Phosphorescence bioimaging using cyclometalated Ir(III) complexes.

Abstract:

:Recent advances in the development of the phosphorescent Ir(III) complexes have made it possible to implement the phosphorescence modality in bioimaging applications. A variety of phosphorescent Ir(III) complexes have been synthesized and assessed in the context of in vitro and in vivo imaging, especially in subcellular organelle staining and the sensing of biologically important analytes. The examples presented here demonstrate that Ir(III) complexes provide attractive alternatives to fluorescent organic compounds in the construction of biolabels and biosensors. The complexes are particularly advantageous with respect to fluorescent compounds in their compatibility with time-gated bioimaging techniques that completely eliminate background signals due to autofluorescence.

journal_name

Curr Opin Chem Biol

authors

You Y

doi

10.1016/j.cbpa.2013.05.023

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

699-707

issue

4

eissn

1367-5931

issn

1879-0402

pii

S1367-5931(13)00100-2

journal_volume

17

pub_type

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