Ergosterol biosynthesis and drug development for Chagas disease.

abstract：:The immunogenicity of anti-malaria synthetic vaccine SPf66 was tested in a region of the Colombian middle Atrato river. The specific serum antibodies against SPf66 were quantified in vaccinees and placebo injected controls for a two-years period post-immunization. The frequency of individuals showing seroconversion of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lopera TM,Restrepo M,Blair S,García HI

更新日期：1998-07-01 00:00:00

abstract：:In this study, HIV-1 viral blood quantitation determined by Nucleic Acid Sequence Based Amplification (NASBA) was compared with other surrogate disease progression markers (antigen p24, CD4/CD8 cell counts and beta-2 microglobulin) in 540 patients followed up at São Paulo, SP, Brazil. HIV-1 RNA detection was statistic...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Sitnik R,Pinho JR

更新日期：1998-05-01 00:00:00

abstract：:Early Cretaceous flagellates with characters typical of trypanosomatids were found in the gut of sand fly larvae, as well as in surrounding debris, in Burmese amber. This discovery supports a hypothesis in which free-living trypanosomatids could have been acquired by sand fly larvae in their feeding environment and th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Poinar G Jr

更新日期：2007-08-01 00:00:00

abstract：:To assess differentiation and relationships between Anopheles lesteri and Anopheles paraliae we established three and five iso-female lines of An. lesteri from Korea and An. paraliae from Thailand, respectively. These isolines were used to investigate the genetic relationships between the two taxa by crossing experime...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Taai K,Baimai V,Saeung A,Thongsahuan S,Min GS,Otsuka Y,Park MH,Fukuda M,Somboon P,Choochote W

更新日期：2013-05-01 00:00:00

abstract：:The cellular nature of the infiltrate in cutaneous lesion of rhesus monkeys experimentally infected with Leishmania (L.) amazonensis was characterized by immunohistochemistry. Skin biopsies from infected animals with active or healing lesions were compared to non-infected controls (three of each type) to quantitate in...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Amaral V,Pirmez C,Gonçalves A,Ferreira V,Grimaldi G Jr

更新日期：2000-03-01 00:00:00

abstract：:We report the finding of Tetrameres spirospiculum Pinto & Vicente, 1995 from Theristicus melanopis melanopis (Threskiornithidae) from Patagonia, Argentina. These constitute new host and locality records. We propose the assignation of this species to the subgenus T. (Gynaecophila) Gubanov, 1950, based on the presence o...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Digiani MC,Cremonte F

更新日期：2001-04-01 00:00:00

abstract：:The schistosomicidal properties of Nigella sativa seeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work w...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mohamed AM,Metwally NM,Mahmoud SS

更新日期：2005-04-01 00:00:00

abstract：:Toxoplasma gondii has a very wide intermediate host range and is thought to be able to infect all warm blooded animals. The parasite causes a spectrum of different diseases and clinical symptoms within the intermediate hosts and following infection most animals develop adaptive humoral and cell-mediated immune respons...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Innes EA,Bartley PM,Maley S,Katzer F,Buxton D

更新日期：2009-03-01 00:00:00

abstract：:The restriction fragment length polymorphism of the 195 bp repeated DNA sequence of Trypanosoma cruzi was analyzed among 23 T. cruzi stocks giving a reliable picture of the whole phylogenetic variability of the species. The profiles observed with the enzymes Hinf I and Hae III were linked together and supported the ex...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bastrenta B,Bosseno MF,Barnabé C,Tibayrenc M,Brenière SF

更新日期：1999-05-01 00:00:00

abstract：:Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis of Chagas cardiomyopathy is incompletely understood, it may involve several mechanisms, including parasite-dependent my...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rassi A Jr,Marin JA Neto,Rassi A

更新日期：2017-03-01 00:00:00

abstract：:BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Penna-Coutinho J,Aguiar AC,Krettli\/ AU

更新日期：2018-12-06 00:00:00

abstract：:Forty-four marsupials, 77 rodents and 161 ticks were captured in an Atlantic Forest Reserve in Cotia county, State of São Paulo, where human cases of Lyme disease (LD) simile were reported. Twenty-one borrelia-like spirochete isolates were recovered from the mammals' blood and rodent livers or spleens, and triturated ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Abel IS,Marzagão G,Yoshinari NH,Schumaker TT

更新日期：2000-09-01 00:00:00

abstract：:In this paper a discussion is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of "processes", "mediators", "strategies for study" and "disease". These concepts overlap considerably. Regarding "processes", granulomas, fibrosis and vasculitis are discussed. The role of mediat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cheever AW

更新日期：1992-01-01 00:00:00

abstract：:Studies based on shell or reproductive organ morphology and genetic considerations suggest extensive intraspecific variation in Biomphalaria snails. The high variability at the morphological and genetic levels, as well as the small size of some specimens and similarities between species complicate the correct identifi...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Vidigal TH,Dias Neto E,Spatz L,Nunes DN,Pires ER,Simpson AJ,Carvalho OS

更新日期：1998-01-01 00:00:00

abstract：:With the currently known distribution of genera and species of the tribe Triatomini Jeannel, 1919, maps and diagrams were prepared, showing the geographical area occupied by the species and their respective dispersion in grades of latitude and altitude. Two genera are not treated: Panstrongylus Berg, 1879, already pub...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Galvão C,Jurberg J,Carcavallo RU,Segura CA,Galíndez Girón I,Curto de Casas SI

