Anesthetic action of opiates: correlations of lipid solubility and spectral edge.

abstract：UNLABELLED:Previous investigations of the effects of potent opioid analgesics on the heart have concentrated on effects on contraction magnitude and time course, but little is known about their effects on cytosolic Ca(2+) regulation in cardiac tissue. In this study, we sought to assess the effects of alfentanil on cont...

journal_title：Anesthesia and analgesia

authors： Graham MD,Hopkins PM,Harrison SM

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Helium produces preconditioning against myocardial infarction by activating prosurvival signaling, but whether nitric oxide (NO) generated by endothelial NO synthase plays a role in this phenomenon is unknown. We tested the hypothesis that NO mediates helium-induced cardioprotection in vivo. METHODS:Rabbits...

journal_title：Anesthesia and analgesia

authors： Pagel PS,Krolikowski JG,Pratt PF Jr,Shim YH,Amour J,Warltier DC,Weihrauch D

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:In this study, we evaluated the efficacy of celiac plexus block for the treatment of feeding intolerance in critically ill patients. METHODS:Nineteen mechanically ventilated medical patients intolerant of enteral nutrition and receiving metoclopramide underwent bilateral celiac plexus block. The anterior pr...

journal_title：Anesthesia and analgesia

authors： Memis D,Inal MT,Temizoz O,Genchallac H,Ozdemir H,Sut N

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Both femoral and obturator nerve blocks have been suggested to be useful in relieving pain after total knee arthroplasty (TKA). We sought to compare their efficacy. METHODS:Sixty patients undergoing elective unilateral TKA under spinal anesthesia received in a randomized, double-blind manner a femoral, obtu...

journal_title：Anesthesia and analgesia

authors： Kardash K,Hickey D,Tessler MJ,Payne S,Zukor D,Velly AM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:High-quality shared decision-making for patients undergoing elective surgical procedures includes eliciting patient goals and treatment preferences. This is particularly important, should complications occur and life-sustaining therapies be considered. Our objective was to determine the preoperative care pre...

journal_title：Anesthesia and analgesia

authors： Udelsman BV,Govea N,Cooper Z,Chang DC,Bader A,Meyer MJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Endoscopic retrograde cholangiopancreatography (ERCP) patients typically receive either tubeless anesthesia or general endotracheal anesthesia (GETA). Patients receiving propofol-based total intravenous anesthesia (TIVA) are at higher risk of sedation-related adverse events (SRAEs) than patients receiving GE...

journal_title：Anesthesia and analgesia

authors： Hagan KB,Carlson R,Arnold B,Nguyen L,Lee J,Weston B,Hernandez M,Feng L,Syed T,Hagberg CA

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:We compared the effectiveness of ondansetron, dimenhydrinate, and placebo for the prevention of postoperative vomiting in children after adenotonsillectomy. In a randomized, placebo-controlled, double-blind study, 74 children, 2-10 yr of age scheduled for adenotonsillectomy as outpatients were given a single...

journal_title：Anesthesia and analgesia

authors： Hamid SK,Selby IR,Sikich N,Lerman J

更新日期：1998-03-01 00:00:00

abstract：:The effects of ropivacaine, a new amide local anesthetic, on uterine blood flow and fetal well-being were compared with those of bupivacaine in 10 chronically instrumented pregnant ewes. In random sequence, animals received two intravenous infusions of each drug. The low infusion rate regimens were chosen to result in...

journal_title：Anesthesia and analgesia

authors： Santos AC,Arthur GR,Roberts DJ,Wlody D,Pedersen H,Morishima HO,Finster M,Covino BG

更新日期：1992-01-01 00:00:00

abstract：:The alpha 2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. Although its effects on cerebral blood flow and the electroencephalogram have been investigated, the effect of this drug on intracranial pressure (ICP) has not been reported previously. Dexmedetomidine therefo...

journal_title：Anesthesia and analgesia

authors： Zornow MH,Scheller MS,Sheehan PB,Strnat MA,Matsumoto M

更新日期：1992-08-01 00:00:00

abstract：:Clonidine decreases central sympathetic activity and anesthetic requirement. We tested whether clonidine improves outcome from incomplete ischemia of the brain in rats. Control rats were anesthetized with 25 micrograms.kg-1.h-1 of intravenous fentanyl and inhalation of 70% nitrous oxide (N2O). Clonidine-treated rats r...

