Intracranial pressure effects of dexmedetomidine in rabbits.

Abstract:

:The alpha 2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. Although its effects on cerebral blood flow and the electroencephalogram have been investigated, the effect of this drug on intracranial pressure (ICP) has not been reported previously. Dexmedetomidine therefore was intravenously administered to 24 New Zealand white rabbits that had been anesthetized with halothane and mechanically ventilated to maintain a constant arterial CO2 tension (PaCO2) between 34 and 39 mm Hg. After placement of an arterial catheter and ventricular cannula, baseline measurements of monitored variables, including heart rate, mean arterial blood pressure, ICP, end-tidal CO2, body temperature, and arterial blood gases, were recorded. Dexmedetomidine (20, 80, or 320 micrograms/kg IV) or saline solution was then infused over a 10-min period. The ICP transiently decreased by 31% in the 20-micrograms/kg group (from a mean value of 9.4 +/- 1.3 [SEM] to 6.5 +/- 1.0 mm Hg, P less than 0.05). In the 320-micrograms/kg group, ICP remained unchanged over the course of the study despite a significant increase in arterial blood pressure (32 mm Hg). The effects of dexmedetomidine on ICP were next investigated in the presence of intracranial hypertension produced by a cryogenic lesion (mean baseline ICP 16.8 mm Hg). In addition to the previously monitored variables, sagittal sinus blood flow was measured by the hydrogen clearance technique before and after the administration of dexmedetomidine (320 micrograms/kg IV). In these experiments, dexmedetomidine was associated with a 14% decrease in sagittal sinus blood flow that was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Zornow MH,Scheller MS,Sheehan PB,Strnat MA,Matsumoto M

doi

10.1213/00000539-199208000-00014

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

232-7

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

75

pub_type

杂志文章
  • Vecuronium-induced depression of phrenic nerve activity during hypoxia in the rabbit.

    abstract::We investigated the effects of a close carotid injection of vecuronium on changes in phrenic nerve activity during different states of oxygenation. Experiments were performed on normothermic and mechanically ventilated adult New Zealand White rabbits with a tracheostomy under continuous thiopental infusion. Carotid ar...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199606000-00026

    authors: Wyon N,Eriksson LI,Yamamoto Y,Lindahl SG

    更新日期:1996-06-01 00:00:00

  • Cerebral awakening concentration of sevoflurane and isoflurane predicted during slow and fast alveolar washout.

    abstract::We studied 49 patients of ASA physical status I to determine cerebral anesthetic concentration on awakening calculated with end-tidal anesthetic concentration, when the end-tidal concentration decreased spontaneously. We also attempted to explain the difference in the average of the bracketing alveolar anesthetic conc...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199311000-00024

    authors: Katoh T,Suguro Y,Kimura T,Ikeda K

    更新日期:1993-11-01 00:00:00

  • Subhypnotic doses of propofol possess direct antiemetic properties.

    abstract::Propofol is associated with a low incidence of postoperative nausea and vomiting. In a prospective, randomized, double-blind, placebo-controlled study, we investigated the possible direct antiemetic properties of a subhypnotic dose of propofol. Fifty-two ASA physical status I or II patients, aged 15-60 yr with nausea ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199204000-00013

    authors: Borgeat A,Wilder-Smith OH,Saiah M,Rifat K

    更新日期:1992-04-01 00:00:00

  • A novel vibrotactile display to improve the performance of anesthesiologists in a simulated critical incident.

    abstract:BACKGROUND:Current methods of information transfer in the operating room between monitor and anesthesiologist rely on visual and auditory modalities. These modalities can easily become overloaded in a high cognitive workload situation, such as in a critical incident. The use of vibrotactile communication has been shown...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e318163f7c2

    authors: Ford S,Daniels J,Lim J,Koval V,Dumont G,Schwarz SK,Ansermino JM

    更新日期:2008-04-01 00:00:00

  • The effect of graded hypothermia (36 degrees C-32 degrees C) on hemostasis in anesthetized patients without surgical trauma.

    abstract:UNLABELLED:The isolated effects of hypothermia on hemostasis have not been investigated in healthy humans. We cooled 16 anesthetized patients scheduled for elective intracranial surgery to 32 degrees C body core temperature and assessed prothrombin time (PT), activated partial thromboplastin time, thrombelastogram (TEG...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000062520.65192.c9

    authors: Kettner SC,Sitzwohl C,Zimpfer M,Kozek SA,Holzer A,Spiss CK,Illievich UM

    更新日期:2003-06-01 00:00:00

  • Spinal cord stimulation in postherpetic neuralgia and in acute herpes zoster pain.

