Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats.

abstract：BACKGROUND:Although our understanding of nociceptive processing during anesthesia has increased greatly over the last decade, many patients still experience hyperalgesia and acute pain postoperatively. The noxious-induced withdrawal reflex (NIWR) model is specifically designed and validated to quantitatively study the ...

journal_title：Anesthesia and analgesia

authors： Sommers MG,Nguyen NK,Veening JG,Vissers KC,Ritskes-Hoitinga M,van Egmond J

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Premedication with midazolam is commonly used in children to reduce anxiety and improve cooperation before anesthesia. However, it has the potential to alter respiratory function because of its muscle relaxant properties. We assessed functional residual capacity (FRC), ventilation homogeneity, using a lung c...

journal_title：Anesthesia and analgesia

authors： von Ungern-Sternberg BS,Erb TO,Habre W,Sly PD,Hantos Z

更新日期：2009-06-01 00:00:00

abstract：UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...

journal_title：Anesthesia and analgesia

authors： Nozaki-Taguchi N,Yamamoto T

更新日期：1998-02-01 00:00:00

abstract：UNLABELLED:Acute withdrawal syndromes, including agitation and a long weaning time, are common adverse effects after long-term sedation with midazolam. We performed this study to determine whether the sequential use of midazolam and propofol could reduce adverse effects as compared with midazolam alone. We studied 26 p...

journal_title：Anesthesia and analgesia

authors： Saito M,Terao Y,Fukusaki M,Makita T,Shibata O,Sumikawa K

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Surgery is associated with activation of neutrophils and their influx into affected tissue. The pathogenic role of superoxide production generated by activated neutrophils has been documented repeatedly. Ketamine suppresses neutrophil oxygen radical production in vitro. In the present study, we compared the ...

journal_title：Anesthesia and analgesia

authors： Zilberstein G,Levy R,Rachinsky M,Fisher A,Greemberg L,Shapira Y,Appelbaum A,Roytblat L

更新日期：2002-09-01 00:00:00

abstract：:Fifty-three swine from the University of Missouri Sinclair Medical Research Farm were used in experimentation to determine their susceptibility to malignant hyperthermia, to determine appropriate anesthetic agents for susceptible swine and to investigate appropriate pharmaceutical agents which could protect against th...

journal_title：Anesthesia and analgesia

authors： Short CE,Paddleford RR,McGrath CJ,Williams CH

更新日期：1976-09-01 00:00:00

abstract：:Computer-based measuring of the level of sedation and hypnosis is difficult and has proven to be challenging. The electroencephalogram (EEG) has been proposed as a potential method. Response entropy (RE) and state entropy (SE) are multifactor, dimensionless parameters of a new technology of EEG monitoring, and we inve...

journal_title：Anesthesia and analgesia

authors： Litscher G

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Blood product transfusion is the most commonly performed hospital procedure. Intraoperative blood product utilization varies between institutions and anesthesiologists. In the United States in 2011, nearly 4 million plasma units were transfused. METHODS:A retrospective analysis of intraoperative plasma orde...

journal_title：Anesthesia and analgesia

authors： Meyer MJ,Dzik WH,Levine WC

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention. METHODS:We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours aft...

journal_title：Anesthesia and analgesia

authors： Weingarten TN,Herasevich V,McGlinch MC,Beatty NC,Christensen ED,Hannifan SK,Koenig AE,Klanke J,Zhu X,Gali B,Schroeder DR,Sprung J

更新日期：2015-08-01 00:00:00

abstract：:Many in vitro effects of volatile anesthetics are known, but the mechanisms of action are still under debate. Because suppression of sensory perception is one of the major goals of general anesthesia, we studied the effects of isoflurane on the processing of somatosensory information in anesthetized rats. Local iontop...

journal_title：Anesthesia and analgesia

authors： Vahle-Hinz C,Detsch O,Siemers M,Kochs E,Bromm B

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Severe exacerbation of chronic neuropathic pain often requires morphine in patients already treated with drugs such as tricyclic antidepressants, carbamazepine and gabapentin. However, it is unclear if a combination of these drugs intensifies the effects of morphine on the respiratory system and, if so, whet...

