A constitutive model of soft tissue: from nanoscale collagen to tissue continuum.

abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

journal_title：Annals of biomedical engineering

authors： Cooper S,McDonald K,Burkat D,Leask RL

更新日期：2017-09-01 00:00:00

abstract：:For several years, Virginia Tech and other schools have measured the frequency and severity of head impacts sustained by collegiate American football players in real time using the Head Impact Telemetry (HIT) System of helmet-mounted accelerometers. In this study, data from 37,128 head impacts collected at Virginia Te...

journal_title：Annals of biomedical engineering

authors： Funk JR,Rowson S,Daniel RW,Duma SM

更新日期：2012-01-01 00:00:00

abstract：:A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow sol...

journal_title：Annals of biomedical engineering

authors： Krishnan S,Udaykumar HS,Marshall JS,Chandran KB

更新日期：2006-10-01 00:00:00

abstract：:A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...

journal_title：Annals of biomedical engineering

authors： Sarntinoranont M,Rooney F,Ferrari M

更新日期：2003-03-01 00:00:00

abstract：:To better understand the relationship between kinetic processes of contraction and the dynamic features of an isometric twitch, studies were conducted using a mathematical model that included: (1) kinetics of cross bridge (XB) cycling; (2) kinetics of thin filament regulatory processes; (3) serial and feedback interac...

journal_title：Annals of biomedical engineering

authors： Campbell KB,Razumova MV,Kirkpatrick RD,Slinker BK

更新日期：2001-05-01 00:00:00

abstract：:Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented here...

journal_title：Annals of biomedical engineering

authors： Simmons AD,Sikavitsas VI

更新日期：2018-01-01 00:00:00

abstract：:A rigorous analysis of blood flow must be based on the branching pattern and vascular geometry of the full vascular circuit of interest. It is experimentally difficult to reconstruct the entire vascular circuit of any organ because of the enormity of the vessels. The objective of the present study was to develop a nov...

journal_title：Annals of biomedical engineering

authors： Mittal N,Zhou Y,Ung S,Linares C,Molloi S,Kassab GS

更新日期：2005-08-01 00:00:00

abstract：:Maintenance of movement accuracy relies on motor learning, by which prior errors guide future behavior. One aspect of this learning process involves the accurate generation of predictions of movement outcome. These predictions can, for example, drive anticipatory movements during a predictive-saccade task. Predictive ...

journal_title：Annals of biomedical engineering

authors： Wong AL,Shelhamer M

更新日期：2013-08-01 00:00:00

abstract：:Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate a...

journal_title：Annals of biomedical engineering

authors： Neidlin M,Korcari A,Macheras G,Alexopoulos LG

更新日期：2018-02-01 00:00:00

abstract：:This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of...

journal_title：Annals of biomedical engineering

authors： Ning T,Bronzino JD

更新日期：1998-07-01 00:00:00

abstract：:A mathematical model is presented that estimates joint kinematics and kinetics using measured external resultant loads and readily available parameters. The musculo-skeletal system was represented by a planar three degrees of freedom open kinematic chain. Information extraction was limited to the flexion-extension fun...

journal_title：Annals of biomedical engineering

authors： Mazzà C,Cappozzo A

更新日期：2004-05-01 00:00:00

abstract：:Rapid technological advances have prompted the development of a wide range of telemonitoring systems to enable the prevention, early diagnosis and management, of chronic conditions. Remote monitoring can reduce the amount of recurring admissions to hospital, facilitate more efficient clinical visits with objective res...

journal_title：Annals of biomedical engineering

authors： Ní Scanaill C,Carew S,Barralon P,Noury N,Lyons D,Lyons GM

更新日期：2006-04-01 00:00:00

abstract：:Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence ...

journal_title：Annals of biomedical engineering

authors： Lantz J,Gupta V,Henriksson L,Karlsson M,Persson A,Carlhäll CJ,Ebbers T

更新日期：2019-02-01 00:00:00

abstract：:Point cathodal stimulation of cardiac tissue was shown previously to produce both a dog-bone shaped virtual cathode transverse to the muscle fibers and two longitudinal virtual anodes. We hypothesize that virtual anodes can cause a region of delayed activation, separating two regions of early activation caused by the ...

journal_title：Annals of biomedical engineering

authors： Wu J,Roden DM,Wikswo JP Jr

更新日期：2000-11-01 00:00:00

abstract：:Further understanding of the mechanical deformation and tear behavior of kidney during suturing helps to enhance surgical task execution that requires fine suture manipulation. This paper aims to develop a model to describe the relationship between the tensile force acting on suture line and the resulted kidney deform...

journal_title：Annals of biomedical engineering

authors： Yu D,Qing Y,Jianxun Z,Jun D

更新日期：2013-04-01 00:00:00

abstract：:Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, ...

journal_title：Annals of biomedical engineering

authors： Mulvihill JJE,Raykin J,Snider EJ,Schildmeyer LA,Zaman I,Platt MO,Kelly DJ,Ethier CR

更新日期：2018-02-01 00:00:00

abstract：:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant ...

