Preanesthetic evaluation and management of malignant hyperthermia in the pig experimental model.


:Fifty-three swine from the University of Missouri Sinclair Medical Research Farm were used in experimentation to determine their susceptibility to malignant hyperthermia, to determine appropriate anesthetic agents for susceptible swine and to investigate appropriate pharmaceutical agents which could protect against the development of malignant hyperthermia. The screening technics used were successful in determining susceptible animals to MH and the anesthesia studies indicated that dissociative anesthetics had less tendency to trigger MH than did halothane and pancuronium was shown to have greater safety as a muscle relaxant than succinylcholine in this group of pigs. Pigs pretreated with reserpine had less tendency to develop symptoms of MH and some were completely protected. The principle undesirable effect was the development of hypotension if sufficient reserpine was used to provide total protection.


Anesth Analg


Anesthesia and analgesia


Short CE,Paddleford RR,McGrath CJ,Williams CH




Has Abstract


1976-09-01 00:00:00












  • The effect of clonidine on the activity of neurons in the rat dorsal raphe nucleus in vitro.

    abstract::The dorsal raphe (DR) nucleus is a system of nuclei in the midline of the lower brainstem, which is considered one of the most important nuclei in the modulation of pain in the central nervous system. Central noradrenergic systems play an important role in the control of cardiovascular regulation and pain transmission...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Alojado ME,Ohta Y,Kemmotsu O

    更新日期:1994-08-01 00:00:00

  • Epidural labor analgesia and neonatal sepsis evaluation rate: a quality improvement study.

    abstract:UNLABELLED:Labor epidural analgesia (LEA) is allegedly associated with maternal fever and an increase in the newborn sepsis work-up (SWU) rate. In this study, we evaluated whether LEA causes an increase in the SWU rate compared with a Control group given parenteral narcotics for labor pain. Maternal and neonatal data w...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kaul B,Vallejo M,Ramanathan S,Mandell G

    更新日期:2001-10-01 00:00:00

  • Odds of transfusion for older adults compared to younger adults undergoing surgery.

    abstract:BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

    更新日期:2014-06-01 00:00:00

  • Postoperative voiding interval and duration of analgesia following peripheral or caudal nerve blocks in children.

    abstract::We studied the time to postoperative micturition and the duration of analgesia in 82 children aged 6 mo to 10 yr undergoing herniorrhaphy or orchiopexy under general anesthesia with N2O and halothane. All received D5 lactate Ringer's solution equivalent to 6 h maintenance intraoperatively, and oral fluids postoperativ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fisher QA,McComiskey CM,Hill JL,Spurrier EA,Voigt RE,Savarese AM,Beaver BL,Boltz MG

    更新日期:1993-01-01 00:00:00

  • Prolonged intrathecal fentanyl analgesia via 32-gauge catheters after thoracotomy.

    abstract::We hypothesized that intrathecal fentanyl infusion would provide excellent analgesia, require lower doses than necessary for the epidural or intravenous route of administration, and reduce the incidence and/or severity of side effects. Accordingly, we studied 12 patients during 48 h after thoracotomy (three pneumonect...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Guinard JP,Chiolero R,Mavrocordatos P,Carpenter RL

    更新日期:1993-11-01 00:00:00

  • Studies of desflurane in outpatient anesthesia.

    abstract::The low solubility of desflurane contributes to rapid emergence after outpatient anesthesia. Compared with isoflurane, recovery times to eye opening, response to verbal commands, and orientation to person, place, and time have been significantly shorter. Even when compared with the rapid, short-acting intravenous anes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: White PF

    更新日期:1992-10-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • The protective effects of volatile anesthestics against the bronchoconstriction induced by an allergic reaction in sensitized rabbit pups.

    abstract:BACKGROUND:Volatile inhaled anesthetics exert a differential protective effect against bronchospasm development after cholinergic stimulation. However, their ability to inhibit the adverse respiratory consequences of an anaphylactic reaction after exposure to an allergen has not been characterized. We therefore compare...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lele E,Petak F,Carnesecchi S,Virag K,Argiroffo CB,Habre W

    更新日期:2013-06-01 00:00:00

  • The effect of perioperative aspirin therapy in peripheral vascular surgery: a decision analysis.

    abstract::Patients who undergo infrainguinal revascularization surgery are at increased risk for perioperative thrombotic complications. Aspirin decreases thrombotic events in the nonoperative setting; however, aspirin is often discontinued to avoid perioperative hemorrhagic complications. We used a decision analysis to determi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,meta分析


    authors: Neilipovitz DT,Bryson GL,Nichol G

    更新日期:2001-09-01 00:00:00

  • Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury.

    abstract::In susceptible patients, halothane, enflurane, isoflurane, and desflurane can produce severe hepatic injury by an immune response directed against reactive anesthetic metabolites covalently bound to hepatic proteins. The incidence of hepatotoxicity appears to directly correlate with anesthetic metabolism catalyzed by ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Njoku D,Laster MJ,Gong DH,Eger EI 2nd,Reed GF,Martin JL