journal_title：Anesthesia and analgesia

authors： Kozer E,Levichek Z,Hoshino N,Kapur B,Leombruno J,Taguchi N,Garcia-Bournissen F,Koren G,Ito S

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Intercostal nerve blocks with liposomal bupivacaine are commonly used for thoracic surgery pain management. However, dose scheduling is difficult because the pharmacokinetics of a single-dose intercostal injection of liposomal bupivacaine has never been investigated. The primary aim of this study was to asse...

journal_title：Anesthesia and analgesia

authors： Manson WC,Blank RS,Martin LW,Alpert SB,Dobrzanski TP,Schneider EB,Ratcliffe SJ,Durieux ME

更新日期：2020-12-01 00:00:00

abstract：:Repeated conventional tracheal intubation attempts may contribute to patient morbidity. Critically-ill patients (n = 2833) suffering from cardiovascular, pulmonary, metabolic, neurologic, or trauma-related deterioration were entered into an emergency intubation quality improvement database. This practice analysis was ...

journal_title：Anesthesia and analgesia

authors： Mort TC

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The effect of interscalene block (ISB) on pulmonary function of obese participants has not been investigated. The goal of this study is to assess the association of obesity (body mass index [BMI] >29 kg/m vs BMI <25 kg/m) and change in forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV...

journal_title：Anesthesia and analgesia

authors： Melton MS,Monroe HE,Qi W,Lewis SL,Nielsen KC,Klein SM

更新日期：2017-07-01 00:00:00

abstract：:In this prospective randomized, double-blind study, we investigated the effect of ondansetron on the lidocaine subarachnoid block. Fifty-four male patients scheduled for transurethral surgery under subarachnoid anesthesia received oral ondansetron 4 mg the evening before surgery and 4 mg IV 15 min before subarachnoid ...

journal_title：Anesthesia and analgesia

authors： Fassoulaki A,Melemeni A,Zotou M,Sarantopoulos C

更新日期：2005-06-01 00:00:00

abstract：:Outcomes after cardiac arrest remain poor more than a half a century after closed chest cardiopulmonary resuscitation (CPR) was first described. This review article is focused on recent insights into the physiology of blood flow to the heart and brain during CPR. Over the past 20 years, a greater understanding of hear...

journal_title：Anesthesia and analgesia

authors： Lurie KG,Nemergut EC,Yannopoulos D,Sweeney M

更新日期：2016-03-01 00:00:00

abstract：:A 53-yr-old man undergoing laparoscopic cholecystectomy experienced cardiac arrest intraoperatively. Patient state index values decreased to single digits during the cardiac arrest and returned to baseline after successful cardiopulmonary resuscitation. ...

journal_title：Anesthesia and analgesia

authors： Nguyen NK,Lenkovsky F,Joshi GP

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Pulmonary complications related to residual neuromuscular blockade lead to morbidity and mortality. Using an interrupted time series design, we tested whether proportions of reintubation for respiratory failure or new noninvasive ventilation were changed after a system-wide transition of the standard reversa...

journal_title：Anesthesia and analgesia

authors： Krause M,McWilliams SK,Bullard KJ,Mayes LM,Jameson LC,Mikulich-Gilbertson SK,Fernandez-Bustamante A,Bartels K

更新日期：2020-07-01 00:00:00

abstract：:Dantrolene effectively treats malignant hyperthermia (MH) hut the current form, Dantrium, must be dissolved to a 0.33 mg/mL, pH 9.5 solution. This study describes lecithin-coated microcrystal formulations of sodium dantrolene (MC-NaD) and neutral dantrolene (MC-D) which reconstitute to 200 mg/mL within 1 min. In rats,...

journal_title：Anesthesia and analgesia

authors： Karan SM,Lojeski EW,Haynes DH,Bina S,Wesche DL,Boedeker BH,Muldoon SM

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Unicondylar knee arthroplasty (UKA) is a commonly performed procedure with significant expected postoperative pain. Peripheral nerve blocks are 1 analgesic option, but some approaches may decrease quadriceps motor strength and interfere with early ambulation. In this study, we compared the analgesia provided...