    abstract:UNLABELLED:We studied the effects of spinal cord stimulation (SCS) on postherpetic neuralgia (PHN). Data of 28 patients were prospectively investigated over a median period of 29 (quartiles 9--39) mo. In addition, four patients with acute herpes zoster (HZ) pain were studied simultaneously. After intractable pain for m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200203000-00040

    authors: Harke H,Gretenkort P,Ladleif HU,Koester P,Rahman S

    更新日期:2002-03-01 00:00:00

  • Sevoflurane provides faster recovery and postoperative neurological assessment than isoflurane in long-duration neurosurgical cases.

    abstract:UNLABELLED:Sevoflurane (SEVO) provides faster emergence than isoflurane (ISO). This advantage is thought to magnify with increased duration of exposure. In addition, SEVO has several of the characteristics of an ideal neuroanesthetic. We designed a prospective, randomized, double-blinded study to compare the recovery p...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200211000-00052

    authors: Gauthier A,Girard F,Boudreault D,Ruel M,Todorov A

    更新日期:2002-11-01 00:00:00

  • Global end-diastolic volume during different loading conditions in a pediatric animal model.

    abstract:BACKGROUND:Estimating volume status in infants and neonates is challenging. Global end-diastolic volume (GEDV) and dynamic variables of preload, such as pulse pressure variation (PPV), may be alternative variables for estimating cardiac preload and fluid responsiveness. Therefore, we designed the present study to evalu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000281152.72734.d0

    authors: Renner J,Meybohm P,Gruenewald M,Steinfath M,Scholz J,Boening A,Bein B

    更新日期:2007-11-01 00:00:00

  • Halogenation and anesthetic potency.

    abstract::Previous studies have shown that the anesthetic potency of organic compounds increases as a given halogen is replaced with successively larger halogens. These studies often are limited in the accuracy of determination of potency, rarely correlate potency with physical properties, and usually fail to include ether comp...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Targ AG,Yasuda N,Eger EI 2nd,Huang G,Vernice GG,Terrell RC,Koblin DD

    更新日期:1989-05-01 00:00:00

  • Bispectral index monitoring: a comparison between normal children and children with quadriplegic cerebral palsy.

    abstract:UNLABELLED:We performed this study to compare the correlation of bispectral index (BIS) values with different sevoflurane concentrations between normal children and those with quadriplegic cerebral palsy with mental retardation (CPMR). Twenty children with CPMR (Group I) and 21 normal children (Group II) between 2 and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200212000-00020

    authors: Choudhry DK,Brenn BR

    更新日期:2002-12-01 00:00:00

  • Left ventricular mass in a patient with Carney's complex.

    abstract:IMPLICATIONS:Carney's complex is characterized by cardiac myxomas, adrenocortical disease, growth hormone-secreting adenomas, and other types of tumors. Its prevalence and incidence are unknown. The anesthesiologist must examine the patient or order tests to exclude cardiac tumors, signs of excess cortisol secretion, a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200210000-00015

    authors: Szokol JW,Franklin M,Murphy GS,Wynnychenko TM,Sener SF

    更新日期:2002-10-01 00:00:00

  • Closed-loop coadministration of propofol and remifentanil guided by bispectral index: a randomized multicenter study.

    abstract:BACKGROUND:We have developed a proportional-integral-derivative controller allowing the closed-loop coadministration of propofol and remifentanil, guided by a Bispectral Index (BIS) monitor, during induction and maintenance of general anesthesia. The controller was compared with manual target-controlled infusion. METH...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1213/ANE.0b013e318205680b

    authors: Liu N,Chazot T,Hamada S,Landais A,Boichut N,Dussaussoy C,Trillat B,Beydon L,Samain E,Sessler DI,Fischler M

    更新日期:2011-03-01 00:00:00

  • Control of intraoperative hypertension with isoflurane in patients with coronary artery disease: effects on regional myocardial blood flow and metabolism.

    abstract::The effect of isoflurane on regional myocardial metabolism and blood flow, when used as an adjunct to fentanyl-nitrous oxide anesthesia, to control intraoperative hypertension was investigated. Twenty-two patients with two- or three-vessel coronary artery disease with an ejection fraction greater than 0.5 and on beta-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-198902000-00006

    authors: Sahlman L,Milocco I,Appelgren L,William-Olsson G,Ricksten SE

    更新日期:1989-02-01 00:00:00

  • Management of 1-Lung Ventilation-Variation and Trends in Clinical Practice: A Report From the Multicenter Perioperative Outcomes Group.

