Abstract:
:The application of molecular cloning has revealed the phenomenal diversity and complexity of the phosphodiesterase isoenzyme family. Thus, more than 30 human phosphodiesterases are now known; all are apparently necessary for the seemingly simple task of hydrolysing the 3'-ester bond of either cyclic adenosine monophosphate or cyclic guanosine monophosphate. The availability of phosphodiesterase isoenzymes as pure recombinant proteins has greatly facilitated the identification of potent, selective inhibitors. The potential of these inhibitors to therapeutically exploit the molecular diversity of the phosphodiesterases has progressed significantly. A number of drugs are in clinical trials for asthma, and Viagra has become the first selective phosphodiesterase inhibitor to be approved by the US Food and Drug Administration.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Perry MJ,Higgs GAdoi
10.1016/s1367-5931(98)80123-3subject
Has Abstractpub_date
1998-08-01 00:00:00pages
472-81issue
4eissn
1367-5931issn
1879-0402pii
S1367-5931(98)80123-3journal_volume
2pub_type
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journal_title:Current opinion in chemical biology
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