
abstract::Genodermatoses are inherited disorders presenting with cutaneous manifestations with or without the involvement of other systems. The majority of these disorders, particularly in cases that present with a cutaneous patterning, may be explained in the context of genetic mosaicism. Despite the barriers to the genetic an...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2020.03.008
更新日期:2020-01-01 00:00:00
abstract::Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan system involvement and significant associated morbidity and mortality. Cutaneous signs and clinical manifestations are of particular importance, as they may be recognized before systemic manifestations, allowing earlier risk stratif...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2018.04.004
更新日期:2018-01-01 00:00:00
abstract::Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endo...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2016.07.005
更新日期:2016-01-01 00:00:00
abstract::The relationship between pregnancy and diseases of the elastic fibers, such as pseudoxanthoma elasticum, cutis laxa, and anetoderma, is discussed in this article. Dermatologists and other physicians must be aware that these problems may be present in pregnant women and must also know how to counsel those who suffer fr...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2005.10.005
更新日期:2006-03-01 00:00:00
abstract::Hand dermatitis is a common diagnosis seen in dermatologic and general practice. It can present with typical morphology, but uncommon manifestations are possible. This review reports on common and uncommon presentations of irritant and allergic hand dermatitis focusing on uncommon localizations, time course, and morph...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2005.01.011
更新日期:2005-09-01 00:00:00
abstract::Dr. Ida Lystic is an assistant professor in the Division of Gastroenterology at the Byron Edwards & Samuel Thompson (BEST) Medical Center. Before becoming one of the BEST doctors, she completed her fellowship training at the Owen T. Henry and Eugene Rutherford (OTHER) Medical Center and her MD degree at the prestigiou...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2018.02.001
更新日期:2018-01-01 00:00:00
abstract::Skin ulcerations may develop as a manifestation of a variety of different diseases or may result from some nondisease phenomena. Inflammatory ulcers refer specifically to those ulcerations in which inflammation is the primary pathologic process resulting in lesion formation; that is, inflammation is the cause rather t...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2006.09.010
更新日期:2007-01-01 00:00:00
abstract::Patient education programs are beneficial in the treatment of chronic diseases. In Germany, France, and other countries worldwide, educating children, adolescents, and adults plus the parents of children with atopic dermatitis (AD) leads to better coping with the skin disease, as well as to a reduction in the severity...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2018.05.006
更新日期:2018-01-01 00:00:00
abstract::Although dermatology does not lead the list of specialties most commonly sued for malpractice, anyone who has been the recipient of a malpractice claim is often traumatized both personally and professionally. Every day dermatologists must address various ethical concerns that have legal implications. Herein, we chose ...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2011.06.004
更新日期:2012-03-01 00:00:00
abstract::Psoriasis is a chronic, inflammatory and hyperproliferative skin disease with a genetic basis. While epidermal hyperplasia and altered keratinocyte differentiation are prominent features, considerable evidence indicates that psoriasis is immunologically mediated. Recently, the identification of HLA-Cw6 as the disease ...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2007.08.007
更新日期:2007-11-01 00:00:00
abstract::In recent years, a bewildering array of emerging rickettsial pathogens have been described throughout the world, including in the tropics. Here we present an updated overview of scrub typhus, murine typhus, and epidemic typhus. We also present an update on the emerging spotted fever group rickettsioses described in th...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2005.11.007
更新日期:2006-05-01 00:00:00
abstract::The world population of adults aged 60 years or more is increasing globally, and this development can impact skin disease morbidity and mortality, as well as being reflected in the health care system organization. There is substantial evidence that the burden from a remarkable number of skin nonmalignant and malignant...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2019.04.005
更新日期:2019-01-01 00:00:00
abstract::The large majority of cases reported worldwide as zygomycosis are infections caused by fungi belonging to the order Mucorales. These infections are invasive, often lethal, and they primarily affect immunocompromised patients. Cutaneous zygomycosis is the third most common clinical presentation, after sinusitis and pul...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2012.01.010
更新日期:2012-11-01 00:00:00
abstract::Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods. Aspects held in common by both m...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2012.08.014
更新日期:2013-03-01 00:00:00
abstract::There are numerous barriers to conducting clinical research in pregnancy, including ethical considerations, logistical difficulties, and federal regulations. Due to these challenges, there is a paucity of data on the safe and appropriate use of dermatologic therapies in pregnancy, even for easily accessed over-the-cou...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2016.02.014
更新日期:2016-05-01 00:00:00
abstract::Dermatologic manifestations of parathyroid-related disorders, although rare in sporadic cases, are not uncommon in familial syndromes. Patients with familial hyperparathyroidism have several types of skin lesions. In multiple endocrine neoplasia 1, patients commonly have angiofibromas (85%) and collagenomas (70%), les...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2006.04.003
更新日期:2006-07-01 00:00:00
abstract::Human epidermis consists of a stratified epithelium mainly composed of keratinocytes and relies on a stem cell compartment to undergo constant regeneration. Genetic mutations affecting the capacity of basal keratinocytes to adhere firmly to the epidermal basement membrane lead to severe, and very often lethal, blister...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2004.07.017
更新日期:2005-07-01 00:00:00
abstract::Medical clinicians are used to being consulted by patients who want to restore their youthful appearance. Although structural changes to the face and body may be achieved with surgery, for example, face lifts, the impression of youth also relies heavily on young-looking skin. It is desirable to have thicker and tighte...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2007.09.006
更新日期:2008-03-01 00:00:00
abstract::Teledermatology has emerged as a promising solution for pediatric and adult patients accessing dermatologic care in a health care environment fraught with barriers to access. Teledermatology has been extensively evaluated in terms of diagnostic accuracy, clinical outcomes, patient and provider satisfaction, and costs,...
journal_title:Clinics in dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.clindermatol.2017.08.009
更新日期:2017-01-01 00:00:00
abstract::Actinic keratoses (AKs) represent the earliest stage in the development of squamous cell carcinoma (SCC) and represent important biomarkers for individuals at risk for development of invasive SCC. Based on clinical morphology, AK can be subdivided into three different grades, which correspond to specific dermatoscopic...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2013.05.028
更新日期:2014-01-01 00:00:00
abstract::White diseases are a heterogenous group characterized by hypopigmentation or depigmentation. Skin and eye color are determined by the number and size of melanosomes present. Melanin is produced by melanosomes in the melanocytes present within the epidermis of the skin, uvea, and retinal pigmented epithelium (RPE). Con...
journal_title:Clinics in dermatology
pub_type: 杂志文章
doi:10.1016/j.clindermatol.2019.07.018
更新日期:2019-01-01 00:00:00