    abstract:BACKGROUND:Lung-protective ventilation (LPV) has been demonstrated to improve clinical outcomes in surgical patients. There are very limited data on the current use of LPV for patients undergoing 1-lung ventilation (1LV) despite evidence that 1LV may be a particularly important setting for its use. In this multicenter ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究

    doi:10.1213/ANE.0000000000002642

    authors: Colquhoun DA,Naik BI,Durieux ME,Shanks AM,Kheterpal S,Bender SP,Blank RS,MPOG Investigators.

    更新日期:2018-02-01 00:00:00

  • Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs.

    abstract::The intracranial and systemic hemodynamic effects of sufentanil (20 micrograms/kg) were studied in 10 mongrel dogs. Baseline anesthesia was maintained with 0.7% end-tidal isoflurane and 50% nitrous oxide in oxygen. Catheters were inserted for blood pressure measurement, arterial and sagittal sinus blood sampling, radi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199102000-00006

    authors: Werner C,Hoffman WE,Baughman VL,Albrecht RF,Schulte J

    更新日期:1991-02-01 00:00:00

  • The effect of peripheral resistance on impedance cardiography measurements in the anesthetized dog.

    abstract::In the vasodilated and septic patient, the impedance method of measuring cardiac output (CO) may underestimate the true value. In this study, we sought to determine whether impedance CO (COIC) measurements are influenced by total peripheral resistance (TPR). In eight anesthetized and ventilated dogs, a high-precision ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000150602.40554.EB

    authors: Critchley LA,Peng ZY,Fok BS,James AE

    更新日期:2005-06-01 00:00:00

  • Anesthetic management of patients with Takayasu's arteritis: a case series and review.

    abstract:UNLABELLED:Takayasu's arteritis is a rare, chronic progressive panendarteritis involving the aorta and its main branches. Anesthesia for patients with Takayasu's arteritis is complicated by their severe uncontrolled hypertension, end-organ dysfunction resulting from hypertension, stenosis of major blood vessels affecti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200107000-00014

    authors: Kathirvel S,Chavan S,Arya VK,Rehman I,Babu V,Malhotra N,Bhukal I,Chari P

    更新日期:2001-07-01 00:00:00

  • Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: differences in risk factors and outcome.

    abstract:OBJECTIVE:In this study we sought to identify differences in risk factors and outcome of critically ill patients with Candida albicans and non-albicans candidemia. METHODS:Nonimmunosuppressed, nonneutropenic patients with candidemia diagnosed after intensive care unit (ICU) admission were included in a prospective obs...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181607262

    authors: Dimopoulos G,Ntziora F,Rachiotis G,Armaganidis A,Falagas ME

    更新日期:2008-02-01 00:00:00

  • Continuous positive airway pressure versus noninvasive pressure support ventilation to treat atelectasis after cardiac surgery.

    abstract::Atelectasis is common after cardiac surgery and may result in impaired gas exchange. Continuous positive airway pressure (CPAP) is often used to prevent or treat postoperative atelectasis. We hypothesized that noninvasive pressure support ventilation (NIPSV) by increasing tidal volume could improve the evolution of at...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000130621.11024.97

    authors: Pasquina P,Merlani P,Granier JM,Ricou B

    更新日期:2004-10-01 00:00:00

  • Prevention of atelectasis formation during induction of general anesthesia.

    abstract:UNLABELLED:General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations. We studied the efficacy of positive end-expiratory pressure (PEEP) application during the induction of general anesthesia (fraction of inspired oxygen [FIO(2)] 1.0) to prevent atelectasis. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000087042.02266.f6

    authors: Rusca M,Proietti S,Schnyder P,Frascarolo P,Hedenstierna G,Spahn DR,Magnusson L

    更新日期:2003-12-01 00:00:00

  • Peripheral flow index is a reliable and early indicator of regional block success.

    abstract::We investigated the usefulness of peripheral flow index (PFI) measurement using a standard pulse oximetry digit probe for early prediction of successful regional blocks. Sixty-six patients scheduled for limb surgery underwent either axillary or sciatic block using a nerve stimulator technique with mepivacaine 1.5%. PF...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000220947.02689.9f

    authors: Galvin EM,Niehof S,Verbrugge SJ,Maissan I,Jahn A,Klein J,van Bommel J

    更新日期:2006-07-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • Tertiary Pediatric Academic Institution's Experience With Intraoperative Neuromonitoring for Nonspinal Surgery in Children With Mucopolysaccharidosis, Based on a Novel Evidence-Based Care Algorithm.

