Autoinflammatory syndromes for the dermatologist.

Abstract:

:While autoimmunity as cause of disease is well-established, other categories of immune-mediated diseases that are not produced by targeting of self-antigens by antibodies is in the process of being described. These so-called autoinflammatory diseases arise when an inappropriate activation of antigen-independent mechanisms occurs. Autoinflammatory diseases course with recurrent attacks of fever and multisystemic inflammation; however, the skin may also be affected by a variety of inflammatory manifestations that often alert the clinician about the presence of an autoinflammatory disease. Recognizing the cutaneous features of these syndromes will aid for prompt diagnosis and early treatment that is key for the quality of life and survival of the affected patients. In this paper, we focus on the skin manifestations of autoinflammatory diseases in children, which is the usual period of appearing of the first symptoms and signs.

journal_name

Clin Dermatol

journal_title

Clinics in dermatology

authors

Dávila-Seijo P,Hernández-Martín A,Torrelo A

doi

10.1016/j.clindermatol.2014.02.004

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

488-501

issue

4

eissn

0738-081X

issn

1879-1131

pii

S0738-081X(14)00038-8

journal_volume

32

pub_type

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