Abstract:
OBJECTIVE:To explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for the prediction of pathologic response to neoadjuvant chemotherapy (NAC) in locally advanced esophageal squamous cell carcinoma (ESCC). MATERIAL AND METHODS:Forty patients with locally advanced ESCC who were treated with NAC followed by radical resection were prospectively enrolled from September 2015 to May 2018. MRI and IVIM were performed within 1 week before and 2-3 weeks after NAC, prior to surgery. Parameters including apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and pseudodiffusion fraction (f) before and after NAC were measured. Pathologic response was evaluated according to the AJCC tumor regression grade (TRG) system. The changes in IVIM values before and after therapy in different TRG groups were assessed. Receiver operating characteristic (ROC) curves analysis was used to determine the best cutoff value for predicting the pathologic response to NAC. RESULTS:Twenty-two patients were identified as TRG 2 (responders), and eighteen as TRG 3 (non-responders) in pathologic evaluation. The ADC, D, and f values increased significantly after NAC. The post-NAC D and ΔD values of responders were significantly higher than those of non-responders. The area under the curve (AUC) was 0.722 for post-NAC D and 0.859 for ΔD in predicting pathologic response. The cutoff values of post-NAC D and ΔD were 1.685 × 10-3 mm2/s and 0.350 × 10-3 mm2/s, respectively. CONCLUSION:IVIM-DWI may be used as an effective functional imaging technique to predict pathologic response to NAC in locally advanced ESCC. KEY POINTS:• The optimal cutoff values of post-NAC D and ΔD for predicting pathologic response to NAC in locally advanced ESCC were 1.685 × 10-3 mm2/s and 0.350 × 10-3 mm2/s, respectively. • Pathologic response to NAC in locally advanced ESCC was favorable in patients with post-NAC D and ΔD values that were higher than the optimal cutoff values. • IVIM-DWI can potentially be used to preoperatively predict pathologic response to NAC in esophageal carcinoma. Accurate quantification of the D value derived from IVIM-DWI may eventually translate into an effective and non-invasive marker to predict therapeutic efficacy.
journal_name
Eur Radioljournal_title
European radiologyauthors
Song T,Yao Q,Qu J,Zhang H,Zhao Y,Qin J,Feng W,Zhang S,Han X,Wang S,Yan X,Li Hdoi
10.1007/s00330-020-07248-zsubject
Has Abstractpub_date
2020-09-08 00:00:00eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07248-zpub_type
杂志文章abstract:OBJECTIVES:To (a) determine the diagnostic validity of axillary ultrasound (AUS) in pT1 tumours and whether fine-needle aspiration (FNA) improves its diagnostic performance, and (b) determine the negative predictive value (NPV) of AUS in a simulation environment (cutoff: two lymph nodes with macrometastases) in patient...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-015-3901-2
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To evaluate the epidemiology of systematic reviews (SRs) published in imaging journals. METHODS:A MEDLINE search identified SRs published in imaging journals from 1 January 2000-31 December 2016. Articles retrieved were screened against inclusion criteria. Demographic and methodological characteristics were ex...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5567-z
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:To investigate the diagnostic value of intravoxel incoherent motion (IVIM) DWI for placenta accreta by comparing diffusion and perfusion characteristics of placentas with accreta lesions (APs) with those of normal placentas (NPs). METHODS:Twenty-five pregnant women with AP and 24 with NP underwent 3-T magne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07200-1
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the feasibility and reproducibility of superb microvascular imaging (SMI) of the neonatal brain and to describe normal imaging features. METHODS:We performed transcranial ultrasound with SMI in 19 healthy term-born neonates. SMI was done according to a structured examination protocol, using two ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5743-1
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and diagnostic value of first-pass myocardial perfusion defects (PD) visualised by contrast-enhanced multidetector computed tomography (MDCT) in patients admitted for a first acute coronary syndrome (ACS). METHODS:Thirty-eight patients with non-ST segment elevation myocardial in...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-010-1725-7
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS:Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5049-8
更新日期:2018-03-01 00:00:00
abstract::Primary misplaced or secondary flipped implanted catheters are located mostly in the right jugular vein. We demonstrate an effective method to replace fix implanted catheters such as Ports, Grochomg or Hickman catheters. Using a femoral venous approach, replacement into the superior vena cava can easily be done with a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1151-y
更新日期:2002-03-01 00:00:00
abstract::The safety of the non-ionic contrast medium iopentol (Imagopaque, Nycomed Imaging AS, Oslo, Norway) when used in cerebral angiography and aortic arch angiography, was the focus of this investigation. Overall quality of visualization and changes in heart rate and blood pressure were, however, also assessed. In total, 3...
