Abstract：
:In recent years, ogliopeptides have enjoyed ever increasing interest in two areas: first, approaches to biomimetic enzyme-like activity; and second, as metal-free catalysts for enantioselective transformations of synthetic interest. The discovery and optimization of peptides for these purposes has often used the methodology of combinatorial chemistry. Examples include the screening of peptide libraries for ester and phosphate cleavage, aided by novel chromogenic and gel-based assays, and optimization of metal-free peptide catalysts for asymmetric epoxidation, enantioselective acylation/phosphorylation, conjugate addition to enimides, and hydrocyanation of imines (Strecker-reaction).
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Berkessel Adoi
10.1016/s1367-5931(03)00065-6subject
Has Abstractpub_date
2003-06-01 00:00:00pages
409-19issue
3eissn
1367-5931issn
1879-0402pii
S1367593103000656journal_volume
7pub_type
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journal_title：Current opinion in chemical biology
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abstract：:Lipopolysaccharide (LPS), a glycolipid found in the outer membrane of Gram-negative bacteria, is a potent elicitor of innate immune responses in mammals. A typical LPS molecule is composed of three different structural domains: a polysaccharide called the O-antigen, a core oligosaccharide, and Lipid A. Lipid A is the ...
journal_title：Current opinion in chemical biology
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