Venous air embolism prophylaxis with a surface-active agent.

Abstract:

:The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation, and blood surface tensions were measured before and after the IV administration of this surfactant. The magnitudes of change in the cardiorespiratory responses measured after venous air embolism were significant (p less than 0.05) reduced in the treated animals. This agent may be advantageous for surgical patients when an increased risk of venous air embolism exists.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Perry JC,Munson ES,Malagodi MH,Shah DO

doi

10.1213/00000539-197511000-00030

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

792-9

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

54

pub_type

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