N-acetylcysteine for the prevention of kidney injury in abdominal aortic surgery: a randomized, double-blind, placebo-controlled trial.


:In this prospective, randomized, placebo-controlled, double-blind trial we studied the effects of IV N-acetylcysteine for prevention of renal injury in patients undergoing abdominal aortic surgery. Seventy patients without previously documented renal dysfunction were randomly allocated to receive either N-acetylcysteine (150 mg/kg mixed in 250 mL of 5% dextrose infused in 20 min, followed by an infusion of 150 mg/kg in 250 mL of 5% dextrose over 24 h) or placebo. The infusion was started after the induction of anesthesia. The primary outcome measure was renal injury as measured by the increases in urinary N-acetyl-beta-d-glucosaminidase (NAG)/creatinine ratio (indicator of renal tubular injury) and urinary albumin/creatinine ratio (indicator of glomerular injury). Renal function was assessed by measuring plasma creatinine and serum cystatin C concentrations. The urinary NAG/creatinine ratio increased significantly from baseline to before crossclamp and remained increased on day 5 in both groups. The urinary albumin/creatinine ratio increased significantly from baseline to 6 h after declamping in the N-acetylcysteine group. However, the changes in the NAG/creatinine ratio and the albumin/creatinine ratio were not significantly different between the two groups. Plasma creatinine and serum cystatin C values remained unchanged during the study period in both groups. In conclusion, N-acetylcysteine did not offer any significant protection from renal injury during elective aortic operation in patients with normal preoperative renal function, and some degree of tubular injury seems to occur before aortic crossclamp.


Anesth Analg


Anesthesia and analgesia


Hynninen MS,Niemi TT,Pöyhiä R,Raininko EI,Salmenperä MT,Lepäntalo MJ,Railo MJ,Tallgren MK




Has Abstract


2006-06-01 00:00:00














  • Decreased insulin requirements with spinal cord stimulation in a patient with diabetes.

    abstract:UNLABELLED:We describe a case of type-2 diabetes mellitus with significant improvement in blood glucose control and significant decrease in insulin requirements after initiation of spinal cord stimulation. We believe that spinal cord stimulation may provide additional beneficial effects in patients with chronic pain an...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kapural L,Hayek SM,Stanton-Hicks M,Mekhail N

    更新日期:2004-03-01 00:00:00

  • Perioperative liver graft function: the role of oxygen transport and utilization.

    abstract::To assess the evolution of satisfactory neohepatic graft function or failure, hemodynamic variables, along with data for oxygen delivery and utilization, were analyzed retrospectively in 99 patients undergoing orthotopic liver transplantation. Caval cross-clamping without venovenous bypass initiated a series of hemody...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Steltzer H,Hiesmayr M,Tüchy G,Zimpfer M

    更新日期:1993-03-01 00:00:00

  • The effects of isoflurane-induced electroencephalographic burst suppression on cerebral blood flow velocity and cerebral oxygen extraction during cardiopulmonary bypass.

    abstract:UNLABELLED:We investigated the effects of isoflurane-induced burst suppression, monitored with electroencephalography (EEG), on cerebral blood flow velocity (CBFV), cerebral oxygen extraction (COE), and autoregulation in 16 patients undergoing cardiac surgery. The experimental procedure was performed during nonpulsatil...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Reinsfelt B,Westerlind A,Houltz E,Ederberg S,Elam M,Ricksten SE

    更新日期:2003-11-01 00:00:00

  • Computed tomography-estimated specific gravity of noncontused brain areas as a marker of severity in human traumatic brain injury.

    abstract::In this study, we assessed the relationship between brain estimated specific gravity (eSG) and clinical symptoms, therapeutic intensity level, and outcome in human traumatic brain injury (TBI). Brain weight, volume, and eSG of the noncontused hemispheric areas were measured from computed tomography (CT) DICOM images o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Degos V,Lescot T,Zouaoui A,Hermann H,Préteux F,Coriat P,Puybasset L

    更新日期:2006-11-01 00:00:00

  • Effects of fentanyl, naloxone, and clonidine on hemodynamics and plasma catecholamine levels in dogs.