journal_title：Anesthesia and analgesia

authors： Henshaw DS,Jaffe JD,Reynolds JW,Dobson S,Russell GB,Weller RS

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Both propofol infusions with oxygen delivered through nasal cannula and isoflurane/N2O (nitrous oxide) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for children undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic...

journal_title：Anesthesia and analgesia

authors： Heard C,Harutunians M,Houck J,Joshi P,Johnson K,Lerman J

更新日期：2015-01-01 00:00:00

abstract：:Our goal in this study was to develop a robotic intubation system and to conduct a feasibility pilot study on the use of a robotic intubation system for endotracheal intubations. The Kepler Intubation System was developed, consisting of a remote control center (joystick and intubation cockpit) linked to a standard vid...

journal_title：Anesthesia and analgesia

authors： Hemmerling TM,Wehbe M,Zaouter C,Taddei R,Morse J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:This study investigated the clinical performance of a model-based, patient-individualized closed-loop (CL) control system for propofol administration using the bispectral index (BIS) as a controlled variable during the induction and maintenance of anesthesia with propofol and remifentanil and studied the inf...

journal_title：Anesthesia and analgesia

authors： Neckebroek M,Boldingh JHL,De Smet T,Struys MMRF

更新日期：2020-06-01 00:00:00

abstract：:The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation,...

journal_title：Anesthesia and analgesia

authors： Perry JC,Munson ES,Malagodi MH,Shah DO

更新日期：1975-11-01 00:00:00

abstract：:Patients with frailty experience substantial physical and emotional distress related to their condition and face increased morbidity and mortality compared with their nonfrail peers. Palliative care is an interdisciplinary medical specialty focused on improving quality of life for patients with serious illness, includ...

journal_title：Anesthesia and analgesia

authors： Crooms RC,Gelfman LP

更新日期：2020-06-01 00:00:00

abstract：:Health care-associated infections are a hospital-wide concern associated with a significant increase in patient morbidity, mortality, and health care costs. Bacterial transmission in the anesthesia work area of the operating room environment is a root cause of 30-day postoperative infections affecting as many as 16% o...

journal_title：Anesthesia and analgesia

authors： Loftus RW,Koff MD,Birnbach DJ

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:This study was designed to determine if, and to what extent, antithrombin III (AT) levels affect the response of the activated clotting time (ACT) to heparin in concentrations used during cardiac surgery, and to characterize the relationship between AT levels and markers of activation of coagulation during c...

journal_title：Anesthesia and analgesia

authors： Despotis GJ,Levine V,Joist JH,Joiner-Maier D,Spitznagel E

更新日期：1997-09-01 00:00:00

abstract：UNLABELLED:Endovascular repair of the aorta (EVAR) is a promising alternative to open repair. Transesophageal echocardiography (TEE) is a sensitive imaging modality for aortic disease. We reviewed our experience with TEE in thoracic EVAR. Seven patients underwent thoracic EVAR under general anesthesia. Intraoperative a...

journal_title：Anesthesia and analgesia

authors： Swaminathan M,Lineberger CK,McCann RL,Mathew JP

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Tissue factor pathway inhibitor (TFPI) is a 40-kDa, endogenous protein that inhibits tissue factor (TF)-initiated coagulation by bonding with activated factor X (FXa). The TFPI/FXa complex then subsequently binds with TF/activated factor VII (FVIIa) complex, ultimately inhibiting thrombin generation. Heparin...

journal_title：Anesthesia and analgesia

authors： Audu P,Nielsen VG,Armstead V,Powell G,Kim J,Kim L,Mehta M

更新日期：2006-10-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell injury, with increased permeability of the alveolar-capillary membrane, leading to pulmonary edema, severe hypoxia, and difficulty w...

journal_title：Anesthesia and analgesia

authors： Lee LK,Medzikovic L,Eghbali M,Eltzschig HK,Yuan X

更新日期：2020-11-01 00:00:00