Abstract:
OBJECTIVES:To investigate the association of contrast-enhanced cone beam breast CT (CE-CBBCT) features, immunohistochemical (IHC) receptors, and molecular subtypes in breast cancer. METHODS:In this retrospective study, patients who underwent preoperative CE-CBBCT and received complete IHC results were analyzed. CE-CBBCT features were evaluated by two radiologists. Observer reproducibility and feature reliability were assessed. The association between CE-CBBCT features, IHC receptors, and molecular subtypes was analyzed using the chi-square, Mann-Whitney, and Kruskal-Wallis tests. Multivariate logistic regression was performed to assess the ability of combined imaging features to discriminate molecular subtypes. ROC curve was used to evaluate prediction performance. RESULTS:A total of 240 invasive cancers identified in 211 women were enrolled. Molecular subtypes of breast cancer were significantly associated with focality number of lesions, lesion type, tumor size, lesion density, internal enhancement pattern, degree of lesion enhancement (ΔHU), mass shape, spiculation, calcifications, calcification distribution, and increased peripheral vascularity of lesion (all p < 0.005), some of which also helped to differentiate IHC receptor status. A multivariate logistic regression model showed that tumor size (odds ratio, OR = 1.244), mass shape (OR = 0.311), spiculation (OR = 0.159), and internal enhancement pattern (OR = 0.227) were associated with differentiation between luminal and non-luminal subtypes (AUC = 0.809). Combined CE-CBBCT features, including lesion type (OR = 0.118), calcifications (OR = 0.181), and ΔHU (OR = 0.962), could be significant indicators of triple-negative versus HER-2-enriched subtypes (AUC = 0.913). CONCLUSIONS:CE-CBBCT features have the potential to help predict IHC receptor status and distinguish molecular subtypes of breast cancer, which could in turn help to develop individual treatment decisions and prognosis predictions. KEY POINTS:• A total of 11 CE-CBBCT features were associated with molecular subtypes, some of which also helped to differentiate IHC receptor status. • Tumor size, irregular mass shape, spiculation, and internal enhancement pattern could help identify luminal subtype. • Lesion type, calcification, and ΔHU could be significant indicators of HER-2- enriched versus triple-negative breast cancers.
journal_name
Eur Radioljournal_title
European radiologyauthors
Ma Y,Liu A,O'Connell AM,Zhu Y,Li H,Han P,Yin L,Lu H,Ye Zdoi
10.1007/s00330-020-07277-8subject
Has Abstractpub_date
2020-10-02 00:00:00eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07277-8pub_type
杂志文章abstract::The authors describe the discovery of ascending colonic variceal veins via celiomesenteric diagnostic angiography following a bout of melena in a 44-year-old woman. Magnetic resonance imaging, including phase-contrast MR venography, allowed visualization of the portal and systemic veins immediately after the initial a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003309900308
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abstract::Developmental nasal midline masses in children are rare lesions. Neuroimaging is essential to characterise these lesions, to determine the exact location of the lesion and most importantly to exclude a possible intracranial extension or connection. Our objective was to evaluate CT and MRI in the diagnosis of developme...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-2008-3
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abstract::A novel ultrasonic imaging method, wideband harmonic imaging, for nonlinear imaging of microbubble contrast agents is evaluated. In wideband harmonic mode, two pulses of alternate phase are send out. The image is then processed from the sum of both pulses, resulting in an image of nonlinear scatterers such as microbub...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/pl00014075
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abstract::The aim of this study was to assess the added diagnostic value of contrast-enhanced US (CEUS) combined with 64-row multidetector CT (CT) in the assessment of hepatocellular nodule vascularity in patients with liver cirrhosis. One hundred and six cirrhotic patients (68 male, 38 female; mean age +/- SD, 70 +/- 7 years) ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1179-3
更新日期:2009-03-01 00:00:00
abstract::Magnetic resonance imaging is currently the gold standard in the assessment of brain myelination. The normal pattern of brain myelination conforms to a fixed chronological sequence. Focal accelerated myelination is a usual pathological state and previously has only been associated with Sturge-Weber syndrome. The purpo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0044-x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To identify clinical prognostic and predictive factors in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) undergoing sorafenib plus transarterial chemoembolization (TACE) and establish a prognostic score for these patients. METHODS:Between January 2012 and December 2017, 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07078-z
