Abstract:
:Electron bifurcation, or the coupling of exergonic and endergonic oxidation-reduction reactions, was discovered by Peter Mitchell and provides an elegant mechanism to rationalize and understand the logic that underpins the Q cycle of the respiratory chain. Thought to be a unique reaction of respiratory complex III for nearly 40 years, about a decade ago Wolfgang Buckel and Rudolf Thauer discovered that flavin-based electron bifurcation is also an important component of anaerobic microbial metabolism. Their discovery spawned a surge of research activity, providing a basis to understand flavin-based bifurcation, forging fundamental parallels with Mitchell's Q cycle and leading to the proposal of metal-based bifurcating enzymes. New insights into the mechanism of electron bifurcation provide a foundation to establish the unifying principles and essential elements of this fascinating biochemical phenomenon.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Peters JW,Beratan DN,Bothner B,Dyer RB,Harwood CS,Heiden ZM,Hille R,Jones AK,King PW,Lu Y,Lubner CE,Minteer SD,Mulder DW,Raugei S,Schut GJ,Seefeldt LC,Tokmina-Lukaszewska M,Zadvornyy OA,Zhang P,Adams MWdoi
10.1016/j.cbpa.2018.07.026subject
Has Abstractpub_date
2018-12-01 00:00:00pages
32-38eissn
1367-5931issn
1879-0402pii
S1367-5931(18)30076-0journal_volume
47pub_type
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