Computational design strategies for combinatorial libraries.

Abstract:

:Medicinal chemistry principles are being increasingly applied to the design of smaller, high purity, information-rich libraries. Recent computational advances in statistical methodology, the design of libraries to reduce ADMET problems, targeting protein families and revisiting natural products as sources of inspiration for scaffolds and reagents are all areas of progressive research.

journal_name

Curr Opin Chem Biol

authors

Rose S,Stevens A

doi

10.1016/s1367-5931(03)00057-7

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

331-9

issue

3

eissn

1367-5931

issn

1879-0402

pii

S1367593103000577

journal_volume

7

pub_type

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