journal_title：Anesthesia and analgesia

authors： Hoffman WE,Cheng MA,Thomas C,Baughman VL,Albrecht RF

更新日期：1991-10-01 00:00:00

abstract：UNLABELLED:Labor epidural analgesia (LEA) is allegedly associated with maternal fever and an increase in the newborn sepsis work-up (SWU) rate. In this study, we evaluated whether LEA causes an increase in the SWU rate compared with a Control group given parenteral narcotics for labor pain. Maternal and neonatal data w...

journal_title：Anesthesia and analgesia

authors： Kaul B,Vallejo M,Ramanathan S,Mandell G

更新日期：2001-10-01 00:00:00

abstract：UNLABELLED:Intrathecal (IT) sufentanil provides effective analgesia for extracorporeal shock wave lithotripsy. However, the optimal dose of sufentanil has not been established. We designed a prospective, randomized, double-blinded study to determine the optimal dose of IT sufentanil. Sixty men were randomized to receiv...

journal_title：Anesthesia and analgesia

authors： Lau WC,Green CR,Faerber GJ,Tait AR,Golembiewski JA

更新日期：1999-10-01 00:00:00

abstract：UNLABELLED:Adenosine and adenosine analogs induce analgesia in humans and presumed antinociception in animal models when administered both systemically and intrathecally. In the present investigation in rats, we studied the effects of intrathecally administered adenosine analogs, with or without systemic coadministrati...

journal_title：Anesthesia and analgesia

authors： Sjölund KF,Sollevi A,Segerdahl M,Lundeberg T

更新日期：1997-09-01 00:00:00

abstract：:The dynamics of IV drug delivery resulting from drug infusions connected to main-line crystalloid carriers can be complex and depend on infusion set dead-volume, drug flow rate, and carrier flow rate. While the concept of dead-volume is intuitive, a lack of appreciation of the interaction with the carrier and drug flo...

journal_title：Anesthesia and analgesia

authors： Lovich MA,Doles J,Peterfreund RA

更新日期：2005-04-01 00:00:00

abstract：:An investigation was made of the analgesic effects of the subcutaneous coadministration of fentanyl, an opioid mu-agonist (15 micrograms/kg), clonidine, an alpha 2-agonist (100 micrograms/kg), and verapamil, a calcium channel blocker (10 mg/kg) in rats. Nociceptive sensitivity was assessed with hot-plate and tail-flic...

journal_title：Anesthesia and analgesia

authors： Horváth G,Benedek G,Szikszay M

更新日期：1990-03-01 00:00:00

abstract：UNLABELLED:The availability of an analgesic compound devoid of the side effects associated with the commonly used opioid and nonsteroidal antiinflammatory drugs would be useful during the perioperative period. Although adenosine has analgesic and anesthetic-sparing properties, it also produces dose-dependent cardiovasc...

journal_title：Anesthesia and analgesia

authors： Wang B,Tang J,White PF,Foster AC,Grettenberger HM,Kopcho J,Wender RH

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Hypothermia (HT) reduces neuronal injury after perinatal asphyxia. The anesthetic gas xenon (XE) may enhance this effect. We investigated the sedative and respiratory effects of variable XE concentrations at 37 degrees C normothermia (NT) or 32 degrees C HT after a hypoxic-ischemic (HI) insult to determine t...

journal_title：Anesthesia and analgesia

authors： Dingley J,Hobbs C,Ferguson J,Stone J,Thoresen M

更新日期：2008-03-01 00:00:00

abstract：:Adenosine, a ubiquitous metabolic intermediate in the body, is involved in nearly every aspect of cell function, including neuromodulation and neurotransmission. Adenosine A(1) and A(2) receptors are widely distributed in the brain and spinal cord, and are a novel, non-opiate target for pain management. The potential ...

journal_title：Anesthesia and analgesia

authors： Gan TJ,Habib AS

更新日期：2007-08-01 00:00:00

abstract：:Several studies have investigated differential block during spinal anesthesia using transcutaneous electrical stimulation (TES) applied to patient's skin. These TES stimuli are claimed to be a surrogate for surgical stimulation, but TES has never been shown to be a realistic surrogate for a surgical stimulus during re...

journal_title：Anesthesia and analgesia

authors： Zaidi AS,Russell IF

更新日期：2005-05-01 00:00:00

abstract：:Cytokine release during surgery can produce a long-lasting hyperalgesia. Thus, preoperatively-administered cytokine inhibitors might reduce the production of cytokines, decreasing central nervous system sensitization and improving the quality of postoperative pain relief. We investigated the hypothesis that preincisio...