    abstract::A 50-micrograms/kg dose of fentanyl, given intravenously in divided doses to dogs under enflurane-nitrous oxide anesthesia caused sharp decreases in heart rate (HR), arterial blood pressure (AP), left ventricular dP/dt, and plasma levels of catecholamines. Naloxone, 20 micrograms/kg given 65-70 min later, completely a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Flacke JW,Flacke WE,Bloor BC,Olewine S

    更新日期:1983-03-01 00:00:00

  • Onset, intensity of blockade and somatosensory evoked potential changes of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine.

    abstract::The onset and intensity of blockade of the lumbosacral dermatomes after epidural anesthesia with alkalinized lidocaine were investigated in a randomized, double-blind study in 26 patients. Control subjects (n = 13) received 20 mL of 1.37% lidocaine (1.5% lidocaine plus 1 mL saline per 10 mL lidocaine) with added 1:200...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benzon HT,Toleikis JR,Dixit P,Goodman I,Hill JA

    更新日期:1993-02-01 00:00:00

  • A core review of temperature regimens and neuroprotection during cardiopulmonary bypass: does rewarming rate matter?

    abstract::Despite a half century of research and the implementation of various risk-reduction strategies among clinicians and basic scientists, patients continue to experience strokes and cognitive dysfunction related to the use of cardiopulmonary bypass (CPB) for cardiac surgery. One strategy to reduce these detrimental effect...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Grigore AM,Murray CF,Ramakrishna H,Djaiani G

    更新日期:2009-12-01 00:00:00

  • Prophylactic antiemetics for laparoscopic cholecystectomy: ondansetron versus droperidol plus metoclopramide.

    abstract::Two hundred adults undergoing laparoscopic cholecystectomy were enrolled in a prospectively randomized, double-blind investigation comparing ondansetron, 4 mg (Group O) with the combination of droperidol, 0.625 mg, and metoclopramide, 10 mg (Group DM). Antiemetic drugs were administered intravenously (IV) after induct...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Steinbrook RA,Freiberger D,Gosnell JL,Brooks DC

    更新日期:1996-11-01 00:00:00

  • Capnographic Parameters in Ventilated Patients: Correspondence with Airway and Lung Tissue Mechanics.

    abstract:BACKGROUND:Although the mechanical status of the lungs affects the shape of the capnogram, the relations between the capnographic parameters and those reflecting the airway and lung tissue mechanics have not been established in mechanically ventilated patients. We, therefore, set out to characterize how the mechanical ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Csorba Z,Petak F,Nevery K,Tolnai J,Balogh AL,Rarosi F,Fodor GH,Babik B

    更新日期:2016-05-01 00:00:00

  • Vasodilation from sufentanil in humans.

    abstract::Sufentanil is a potent opioid that occasionally has been associated with hypotension. The mechanism behind this hypotension is unclear. We hypothesized that sufentanil had a direct effect on vascular smooth muscle to cause vasodilation. Sufentanil was infused into the brachial artery of 10 young, healthy volunteers at...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ebert TJ,Ficke DJ,Arain SR,Holtz MN,Shankar H

    更新日期:2005-12-01 00:00:00

  • Blood pressure, not cardiac output, determines blood loss during induced hypotension.

    abstract::Cardiac output characteristically decreases during trimethaphan infusion but is well maintained or increased during sodium nitroprusside infusion. We postulated that at similar levels of mean arterial pressure, sodium nitroprusside might be associated with greater blood loss than trimethaphan due to the increase in ca...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sivarajan M,Amory DW,Everett GB,Buffington C

    更新日期:1980-03-01 00:00:00

  • Ketamine potentiates nondepolarizing neuromuscular relaxants in a primate.

    abstract::Ketamine has many neuromuscular effects in vitro. Its neuromuscular effects in vivo have been controversial and inconsistent. To systematically examine its neuromuscular effects over a wide dose range and its interaction with all popular nondepolarizing neuromuscular relaxants, the effects of ketamine 2, 5, and 10 mg/...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsai SK,Lee C

    更新日期:1989-01-01 00:00:00

  • Intraarticular tramadol-bupivacaine combination prolongs the duration of postoperative analgesia after outpatient arthroscopic knee surgery.