    abstract:BACKGROUND:Musculoskeletal deformities in mucopolysaccharidoses (MPSs) patients pose unique challenges when patients present for surgery, especially nonspinal surgery. MPS patients have developed postsurgical neurological deficits after nonspinal surgery. While the incidence of neurological deficits after nonspinal sur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004215

    authors: Kandil AI,Pettit CS,Berry LN,Busso VO,Careskey M,Chesnut E,Buck DW,Leslie ND,Tamai J,McAuliffe JJ,Chidambaran V

    更新日期:2020-06-01 00:00:00

  • Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats.

    abstract::In this study we investigated the effects of a racemic mixture of bupivacaine (RS(+/-)bupivacaine) and its isomers (S(-)bupivacaine and R(+)bupivacaine) on the Ca2+ handling by ventricular myocytes from Wistar rats. Single ventricular myocytes were enzymatically isolated and loaded with the fluorescent Ca2+ indicator ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000195341.65260.87

    authors: Chedid NG,Sudo RT,Aguiar MI,Trachez MM,Masuda MO,Zapata-Sudo G

    更新日期:2006-03-01 00:00:00

  • Insulin infusion improves neutrophil function in diabetic cardiac surgery patients.

    abstract:UNLABELLED:Diabetic patients are at increased risk of wound infection after major surgery, but the effect of perioperative glucose control on postoperative wound infection rates after surgery is uncertain. We tested the effect of an insulin infusion on perioperative neutrophil function in diabetic patients scheduled fo...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199905000-00008

    authors: Rassias AJ,Marrin CA,Arruda J,Whalen PK,Beach M,Yeager MP

    更新日期:1999-05-01 00:00:00

  • Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block.

    abstract::In this review, we summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small degre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3181da832d

    authors: Murphy GS,Brull SJ

    更新日期:2010-07-01 00:00:00

  • Transient atrioventricular block after release of aortic cross-clamp.

    abstract::To determine the incidence of atrioventricular (A-V) block, 86 patients, aged 58.9 +/- 10.4 yr, undergoing elective coronary artery bypass grafting (CABG) during aortic cross-clamping (ACC) and cold potassium cardioplegia were investigated. The incidence and duration of complete A-V block after release of the aortic c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199501000-00009

    authors: Baraka AS,Taha SK,Yazbeck VK,Rizkallah PA,Zughbi JP,Aouad MJ,Rouhana CS,Nader AM

    更新日期:1995-01-01 00:00:00

  • Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype.

    abstract::We investigated the efficacy of granisetron and dolasetron in preventing postoperative nausea and vomiting. Because the metabolism of the various antiemetic 5-hydroxytryptamine type 3 (5-HT3) antagonists involves different isoforms of the hepatic cytochrome P450 system, we examined the relationship between the clinica...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000200364.55798.3f

    authors: Janicki PK,Schuler HG,Jarzembowski TM,Rossi M 2nd

    更新日期:2006-04-01 00:00:00

  • Noninfectious Fever in the Near-Term Pregnant Rat Induces Fetal Brain Inflammation: A Model for the Consequences of Epidural-Associated Maternal Fever.

    abstract:BACKGROUND:Women laboring with epidural analgesia experience fever much more frequently than do women who chose other forms of analgesia, and maternal intrapartum fever is associated with numerous adverse consequences, including brain injury in the fetus. We developed a model of noninfectious inflammatory fever in the ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002479

    authors: Segal S,Pancaro C,Bonney I,Marchand JE

    更新日期:2017-12-01 00:00:00

  • Electroencephalography-Guided Anesthetic Delivery for Preventing Postoperative Delirium in Adults: An Updated Meta-analysis.

    abstract:BACKGROUND:Postoperative delirium is a major debilitating complication for patients and is associated with poor outcomes. Previous studies have suggested that excessive general anesthesia may lead to postoperative delirium. Electroencephalography (EEG)-based monitors have been administered in clinical practice in an at...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析

    doi:10.1213/ANE.0000000000004746

    authors: Sun Y,Ye F,Wang J,Ai P,Wei C,Wu A,Xie W

    更新日期:2020-09-01 00:00:00