Abstract:
OBJECTIVES:To identify clinical prognostic and predictive factors in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) undergoing sorafenib plus transarterial chemoembolization (TACE) and establish a prognostic score for these patients. METHODS:Between January 2012 and December 2017, 184 consecutive patients with HCC and PVTT were concurrently treated with sorafenib and TACE. Univariate and multivariate analyses were performed to explore the clinical factors independently correlated with overall survival (OS). A prognostic score was then developed to identify different prognoses in an initial cohort and validated in an external cohort (n = 72). RESULTS:In the multivariate analysis, performance status, extension of PVTT, initial radiological response, and sorafenib-related dermatologic toxicity were identified as predictors associated with OS. These factors were used to develop a prognostic score (PPRD score, range from 0 to 11). The median survival was found to decrease as the PPRD score increased, and patients were stratified into a favorable group (0 points), intermediate group (1-4 points), and dismal group (> 4 points). The median survival of patients in the three groups was 34.0 months, 20.0 months, and 7.0 months, respectively (p < 0.001). Additionally, the time to progression (TTP) (p < 0.001) was stratified along the same prognostic groups. The external validation cohort confirmed the prognostic scores. CONCLUSIONS:The proposed score system can accurately stratify the outcomes of patients with HCC and PVTT treated with sorafenib plus TACE to help identify which group of patients may benefit from treatment. KEY POINTS:• The survival benefits of patients with advanced HCC treated with sorafenib plus TACE remains controversial. • The independent factors associated with survival were identified to develop a prognostic score, called the PPRD score (standing for performance status, PVTT grade, radiological response, and sorafenib-related dermatologic toxicity); the median survival decreases as the score increases. • The scoring system can accurately stratify the survival benefits of patients with HCC and PVTT treated with combination therapy and help to identify which group of patients may benefit from the treatment. Graphical abstract.
journal_name
Eur Radioljournal_title
European radiologyauthors
Zhang Y,Miao H,Xie W,Jiang S,Song Z,Huang G,Fan W,Wang Y,Li J,Chen Ydoi
10.1007/s00330-020-07078-zsubject
Has Abstractpub_date
2021-01-01 00:00:00pages
232-243issue
1eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07078-zjournal_volume
31pub_type
杂志文章abstract::Magnetic resonance colpocystorectography (MR-CCRG) is presented in the evaluation of patients with pelvic-floor disorders. Five healthy volunteers and 44 female patients with isolated or combined visceral descent underwent dynamic MRI and dynamic fluoroscopy (DF). MR-CCRG was performed with the patient in a supine pos...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050294
更新日期:1997-01-01 00:00:00
abstract:UNLABELLED:This paper summarizes information about breast MRI to be provided to women and referring physicians. After listing contraindications, procedure details are described, stressing the need for correct scheduling and not moving during the examination. The structured report including BI-RADS® categories and furth...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-015-3807-z
更新日期:2015-12-01 00:00:00
abstract::Testicular microlithiasis (TM) is an uncommon condition characterized by calcium deposits within the seminiferous tubules. On ultrasound (US), it is seen as multiple, uniform, nonshadowing echogenic foci in the testis. Although its true prevalence in the general population is still unknown, reported prevalences range ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-2014-5
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:Fractional flow reserve computed tomography (FFRCT) depends upon nitroglycerin (NTG) inducing maximal hyperemia. However, the impact of NTG dosages on FFRCT analysis including coronary volume-to-mass ratio (V/M) is unknown. METHODS:Eighty patients with repeat coronary CT angiograms (CCTAs) with different su...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06293-7
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether a four-phasic CM administration protocol reduces the risk of extravasation compared to the routinely used three-phasic protocol in coronary CTA. METHODS:Pa...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-017-4866-0
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To investigate the value of pre-treatment amide proton transfer-weighted (APTw) imaging for predicting survival of patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Pre-treatment APTw imaging was performed in 77 NPC patients and the mean, 90th percentile, skewness, and kurtosis of APT asymm...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06985-5
更新日期:2020-11-01 00:00:00
abstract::Diffusion MRI has mainly been used for detection of acute ischemia, and for distinction of cytotoxic and vasogenic edema. We applied diffusion MRI in patients with tuberous sclerosis in order to evaluate diffusion imaging characteristics of parenchymal changes. Five children with known tuberous sclerosis were included...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101029
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To retrospectively evaluate the feasibility of CT assessment-based direct surgical resection of part-solid nodules (PSNs) with solid components > 5 mm without preoperative percutaneous transthoracic needle biopsies (PTNBs). METHODS:From January 2009-December 2014, 85 PSNs with solid components > 5 mm on CT ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4917-6
更新日期:2017-12-01 00:00:00
abstract::Diffusion-weighted imaging allows for measurement of tissue microstructure and reflects the random motion of water protons. It provides a new method to study bone marrow and bone marrow alterations on the basis of altered water-proton mobility in various diseases. Different diffusion-weighted methods have proved to be...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-1873-0
更新日期:2003-07-01 00:00:00
abstract::Our objective was to study Gd-EOB-DTPA for the characterization of focal liver lesions by means of dynamic MR imaging. A double-blind and randomized dose-ranging phase-2 clinical trial was performed in 31 patients (liver metastases n = 23, hepatocellular carcinoma n = 4, and hemangioma n = 4) at a field strength of 1....