    更新日期:1997-01-01 00:00:00

  • The pain visual analog scale: is it linear or nonlinear?

    abstract:UNLABELLED:The visual analog scale (VAS) is a tool widely used to measure pain, yet controversy surrounds whether the VAS score is ratio or ordinal data. We studied 52 postoperative patients and measured their pain intensity using the VAS. We then asked them to consider different amounts of pain (conceptually twice as ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Myles PS,Troedel S,Boquest M,Reeves M

    更新日期:1999-12-01 00:00:00

  • Decreased insulin requirements with spinal cord stimulation in a patient with diabetes.

    abstract:UNLABELLED:We describe a case of type-2 diabetes mellitus with significant improvement in blood glucose control and significant decrease in insulin requirements after initiation of spinal cord stimulation. We believe that spinal cord stimulation may provide additional beneficial effects in patients with chronic pain an...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kapural L,Hayek SM,Stanton-Hicks M,Mekhail N

    更新日期:2004-03-01 00:00:00

  • Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats.

    abstract:BACKGROUND:In the present study, we examined the effects and mechanisms of the Chinese herb resveratrol on attenuation of morphine tolerance in rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters; one catheter was connected to a mini-osmotic pump, used for either morphine (15 μg/h) or saline (1 ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsai RY,Chou KY,Shen CH,Chien CC,Tsai WY,Huang YN,Tao PL,Lin YS,Wong CS

    更新日期:2012-10-01 00:00:00

  • Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.

    abstract:UNLABELLED:The nonhalogenated anesthetic alkanes, cyclopropane and butane, do not enhance gamma-aminobutyric acid-elicited GABAergic currents, suggesting that these agents produce anesthesia via interactions with other molecular targets. Perhalogenated nonimmobilizing alkanes, such as 1,2-dichlorohexafluorocyclobutane ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Raines DE,Claycomb RJ,Forman SA

    更新日期:2002-09-01 00:00:00

  • Estimation of optimal modeling weights for a Bayesian-based closed-loop system for propofol administration using the bispectral index as a controlled variable: a simulation study.

    abstract:BACKGROUND:Implementing Bayesian methods in a model-based closed-loop system requires the integration of a standard response model with a patient-specific response model. This process makes use of specific modeling weights, called Bayesian variances, which determine how the specific model can deviate from the standard ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: De Smet T,Struys MM,Greenwald S,Mortier EP,Shafer SL

    更新日期:2007-12-01 00:00:00

  • The Effectiveness of Applying Soft Tissue Bonding Adhesive Composed of 2-Ethyl Cyanoacrylate to Epidural Catheter Fixations Using Film Dressings: An Open-Label, Randomized, Parallel-Group Comparative Study.

    abstract:BACKGROUND:Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for clinical use and can be used for surgical adhesion to both skin and b...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Tadokoro T,Kakinohana M,Navarro M,Goya M,Odo Y

    更新日期:2019-07-01 00:00:00

  • The effect of systemic zonisamide (Zonegran) on thermal hyperalgesia and mechanical allodynia in rats with an experimental mononeuropathy.

    abstract:UNLABELLED:We studied the ability of zonisamide (Zonegran) to relieve thermal hyperalgesia and/or mechanical allodynia in the chronic constriction injury model of neuropathic pain. Zonisamide (25, 50, or 100 mg/kg) or saline was administered in a blinded, randomized manner by intraperitoneal injection on postoperative ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hord AH,Denson DD,Chalfoun AG,Azevedo MI

    更新日期:2003-06-01 00:00:00

  • Availability of anesthesia equipment in Chinese hospitals: is the safety of anesthesia patient care assured?

    abstract::Availability of physiologic monitoring equipment to ensure the safe administration of anesthesia is an expected standard in many parts of the world. Many hospitals in China may not have an adequate quantity and variety of anesthesia delivery and patient monitoring equipment to assure safe administration of anesthesia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Juan X,Xinqiao F,Shanglong Y,Yuguang H,Buwei Y,Shiying Y,Pengqian F,Hanqing Z

    更新日期:2012-06-01 00:00:00

  • Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop.

    abstract::To learn the latest developments in the various forms of postoperative cognitive dysfunction, a group of scientists and physicians met in Stockholm for a full day of presentations and interactive discussions. This article summarizes the discussion; highlighting progress, challenges, and new directions in the area of p...

    journal_title:Anesthesia and analgesia



    authors: Terrando N,Eriksson LI,Eckenhoff RG

    更新日期:2015-03-01 00:00:00

  • Intramuscular versus surface electromyography of the diaphragm for determining neuromuscular blockade.

