Abstract：
:Natural products continue to provide privileged scaffolds for drug discovery. However, challenges in supply and structure diversification can limit development. Here, we discuss recent (2017-2020) examples of synthetic biology approaches used to address challenges in supply and contribute to structure diversification of selected plant and bacterial natural products. Our examples include plant terpenoids, alkaloids, and lignans and bacterial polyketides, nonribosomal peptides, and ribosomally synthesized and posttranslationally modified peptides.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Romanowski S,Eustáquio ASdoi
10.1016/j.cbpa.2020.09.006subject
Has Abstractpub_date
2020-10-01 00:00:00pages
137-145eissn
1367-5931issn
1879-0402pii
S1367-5931(20)30127-7journal_volume
58pub_type
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
pub_type： 杂志文章,评审
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journal_title：Current opinion in chemical biology
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doi：10.1016/j.cbpa.2017.06.004
更新日期：2017-08-01 00:00:00
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journal_title：Current opinion in chemical biology
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更新日期：1999-04-01 00:00:00
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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更新日期：2010-06-01 00:00:00
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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更新日期：2018-04-01 00:00:00
abstract：:The micro-environment in which stem cells reside regulates their fate, and synthetic materials have recently been designed to emulate these regulatory processes for various medical applications. Ligands inspired by the natural extracellular matrix, cell-cell contacts, and growth factors have been incorporated into syn...
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更新日期：2007-08-01 00:00:00