journal_title:European radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003300050150
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To compare two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) measurements of ablation zones (AZs) related to the shaft of two different large-volume monopolar multi-tined expandable electrodes. METHODS:Percutaneous radiofrequency (RF) ablation was performed in 12 pigs (81.6 +/- 7.8 kg...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1639-4
更新日期:2010-05-01 00:00:00
abstract::The purpose was to provide a diffusion-weighted whole-body magnetic resonance (MR) imaging sequence with background body signal suppression (DWIBS) at 3.0 Tesla. A diffusion-weighted spin-echo echo-planar imaging sequence was combined with the following methods of fat suppression: short TI inversion recovery (STIR), s...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0717-8
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To investigate the impact of an adaptive statistical iterative reconstruction (ASiR) algorithm on diagnostic accuracy and confidence for the diagnosis of hypervascular liver tumours, as well as the reader's perception of image quality, using a low tube voltage (80 kVp), high tube current computed tomography ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2964-1
更新日期:2013-12-01 00:00:00
abstract::In acute nonvariceal gastrointestinal (GI) bleeding, immediate arteriographic haemostasis is presently assumed to be a therapeutic advantage. This study assesses whether the risk of a delayed haemostasis, caused by arteriographic findings precluding embolization, might influence patient outcome. We performed a 5.5-yea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1882-z
更新日期:2003-12-01 00:00:00
abstract::The purpose of the present study was to evaluate the usefulness of a new gray-scale test pattern (NGTP) that was developed to easily adjust the gradients of thoracic CT imaging and enable visual consistency. The Society of Motion Picture and Television Engineers (SMPTE) pattern and the NGTP were used for comparison. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2315-3
更新日期:2004-12-01 00:00:00
abstract::Computed tomography with rectal air insufflation was compared with transrectal ultrasonography (TRUS) in 63 patients. The CT protocol involved pre- and postcontrast scans with 5 mm slice thickness following air insufflation in IV antiperistaltic agent. Of the patients, 79 % were scanned in the prone position. Results ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050102
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Evaluate the ability of MR diffusion-weighted imaging (DWI) to predict patency capsule retention in Crohn's disease (CD). METHODS:Clinical and imaging data were prospectively reviewed for 80 CD patients following patency capsule administration and MR-DWI under institutional review board (IRB) approval with ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4857-1
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS:EOB-enhanced MR images of 19 patients with CoCC,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4811-2
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging sequence (DW-SS-EPI) and to evaluate whether ADC measurements can be used to characterize lesions. One hundred and two patie...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0785-9
更新日期:2008-03-01 00:00:00
abstract::Digitization of medicine requires systematic handling of the increasing amount of health data to improve medical diagnosis. In this context, the integration of the versatile diagnostic information, e.g., from anamnesis, imaging, histopathology, and clinical chemistry, and its comprehensive analysis by artificial intel...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06874-x
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects. METHODS:Data used in the preparation of this article were obtained...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5147-7
更新日期:2018-04-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07241-6
更新日期:2020-09-28 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050738
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to examine whether visual MRI rating scales used in diagnostics of cognitive disorders can be estimated computationally and to compare the visual rating scales with their computed counterparts in differential diagnostics. METHODS:A set of volumetry and voxel-based morphometry ima...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06067-1
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To study the effect of inspiration on airway dimensions measured in voluntary inspiration breath-hold examinations. METHODS:961 subjects with normal spirometry were selected from the Danish Lung Cancer Screening Trial. Subjects were examined annually for five years with low-dose CT. Automated software was u...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-014-3261-3
更新日期:2014-09-01 00:00:00
abstract::The arrival of new surgical transplantation techniques, such as split living donor or auxiliary liver transplantation, have increased the incidence of vascular and biliary complications. The causes, symptoms, and diagnostic modalities of arterial, portal caval, and biliary complications are detailed. Interventional te...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-2196-x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for detecting primary tumour, nodal and distant metastases in pregnant women with cancer. METHODS:Twenty pregnant patients underwent WB-DWI/MRI in additional to conventional imaging. Reproducibility of WB-DWI/MRI between two reade...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5126-z
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the frequency of diagnosis of high-risk lesions at MRI-guided vacuum-assisted breast biopsy (MRgVABB) and to determine whether underestimation may be predicted. METHODS:Retrospective review of the medical records of 161 patients who underwent MRgVABB was performed. The underestimation rate was d...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1949-6
更新日期:2011-03-01 00:00:00
abstract::Methods of imaging and intervention in acute non-traumatic vascular arterial conditions has changed substantially during recent years. Computed tomography, MRI angiography and, more recently, intravascular ultrasonography (IVUS) have replaced to a large extent conventional diagnostic angiography. An increasing number ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1526-8
更新日期:2002-11-01 00:00:00
abstract::To evaluate long-term effects of arterial embolization (AE) for postpartum hemorrhage (PPH) on menses recovery and subsequent pregnancies. One hundred thirteen consecutive patients, recruited from 1999 to 2006, who had undergone AE for severe PPH were evaluated in a retrospective monocentric study. As embolization age...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1140-5
更新日期:2009-02-01 00:00:00