    abstract:BACKGROUND:Intraarticular (IA) local anesthetics are often used for the management and prevention of pain after arthroscopic knee surgery. Recently, IA tramadol was also used for the management of these patients. However, the IA combination of local anesthetic and tramadol has not been evaluated in arthroscopic outpati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Zeidan A,Kassem R,Nahleh N,Maaliki H,El-Khatib M,Struys MM,Baraka A

    更新日期:2008-07-01 00:00:00

  • Anatomical landmarks for femoral nerve block: a comparison of four needle insertion sites.

    abstract:UNLABELLED:The site for needle insertion in femoral nerve block varies significantly among various descriptions of the technique. To determine the site with the highest likelihood of needle-femoral nerve contact, femoral nerve block was simulated in a human cadaver model (17 femoral triangles from 9 adult cadavers). Fo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vloka JD,Hadzić A,Drobnik L,Ernest A,Reiss W,Thys DM

    更新日期:1999-12-01 00:00:00

  • Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

    abstract:BACKGROUND:Perioperative major adverse cardiovascular and cerebrovascular events (MACCEs) are incompletely understood, and risk prediction is imprecise. Atherogenic leukocytes are crucial in cardiovascular events. However, it is unclear if surgical interventions affect leukocyte counts or activation status. Therefore, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Handke J,Scholz AS,Gillmann HJ,Janssen H,Dehne S,Arens C,Kummer L,Uhle F,Weigand MA,Motsch J,Larmann J

    更新日期:2019-06-01 00:00:00

  • Preemptive and Preventive Pain Psychoeducation and Its Potential Application as a Multimodal Perioperative Pain Control Option: A Systematic Review.

    abstract::The common treatment for postoperative pain is prescription opioids. Yet, these drugs have limited effect in preventing chronic pain from surgical intervention and have in part contributed to the opioid epidemic. Recently, preemptive analgesia and multimodal analgesia have been proposed with widely gained acceptance i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Horn A,Kaneshiro K,Tsui BCH

    更新日期:2020-03-01 00:00:00

  • Effect of cardiopulmonary bypass on plasma levels of nifedipine.

    abstract::Blood levels of many medications are acutely lowered by cardiopulmonary bypass (CPB). Because nifedipine is often used to provide protection from coronary ischemia, a determination of the effect of CPB on plasma nifedipine levels might help to determine the potential clinical benefit of nifedipine during and after byp...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Katz RI,Kanchuger MS,Patton KF,Eide TR

    更新日期:1990-10-01 00:00:00

  • Gallamine administered by combined bolus and infusion.

    abstract::A technique combining an intravenous bolus and intravenous infusion regimen of gallamine based on its pharmacokinetics was developed to produce continuous relaxation during surgery. The combination of a bolus dose of gallamine, 2.5 mg/kg, and infusion, 0.8 mg/kg/hr, was tested in 11 patients. In 10 patients, surgery c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shanks CA,Funk DI,Avram MJ,Henthorn TK

    更新日期:1982-10-01 00:00:00

  • Leg warming minimizes core hypothermia during abdominal surgery.

    abstract::The efficacy of leg skin warming in preventing hypothermia and shivering was evaluated in two separate prospective, randomized trials in patients undergoing abdominal surgery. In the first trial, 22 patients were randomized to receive no hypothermia prevention (control group) or active warming with an electric warming...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Camus Y,Delva E,Just B,Lienhart A

    更新日期:1993-11-01 00:00:00

  • The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation.

    abstract:BACKGROUND:The possibility that μ opioid agonists can influence cancer recurrence is a subject of recent interest. Epidemiologic studies suggested that there were differences in cancer recurrence in breast and prostate cancer contingent on anesthetic regimens. In this study, we identify a possible mechanism for these e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mathew B,Lennon FE,Siegler J,Mirzapoiazova T,Mambetsariev N,Sammani S,Gerhold LM,LaRiviere PJ,Chen CT,Garcia JG,Salgia R,Moss J,Singleton PA

    更新日期:2011-03-01 00:00:00

  • Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia.

    abstract::Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 micrograms.kg-1.min-1) was a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

    更新日期:1991-11-01 00:00:00

  • Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles.

    abstract:UNLABELLED:We compared sedation quality, intraocular pressure (IOP) changes, and recovery profiles in patients who received propofol or propofol-ketamine sedation during placement of the retrobulbar nerve block (RBB). Seventy elderly patients undergoing cataract extraction according to a prospective, randomized, double...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frey K,Sukhani R,Pawlowski J,Pappas AL,Mikat-Stevens M,Slogoff S