更新日期:2021-01-01 00:00:00
abstract::This article presents a case of leiomyosarcomatosis with widespread lesions involving the soft tissues and the most unlikely organs such as thyroid and salivary glands, pancreas, ligamentum teres, bladder wall, and bones without lymph node or distant metastasis. The CT and US findings of this rare phenomenon are discu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050738
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To investigate whether the addition of nitroglycerine to transcatheter arterial (chemo)embolization (TAE/TACE) can increase the delivery and effectiveness of TAE/TACE in patients with hepatocellular carcinoma (HCC) by dual-energy CT. METHODS:HCC patients (BCLC stage A or B) were randomized to (n = 51) or no...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-012-2484-4
更新日期:2012-10-01 00:00:00
abstract::Incomplete inversion of the hippocampus, an imperfect fetal development, has been described in patients with epilepsy or severe midline malformations. We studied this condition in a nonepileptic population without obvious developmental anomalies. We analyzed the coronal MR images of 50 women and 50 men who did not hav...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0735-6
更新日期:2008-01-01 00:00:00
abstract:KEY POINTS:• Abbreviated MRI (AMRI) protocols consist of acquiring only a minimal number of MRI sequences for HCC surveillance with acceptable diagnostic performance compared to complete MRI.• AMRI protocol options include non-contrast AMRI, dynamic AMRI or hepatobiliary phase AMRI post gadoxetate injection.• The best ...
journal_title:European radiology
pub_type: 社论
doi:10.1007/s00330-020-06904-8
更新日期:2020-08-01 00:00:00
abstract::An electromagnetic-based tracking and navigation system was evaluated for interventional radiology. The electromagnetic tracking system (CAPPA IRAD EMT, CASinnovations, Erlangen, Germany) was used for real-time monitoring of punctures of the lumbar facet joints and intervertebral disks in a spine phantom, three pig ca...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1227-z
更新日期:2009-04-01 00:00:00
abstract::The potential relative beneficial aspects of upright, weight-bearing (pMRI), dynamic-kinetic (kMRI) spinal imaging over that of recumbent MRI (rMRI) include the revelation of occult spinal disease dependent on true axial loading, the unmasking of kinetic-dependent spinal disease and the ability to scan the patient in ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2666-4
更新日期:2005-09-01 00:00:00
abstract::Nonvariceal upper gastrointestinal bleeding (NUGB) remains a major medical problem even after advances in medical therapy with gastric acid suppression and cyclooxygenase (COX-2) inhibitors. Although the incidence of upper gastrointestinal bleeding presenting to the emergency room has slightly decreased, similar decre...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-006-0477-x
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to describe a new method to quickly estimate left atrial enlargement (LAE) on Computed Tomography. METHODS:Left atrial (LA) volume was assessed with a 3D-threshold Hounsfield unit detection technique, including left atrial appendage and excluding pulmonary venous confluence, in 2...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5041-3
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson's disease (PD) in patients at 3 Tesla. METHODS:Twenty-seven PD patients (17 men and 10 women; age range, 54-77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55-73 year...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3241-7
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:To assess the prognostic value of pre-therapeutic computed tomography (CT) attenuation of liver metastases for overall survival (OS) in metastatic colorectal cancer (mCRC). METHODS:In the open-label, randomised, prospective phase-III FIRE-3 trial, patients with histologically confirmed mCRC received fluorou...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-018-5454-7
更新日期:2018-12-01 00:00:00
abstract::The aim of this study was to evaluate MR imaging findings of the associated findings in surrounding tissues of the extra-articular soft tissue ganglion cysts around the knee. We retrospectively reviewed MR images of 30 patients who had surgically confirmed extra-articular soft tissue ganglion cysts around the knee wit...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1969-6
更新日期:2004-01-01 00:00:00
