Abstract:
:Natural sources offer a wealth of chemically diverse compounds that have been evolutionary preselected to modulate biochemical pathways. Several industrial and academic groups are accessing this source using advanced technology platforms. Methods have been reported to generate large and diverse natural-product libraries optimised for high-throughput screening and for a fast discovery process. In addition to prefractionated and pure natural-product libraries, parallel synthesis gives access to synthetic, semi-synthetic and natural-product-like libraries. Natural-product chemistry and organic synthesis are powerful tools for optimising natural leads and for generating new diversity from natural scaffolds. The amalgamation of both may be expected to become an important strategy in future drug design.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Abel U,Koch C,Speitling M,Hansske FGdoi
10.1016/s1367-5931(02)00338-1subject
Has Abstractpub_date
2002-08-01 00:00:00pages
453-8issue
4eissn
1367-5931issn
1879-0402pii
S1367593102003381journal_volume
6pub_type
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