    更新日期:1999-08-01 00:00:00

  • Plasma cholinesterase: gene and variations.

    abstract::The traditional tests that have been used for the past 30 yr to determine plasma cholinesterase phenotype--measurement of esterase activity with a variety of substrates, dibucaine inhibition, fluoride inhibition, and Ro2-0683 inhibition--are inadequate for identifying some variants of this enzyme and leave many cases ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Pantuck EJ

    更新日期:1993-08-01 00:00:00

  • The laryngeal mask for percutaneous endoscopic gastrostomy.

    abstract:IMPLICATIONS:We report the successful use of the laryngeal mask airway for percutaneous endoscopic gastrostomy in an adult patient with a known difficult airway and severe cerebral palsy. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Brimacombe J,Newell S,Bergin A,McCarthy J,Barry J

    更新日期:2000-09-01 00:00:00

  • Train-of-four and tetanic fade are not always a prejunctional phenomenon as evaluated by toxins having highly specific pre- and postjunctional actions.

    abstract:BACKGROUND:Nerve-stimulated fade in muscle is generally accepted as a prejunctional phenomenon mediated by block of prejunctional acetylcholine receptors (AChRs) at the nerve terminal, whereas decrease of twitch tension is considered a postjunctional effect due to block of muscle AChRs. Using ligands with specific pre-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nagashima M,Yasuhara S,Martyn JA

    更新日期:2013-05-01 00:00:00

  • Comparison of hypobaric, hyperbaric, and isobaric solutions of bupivacaine during continuous spinal anesthesia.

    abstract::This study was designed to compare the anesthetic properties of hypobaric bupivacaine with those of isobaric and hyperbaric solutions when administered in the supine position in an elderly population undergoing hip surgery using continuous spinal anesthesia. Plain bupivacaine (0.5%) was mixed with equal volumes of 10%...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Van Gessel EF,Forster A,Schweizer A,Gamulin Z

    更新日期:1991-06-01 00:00:00

  • Comparison of ketamine and thiopental in healthy volunteers: effects on mental status, mood, and personality.

    abstract::The purpose of this study was to compare the psychological effects of ketamine and thiopental anesthesia. In a double-blind comparison, 20 normal female volunteers were given 2.5 mg/kg ketamine intravenously and 20 were given 5.0 mg/kg thiopental intravenously. Subjects were assessed with a variety of objective and su...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Moretti RJ,Hassan SZ,Goodman LI,Meltzer HY

    更新日期:1984-12-01 00:00:00

  • Spinal and cortical evoked potential studies in the ketamine-anesthetized rabbit: fentanyl exerts component-specific, naloxone-reversible changes dependent on stimulus intensity.

    abstract::This study examined the changes in spinal and cortical evoked potentials (EPs) produced by fentanyl in the rabbit. The reversibility of these effects by naloxone and the effects of varying stimulus intensity also were examined. Eleven ketamine-anesthetized rabbits underwent analysis of spinal and cortical EPs produced...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lee VC

    更新日期:1994-02-01 00:00:00

  • Computer-controlled regulation of sodium nitroprusside infusion.

    abstract::We built and tested a combined proportional/derivative and minimum variance adaptive control algorithm for the regulation of blood pressure using sodium nitroprusside (SNP). In ten dogs the pressure was reduced by 30 mm Hg for 1 hr. The blood pressure came to within 5 mm Hg of the desired pressure in 1.7 +/- 4 min and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Meline LJ,Westenskow DR,Pace NL,Bodily MN

    更新日期:1985-01-01 00:00:00

  • Pancuronium or vecuronium for treatment of shivering after cardiac surgery.

    abstract::This randomized double-blind study compared the hemodynamic and metabolic effects of pancuronium and vecuronium during treatment of shivering after cardiac surgery with hypothermic cardiopulmonary bypass. Thirty sedated and pain-free patients who shivered after cardiac surgery were treated with pancuronium (n = 15) or...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dupuis JY,Nathan HJ,DeLima L,Wynands JE,Russell GN,Bourke M

    更新日期:1994-09-01 00:00:00