更新日期：1998-01-01 00:00:00

abstract：:BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Nunes AR,Alves BEB,Pereira HW,Nascimento YM,Morais IC,Fernandes JV,Araújo JM,Lanza DC

更新日期：2018-01-01 00:00:00

abstract：:Toxocara cati is a common feline parasite transmitted by the ingestion of embryonated eggs, by the transmammary route or by predation of paratenic hosts harbouring third-stage larvae in their bodies. In the present study, the larval distribution of T. cati in tissues and organs of Rattus norvegicus experimentally infe...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Santos SV,Lescano SZ,Castro JM,Chieffi PP

更新日期：2009-09-01 00:00:00

abstract：:Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and sh...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pereira RV,Vieira HG,Oliveira VF,Gomes Mde S,Passos LK,Borges Wde C,Guerra-Sá R

更新日期：2014-02-01 00:00:00

abstract：:Chagas heart disease (CHD) results from infection with the protozoan parasite Trypanosoma cruzi and is the leading cause of infectious myocarditis worldwide. It poses a substantial public health burden due to high morbidity and mortality. CHD is also the most serious and frequent manifestation of chronic Chagas diseas...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rassi A Jr,Rassi A,Marin-Neto JA

更新日期：2009-07-01 00:00:00

abstract：:Leptospirosis in humans usually involves hypokalaemia and hypomagnesaemia and the putative mechanism underlying such ionic imbalances may be related to nitric oxide (NO) production. We previously demonstrated the correlation between serum levels of NO and the severity of renal disease in patients with severe leptospir...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Santos CS,Azevedo EC,Soares LM,Carvalho MO,dos Santos AC,das Chagas AD Jr,da Silva CL,Chagas UM,dos Reis MG,Athanazio DA

更新日期：2013-06-01 00:00:00

abstract：:A new species of planorbid mollusc, Plesiophysa dolichomastix (Greek dolichos = long, mastix = flagellum), collected from Lagoa da Pedra, municipality of Santa Rosa, state of Goiás, Brazil (15 degrees 01'S, 47 degrees 13'W) is described. It is indistinguishable by the shell characters from the five congeneric species ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Paraense WL

更新日期：2002-06-01 00:00:00

abstract：:In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas disease. More than two thousand children under the age of 14 have be...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Villa L,Morote S,Bernal O,Bulla D,Albajar-Vinas P

更新日期：2007-10-30 00:00:00

abstract：:This review presents up-to-date information on the distribution and control measures of babesiosis in Latin America. Bovine babesiosis caused by Babesia bovis and B. bigemia will be emphasized. The disease is endemic in most countries and poses a serious economic burden on livestock production in the region (U.S. $136...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Montenegro-James S

更新日期：1992-01-01 00:00:00

abstract：:Ketoconazole, an azole antifungic drug which is already in the market has also been demonstrated to be active against Trypanosoma cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity against different T. cruzi strains naturally resistant or susceptible to bot...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brener Z,Cançado JR,Galvão LM,da Luz ZM,Filardi Lde S,Pereira ME,Santos LM,Cançado CB

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to test if serological distinction between patients with active and inactive neurocysticercosis (NCC), could be accomplished by the recognition of immunodominant peptides in total saline antigenic extract of Taenia solium metacestodes by IgG antibody in cerebrospinal fluid (CSF) and serum pai...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Barcelos IS,Moura LP,Costa VP,Ferreira MS,Costa-Cruz JM

更新日期：2007-09-01 00:00:00

abstract：:Raoultella planticola is an emerging zoonotic pathogen that is associated with rare but life-threatening cases of bacteremia, biliary tract infections, and urinary tract infections. Moreover, increasing antimicrobial resistance in the organism poses a potential threat to public health. In spite of its importance as a ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Huang YT,Chuang WY,Ho BC,Wu ZY,Kuo RC,Ko M,Liu PY

更新日期：2018-08-27 00:00:00

abstract：:St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) present ecological and antigenic similarities and are responsible for serious human diseases. In addition, WNV is a significant pathogen in terms of equine health. The purpose of our study was to analyse the seroprevalence of SLEV and WNV in equine sera col...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Tauro L,Marino B,Diaz LA,Lucca E,Gallozo D,Spinsanti L,Contigiani M

更新日期：2012-06-01 00:00:00

abstract：:Trypanosoma rangeli, a parasite generally considered non-pathogenic for man, is the second species of human trypanosome to be reported from the New World. The geographical distribution of T. rangeli often overlaps with that of T. cruzi, the same vertebrate and invertebrate hosts being infected. Their differentiation t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Guhl F,Vallejo GA

更新日期：2003-06-01 00:00:00

abstract：:Acoustic signalling has been extensively studied in insect species, which has led to a better understanding of sexual communication, sexual selection and modes of speciation. The significance of acoustic signals for a blood-sucking insect was first reported in the XIX century by Christopher Johnston, studying the hear...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Vigoder Fde M,Ritchie MG,Gibson G,Peixoto AA

更新日期：2013-01-01 00:00:00

abstract：:The anesthetic effect of some water-soluble anesthesic or narcotic drugs currently used in mice was tested in molluscs of the Biomphalaria genus. Sodium thiopental was very toxic to the snails resulting in high rates of mortality in all the treatment schedules tested. Cetamine base, at concentration of 0.25 mg/ml of w...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Martins-Sousa R,Negrão-Corrêa D,Bezerra F,Coelho P

更新日期：2001-04-01 00:00:00