journal_title:European radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/pl00006884
更新日期:1997-01-01 00:00:00
abstract::Preoperative MRI of the breasts has been proven to be the most sensitive imaging modality in the detection of multifocal or multicentric tumor manifestations as well as simultaneous contralateral breast cancer. The aim of the presented retrospective study was to evaluate the benefit of preoperative MRI for patients wi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2351-z
更新日期:2004-10-01 00:00:00
abstract::Whole-body MRI (WB-MRI) has been successfully applied for oncologic and cardiovascular diagnostics, whereas imaging in myopathies usually employs dedicated protocols restricted to areas of specific interest. In this study, we propose a comprehensive neuromuscular WB-MRI protocol. Eighteen patients with degenerative an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1071-1
更新日期:2008-12-01 00:00:00
abstract::A case of a surgically confirmed cystic lymphangioma of the spleen is presented. Preoperative imaging consisted of US, contrast-enhanced CT and MRI, all showing a multiloculated lesion with small cystic cavities divided by thin septa, corresponding to dilated lymphatic spaces. Preoperative studies correlated well with...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000738
更新日期:2001-01-01 00:00:00
abstract::Triage decisions in patients suffering from acute chest pain remain a challenge. The patient's history, initial cardiac enzyme levels, or initial electrocardiograms (ECG) often do not allow selecting the patients in whom further tests are needed. Numerous vascular and non-vascular chest problems, such as pulmonary emb...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-008-1231-3
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To develop a non-invasive MRI method for evaluation of liver fibrosis, with histological analysis as the reference standard. METHODS:The study protocol was approved by the Institutional Review Board for Human Studies of our hospital, and written informed consent was obtained from all subjects. Seventy-nine ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2249-5
更新日期:2012-01-01 00:00:00
abstract::The purpose of this prospective study was to measure lung attenuation at paired HRCT obtained at full inspiratory/expiratory position, to correlate with pulmonary function tests (PFTs) and to characterize different types of ventilatory impairment. One hundred fifty-five patients with and without pulmonary disease unde...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1514-z
更新日期:2002-11-01 00:00:00
abstract::Bilioma is a rare complication of traumatic liver injury, and the precise site of bile leak is often difficult to demonstrate with a non-invasive technique. We report a case of post-traumatic bile leak in a 15-year-old girl in whom spiral CT after intravenous cholangiography allowed excellent preoperative demonstratio...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050637
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To identify which breast lesion descriptors in the ACR BI-RADS® MRI lexicon are most strongly associated with the diagnosis of breast cancer when performing breast MR imaging at 3 T. METHODS:150 patients underwent breast MR imaging at 3 T. Lesion size, morphology and enhancement kinetics were assessed accord...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2256-6
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of core-needle biopsy (CNB) by comparing the results of CNB and repeated fine-needle aspiration (FNA) for thyroid nodules with initially non-diagnostic FNA results. METHODS:From October 2008 to December 2011, 360 nodules - 180 consecutive repeated FNAs and 180 consecutive CNBs -- from 36...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3325-4
更新日期:2014-11-01 00:00:00
abstract::The prevalence of benign focal liver lesions (BFLL) is high both in the general population and in patients with known malignancies. The gray-scale ultrasound (US) technique is usually the first-line imaging modality used in the radiological workup of such lesions, but unfortunately it lacks specificity. Furthermore, D...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2668-2
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To demonstrate the non-inferiority of synthetic image (SI) mammography versus full-field digital mammography (FFDM) in breast tomosynthesis (DBT) examinations. METHODS:An observational, retrospective, single-centre, multireader blinded study was performed, using 2384 images to directly compare SI and FFDM ba...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-017-4991-9
更新日期:2018-02-01 00:00:00
abstract::The use of Power Doppler sonography in nodal diseases provides an improvement of early and noninvasive diagnosis of regional metastatic involvement. By using Power Doppler sonography it is possible to characterize lymph nodes as reactively enlarged, metastases, malignant lymphoma, tuberculosis and to study cervical cy...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101111
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:To investigate the feasibility of a newly developed noise reduction technique at coronary CT angiography (CTA) that uses multi-phase data-averaging and non-rigid image registration. METHODS:Sixty-five patients underwent coronary CTA with prospective ECG-triggering. The range of the phase window was set at 7...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3381-9
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To identify clinical prognostic and predictive factors in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) undergoing sorafenib plus transarterial chemoembolization (TACE) and establish a prognostic score for these patients. METHODS:Between January 2012 and December 2017, 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07078-z
更新日期:2021-01-01 00:00:00
abstract::In a controlled patient study we investigated the potential of attenuation-based on-line modulation of the tube current to reduce milliampere values (mAs) in CT examinations of children without loss of image quality. mAs can be reduced for non-circular patient cross sections without an increase in noise if tube curren...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1255-4
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. METHODS:Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = ...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-015-3973-z
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:Juvenile localized scleroderma (JLS) is a rare chronic autoimmune disease which can also affect bones and muscles. Nevertheless, muscle loss was not previously investigated in patients with JLS. Thus, the aim of this study was to retrospectively evaluate deep involvement and assess and quantify sarcopenia in...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06764-2
更新日期:2020-07-01 00:00:00
abstract::To assess the immediate efficacy of percutaneous vertebroplasty (PVP) in relief of pain and improving mobility of patients with vertebral compression fractures (VCF) secondary to osteoporosis, 205 cases (175 patients) underwent 250 percutaneous injections of polymethylmethacrylate (PMMA; unilateral, 247 levels; bilate...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2549-0
更新日期:2005-02-01 00:00:00
abstract::Spontaneous and isolated dissection of the superior mesenteric artery is a rare and often fatal event which has been successfully treated by surgery in several reported cases. We present a patient with acute mesenteric ischemia due to superior mesenteric artery dissection who was successfully treated by percutaneous e...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000520
更新日期:2000-01-01 00:00:00
abstract::Over the past decade, significant advances have been made in the field of subarachnoid haemorrhage (SAH). Prompt diagnosis with high-resolution CT and intensive critical care support remain key aspects of good patient management. Early identification and definitive treatment of underlying ruptured aneurysms is general...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-005-2665-5
更新日期:2005-06-01 00:00:00
abstract::An electromagnetic-based tracking and navigation system was evaluated for interventional radiology. The electromagnetic tracking system (CAPPA IRAD EMT, CASinnovations, Erlangen, Germany) was used for real-time monitoring of punctures of the lumbar facet joints and intervertebral disks in a spine phantom, three pig ca...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1227-z
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To develop a fully automated AI system to quantitatively assess the disease severity and disease progression of COVID-19 using thick-section chest CT images. METHODS:In this retrospective study, an AI system was developed to automatically segment and quantify the COVID-19-infected lung regions on thick-secti...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07042-x
更新日期:2020-12-01 00:00:00