    abstract::We determined the neuromuscular blockade of 0.2 mg. kg(-1) mivacurium at the diaphragm by using two new methods of electromyographic (EMG) monitoring and compared it with acceleromyography of the orbicularis oculi (OO) and the corrugator supercilii (CS) muscle. After the induction of anesthesia in 15 patients undergoi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Hemmerling TM,Schmidt J,Wolf T,Hanusa C,Siebzehnruebl E,Schmitt H

    更新日期:2001-01-01 00:00:00

  • Application of a High-Flow Nasal Cannula for Prevention of Postextubation Atelectasis in Children Undergoing Surgery: A Randomized Controlled Trial.

    abstract:BACKGROUND:General anesthesia-induced atelectasis is common, and persistent postoperative atelectasis is associated with pulmonary complications. We aimed to evaluate the preventive effects of a high-flow nasal cannula (HFNC) on postoperative atelectasis and respiratory complications in infants and small children. MET...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lee JH,Ji SH,Jang YE,Kim EH,Kim JT,Kim HS

    更新日期:2020-11-10 00:00:00

  • The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.

    abstract:UNLABELLED:This study was performed to evaluate both the effects of pentobarbital on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol and the relationship between its effect on blood pressure and the integrity of the BBB. Under isoflurane anesthesia, rats in the control group were infused with 25% m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Chi OZ,Chun TW,Liu X,Weiss HR

    更新日期:1998-06-01 00:00:00

  • A new highly reliable instrument for the assessment of pre- and postoperative gynecological pain.

    abstract:UNLABELLED:In this study, we evaluated the reliability of a newly developed method for pain assessment, which is based on perceptual matching by Pain Matcher, Cefar Medical AB, Lund, Sweden, during minor gynecological surgery. In addition, the responsiveness to two different anesthetic methods-electro-acupuncture or a ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Stener-Victorin E,Kowalski J,Lundeberg T

    更新日期:2002-07-01 00:00:00

  • Decision Support for the Capacity Management of Bronchoscopy Devices: Optimizing the Cost-Efficient Mix of Reusable and Single-Use Devices Through Mathematical Modeling.

    abstract:BACKGROUND:Increasing costs of material resources challenge hospitals to stay profitable. Particularly in anesthesia departments and intensive care units, bronchoscopes are used for various indications. Inefficient management of single- and multiple-use systems can influence the hospitals' material costs substantially....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Edenharter GM,Gartner D,Pförringer D

    更新日期:2017-06-01 00:00:00

  • Preoperative Warming Versus no Preoperative Warming for Maintenance of Normothermia in Women Receiving Intrathecal Morphine for Cesarean Delivery: A Single-Blinded, Randomized Controlled Trial.

    abstract:BACKGROUND:Rates of hypothermia for women undergoing spinal anesthesia for cesarean delivery are high and prevention is desirable. This trial compared the effectiveness of preoperative warming versus usual care among women receiving intrathecal morphine, which is thought to exacerbate perioperative heat loss. METHODS:...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Munday J,Osborne S,Yates P,Sturgess D,Jones L,Gosden E

    更新日期:2018-01-01 00:00:00

  • Small-dose ketamine reduces the pain of propofol injection.

    abstract:BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

    更新日期:2006-12-01 00:00:00

  • The accuracy of noninvasive and continuous total hemoglobin measurement by pulse CO-Oximetry in human subjects undergoing hemodilution.

    abstract:BACKGROUND:Total hemoglobin (tHb) is one the most frequently ordered laboratory measurements. Pulse CO-Oximetry™ (Masimo Corp., Irvine, CA) is a multi-wavelength spectrophotometric method for noninvasive and continuous hemoglobin monitoring (SpHb). In this study, we evaluated the accuracy of SpHb compared with laborato...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Macknet MR,Allard M,Applegate RL 2nd,Rook J

    更新日期:2010-12-01 00:00:00

  • Spinal anesthesia with bupivacaine decreases cerebral blood flow in former preterm infants.

    abstract:UNLABELLED:Spinal anesthesia is commonly used in former preterm infants (FPI). In these patients, hypotension induced by spinal anesthesia may impair cerebral blood flow. We measured cerebral blood flow velocity (CBFV) by transcranial Doppler ultrasound to assess the effect of hypotension induced by spinal anesthesia o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bonnet MP,Larousse E,Asehnoune K,Benhamou D

    更新日期:2004-05-01 00:00:00

  • Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.

    abstract:IMPLICATIONS:Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hord AH,Denson DD,Azevedo MI

    更新日期:2001-11-01 00:00:00

  • Validation of the bispectral index monitor during conscious and deep sedation in children.

    abstract:UNLABELLED:In this study, we tested the validity of the bispectral index (BIS) monitor during conscious and deep sedation of children by comparing it with the University of Michigan Sedation Scale (UMSS), a validated observational pediatric sedation scale. Eighty-six children <12 yr of age were enrolled in this observa...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: McDermott NB,VanSickle T,Motas D,Friesen RH

    更新日期:2003-07-01 00:00:00