journal_title：Annals of biomedical engineering

authors： Hopkins CG,McHugh PE,McGarry JP

更新日期：2010-07-01 00:00:00

abstract：:The study was to explore the effects of BMP-2 gene modified canine bone marrow stromal cells (bMSCs) mediated by a nonviral PEI derivative (GenEscort™ II) in promoting bone formation in vitro and in vivo. Canine bMSCs were cultured and transfected with plasmids containing bone morphogenetic protein-2 gene (pBMP-2) or ...

journal_title：Annals of biomedical engineering

authors： Lü K,Zeng D,Zhang Y,Xia L,Xu L,Kaplan DL,Jiang X,Zhang F

更新日期：2011-06-01 00:00:00

abstract：:Platelet thrombosis under arterial conditions remains a large clinical problem. Previous in vitro experiments have concentrated on early adherence without thrombotic occlusion. We have developed a controllable hemodynamic system that creates intravascular thrombosis to occlusion. Lightly heparinized (3.5 USP units/mL)...

journal_title：Annals of biomedical engineering

authors： Para A,Bark D,Lin A,Ku D

更新日期：2011-07-01 00:00:00

abstract：:Some investigators have attempted to estimate the Reynolds shear stress on the basis of a single component of velocity. The purpose of this investigation is to determine the validity of such estimates in a complex flow field, such as occurs in the cardiovascular system in the region of the aortic valve. Turbulent velo...

journal_title：Annals of biomedical engineering

authors： Walburn FJ,Sabbah HN,Stein PD

更新日期：1985-01-01 00:00:00

abstract：:The finite element method is employed to simulate two-dimensional (axisymmetric) drug diffusion from a finite drug reservoir into the skin. The numerical formulation is based on a general mathematical model for multicomponent nonlinear diffusion that takes into account the coupling effects between the different compon...

journal_title：Annals of biomedical engineering

authors： Rim JE,Pinsky PM,van Osdol WW

更新日期：2005-10-01 00:00:00

abstract：:Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...

journal_title：Annals of biomedical engineering

authors： Wheeler TS,Sbravati ND,Janorkar AV

更新日期：2013-10-01 00:00:00

abstract：:For treatment of complex congenital heart disease, computer simulation using a three-dimensional heart model may help to improve outcomes by enabling detailed preoperative evaluations. However, no highly integrated model that accurately reproduces a patient's pathophysiology, which is required for this simulation has ...

journal_title：Annals of biomedical engineering

authors： Kariya T,Washio T,Okada JI,Nakagawa M,Watanabe M,Kadooka Y,Sano S,Nagai R,Sugiura S,Hisada T

更新日期：2020-06-01 00:00:00

abstract：:A lumped parameter compartmental model for the nonsteady flow of the cerebrovascular fluid is constructed. The model assumes constant resistances that relate fluid flux to pressure gradients, and compliances between compartments that relate fluid accumulation to rate of pressure changes. Resistances are evaluated by u...

journal_title：Annals of biomedical engineering

authors： Sorek S,Bear J,Karni Z

更新日期：1989-01-01 00:00:00

abstract：:There has been considerable debate on the relative importance of biochemical stimuli and mechanical deformation in neutrophil adhesion in lung capillaries, a process observed following bacterial infection in the body. In contrast to venules, where the vessel diameter is larger than the leukocyte diameter (6-9 microm) ...

journal_title：Annals of biomedical engineering

authors： Pai A,Sundd P,Tees DF

更新日期：2008-04-01 00:00:00

abstract：:This paper discusses the dynamics of the circus movement around a one-dimensional continuous and uniform loop of model cardiac cells. The membrane ionic currents are represented by a modified Beeler-Reuter formulation. The description of the quasiperiodic regimes initiated in a previous paper is completed and their eq...

journal_title：Annals of biomedical engineering

authors： Vinet A

更新日期：2000-07-01 00:00:00

abstract：:In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage bone-transport surgery. We hypothesize that mechanical loading modulates this process. Using high-definition optical strain measurements we determined prevailing perio...

journal_title：Annals of biomedical engineering

authors： McBride SH,Dolejs S,Brianza S,Knothe U,Knothe Tate ML

更新日期：2011-05-01 00:00:00

abstract：:Similarities between photoreceptor Kx channels and EAG and KCNQ channels suggest that the Kx channel may be related to one or both of these families of potassium channels. To provide a basis for further comparison of these channels, as well as to reveal the role of zinc (endogenously present in photoreceptors) in Kx c...

journal_title：Annals of biomedical engineering

authors： Kourennyi DE,Liu X,Barnes S

更新日期：2002-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible brain disorder which represents the most common form of dementia in western countries. An early and accurate diagnosis of AD would enable to develop new strategies for managing the disease; however, nowadays there is no single test that can accurately predict the development...

journal_title：Annals of biomedical engineering

authors： Alonso JF,Poza J,Mañanas MA,Romero S,Fernández A,Hornero R

更新日期：2011-01-01 00:00:00

abstract：:Knowledge of strain-rate sensitivity of soft tissue viscoelastic and nonlinear elastic properties is important for accurate predictions of biomechanical behavior and for quantitative assessment of the effects of disease or surgical/pharmaceutical intervention. Soft tissues are known to exhibit mild rate sensitivity, b...

journal_title：Annals of biomedical engineering

authors： Doehring TC,Carew EO,Vesely I

更新日期：2004-02-01 00:00:00