abstract::Because of the increasing incidence of primary central nervous system lymphoma (PCNSL), it is essential to recognize this disease in order to start appropriate treatment. We present the characteristic CT and MRI features of this tumour. The findings of 32 CT and 31 MR of 37 immunocompetent patients with biopsy-proved ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101037
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent. METHODS:CTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2919-6
更新日期:2013-11-01 00:00:00
abstract::We retrospectively reviewed surgical biopsy findings of lesions diagnosed as radial scars (RS) at stereotactic core-needle biopsy (SCNB). RS was diagnosed in 52 of 1415 (3.7%) consecutive mammographically detected lesions that underwent 14-gauge automated SCNB. Subsequent surgical biopsy findings were available for 43...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0196-3
更新日期:2006-08-01 00:00:00
abstract::The goal of this study was 3-month clinical outcome in nonanticoagulated patients with clinically suspected acute pulmonary embolism (PE) following a negative spiral CT. During a 6-month period 305 patients underwent spiral CT, of whom only 8 also had a lung scintigraphy. In patients with a final CT report read as not...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000539
更新日期:2001-01-01 00:00:00
abstract::Magnetic resonance angiography (MRA) has become an imaging modality which comprises various techniques based on two concepts: methods relying on the natural flow effects, the time-of-flight and phase-contrast technique, either in two- or three-dimensional acquisition mode, and the more recently developed contrast-enha...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050834
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To investigate the value of pre-treatment amide proton transfer-weighted (APTw) imaging for predicting survival of patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Pre-treatment APTw imaging was performed in 77 NPC patients and the mean, 90th percentile, skewness, and kurtosis of APT asymm...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06985-5
更新日期:2020-11-01 00:00:00
abstract::Aortic dissection is the most frequent cause of aortic emergency, and its outcome is still frequently fatal. The management of this pathology has changed with the development of endovascular means. Nowadays, imaging modalities are helpful in management decision-making by providing information such as identification of...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2441-y
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:This systematic review examines the agreement between assessed skeletal age by the Greulich and Pyle atlas (GP skeletal age) and chronological age. METHODS:We searched electronic databases until January 2017 for studies reporting GP skeletal age and confirmed chronological age in healthy individuals aged 10...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5718-2
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To investigate the prediction of 1-year survival (1-YS) in patients with metastatic colorectal cancer with use of a systematic comparative analysis of quantitative imaging biomarkers (QIBs) based on the geometric and radiomics analysis of whole liver tumor burden (WLTB) in comparison to predictions based on ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07192-y
更新日期:2021-02-01 00:00:00
abstract::Because of its sensitivity and high tissue contrast, magnetic resonance imaging (MRI) is the technique of choice for structural imaging in epilepsy. In this review the effect of using optimised scanning protocols and the use of high field MR systems on detection sensitivity is discussed. Also, the clinical relevance o...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0710-2
更新日期:2008-01-01 00:00:00
abstract::The development and progression of a hepatocellular carcinoma (HCC) in a chronically diseased liver, i.e., the carcinogenesis, comprise a multistep and long-term process. Morphologically, this process is associated with the presence of distinct nodular lesions in the liver that are called 'preneoplastic lesions.' Thes...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0602-5
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the association of relaxation-compensated chemical exchange saturation transfer (CEST) MRI with overall survival (OS) and progression-free survival (PFS) in newly diagnosed high-grade glioma (HGG) patients. METHODS:Twenty-six patients with newly diagnosed high-gr...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06066-2
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for the prediction of pathologic response to neoadjuvant chemotherapy (NAC) in locally advanced esophageal squamous cell carcinoma (ESCC). MATERIAL AND METHODS:Forty patients with locally advanced ESCC who were treated...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07248-z
更新日期:2020-09-08 00:00:00