Abstract:
:Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Aron AT,Reeves AG,Chang CJdoi
10.1016/j.cbpa.2017.12.010subject
Has Abstractpub_date
2018-04-01 00:00:00pages
113-118eissn
1367-5931issn
1879-0402pii
S1367-5931(17)30134-5journal_volume
43pub_type
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