journal_title：Anesthesia and analgesia

authors： Lu CH,Chao PC,Borel CO,Yang CP,Yeh CC,Wong CS,Wu CT

更新日期：2004-11-01 00:00:00

abstract：:Combinations of alpha 2 agonists and opiates are used in the clinical management of pain to harness their potential synergistic interaction for analgesia while limiting their side-effects. To better predict the clinical consequences of this combination, we studied the behavioral effects of dexmedetomidine, a highly se...

journal_title：Anesthesia and analgesia

authors： Hayashi Y,Guo TZ,Maze M

更新日期：1996-09-01 00:00:00

abstract：:In this study we attempted to define the minimal dosage of alfentanil (AF) needed in combination with nitrous oxide to provide satisfactory anesthetic conditions for lower abdominal gynecologic surgery. General anesthesia was induced in 12 women with AF (150 micrograms X kg-1) and 66% N2O in O2. An infusion of AF was ...

journal_title：Anesthesia and analgesia

authors： Ausems ME,Hug CC Jr,de Lange S

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Because children's anxiety influences pain perception, perioperative anxiety should be evaluated in clinical practice with a unique, useful, and valid tool to optimize pain management. In this study, we evaluated psychometric properties of the visual analog scale (VAS)-anxiety for children and to study its p...

journal_title：Anesthesia and analgesia

authors： Bringuier S,Dadure C,Raux O,Dubois A,Picot MC,Capdevila X

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Variations in the butyrylcholinesterase (BCHE) gene can prolong neuromuscular block after the administration of the neuromuscular blocking drugs succinylcholine and mivacurium. The most frequent variations in the BCHE gene are the atypical (A) and Kalow (K) variants. We, therefore, developed a detection appr...

journal_title：Anesthesia and analgesia

authors： Levano S,Keller D,Schobinger E,Urwyler A,Girard T

更新日期：2008-01-01 00:00:00

abstract：:Previous in vivo studies of the coronary vascular effects of halothane (HAL) were complicated by varying hemodynamic conditions and global cardiac work demands. Accordingly, the current study evaluated changes in coronary blood flow (CBF) and associated variables during selective intracoronary administrations of HAL i...

journal_title：Anesthesia and analgesia

authors： Crystal GJ,Khoury E,Gurevicius J,Salem MR

更新日期：1995-02-01 00:00:00

abstract：:A recognized side effect of chemonucleolysis is life-threatening anaphylaxis to chymopapain. In the clinical trials of chymopapain, 13 cases of anaphylaxis were reported in 1585 administrations (0.82%). Two patients died. Data from a postmarketing survey (48,239 questionnaires) were reviewed to identify factors influe...

journal_title：Anesthesia and analgesia

authors： Moss J,Roizen MF,Nordby EJ,Thisted R,Apfelbaum JL,Schreider BD,McDermott DJ

更新日期：1985-12-01 00:00:00

abstract：:The effect of laparoscopy on cardiac function is controversial. We hypothesized that cardiac dysfunction related to increased afterload could be predominant in patients undergoing elective abdominal aortic repair. To test this hypothesis, we conducted a transesophageal echocardiographic study in 15 patients during lap...

journal_title：Anesthesia and analgesia

authors： Alfonsi P,Vieillard-Baron A,Coggia M,Guignard B,Goeau-Brissonniere O,Jardin F,Chauvin M

更新日期：2006-05-01 00:00:00

abstract：:As infectious complications from blood transfusion have decreased because of improved donor questionnaires and sophisticated infectious disease blood screening, noninfectious serious hazards of transfusion (NISHOTs) have emerged as the most common complications of transfusion. The category of NISHOTs is very broad, in...

journal_title：Anesthesia and analgesia

authors： Hendrickson JE,Hillyer CD

更新日期：2009-03-01 00:00:00

abstract：:In this prospective, randomized, placebo-controlled, double-blind trial we studied the effects of IV N-acetylcysteine for prevention of renal injury in patients undergoing abdominal aortic surgery. Seventy patients without previously documented renal dysfunction were randomly allocated to receive either N-acetylcystei...

journal_title：Anesthesia and analgesia

authors： Hynninen MS,Niemi TT,Pöyhiä R,Raininko EI,Salmenperä MT,Lepäntalo MJ,Railo MJ,Tallgren MK

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients undergoing radical retropubic prostatectomy (RRP) under general a...

journal_title：Anesthesia and analgesia

authors： Habib AS,White WD,El Gasim MA,Saleh G,Polascik TJ,Moul JW,Gan TJ

更新日期：2008-09-01 00:00:00