Abstract:
:Natural products containing a gamma-butyrolactone ring are abundant in nature; however, few general synthetic approaches to their stereoselective synthesis with broad structural variety are known. In this article, recent developments towards mono- and polycyclic gamma-butyrolactone natural products and analogs are discussed. A special focus is given to asymmetric methods applying transition metal or organocatalysts that allow not only the efficient introduction of a broad variety of functional groups but ideally also the flexible construction of various natural-product-like, polycyclic scaffolds from common precursors.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Seitz M,Reiser Odoi
10.1016/j.cbpa.2005.03.005subject
Has Abstractpub_date
2005-06-01 00:00:00pages
285-92issue
3eissn
1367-5931issn
1879-0402pii
S1367-5931(05)00052-9journal_volume
9pub_type
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